<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Ica Yulianti Pulungan</style></author><author><style face="normal" font="default" size="100%">Ermi Girsang</style></author><author><style face="normal" font="default" size="100%">Ermi Girsang</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Protective Role of Centella asiatica Extract Against Carbon Tetrachloride–Induced Hepatic Damage: A Biochemical and Ultrasonographic Study</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Anti-inflammatory</style></keyword><keyword><style  face="normal" font="default" size="100%">Antioxidant</style></keyword><keyword><style  face="normal" font="default" size="100%">Centella asiatica</style></keyword><keyword><style  face="normal" font="default" size="100%">Cytokines</style></keyword><keyword><style  face="normal" font="default" size="100%">Hepatoprotective</style></keyword><keyword><style  face="normal" font="default" size="100%">Ultrasonography</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2025</style></year><pub-dates><date><style  face="normal" font="default" size="100%">December 2025</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">17</style></volume><pages><style face="normal" font="default" size="100%">760-769</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;This study aimed to evaluate the hepatoprotective activity of &lt;em&gt;Centella asiatica&lt;/em&gt; extract on Wistar rats induced with carbon tetrachloride (CCl&lt;sub&gt;₄&lt;/sub&gt;). The extract is known to contain active compounds such as flavonoids, phenolics, and triterpenoids, which contribute to its antioxidant and anti-inflammatory effects. The total phenolic and flavonoid contents were 70.31 mg GAE/g and 13.49 mg QE/g, respectively, with very strong antioxidant activity (IC&lt;sub&gt;₅₀&lt;/sub&gt; = 48.45 ppm). Evaluation through ultrasonography and histopathology revealed structural improvement in the liver of treated groups, particularly at doses of 200 and 300 mg/ kgBW, marked by reduced abnormal echogenicity and improved liver parenchyma, along with a decrease in histopathological score from 2 to 1. The administration of the extract also significantly reduced proinflammatory cytokines TNF-α and IL-6 (P≤0.05), as well as CRP levels, indicating strong anti-inflammatory potential. In addition, liver function showed meaningful recovery, with the highest albumin level recorded at 200 mg/kgBW (3.00 ± 0.52 g/dL), and a significant reduction in bilirubin level at 300 mg/kgBW to 0.102 ± 0.040 mg/dL. Significant decreases were also observed in SGOT and SGPT enzyme levels in the treatment groups, especially at 300 mg/kgBW, indicating protection of hepatocyte integrity. In conclusion, this study demonstrated that Centella asiatica extract possesses hepatoprotective effects through antiinflammatory, antioxidant, and liver function-restorative mechanisms. These findings support the potential development of pegagan as a phytopharmaceutical agent for adjunct therapy in liver disorders and highlight the need for further studies on its active compounds and long-term safety.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">760</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Ica Yulianti Pulungan&lt;sup&gt;1*&lt;/sup&gt;, Ermi Girsang&lt;sup&gt;2&lt;/sup&gt;, Yolanda Eliza Putri Lubis&lt;sup&gt;3&lt;/sup&gt; &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Doctoral Program, Faculty of Medicine, Dentistry, and Health Science, Universitas Prima Indonesia, Medan 20118, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Biochemistry and Molecular Biology, Faculty of Medicine, Dentistry, and Health Science, Universitas Prima Indonesia, Universitas Prima Indonesia, Medan 20118, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Public Health and Preventive Medicine, Faculty of Medicine, Dentistry, and Health Science, Universitas Prima Indonesia, Universitas Prima Indonesia, Medan 20118, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Inda Kania Meilani</style></author><author><style face="normal" font="default" size="100%">Ermi Girsang</style></author><author><style face="normal" font="default" size="100%">Yolanda Eliza Putri Lubis</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Ultrasonographic and Biochemical Evaluation of the Hepatoprotective Effect of Cinnamomum burmannii Bark Extract in Carbon Tetrachloride–Induced Liver Injury</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Anti-inflammatory</style></keyword><keyword><style  face="normal" font="default" size="100%">Antioxidant</style></keyword><keyword><style  face="normal" font="default" size="100%">Cinnamon</style></keyword><keyword><style  face="normal" font="default" size="100%">Cytokine</style></keyword><keyword><style  face="normal" font="default" size="100%">Hepatoprotective</style></keyword><keyword><style  face="normal" font="default" size="100%">Histopathology</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2025</style></year><pub-dates><date><style  face="normal" font="default" size="100%">December 2025</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">17</style></volume><pages><style face="normal" font="default" size="100%">751-759</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;This study aimed to evaluate the hepatoprotective activity of ethanolic extract of cinnamon (&lt;em&gt;Cinnamomum burmannii&lt;/em&gt;) in male Wistar rats induced with carbon tetrachloride (CCl&lt;sub&gt;₄&lt;/sub&gt;). Cinnamon extract is known to contain bioactive compounds such as flavonoids and polyphenols, which play significant roles in antioxidant and anti-inflammatory mechanisms. Phytochemical analysis revealed that the extract contained total phenolic content of 71.55 mg GAE/g and flavonoid content of 0.41 mg QE/g, with a potent antioxidant activity indicated by an IC&lt;sub&gt;₅₀&lt;/sub&gt; value of 18.19 ppm. Administration of the extract for 28 days at a dose of 300 mg/kg body weight resulted in a significant reduction (P&amp;lt;0.05) in pro-inflammatory cytokines TNF-α, IL-6, and CRP levels compared to the negative control group. The 300 mg/kg dose showed the highest efficacy, with TNF-α levels approaching those of the normal group. Furthermore, liver function parameters improved, as evidenced by significant reductions in SGOT and SGPT enzyme levels, an increase in serum albumin (2.96 ± 0.52 g/dL), and a decrease in serum bilirubin to 0.102 ± 0.040 mg/dL. Ultrasonographic examination showed improved liver parenchymal homogeneity and a reduction in the number of nodules. Histopathological findings revealed a decrease in liver tissue damage score from moderate to mild. These findings suggest that &lt;em&gt;Cinnamomum burmannii&lt;/em&gt; extract has potential hepatoprotective effects through antiinflammatory, antioxidant, and hepatocellular recovery mechanisms. Therefore, this extract holds promise as a phytopharmaceutical candidate for complementary therapy in liver function disorders; however, further studies are required to isolate the active compounds and evaluate long-term toxicity.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">751</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Inda Kania Meilani&lt;sup&gt;1*&lt;/sup&gt;, Ermi Girsang&lt;sup&gt;2&lt;/sup&gt;, Yolanda Eliza Putri Lubis&lt;sup&gt;3&lt;/sup&gt; &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Doctoral Program, Faculty of Medicine, Dentistry, and Health Science, Universitas Prima Indonesia, Medan 20118, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Biochemistry and Molecular Biology, Faculty of Medicine, Dentistry, and Health Science, Universitas Prima Indonesia, Universitas Prima Indonesia, Medan 20118, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Public Health and Preventive Medicine, Faculty of Medicine, Dentistry, and Health Science, Universitas Prima Indonesia, Universitas Prima Indonesia, Medan 20118, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Geetha Balasubramaniam</style></author><author><style face="normal" font="default" size="100%">Mahendran Sekar</style></author><author><style face="normal" font="default" size="100%">Maithili Varadarajan</style></author><author><style face="normal" font="default" size="100%">Shrishailappa Badami</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Antioxidant and Hepatoprotective Activities of Strobilanthes kunthianus against Carbon Tetrachloride-Induced Hepatotoxicity in Rats</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Antioxidant</style></keyword><keyword><style  face="normal" font="default" size="100%">Carbon tetrachloride</style></keyword><keyword><style  face="normal" font="default" size="100%">Hepatoprotective</style></keyword><keyword><style  face="normal" font="default" size="100%">Hepatotoxicity</style></keyword><keyword><style  face="normal" font="default" size="100%">Liver disease</style></keyword><keyword><style  face="normal" font="default" size="100%">Strobilanthes kunthianus</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2020</style></year><pub-dates><date><style  face="normal" font="default" size="100%">August 2020</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">12</style></volume><pages><style face="normal" font="default" size="100%">1143-1151</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background:&lt;em&gt; &lt;/em&gt;&lt;/strong&gt;&lt;em&gt;Strobilanthes kunthianus&lt;/em&gt; Nees T Anders (Neela kurinji) is a shrub in the grasslands of Nilgiris, Western Ghats in India. It is well known for many biological properties including antioxidant. However, there is no &lt;em&gt;in-vivo&lt;/em&gt; antioxidant and hepatoprotective activities has been carried out previously on&lt;em&gt; S. kunthianus. &lt;/em&gt;Objectives: The present study was aimed to evaluate the antioxidant and hepatoprotective activities of methanolic flower extract of &lt;em&gt;S. kunthianus&lt;/em&gt; (MFESK) against carbon tetrachloride (CCl&lt;sub&gt;4&lt;/sub&gt;)-induced hepatotoxicity in experimental rats. &lt;strong&gt;Materials and Methods:&lt;/strong&gt; The Wistar rats were divided into six groups comprising six animals to each. Group I was served as normal control and group II as CCl&lt;sub&gt;4&lt;/sub&gt; treated. Both these groups were received sodium CMC (0.3%, 5 ml/kg). Groups III, IV and V animals were treated with MFESK at different dose levels (100, 150 and 200 mg/kg). Group VI was treated with standard silymarin (100 mg/kg). All these treatments were given orally for eight consecutive days. On the 8&lt;sup&gt;th&lt;/sup&gt; day of treatment, except the normal group I, all the other group of animals from III to VI were received CCl&lt;sub&gt;4&lt;/sub&gt; in liquid paraffin (1:1, 1 ml/kg, i.p., single dose) after 1 h of the vehicle. On the 9&lt;sup&gt;th&lt;/sup&gt; day, the animals were anesthetized and blood was collected from the abdominal artery, then the serum was separated and used for the biochemical estimations. Serum marker enzymes such as ASAT, ALAT, ALP, TGL, CR, TP, TC, TB and albumin were measured using Ecoline kits by using autoanalyzer. Further, blood serum and the supernatant solution of homogenized liver and kidney were used for the estimation of antioxidant parameters such as CAT, SOD and TBARS by spectrophotometrically. &lt;strong&gt;Results: &lt;/strong&gt;The administration of CCl&lt;sub&gt;4&lt;/sub&gt; caused a significant increase (P&amp;lt;0.001) in the levels of ASAT, ALAT, ALP, TGL, TC, TB and TBARS and decrease in the levels of CR, TP, Albumin, CAT and SOD in serum. A significant (P&amp;lt;0.001 and P&amp;lt;0.01) restoration of these values towards the normal level was observed in all the three tested doses of MFESK. Similar results were observed for CAT, SOD and TBARS in both liver and kidney tissues. These results designated the strong antioxidant and hepatoprotective nature of MFESK. The histopathological investigation of liver and kidney tissues also confirmed the observed activities. &lt;strong&gt;Conclusion:&lt;/strong&gt; These findings afford incitement for the development of a novel hepatoprotective herbal drugs.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">1143</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Geetha Balasubramaniam&lt;sup&gt;1,2,&lt;/sup&gt;*, Mahendran Sekar&lt;sup&gt;3&lt;/sup&gt;, Maithili Varadarajan&lt;sup&gt;4&lt;/sup&gt;, Shrishailappa Badami&lt;sup&gt;5 &lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Pharmaceutical Chemistry, Swamy Vivekanandha College of Pharmacy, Elayampalayam, Tiruchengode – 637205, Tamilnadu, INDIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Pharmaceutical Chemistry, JSS College of Pharmacy, JSS Academy of Higher Education and Research, Rocklands, Udhagamandalam – 643001, Nilgiris, Tamilnadu, INDIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Pharmaceutical Chemistry, Faculty of Pharmacy and Health Sciences, Universiti Kuala Lumpur Royal College of Medicine Perak, Ipoh – 30450, Perak, MALAYSIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Department of Pharmacognosy, Padmavathi College of Pharmacy, Dharamapuri – 635205, Tamilnadu, INDIA. 5Chaitanya Vikas Yoga &amp;amp; Nature Cure Centre, Rajatgiri, Dharwad – 580004, Karnataka, INDIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Geetha Balasubramaniam</style></author><author><style face="normal" font="default" size="100%">Mahendran Sekar</style></author><author><style face="normal" font="default" size="100%">Maithili Varadarajan</style></author><author><style face="normal" font="default" size="100%">Shrishailappa Badami</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Antioxidant and Hepatoprotective Activities of Strobilanthes kunthianus against Carbon Tetrachloride-Induced Hepatotoxicity in Rats</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Antioxidant</style></keyword><keyword><style  face="normal" font="default" size="100%">Carbon tetrachloride</style></keyword><keyword><style  face="normal" font="default" size="100%">Hepatoprotective</style></keyword><keyword><style  face="normal" font="default" size="100%">Hepatotoxicity</style></keyword><keyword><style  face="normal" font="default" size="100%">Liver disease</style></keyword><keyword><style  face="normal" font="default" size="100%">Strobilanthes kunthianus</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2020</style></year><pub-dates><date><style  face="normal" font="default" size="100%">August 2020</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">12</style></volume><pages><style face="normal" font="default" size="100%">1143-1151</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background:&lt;em&gt; &lt;/em&gt;&lt;/strong&gt;&lt;em&gt;Strobilanthes kunthianus&lt;/em&gt; Nees T Anders (Neela kurinji) is a shrub in the grasslands of Nilgiris, Western Ghats in India. It is well known for many biological properties including antioxidant. However, there is no &lt;em&gt;in-vivo&lt;/em&gt; antioxidant and hepatoprotective activities has been carried out previously on&lt;em&gt; S. kunthianus. &lt;/em&gt;Objectives: The present study was aimed to evaluate the antioxidant and hepatoprotective activities of methanolic flower extract of &lt;em&gt;S. kunthianus&lt;/em&gt; (MFESK) against carbon tetrachloride (CCl&lt;sub&gt;4&lt;/sub&gt;)-induced hepatotoxicity in experimental rats. &lt;strong&gt;Materials and Methods:&lt;/strong&gt; The Wistar rats were divided into six groups comprising six animals to each. Group I was served as normal control and group II as CCl&lt;sub&gt;4&lt;/sub&gt; treated. Both these groups were received sodium CMC (0.3%, 5 ml/kg). Groups III, IV and V animals were treated with MFESK at different dose levels (100, 150 and 200 mg/kg). Group VI was treated with standard silymarin (100 mg/kg). All these treatments were given orally for eight consecutive days. On the 8&lt;sup&gt;th&lt;/sup&gt; day of treatment, except the normal group I, all the other group of animals from III to VI were received CCl&lt;sub&gt;4&lt;/sub&gt; in liquid paraffin (1:1, 1 ml/kg, i.p., single dose) after 1 h of the vehicle. On the 9&lt;sup&gt;th&lt;/sup&gt; day, the animals were anesthetized and blood was collected from the abdominal artery, then the serum was separated and used for the biochemical estimations. Serum marker enzymes such as ASAT, ALAT, ALP, TGL, CR, TP, TC, TB and albumin were measured using Ecoline kits by using autoanalyzer. Further, blood serum and the supernatant solution of homogenized liver and kidney were used for the estimation of antioxidant parameters such as CAT, SOD and TBARS by spectrophotometrically. &lt;strong&gt;Results: &lt;/strong&gt;The administration of CCl&lt;sub&gt;4&lt;/sub&gt; caused a significant increase (P&amp;lt;0.001) in the levels of ASAT, ALAT, ALP, TGL, TC, TB and TBARS and decrease in the levels of CR, TP, Albumin, CAT and SOD in serum. A significant (P&amp;lt;0.001 and P&amp;lt;0.01) restoration of these values towards the normal level was observed in all the three tested doses of MFESK. Similar results were observed for CAT, SOD and TBARS in both liver and kidney tissues. These results designated the strong antioxidant and hepatoprotective nature of MFESK. The histopathological investigation of liver and kidney tissues also confirmed the observed activities. &lt;strong&gt;Conclusion:&lt;/strong&gt; These findings afford incitement for the development of a novel hepatoprotective herbal drugs.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">1143</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Geetha Balasubramaniam&lt;sup&gt;1,2,&lt;/sup&gt;*, Mahendran Sekar&lt;sup&gt;3&lt;/sup&gt;, Maithili Varadarajan&lt;sup&gt;4&lt;/sup&gt;, Shrishailappa Badami&lt;sup&gt;5 &lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Pharmaceutical Chemistry, Swamy Vivekanandha College of Pharmacy, Elayampalayam, Tiruchengode – 637205, Tamilnadu, INDIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Pharmaceutical Chemistry, JSS College of Pharmacy, JSS Academy of Higher Education and Research, Rocklands, Udhagamandalam – 643001, Nilgiris, Tamilnadu, INDIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Pharmaceutical Chemistry, Faculty of Pharmacy and Health Sciences, Universiti Kuala Lumpur Royal College of Medicine Perak, Ipoh – 30450, Perak, MALAYSIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Department of Pharmacognosy, Padmavathi College of Pharmacy, Dharamapuri – 635205, Tamilnadu, INDIA. 5Chaitanya Vikas Yoga &amp;amp; Nature Cure Centre, Rajatgiri, Dharwad – 580004, Karnataka, INDIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Afaf E Abdel Ghani</style></author><author><style face="normal" font="default" size="100%">Sayed AA El-Toumy</style></author><author><style face="normal" font="default" size="100%">Wagdi IA El-Dougdoug</style></author><author><style face="normal" font="default" size="100%">Ahmed M Mansour</style></author><author><style face="normal" font="default" size="100%">Wafaa HB Hassan</style></author><author><style face="normal" font="default" size="100%">Hanaa M Hassan</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Chemical Profile and Hepatoprotective Activity of Ethyl Acetate Extracts of Euphorbia paralias and Euphorbia geniculata (Euphorbiaceae) from Egypt</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Euphorbia</style></keyword><keyword><style  face="normal" font="default" size="100%">Hepatoprotective</style></keyword><keyword><style  face="normal" font="default" size="100%">Polyphenolics</style></keyword><keyword><style  face="normal" font="default" size="100%">UPLC-ESI-MS/MS</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2020</style></year><pub-dates><date><style  face="normal" font="default" size="100%">June 2020</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">12</style></volume><pages><style face="normal" font="default" size="100%">762-770</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background:&lt;/strong&gt; Plants belonging to the genus Euphorbia were used traditionally to treat several health disorders and diseases. &lt;strong&gt;Objective:&lt;/strong&gt; the aim of this study is evaluation of secondary metabolites and hepatoprotective activity of the ethyl acetate fractions of the aerial parts of &lt;em&gt;Euphorbia paralias &lt;/em&gt;(&lt;em&gt;Ep&lt;/em&gt;) and &lt;em&gt;Euphorbia geniculata&lt;/em&gt; (&lt;em&gt;Eg&lt;/em&gt;). &lt;strong&gt;Materials and Methods: &lt;/strong&gt;UPLC-ESI-MS/ MS technique was used for identification of the secondary metabolites. The hepatoprotective potential of the two plants was evaluated for the first time in male rats with thioacetamide induced liver injury. &lt;strong&gt;Results: &lt;/strong&gt;A total of 32 secondary metabolites were identified in the ethyl acetate fractions of the aerial parts of both species. Ellagitannins such as tetragalloyl hexoside, ellagic acid, gallic acid, and flavonoids such as kaempferol-3-O-β-(6''-galloyl-Oglucopyranoside), quercetin glycosides (glucoside and arabinoside) were found to be the major components in &lt;em&gt;Ep &lt;/em&gt;whereas flavonoid glycosides including quercetin rutinoside, quercetin glycosides (glucoside, arabinoside and rhamnoside) and kaempeferol glycoside derivatives were highly abundant in &lt;em&gt;Eg. &lt;/em&gt;Administration of thioacetamide resulted in marked elevation in liver enzymes, elevation of lipid profile and alteration in oxidative stress parameters. While pretreatment of rats with &lt;em&gt;Ep&lt;/em&gt; and&lt;em&gt; Eg&lt;/em&gt; ethyl acetate fractions significantly attenuated the hepatic toxicity through reduction of liver biomarkers, improving the redox status of the tissue and so brought down the serum biochemical parameters and lipid profile nearly toward the normal levels. &lt;strong&gt;Conclusion: &lt;/strong&gt;The studied fractions show hepatoprotective potential with promising value as hepatoprotective drugs of natural origin in comparison with silymarin as the standard hepatoprotective drug.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">4</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">762</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Afaf E. Abdel Ghani&lt;sup&gt;1&lt;/sup&gt;, Sayed A. A. El-Toumy&lt;sup&gt;1&lt;/sup&gt;, Wagdi I. A. El-Dougdoug&lt;sup&gt;2&lt;/sup&gt;, Ahmed M. Mansour&lt;sup&gt;2&lt;/sup&gt;, Wafaa H. B. Hassan&lt;sup&gt;2&lt;/sup&gt;, Hanaa M. Hassan&lt;sup&gt;3,&lt;/sup&gt;* &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Pharmacognosy, Faculty of Pharmacy, Zagazig University, 44519 Zagazig, Egypt.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Chemistry of Tannins, National Research Center, El-Dokki- Cairo, 12622 Egypt.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Organic Chemistry, Faculty of Science, Benha University, 13518 Benha, Egypt.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Department of Pharmacology and Toxicology Faculty of Pharmacy, El-Alazhar University Cairo Egypt.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Department of Pharmacognosy Faculty of Pharmacy, Zagazig University,, Zagazig, Egypt.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;6&lt;/sup&gt;Pharmacy department Banha Educational Hospital, 13518 Banha, Banha, Egypt.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Sagástegui-Guarniz William Antonio</style></author><author><style face="normal" font="default" size="100%">Silva-Correa Carmen R</style></author><author><style face="normal" font="default" size="100%">Villarreal-La Torre Víctor E</style></author><author><style face="normal" font="default" size="100%">Cruzado-Razco José L</style></author><author><style face="normal" font="default" size="100%">Calderón-Peña Abhel A</style></author><author><style face="normal" font="default" size="100%">Aspajo-Villalaz Cinthya L</style></author><author><style face="normal" font="default" size="100%">Gamarra-Sánchez César D</style></author><author><style face="normal" font="default" size="100%">Ruiz-Reyes Segundo G</style></author><author><style face="normal" font="default" size="100%">Chávez-Flores Juana E</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Hepatoprotective and Nephroprotective Activity of Artemisia absinthium L. on Diclofenac-induced Toxicity in Rats</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Artemisia absinthium</style></keyword><keyword><style  face="normal" font="default" size="100%">Biochemical parameters</style></keyword><keyword><style  face="normal" font="default" size="100%">Diclofenac</style></keyword><keyword><style  face="normal" font="default" size="100%">Hepatoprotective</style></keyword><keyword><style  face="normal" font="default" size="100%">Histopathology</style></keyword><keyword><style  face="normal" font="default" size="100%">Nephroprotective</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2020</style></year><pub-dates><date><style  face="normal" font="default" size="100%">August 2020</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">12</style></volume><pages><style face="normal" font="default" size="100%">1032-1041</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background:&lt;/strong&gt; Artemisia absinthium L. is known for its antimalarial activity however, hepatoprotective activity of aqueous extracts has also been reported but, nephroprotective activity not yet evaluated. &lt;strong&gt;Objective:&lt;/strong&gt; To evaluate the hepatoprotective and nephroprotective activities of &lt;em&gt;A. absinthium &lt;/em&gt;against diclofenac-induced toxicity on rats. Materials and Methods: Three different doses of methanol and ethyl acetate extract of &lt;em&gt;A. absinthium &lt;/em&gt;(50, 100 and 200 mg/kg/day) were evaluated and compared with silymarin 100 mg/kg. Rats received these doses for 5 days and on the 3rd and 4th day diclofenac (50 mg/kg i.p.) was administered 1 h after treatment. Animals were sacrificed 48 h after the last injection of diclofenac. Biochemical blood parameters like aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), urea and creatinine, and histopathologic changes of liver and kidney were studied and evaluated. &lt;strong&gt;Results:&lt;/strong&gt;&lt;strong&gt; &lt;/strong&gt;&lt;em&gt;A. absinthium &lt;/em&gt;reduced the elevated blood levels of ALT, AST, ALP, urea and creatinine with the methanol extract to 200 mg/kg/day being more effective. The histopathologic evaluation suggested that &lt;em&gt;A. absinthium &lt;/em&gt;decreased hepatic and renal necrosis induced by diclofenac. &lt;strong&gt;Conclusions: &lt;/strong&gt;Hepatoprotective and nephroprotective activities of methanol and ethyl acetate extract of &lt;em&gt;A. absinthium&lt;/em&gt; were demonstrated, being methanol extract to 200 mg/kg/day the most effective. This provides scientific support for the use of medicinal plants such as&lt;em&gt; A. absinthium &lt;/em&gt;in the treatment of liver and kidney disorders.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">1032</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Sagástegui-Guarniz William Antonio&lt;sup&gt;1&lt;/sup&gt;, Silva-Correa Carmen R&lt;sup&gt;1&lt;/sup&gt;, Villarreal-La Torre Víctor E&lt;sup&gt;1,&lt;/sup&gt;*, Cruzado-Razco José L&lt;sup&gt;1&lt;/sup&gt;, Calderón- Peña Abhel A&lt;sup&gt;2&lt;/sup&gt;, Aspajo-Villalaz Cinthya L&lt;sup&gt;2&lt;/sup&gt;, Gamarra-Sánchez César D&lt;sup&gt;1&lt;/sup&gt;, Ruiz-Reyes Segundo G&lt;sup&gt;1&lt;/sup&gt;, Chávez-Flores Juana E&lt;sup&gt;3&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Facultad de Farmacia y Bioquímica, Universidad Nacional de Trujillo, PERÚ.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Facultad de Ciencias Biológicas, Universidad Nacional de Trujillo, PERÚ.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Facultad de Farmacia y Bioquímica, Universidad Norbert Wiener, PERÚ.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Puneshwar Keshari</style></author><author><style face="normal" font="default" size="100%">Pradeep</style></author><author><style face="normal" font="default" size="100%">Sudhakar Bhat</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Evaluation of Hepatoprotective Potential of Rhododendron arboreum Sm. Stem Bark as Abhava Pratinidhi Dravya (Substitute) of Rohitaka (Tecomella undulata (Sm.) Seem.) Against Paracetamol Induced Hepatotoxicity in Experimental Rats</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Abhava Pratinidhi Dravya</style></keyword><keyword><style  face="normal" font="default" size="100%">Choorna</style></keyword><keyword><style  face="normal" font="default" size="100%">Hepatoprotective</style></keyword><keyword><style  face="normal" font="default" size="100%">Kwatha</style></keyword><keyword><style  face="normal" font="default" size="100%">Rhododendron arboreum</style></keyword><keyword><style  face="normal" font="default" size="100%">Rohitaka</style></keyword><keyword><style  face="normal" font="default" size="100%">Substitute</style></keyword><keyword><style  face="normal" font="default" size="100%">Tecomella undulata</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2019</style></year><pub-dates><date><style  face="normal" font="default" size="100%">September 2019</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">11</style></volume><pages><style face="normal" font="default" size="100%">1148-1154</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background:&lt;/strong&gt; Rohitaka (&lt;em&gt;Tecomella undulata&lt;/em&gt; (Sm.) Seem.) has been considered as threatened and listed as rare at international level (IUCN, 2000). In Ayurveda classics, Rohitaka is described as Yakritpleehgulmodarhara (useful in liver and spleenic disorders). &lt;em&gt;Rhododendron arboreum&lt;/em&gt; Sm. is used by folklore practitioners for treatment of Jaundice and marketed as Rohitaka in Nepal. &lt;strong&gt;Aim: &lt;/strong&gt;To evaluate &lt;em&gt;Rhododendron arboreum&lt;/em&gt; Sm. as an effective pratinidhi dravya (substitute) in abhava (absence) of Rohitaka (&lt;em&gt;Tecomella undulata&lt;/em&gt; (Sm.) Seem.) with special reference to hepatoprotective activity in paracetamol induced hepatotoxicity in rats. &lt;strong&gt;Materials and Methods:&lt;/strong&gt; In the present study, hepatoprotective effect of Choorna (powder) and Kwatha (decoction) of &lt;em&gt;Rhododendron arboreum&lt;/em&gt; Sm. and &lt;em&gt;Tecomella undulata&lt;/em&gt; (Sm.) Seem. (Choorna-0.54 g/kg body wt. and Kwatha- 4.32 ml/kg body wt. p. o. for 10 days along with paracetamol toxicant 3 g/kg body wt. p. o. on 6&lt;sup&gt;th&lt;/sup&gt; and 8&lt;sup&gt;th &lt;/sup&gt;day) were investigated against paracetamol induced hepatotoxicity. Silymarin (100 mg/kg body wt.) was used as standard hepatoprotective reference drug. &lt;strong&gt;Statistical Analysis Used:&lt;/strong&gt; The obtained data were analyzed by ANOVA with Dunnet's multiple ‘t’ test and level of p&amp;lt;0.05 was considered as statistically significant. &lt;strong&gt;Results: &lt;/strong&gt;Paracetamol treatment led to elevated levels of liver marker enzymes and disorientation in histological observations which were significantly reversed by treatment with &lt;em&gt;Rhododendron arboreum&lt;/em&gt; Sm. and &lt;em&gt;Tecomella undulata&lt;/em&gt; (Sm.) Seem. dependent on dosage forms. &lt;strong&gt;Conclusion: &lt;/strong&gt;The study revealed that both the drugs have similar hepatoprotective effect and thus &lt;em&gt;Rhododendron arboreum&lt;/em&gt; Sm. as “Abhava Pratinidhi Dravya” for &lt;em&gt;Tecomella undulata&lt;/em&gt; (Sm.) Seem. with special reference to hepatoprotective activity is justified.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">1148</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Puneshwar Keshari*, Pradeep, Sudhakar Bhat &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;Department of Dravyaguna, SDM College of Ayurveda and Hospital, Hassan- 573201, Karnataka, INDIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Preetham Jinadatta</style></author><author><style face="normal" font="default" size="100%">Kiran Sundera Raja Rao</style></author><author><style face="normal" font="default" size="100%">Sharath Rajshekarappa</style></author><author><style face="normal" font="default" size="100%">Sujan Ganapathy Pasura Subbaiah</style></author><author><style face="normal" font="default" size="100%">Mruthunjaya Kenganora</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">In vitro Antioxidant and Hepatoprotective Activity of Bridelia scandens (Roxb.)Willd</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Bridelia scandens</style></keyword><keyword><style  face="normal" font="default" size="100%">BRL3A</style></keyword><keyword><style  face="normal" font="default" size="100%">Hepatoprotective</style></keyword><keyword><style  face="normal" font="default" size="100%">MTT</style></keyword><keyword><style  face="normal" font="default" size="100%">ORAC</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2017</style></year><pub-dates><date><style  face="normal" font="default" size="100%">November 2017</style></date></pub-dates></dates><urls><web-urls><url><style face="normal" font="default" size="100%">http://fulltxt.org/article/392</style></url></web-urls></urls><volume><style face="normal" font="default" size="100%">9</style></volume><pages><style face="normal" font="default" size="100%">s117-s121</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;Natural products are emerging out as potent and alternative therapies for many diseases. Today herbs have become the part of mankind, because of its manifold ways in targeting diseased cells with minimal effects on normal cells and tissues. The present research investigated the &lt;em&gt;in vitro&lt;/em&gt; antioxidant activity and hepatoprotective of &lt;em&gt;B.scandens&lt;/em&gt; leaf. Preliminary phytochemical analysis exhibited the presence of most of the constituent in ethanol extract (BSE). Antioxidant capacity of various extracts of &lt;em&gt;B.scandens&lt;/em&gt; was examined. DPPH assay revealed that ethanol extract has a good antioxidant with IC&lt;sub&gt;50&lt;/sub&gt; value of 31.68&amp;mu;g/ml, whereas standard ascorbic acid with 8.78 &amp;mu;g/ml. BSE revealed dose dependent response with increase in concentration for reducing power assay. ORAC assay directly measured the scavenging capacity and BSE (2485 trolox eq/gm) was found to be potent than other extracts. &lt;em&gt;In vitro&lt;/em&gt; hepatoprotective activity was performed for BSE using MTT assay in BRL 3A cell line, which revealed nontoxic dose with CTC&lt;sub&gt;50&lt;/sub&gt; value more than 1000 &amp;mu;g/ml. At the dose 200 &amp;mu;g/ml, BSE and standard silymarin offered cell protection of 57% and 76 % respectively. Present study concludes that &lt;em&gt;B.scandens&lt;/em&gt; leaf extract possess antioxidant potential and protect the liver cells against CCl&lt;sub&gt;4&lt;/sub&gt; damage. However in vivo studies are being carried out to validate the traditional usage of &lt;em&gt;Bridelia scandens&lt;/em&gt;.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">6s</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">s117</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Preetham Jinadatta&lt;sup&gt;1&lt;/sup&gt;*, Kiran Sundera Raja Rao&lt;sup&gt;1&lt;/sup&gt;, Sharath Rajshekarappa&lt;sup&gt;2&lt;/sup&gt;, Sujan Ganapathy Pasura Subbaiah&lt;sup&gt;3&lt;/sup&gt;, Mruthunjaya Kenganora&lt;sup&gt;4 &lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Biotechnology, Dayananda Sagar College of Engineering, Kumaraswamy Layout, Bangalore-560078, Karnataka, INDIA.&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Biotechnology, M.S. Ramaiah Institute of Technology, MSRIT Post Bangalore 560054, Karnataka, INDIA.&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Research and Development Centre, Indusviva International Private Limited, No.7450, Near Navayuga Toll Gate Office, NH-4, Nelamangala, Bangalore &amp;ndash; 562123, INDIA.&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Department of Pharmacognosy, JSS College of Pharmacy, JSS University, Mysuru-570015 Karnataka, INDIA.&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Vijaya Anand</style></author><author><style face="normal" font="default" size="100%">Manikandan</style></author><author><style face="normal" font="default" size="100%">Vijaya Kumar</style></author><author><style face="normal" font="default" size="100%">Sampath Kumar</style></author><author><style face="normal" font="default" size="100%">Pushpa</style></author><author><style face="normal" font="default" size="100%">Agaath Hedina</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Phytopharmacological overview of Psidium guajava Linn.</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Anticancer.</style></keyword><keyword><style  face="normal" font="default" size="100%">Antidiabetic</style></keyword><keyword><style  face="normal" font="default" size="100%">Antimicrobial</style></keyword><keyword><style  face="normal" font="default" size="100%">Antioxidant</style></keyword><keyword><style  face="normal" font="default" size="100%">Hepatoprotective</style></keyword><keyword><style  face="normal" font="default" size="100%">Psidium guajava</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2016</style></year><pub-dates><date><style  face="normal" font="default" size="100%">June/2016</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">8</style></volume><pages><style face="normal" font="default" size="100%">314-320</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;em&gt;Psidium guajava &lt;/em&gt;Linn. possesses useful medicinal benefits. It has been recognized as the medicinally essential phytoconstituents, such as phenolic, flavonoid and carotenoid. Numerous pharmacological investigation have confirmed that the ability of this plant is to exhibit antimicrobial, antidiabetic, cardioprotective, neuroprotective, hepatoprotective, antioxidant and anticancer activities and it supports the traditional uses. This is a comprehensive of the phytoconstituents and pharmacological benefits.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">4</style></issue><work-type><style face="normal" font="default" size="100%">Review Article</style></work-type><section><style face="normal" font="default" size="100%">314</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p&gt;&lt;strong&gt;Vijaya Anand&lt;sup&gt;1&lt;/sup&gt;, Manikandan&lt;sup&gt;2&lt;/sup&gt;, Vijaya Kumar&lt;sup&gt;2&lt;/sup&gt;, Sampath Kumar&lt;sup&gt;3&lt;/sup&gt;, Pushpa&lt;sup&gt;4&lt;/sup&gt;, Agaath Hedina&lt;sup&gt;1&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Human Genetics and Molecular Biology, Bharatiar University, Coimbatore-641 046, Tamil Nadu, INDIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Biochemistry, M.I.E.T. Arts and Science College,Tiruchirappalli-620 007, Tamil Nadu, INDIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Chemistry and Biosciences, SASTRA University, Kumbakonam-612 001, Tamil Nadu, INDIA.&lt;/p&gt;

&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Department of Microbiology, Cauvery College for Women, Tiruchirappalli-620 018,Tamil Nadu, INDIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Shaik Aminabee</style></author><author><style face="normal" font="default" size="100%">Atmakuri Lakshmana Rao</style></author></authors><secondary-authors><author><style face="normal" font="default" size="100%">Maram Chinna Eswaraiah</style></author></secondary-authors></contributors><titles><title><style face="normal" font="default" size="100%">Hepatoprotective Activity of Michelia nilagirica against Paracetamol Induced Hepatic Injury in Rats</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Albino rats</style></keyword><keyword><style  face="normal" font="default" size="100%">Hepatoprotective</style></keyword><keyword><style  face="normal" font="default" size="100%">Michelia nilagirica</style></keyword><keyword><style  face="normal" font="default" size="100%">Paracetamol</style></keyword><keyword><style  face="normal" font="default" size="100%">Screening</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2015</style></year><pub-dates><date><style  face="normal" font="default" size="100%">Jul-Aug 2015</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">7</style></volume><pages><style face="normal" font="default" size="100%">228-235</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;&lt;strong&gt;Background:&lt;/strong&gt; Michelia nilagirica belonging to the family Mangoliaceae is commonly used by many traditional healers in most of the herbal preparations for diabetes and kidney diseases. &lt;strong&gt;Objective: &lt;/strong&gt;Different fractions isolated from ethanolic extract of whole plant of Michelia nilagirica is investigated for hepatoprotective activity in wistar albino rats against paracetamol induced hepatic injury. &lt;strong&gt;Materials &amp;amp; Methods:&lt;/strong&gt; Rats were divided into eight groups. Each group contains six animals. Hepatic injury was achieved by injecting paracetamol at a dose of 2 mg/kg p.o. &lt;strong&gt;Results:&lt;/strong&gt; The hepatoprotective action is seen with fraction A by reduction in serum marker enzymes like Aspartate transaminase (AST), Alanine transaminase (ALT). It also reduced the elevated levels of Alkaline phosphotase (ALP) &amp;amp; Serum bilirubin. &lt;strong&gt;Conclusion:&lt;/strong&gt; Histopathological studies further confined the hepatoprotective activity of fraction A against paracetamol treated group. The results obtained were compared with silymarin (100 mg/kg, orally), a standard drug.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">4</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">228</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p&gt;&lt;strong&gt;Shaik Aminabee&lt;sup&gt;1&lt;/sup&gt;, Atmakuri Lakshmana Rao&lt;sup&gt;*1&lt;/sup&gt; and Maram Chinna Eswaraiah&lt;sup&gt;2 1&lt;/sup&gt;&lt;/strong&gt;Department of Pharmacology, V. V. Institute of Pharmaceutical Sciences, Gudlavalleru, Andhra Pradesh, INDIA 2Department of Pharmacognosy, Anurag College of Pharmacy, Kodad, Telangana, INDIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Shaik Aminabee</style></author><author><style face="normal" font="default" size="100%">Atmakuri Lakshmana Rao</style></author><author><style face="normal" font="default" size="100%">Maram Chinna Eswaraiah</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Hepatoprotective Activity of Michelia nilagirica against Paracetamol Induced Hepatic Injury in Rats</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Albino rats</style></keyword><keyword><style  face="normal" font="default" size="100%">Hepatoprotective</style></keyword><keyword><style  face="normal" font="default" size="100%">Michelia nilagirica</style></keyword><keyword><style  face="normal" font="default" size="100%">Paracetamol</style></keyword><keyword><style  face="normal" font="default" size="100%">Screening.</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2015</style></year><pub-dates><date><style  face="normal" font="default" size="100%">29th Apr, 2015</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">7</style></volume><pages><style face="normal" font="default" size="100%">228-235</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Background:&lt;/strong&gt;&lt;em&gt;Michelia nilagirica&lt;/em&gt; belonging to the family &lt;em&gt;Mangoliaceae&lt;/em&gt; is commonly used by many traditional healers in most of the herbal preparations for diabetes and kidney diseases. &lt;strong&gt;Objective:&lt;/strong&gt; Different fractions isolated from ethanolic extract of whole plant of Michelia nilagirica is investigated for hepatoprotective activity in wistar albino rats against paracetamol induced hepatic injury. &lt;strong&gt;Materials &amp;amp; Methods: &lt;/strong&gt;Rats were divided into eight groups. Each group contains six animals. Hepatic injury was achieved by injecting paracetamol at a dose of 2 mg/kg p.o. &lt;strong&gt;Results: &lt;/strong&gt;The hepatoprotective action is seen with fraction A by reduction in serum marker enzymes like Aspartate transaminase (AST), Alanine transaminase (ALT). It also reduced the elevated levels of Alkaline phosphotase (ALP) &amp;amp; Serum bilirubin. &lt;strong&gt;Conclusion:&lt;/strong&gt; Histopathological studies further confined the hepatoprotective activity of fraction A against paracetamol treated group. The results obtained were compared with silymarin (100 mg/kg, orally), a standard drug.&lt;/p&gt;&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Key words: &lt;/strong&gt;Albino rats, Hepatoprotective, &lt;em&gt;Michelia nilagirica&lt;/em&gt;, Paracetamol, Screening.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">4</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">228</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Shaik Aminabee&lt;sup&gt;1&lt;/sup&gt;, Atmakuri Lakshmana Rao&lt;sup&gt;*1&lt;/sup&gt; and Maram Chinna Eswaraiah&lt;sup&gt;2 &lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Pharmacology, V. V. Institute of Pharmaceutical Sciences, Gudlavalleru, Andhra Pradesh, INDIA&lt;/p&gt;&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Pharmacognosy, Anurag College of Pharmacy, Kodad, Telangana, INDIA.&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Hasan S. Yusufoglu</style></author><author><style face="normal" font="default" size="100%">Aftab Alam</style></author><author><style face="normal" font="default" size="100%">Mohamad Ayman A. Salkini</style></author><author><style face="normal" font="default" size="100%">Ahmed M. Zaghloul</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Anti-inflammatory and hepatoprotective activities of methanolic extract of Anthemis scrobicularis herbs</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Anthemis scrobicularis</style></keyword><keyword><style  face="normal" font="default" size="100%">Anti-inflammatory</style></keyword><keyword><style  face="normal" font="default" size="100%">Carbon tetrachloride</style></keyword><keyword><style  face="normal" font="default" size="100%">Hepatoprotective</style></keyword><keyword><style  face="normal" font="default" size="100%">Histopathology</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2014</style></year><pub-dates><date><style  face="normal" font="default" size="100%">8th April 2014</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">6</style></volume><pages><style face="normal" font="default" size="100%">55-61</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;The anti-inflammatory and hepatoprotective activitiesof the methanolic extract of Anthemis scrobicularis(ANS) herbs were evaluated in rats against carrageenan induced inflammation and carbon tetrachloride (CCl&lt;sub&gt;4&lt;/sub&gt;)induced hepatic injury. To evaluate the anti-inflammatory effects of ANS, twenty male rats were divided into four equal groups. Injection of 100 &amp;mu;l carrageenan in normal saline into the subplantar region of the hind paw of rats clearly induced paw edema. The volume of paw edema was attenuated following oral administration of ANS. For hepatoprotective effects, twenty five rats were equally divided into five groups.The hepatotoxicity, induced by a single dose of CCl&lt;sub&gt;4&lt;/sub&gt;, produced significant (p&amp;lt;0.001) increase of the levels of serumtransaminase, phosphatase, bilirubin and a decrease in proteins were also noticed. The oxidative stress marker such as malondialdehyde (MDA)was increased and nonprotein sulfhydryl (NP-SH) was decreased in the hepatotoxic tissues. Pre-medication of CCl&lt;sub&gt;4&lt;/sub&gt;-intoxicated rats with ANS at the doses 250 and 500 mg/kg reversed the abnormal liver diagnostic stricture. The results showed that ANS is toxicologically safe when orally administered and possess highly significant anti-inflammatory and hepatoprotective activities and the potentials usefulness of Anthemis scrobicularis in hepatic and inflammatory disease.&lt;/p&gt;&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Key words&lt;/strong&gt;: Anthemis scrobicularis, Anti-inflammatory, Hepatoprotective, Carbon tetrachloride, Histopathology.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Hasan S. Yusufoglu&lt;sup&gt;1,*&lt;/sup&gt;, Aftab Alam&lt;sup&gt;1&lt;/sup&gt;, Mohamad Ayman A. Salkini&lt;sup&gt;1&lt;/sup&gt;, Ahmed M. Zaghloul&lt;/strong&gt;&lt;sup&gt;&lt;strong&gt;1, 2&lt;/strong&gt;&lt;/sup&gt;&lt;/p&gt;&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Pharmacognosy Dept. College of Pharmacy - Salman Bin Abdulaziz University, Al-Kharj, KSA&lt;/p&gt;&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Pharmacognosy Department, College of Pharmacy, Mansoura University, Egypt.&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Noor Kamil</style></author><author><style face="normal" font="default" size="100%">Hafi z Syed Imran-ul-Haque</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Hepatoprotective Effect of Calotropis procera in Isoniazid and Rifampicin Induced Hepatotoxicity</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Calotropis procera</style></keyword><keyword><style  face="normal" font="default" size="100%">Hepatoprotective</style></keyword><keyword><style  face="normal" font="default" size="100%">isoniazid</style></keyword><keyword><style  face="normal" font="default" size="100%">rifampicin</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2014</style></year><pub-dates><date><style  face="normal" font="default" size="100%">2nd July 2014</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">6</style></volume><pages><style face="normal" font="default" size="100%">9-14</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align:justify&quot;&gt;&lt;strong&gt;Objective:&lt;/strong&gt; In this study anti-tubercular drugs (isoniazid and rifampicin) induced liver toxicity has been studied for the hepatoprotective effect of hydroethanolic extract of &lt;em&gt;Calotropis procera&lt;/em&gt; (CP) flowers in rats. &lt;strong&gt;Materials and Method:&lt;/strong&gt; Animals were divided into four groups, group Awas given normal saline (1ml/kg), group B received Isoniazid (INH) (50mg/kg) and Rifampicin (RMP)(100mg/kg) group C received INH (50mg/kg), RMP(100mg/kg) and CP(150mg/kg)orally for fourteen days. &lt;strong&gt;Results:&lt;/strong&gt; Biochemical markers of liver toxicity such as AST,ALT,ALP, bilirubin and tissue histology were done inall groups. Anti-Tubercular (Anti-TB) drugs (INH 50mg/kg and RMP100mg/kg) have enhanced the ALT, AST, ALP, bilirubin and histological changes in liver, whereas co-administration of anti-TB drugs with Calotropis procera has reduced these levels within the normal range. &lt;strong&gt;Conclusion:&lt;/strong&gt; Findings of this study showed the hepatoprotective effct of Calotropis Proceraagainst Isoniazid and Rifampicinadministration to reduce the liver damage for chronic treatment.&lt;/p&gt;&lt;p style=&quot;text-align:justify&quot;&gt;&lt;strong&gt;Key words:&lt;/strong&gt; Isoniazid, Rifampicin, &lt;em&gt;Calotropis procera&lt;/em&gt;, Hepatoprotective.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Noor Kamil&lt;sup&gt;1&lt;/sup&gt;, Hafiz Syed Imran-ul-Haque&lt;/strong&gt;&lt;sup&gt;&lt;strong&gt;2 &lt;/strong&gt;&lt;/sup&gt;&lt;/p&gt;&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Pharmaceutical Sciences, College of Clinical Pharmacy, King Faisal University, Al-Ahsa 31982-KSA,&lt;/p&gt;&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Pharmacology, Dow International Medical College, Dow University of Health Sciences, Karachi-Pakistan.&lt;/p&gt;</style></auth-address></record></records></xml>