<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Suresh Kumar Karri</style></author><author><style face="normal" font="default" size="100%">Angappan Sheela</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Comparative in vitro Antidiabetic and Immunomodulatory Evaluation of Standardized Five Select Medicinal Herbs and Spectral Analysis of Boerhavia erecta L. (Nyctaginaceae)</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Cytotoxicity</style></keyword><keyword><style  face="normal" font="default" size="100%">NBT assay</style></keyword><keyword><style  face="normal" font="default" size="100%">Nitric oxide</style></keyword><keyword><style  face="normal" font="default" size="100%">Pharmacognostic</style></keyword><keyword><style  face="normal" font="default" size="100%">Phytochemical</style></keyword><keyword><style  face="normal" font="default" size="100%">Quality control</style></keyword><keyword><style  face="normal" font="default" size="100%">TNF -α</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2017</style></year><pub-dates><date><style  face="normal" font="default" size="100%">April 2017 </style></date></pub-dates></dates><urls><web-urls><url><style face="normal" font="default" size="100%">/files/PJ-9-3/10.5530pj.2017.3.57</style></url></web-urls></urls><volume><style face="normal" font="default" size="100%">9</style></volume><pages><style face="normal" font="default" size="100%">336-344</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Aim:&lt;/strong&gt; The present work compares standardized hydro-alcoholic extracts of root and stem parts of &lt;em&gt;Boerhavia erecta L.&lt;/em&gt; (&lt;em&gt;Nyctaginaceae&lt;/em&gt;), l&lt;em&gt;eaves of Plumeria acuminate&lt;/em&gt; R. Br. (Apocyanaceae), rhizomes of &lt;em&gt;Alpinia galanga&lt;/em&gt; Sw. (&lt;em&gt;Zingiberaceae&lt;/em&gt;), whole plant of &lt;em&gt;Picrorhiza kurroa&lt;/em&gt; Royle ex Benth. (Plantaginaceae), fruits of Trapa natans L. (Trapaceae) for their &lt;em&gt;in vitro&lt;/em&gt; antidiabetic and immunomodulatory activities, commonly used by the Trichigadi tribes (Kotas) of south India for various inflammatory disorders. &lt;strong&gt;Materials and Methods:&lt;/strong&gt; Antidiabetic activity of these herbal extracts was assessed through inhibition of glycosylation of hemoglobin and glucose uptake in yeast cells methods at 50, 100 and 200 &amp;mu;g/mL for 72 h. Their respective immunomodulatory activities were evaluated through preservation of heat and hypotonic induced hemolysis, nitroblue terazolium assay and by inhibition of TNF-&amp;alpha; and nitric oxide (NO) production in RAW cell lines. &lt;strong&gt;Results:&lt;/strong&gt; B. erecta has shown least cytotoxicity (CTC&lt;sub&gt;50&lt;/sub&gt; 15.7%) and highest % inhibition of TNF-&amp;alpha; (58.1) and NO (45.6), statistically significant (p&amp;lt;0.01) to that of normal control. Also, B. erecta (BE), and P. acuminate (PA) exhibited relatively better IC50 values for TNF-&amp;alpha; and NO at a concentration less than their respective CTC&lt;sub&gt;50&lt;/sub&gt; values. &lt;strong&gt;Conclusions&lt;/strong&gt;: Spectral analysis of chloroform fraction of BE hydro-alcoholic extract established the presence of biologically active molecule in it. Root and stem parts of BE extract not only proved to be safe but also demonstrated relatively better efficacy than other established medicinal herbs in selected immune models, may be due to flavonoids or phenolic groups. Further &lt;em&gt;in vivo&lt;/em&gt; studies on active molecule of BE towards antidiabetic and immunomodulatory activity are warranted.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">336</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Suresh Kumar Karri, Angappan Sheela* &lt;/strong&gt;&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;Department of Chemistry, School of Advanced Sciences, VIT University, Vellore 632014, Tamil Nadu, INDIA.&lt;/p&gt;</style></auth-address></record></records></xml>