<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Nita Triadisti</style></author><author><style face="normal" font="default" size="100%">Rani Sauriasari</style></author><author><style face="normal" font="default" size="100%">Berna Elya</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Antioxidant Activity of Fractions from Garcinia hombroniana Pierre Leaves Extracts</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Column chromatography</style></keyword><keyword><style  face="normal" font="default" size="100%">Free Radicals</style></keyword><keyword><style  face="normal" font="default" size="100%">Spectrophotometric thin layer chromatography</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2018</style></year><pub-dates><date><style  face="normal" font="default" size="100%">June 2018</style></date></pub-dates></dates><urls><web-urls><url><style face="normal" font="default" size="100%">http://fulltxt.org/article/650</style></url></web-urls></urls><volume><style face="normal" font="default" size="100%">10</style></volume><pages><style face="normal" font="default" size="100%">682-685</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Introduction:&lt;/strong&gt; Radicals were compounds that generated in normal metabolism and create cell damage. A significant increase of free radical and decreased radical elimination can lead to oxidative stress. Oxidative stress plays an important role in the development of many diseases. Enhanced supply of antioxidants will help prevent the morbidity of many diseases. &lt;em&gt;Garcinia hombroniana&lt;/em&gt; Pierre has potency as an antioxidant, but study to evaluate the active fractions as an antioxidant has not been done. &lt;strong&gt;Objective:&lt;/strong&gt; The objective of the study was to evaluate antioxidant activity of fractions separated from ethyl acetate (EtOAc) and methanol (MeOH) extract of &lt;em&gt;Garcinia hombroniana&lt;/em&gt; leaves and to obtain active fractions to facilitate finding a pure antioxidant compound. &lt;strong&gt;Methods:&lt;/strong&gt; The extract was fractionated using column chromatography, while antioxidant activity assay was conducted &lt;em&gt;in vitro&lt;/em&gt; using spectrophotometric methods with DPPH and FRAP method. &lt;strong&gt;Results:&lt;/strong&gt; EtOAc extract of &lt;em&gt;G. hombroniana&lt;/em&gt; leaves yielded EA-8 with radical scavenging percentage 32.67% (10 ppm, with DPPH method) and EA-11 with antioxidant activity percentage 25.73% (10 ppm, with FRAP method) as the most active fraction from EtOAc extract, while MeOH extract yielded M-3 with radical scavenging percentage 37.42% (10 ppm, with DPPH method) and 26.70% (10 ppm, with FRAP method) as the most active fraction from MeOH extract &lt;strong&gt;Conclusion:&lt;/strong&gt; Most active fractions has good antioxidant activity, worthy for further study to isolate antioxidant compound which is responsible for antioxidant activity. However, the percentage of radical scavenging or antioxidant activity of all active fractions were smaller than quercetin as a positive control.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">4</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">682</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Nita Triadisti&lt;sup&gt;1,2&lt;/sup&gt;*, Rani Sauriasari&lt;sup&gt;1&lt;/sup&gt;, Berna Elya&lt;sup&gt;1&lt;/sup&gt;* &lt;/strong&gt;&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Faculty of Pharmacy, Universitas Indonesia 16424, Depok, INDONESIA.&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Faculty of Pharmacy, Universitas Muhammadiyah Banjarmasin, 70114, Banjarmasin, INDONESIA.&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Nita Triadisti</style></author><author><style face="normal" font="default" size="100%">Rani Sauriasari</style></author><author><style face="normal" font="default" size="100%">Berna Elya</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Fractionation and α-glucosidase Inhibitory Activity of Fractions from Garcinia hombroniana Pierre Leaves Extracts</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Column chromatography</style></keyword><keyword><style  face="normal" font="default" size="100%">Diabetes mellitus</style></keyword><keyword><style  face="normal" font="default" size="100%">Fractionation</style></keyword><keyword><style  face="normal" font="default" size="100%">Thin layer Chromatography</style></keyword><keyword><style  face="normal" font="default" size="100%">α-glucosidase</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2017</style></year><pub-dates><date><style  face="normal" font="default" size="100%">May 2017</style></date></pub-dates></dates><urls><web-urls><url><style face="normal" font="default" size="100%">/files/PJ-9-4/10.5530pj.2017.4.79</style></url></web-urls></urls><volume><style face="normal" font="default" size="100%">9</style></volume><pages><style face="normal" font="default" size="100%">488-492</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Background:&lt;/strong&gt; Diabetes mellitus become one of the biggest global health problems of the 21st century. Type 2 diabetes play role for the majority of cases of diabetes worldwide which is characterized by the increase of postprandial blood glucose level. Maintaining postprandial glucose level through inhibition of &amp;alpha;-glucosidase is one of the essential strategies in the treatment of diabetes. Inhibitory effect of &amp;alpha;-glucosidase was commonly used to identify active compounds potentially to treat diabetes. Natural resources have potency as antidiabetic that can be used in diabetes treatment. &lt;strong&gt;Objective:&lt;/strong&gt; The objective of the study is to separate active fraction in the crude extract of &lt;em&gt;Garcinia hombroniana&lt;/em&gt; leaves to facilitate obtaining a pure biologically active compound as the &amp;alpha;-glucosidase inhibitor. &lt;strong&gt;Methods:&lt;/strong&gt; Fractionation to separate active fraction was performed using column and thin layer chromatography methods while &amp;alpha;-glucosidase inhibitory activity assay was performed i&lt;em&gt;n vitro&lt;/em&gt; using spectrophotometric methods at &amp;lambda; 400 nm. &lt;strong&gt;Results:&lt;/strong&gt; Ethyl acetate and methanol extract of &lt;em&gt;G. hombroniana&lt;/em&gt; yielded 14 and 12 fractions, respectively. Two fractions with the higher percent inhibition compared to other factions are fraction 8 from ethyl acetate extract (FEA8) and fraction 3 from methanol extract (FM3). The IC&lt;sub&gt;50&lt;/sub&gt; values of FEA8, FM3 and acarbose are 16.370 &amp;mu;g/mL, 59.042 &amp;mu;g/mL, and 39.534 &amp;mu;g/mL respectively. &lt;strong&gt;Conclusion:&lt;/strong&gt; Fraction 8 from ethyl acetate extract of &lt;em&gt;G. hombroniana&lt;/em&gt; leaves (FEA8) was separated and known in this study as the most bioactive &amp;alpha;-glucosidase inhibitor agent compared with another extract, fractions, and acarbose.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">4</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">488</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Nita Triadisti&lt;sup&gt;*&lt;/sup&gt;, Rani Sauriasari, Berna Elya&lt;sup&gt;* &lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;em&gt;Faculty of Pharmacy, University of Indonesia, 16424, Depok, INDONESIA.&lt;/em&gt;&lt;/p&gt;</style></auth-address></record></records></xml>