<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Elmi Sariani Hasibuan</style></author><author><style face="normal" font="default" size="100%">Ayus Diningsih</style></author><author><style face="normal" font="default" size="100%">Cory Linda Futri Harahap</style></author><author><style face="normal" font="default" size="100%">Anto J. Hadi</style></author><author><style face="normal" font="default" size="100%">Hafni Nur Insan</style></author><author><style face="normal" font="default" size="100%">Rini Fitriani Dongoran</style></author><author><style face="normal" font="default" size="100%">Haslinah Ahmad</style></author><author><style face="normal" font="default" size="100%">Hapiz Arlanda Sani</style></author><author><style face="normal" font="default" size="100%">Anwar Mallongi</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Microencapsulation of Paracetamol with Polycaprolacone Coating</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Microencapsulation</style></keyword><keyword><style  face="normal" font="default" size="100%">Paracetamol</style></keyword><keyword><style  face="normal" font="default" size="100%">Polycaprolactone</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2025</style></year><pub-dates><date><style  face="normal" font="default" size="100%">January 2025</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">17</style></volume><pages><style face="normal" font="default" size="100%">89-94</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;Paracetamol is widely used as a medicine for fever and pain. Paracetamol has a normal half-life in the blood of 2 hours. If paracetamol is consumed frequently it will cause stomach irritation. This research aims to cover the unpleasant taste of paracetamol by microencapsulating using a coating and changing the release of paracetamol microcapsules. In this study, the coating material used was polycaprolactone because polycaprolactone is a biodegradable coating material. The amount of coating used in this study was 1.5g, 3g and 4.5g. Paracetamol microencapsulation was carried out in evaluation tests, namely organoleptic examination and particle size. Then a characterization test was carried out, namely the surface morphology test of the paracetamol microencapsulation using the Scanning Electron Microscopy (SEM), Fourier Transform Infrared Spectroscopy (FTIR) method and the dissolution test. The research results showed that the concentration obtained by Formula 1 was 95.66%, Formula 2 was 97.17 and F3 was 98.81. The dissolution test results showed that the largest dissolution percentage of microcapsules in formula 1 was 97.85% at 50 minutes, formula 2 was 98.13 at 55 minutes and formula 3 was 98.91% at 60 minutes. Microencapsulation of paracetamol with polycaprolactone can cover the bitter taste and changing the release of paracetamol microcapsules into sustained release preparations.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">89</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Elmi Sariani Hasibuan&lt;sup&gt;1*&lt;/sup&gt;, Ayus Diningsih&lt;sup&gt;1&lt;/sup&gt;, Cory Linda Futri Harahap&lt;sup&gt;1&lt;/sup&gt;, Anto J. Hadi&lt;sup&gt;2&lt;/sup&gt;, Hafni Nur Insan&lt;sup&gt;2&lt;/sup&gt;, Rini Fitriani Dongoran&lt;sup&gt;2&lt;/sup&gt;, Haslinah Ahmad&lt;sup&gt;2&lt;/sup&gt;, Hapiz Arlanda Sani&lt;sup&gt;2&lt;/sup&gt;, Anwar Mallongi&lt;sup&gt;3,*&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Departemen Farmasi, Fakultas Kesehatan, Universitas Aufa Royhan, Padangsidimpuan, Sumatera Utara, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Departemen Kesehatan Masyarakat, Fakultas Kesehatan, Universitas Aufa Royhan, Padangsidimpuan, Sumatera Utara, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Environmental Health, Faculty of Public Health, Hasanuddin University, Makassar, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">I Made Subhawa Harsa</style></author><author><style face="normal" font="default" size="100%">Andiani</style></author><author><style face="normal" font="default" size="100%">Sulistiawati</style></author><author><style face="normal" font="default" size="100%">Lilik Herawati</style></author><author><style face="normal" font="default" size="100%">Hanik Badriyah Hidayati</style></author><author><style face="normal" font="default" size="100%">Kuntaman</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Comparative Study of Paracetamol vs Paracetamol Plus Acupressure for Pain Relief in Diabetic Neuropathy Patients</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Acupressure</style></keyword><keyword><style  face="normal" font="default" size="100%">Diabetic neuropathic pain</style></keyword><keyword><style  face="normal" font="default" size="100%">Paracetamol</style></keyword><keyword><style  face="normal" font="default" size="100%">Type II diabetes mellitus</style></keyword><keyword><style  face="normal" font="default" size="100%">Visual analogue scale</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2024</style></year><pub-dates><date><style  face="normal" font="default" size="100%">June 2024</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">16</style></volume><pages><style face="normal" font="default" size="100%">602-605</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background: &lt;/strong&gt;Diabetes Mellitus (DM) is a chronic metabolic disorder that causes neuropathy. Diabetic neuropathy causes severe pain and needs therapy to relieve its pain. In Indonesia, the therapy uses paracetamol, sometimes combined with acupressure. However, the efficacy of the combination therapy needs to be better understood.&lt;strong&gt; Purpose:&lt;/strong&gt; This study aimed to elucidate the efficacy of paracetamol vs paracetamol combined with acupressure for pain relief in diabetic neuropathy patients. &lt;strong&gt;Materials and methods:&lt;/strong&gt; This study used a cross-sectional study design. Total of 70 participants were agreed to involved in this study. The patients were then interviewed, and their visual analogue scale was assessed. The data was then analysed statistically using Pearson’s correlation. &lt;strong&gt;Result:&lt;/strong&gt; Out of the 70 patients diagnosed with type II DM, 40 had Diabetic Neuropathic Pain (DNP). Shockingly, most of the patients with type II DM and DNP were females, accounting for 33 out of 40 cases (82.50%). The study found a significant correlation between the type of therapy and the decrease in VAS scores for diabetic patients with neuropathic pain (p≤0.05). Patients treated with paracetamol and acupressure showed more improvement in the VAS score than those treated with only paracetamol. &lt;strong&gt;Conclusion: &lt;/strong&gt;The study suggests that the combination treatment could benefit DNP as an analgesic for type II DM patients. Advanced study is required to be performed using larger samples so that accurate data can be obtained.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">602</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p&gt;&lt;strong&gt;I Made Subhawa Harsa&lt;sup&gt;1,2&lt;/sup&gt;, Andiani&lt;sup&gt;1,3&lt;/sup&gt;, Sulistiawati&lt;sup&gt;4&lt;/sup&gt;* , Lilik Herawati&lt;sup&gt;5&lt;/sup&gt;, Hanik Badriyah Hidayati&lt;sup&gt;6&lt;/sup&gt; , Kuntaman&lt;sup&gt;7&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;1&lt;/sup&gt;Doctoral Program of Medical Science, Faculty of Medicine, Universitas Airlangga, INDONESIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Physiology, Faculty of Medicine, Universitas Wijaya Kusuma Surabaya, INDONESIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Public Health and Preventive Medicine, Faculty of Medicine, Universitas Wijaya Kusuma Surabaya, INDONESIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;4&lt;/sup&gt;Department of Public Health and Preventive Medicine, Faculty of Medicine, Universitas Airlangga, INDONESIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;5&lt;/sup&gt;Department of Physiology, Faculty of Medicine, Universitas Airlangga, INDONESIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;6&lt;/sup&gt;Department of Neurology, Faculty of Medicine, Universitas Airlangga, INDONESIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;7&lt;/sup&gt;Department of Microbiology, Faculty of Medicine, Universitas Airlangga, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Faiz Muhammad Ammar</style></author><author><style face="normal" font="default" size="100%">Christrijogo Sumartono Waloejo</style></author><author><style face="normal" font="default" size="100%">Herdiani Sulistyo Putri</style></author><author><style face="normal" font="default" size="100%">Kohar Hari Santoso</style></author><author><style face="normal" font="default" size="100%">Prananda Surya Airlangga</style></author><author><style face="normal" font="default" size="100%">Budi Utomo</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Effect of Cacao Bean Extract as a Paracetamol Adjuvant on Pain Scale and Tumor Necrosis Factor-Alpha in Neuropathic Pain: An Animal Model Study</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Cacao</style></keyword><keyword><style  face="normal" font="default" size="100%">Neuropathic pain</style></keyword><keyword><style  face="normal" font="default" size="100%">pain scale</style></keyword><keyword><style  face="normal" font="default" size="100%">Paracetamol</style></keyword><keyword><style  face="normal" font="default" size="100%">TNF-α</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2024</style></year><pub-dates><date><style  face="normal" font="default" size="100%">December 2024</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">16</style></volume><pages><style face="normal" font="default" size="100%">1336-1341</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction:&lt;/strong&gt; One treatment for neuropathic pain is paracetamol. Meanwhile, cacao bean extract is a traditional remedy developed for pain management. &lt;strong&gt;Objective:&lt;/strong&gt; Analyzing effect of combining cacao bean extract and paracetamol on pain scale and tumor necrosis factor-alpha (TNF-α) in neuropathic pain. &lt;strong&gt;Methods:&lt;/strong&gt; Subjects were randomized post-test only control group design from 28 mice (Mus musculus) to 4 groups: G&lt;sub&gt;0&lt;/sub&gt; (control), G&lt;sub&gt;1&lt;/sub&gt; (paracetamol only), G&lt;sub&gt;2&lt;/sub&gt; (cacao + paracetamol), and G&lt;sub&gt;3&lt;/sub&gt; (cacao + ½ doses paracetamol). The subject assessed pain scale using von Frey test and TNF-α. The statistical analysis includes paired t-tests, Wilcoxon, one-way ANOVA, Kruskal Wallis, and Pearson correlation tests with p &amp;lt;0.05. &lt;strong&gt;Results:&lt;/strong&gt; The combination of cacao bean extract and paracetamol resulted in a pain scale of 2.57 ± 1.10 gf, with significant differences observed among the four groups (p &amp;lt;0.001). Significant differences in pain scale scores were found in four groups (p &amp;lt;0.001), including G&lt;sub&gt;0&lt;/sub&gt; (p = 0.006), G&lt;sub&gt;1&lt;/sub&gt; (p &amp;lt;0.001), G&lt;sub&gt;2&lt;/sub&gt; (p &amp;lt;0.001), and G&lt;sub&gt;3&lt;/sub&gt; (p &amp;lt;0.001). After treatment, the average TNF-α levels was 86.96 ± 23.73 ng/mL, with significant differences observed among the four groups (p &amp;lt;0.001). There was a strong correlation between the pain scale and TNF-α levels (p &amp;lt;0.001). &lt;strong&gt;Conclusion: &lt;/strong&gt;In an animal model of neuropathic pain, using cacao bean extract as a paracetamol adjuvant significantly reduces pain scale (as measured by the von Frey test) and TNF-α levels.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">1336</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Faiz Muhammad Ammar&lt;sup&gt;1,2&lt;/sup&gt;, Christrijogo Sumartono Waloejo&lt;sup&gt;1,2&lt;/sup&gt;, Herdiani Sulistyo Putri&lt;sup&gt;1,2*&lt;/sup&gt;, Kohar Hari Santoso&lt;sup&gt;1,2&lt;/sup&gt;, Prananda Surya Airlangga&lt;sup&gt;1,2&lt;/sup&gt;, Budi Utomo&lt;sup&gt;3&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Anesthesiology and Reanimation, Dr. Soetomo General Academic Hospital, Surabaya, Indonesia&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Anesthesiology and Reanimation, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Public Health and Preventive Medicine, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Noor Ahmed Abed</style></author><author><style face="normal" font="default" size="100%">Musab Mohammed Khalaf</style></author><author><style face="normal" font="default" size="100%">Mohammed Khalid Jamaludeen Alnori</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%"> The Potential Effect of Silymarin Against Paracetamol-Induced Hepatotoxicity in Male Albino Rats</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">APAP</style></keyword><keyword><style  face="normal" font="default" size="100%">Hepatotoxicity</style></keyword><keyword><style  face="normal" font="default" size="100%">NAC</style></keyword><keyword><style  face="normal" font="default" size="100%">Paracetamol</style></keyword><keyword><style  face="normal" font="default" size="100%">Silymarin</style></keyword><keyword><style  face="normal" font="default" size="100%">TNF-α</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2022</style></year><pub-dates><date><style  face="normal" font="default" size="100%">October 2022</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">14</style></volume><pages><style face="normal" font="default" size="100%">558-564</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background&lt;/strong&gt;: Being the main metabolic organ, liver stays in touch with toxicity of introduced materials including, drugs. Protection is priceless to avoid complication of liver toxicity. &lt;strong&gt;Objectives&lt;/strong&gt;: This research aimed to assess the protective impact of silymarin (SIL) on hepatotoxicity based on acute paracetamol (APAP) intoxication in rats in comparison with N-acetylcysteine (NAC). &lt;strong&gt;Methods: &lt;/strong&gt;To do so serum was collected and the liver was analyzed for histological findings on rat model-paracetamol toxicity whether alone or in combination with SIL or NAC. The scenario was based on either preconditioning with SIL/NAC before induction of toxicity or afterwards. Serum liver function tests, pro-oxidant/antioxidant status, and proinflammatory markers were detected alongside liver histological study. &lt;strong&gt;Results: &lt;/strong&gt;The results showed that liver function indices, oxidative state, and pro-inflammatory parameters were significantly changed, and histopathological alterations were detected in the liver of the intoxicated group. These modifications were inverted in groups treated with either SIL or NAC. The results of the current study suggested that SIL might be employed as a hepatoprotective drug against liver damage induced by APAP because of its ability to reduce lipid peroxidation, improve antioxidant defense status, and have anti-inflammatory effects.&lt;strong&gt; Conclusion:&lt;/strong&gt; These results are equivalent to NAC therapy which is a standard drug against APAPrelated hepatotoxicity.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">558</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Noor Ahmed Abed&lt;sup&gt;1&lt;/sup&gt;, Musab Mohammed Khalaf&lt;sup&gt;1&lt;/sup&gt;, Mohammed Khalid Jamaludeen Alnori&lt;sup&gt;2,*&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Pharmacology and Toxicology, College of Pharmacy, University of Mosul, IRAQ.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Clinical Laboratory Sciences, College of Pharmacy, University of Mosul, IRAQ.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Carmen R. Silva-Correa</style></author><author><style face="normal" font="default" size="100%">Víctor E. Villarreal-La Torre</style></author><author><style face="normal" font="default" size="100%">José L. Cruzado-Razco</style></author><author><style face="normal" font="default" size="100%">William Antonio Sagástegui- Guarniz</style></author><author><style face="normal" font="default" size="100%">María V. González-Blas</style></author><author><style face="normal" font="default" size="100%">Anabel D. González-Siccha</style></author><author><style face="normal" font="default" size="100%">Abhel A. Calderón-Peña</style></author><author><style face="normal" font="default" size="100%">Cinthya L. Aspajo- Villalaz</style></author><author><style face="normal" font="default" size="100%">Luz M. Guerrero-Espino</style></author><author><style face="normal" font="default" size="100%">Jorge Del Rosario-Chávarri</style></author><author><style face="normal" font="default" size="100%">Julio Hilario-Vargas</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Antioxidant and Hepatoprotective Activity of Ethanol Extract of Annona cherimola Mill. On Paracetamol-Induced Liver Toxicity in Rats</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Antioxidants</style></keyword><keyword><style  face="normal" font="default" size="100%">DPPH</style></keyword><keyword><style  face="normal" font="default" size="100%">Liver</style></keyword><keyword><style  face="normal" font="default" size="100%">Paracetamol</style></keyword><keyword><style  face="normal" font="default" size="100%">Rat</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2021</style></year><pub-dates><date><style  face="normal" font="default" size="100%">July 2021</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">13</style></volume><pages><style face="normal" font="default" size="100%">874-882</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background: &lt;/strong&gt;&lt;em&gt;Annona cherimola&lt;/em&gt; Mill. (&lt;em&gt;A. cherimola&lt;/em&gt;) is mainly characterized by its antioxidant and cytoprotective properties due to their content of phenolic compounds. &lt;strong&gt;Objective:&lt;/strong&gt; To evaluate antioxidant and hepatoprotective activity of ethanol extract of leaves from &lt;em&gt;A. cherimola &lt;/em&gt;against induced toxicity by paracetamol in rats. &lt;strong&gt;Methods&lt;/strong&gt;: Amount of total phenolics compounds of ethanol extract of &lt;em&gt;A. cherimola &lt;/em&gt;Mill. was determined by the Folin-Ciocalteu method and antioxidant activity was evaluated by DPPH method. Three doses of the ethanol extract of leaves of &lt;em&gt;A. cherimola&lt;/em&gt; (250, 500 and 750 mg/Kg/day) were administered to rats and it was evaluated biochemical blood parameters: aspartate aminotransferase (AST), alanine aminotransferase (ALT) and alkaline phosphatase (ALP) were measured, liver tissue was removed for histopathological analysis. &lt;strong&gt;Results: &lt;/strong&gt;Ethanol extract of leaves from&lt;em&gt; A. cherimola &lt;/em&gt;had 41.26 mg GAE/g extract and antioxidant DPPH Scavenging Activity had 85.51%.&lt;em&gt; A. cherimola &lt;/em&gt;reduced blood levels of ALT, AST and ALP, compared to control group Paracetamol, ethanol extract, being more effective at doses of 750 mg/Kg/day. Histopathological evaluation suggested that &lt;em&gt;A. cherimola&lt;/em&gt; decreased hepatic necrosis and degenerative process induced by paracetamol. &lt;strong&gt;Conclusions: &lt;/strong&gt;Hepatoprotective activity of ethanol extract of leaves of&lt;em&gt; A. cherimola&lt;/em&gt; was demonstrated, being hepatoprotective activity dose dependent and the mechanism may involve antioxidant activity and total polyphenols found in extract of this plant.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">4</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">874</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Carmen R. Silva-Correa&lt;sup&gt;1&lt;/sup&gt;, Víctor E. Villarreal-La Torre&lt;sup&gt;1,&lt;/sup&gt;*, José L. Cruzado-Razco&lt;sup&gt;1&lt;/sup&gt;, William Antonio Sagástegui-Guarniz&lt;sup&gt;1&lt;/sup&gt;, María V. González-Blas&lt;sup&gt;1&lt;/sup&gt;, Anabel D. González-Siccha&lt;sup&gt;1&lt;/sup&gt;, Abhel A. Calderón-Peña&lt;sup&gt;2&lt;/sup&gt;, Cinthya L. Aspajo-Villalaz&lt;sup&gt;2&lt;/sup&gt;, Luz M. Guerrero- Espino&lt;sup&gt;3&lt;/sup&gt;, Jorge Del Rosario- Chávarri&lt;sup&gt;2&lt;/sup&gt;, Julio Hilario-Vargas&lt;sup&gt;3&lt;/sup&gt; &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Facultad de Farmacia y Bioquímica, Universidad Nacional de Trujillo, PERÚ.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Facultad de Ciencias Biológicas, Universidad Nacional de Trujillo, PERÚ.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Departamento de Fisiología, Facultad de Medicina, Universidad Nacional de Trujillo, PERÚ.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Ruiz-Reyes SG</style></author><author><style face="normal" font="default" size="100%">Villarreal-La Torre Víctor E</style></author><author><style face="normal" font="default" size="100%">Silva-Correa Carmen R</style></author><author><style face="normal" font="default" size="100%">Sagástegui Guarniz William Antonio</style></author><author><style face="normal" font="default" size="100%">Cruzado-Razco José L</style></author><author><style face="normal" font="default" size="100%">Gamarra-Sánchez César D</style></author><author><style face="normal" font="default" size="100%">Venegas Casanova Edmundo A</style></author><author><style face="normal" font="default" size="100%">Miranda-Leyva Manuel</style></author><author><style face="normal" font="default" size="100%">Valdiviezo Campos Juan Ernesto</style></author><author><style face="normal" font="default" size="100%">Cuellar-Cuellar Armando</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Hepatoprotective Activity of Cordia lutea Lam Flower Extracts Against Paracetamol‑Induced Hepatotoxicity in Rats</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Acetaminophen</style></keyword><keyword><style  face="normal" font="default" size="100%">Biochemical parameters</style></keyword><keyword><style  face="normal" font="default" size="100%">Cordia lutea</style></keyword><keyword><style  face="normal" font="default" size="100%">Hepatoprotection</style></keyword><keyword><style  face="normal" font="default" size="100%">Histopathology</style></keyword><keyword><style  face="normal" font="default" size="100%">Paracetamol</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2021</style></year><pub-dates><date><style  face="normal" font="default" size="100%">March 2021</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">13</style></volume><pages><style face="normal" font="default" size="100%">309-316</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background:&lt;/strong&gt; Paracetamol or acetaminophen overdose leads to hepatotoxicity. This study evaluates the effect of &lt;em&gt;Cordia lutea&lt;/em&gt; extract on paracetamol-induced hepatotoxicity in rats. &lt;strong&gt;Methods:&lt;/strong&gt; Three different doses of dry fluid extract of &lt;em&gt;C. lutea&lt;/em&gt; (200, 400 and 600 mg / Kg) were evaluated and compared with Silymarin 200 mg / Kg. Biochemical parameters such as alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), direct bilirubin, indirect bilirubin, total bilirubin, albumin, globulin and total proteins were evaluated, and histopathological changes in the liver were studied and evaluated. &lt;strong&gt;Results: &lt;/strong&gt;&lt;em&gt;C. lutea &lt;/em&gt;reduced the levels of ALT, AST, ALP and increases proteins significantly, although the reduction of bilirubin was not significant, the extract at 400 mg / Kg reduced the levels better than the extract at 600 mg / Kg. The histopathological evaluation suggested that &lt;em&gt;C. lutea&lt;/em&gt; extract reduced paracetamol-induced liver necrosis. &lt;strong&gt;Conclusions: &lt;/strong&gt;The extract of &lt;em&gt;C. lutea&lt;/em&gt; has a marked hepatoprotective effect, significantly reducing the levels of ALT, AST and ALP, in addition to increasing the levels of albumin, globulin and total proteins, in&lt;em&gt; Rattus norvegicus&lt;/em&gt; var. &lt;em&gt;albinus&lt;/em&gt;.&lt;em&gt; C. lutea &lt;/em&gt;extract is an excellent candidate for use in paracetamol-induced liver diseases.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">2</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">309</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Ruiz-Reyes SG, Villarreal-La Torre Víctor E*, Silva-Correa Carmen R, Sagástegui Guarniz William Antonio, Cruzado-Razco José L, Gamarra-Sánchez César D, Venegas Casanova Edmundo A, Miranda-Leyva Manuel, Valdiviezo Campos Juan Ernesto, Cuellar-Cuellar Armando&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;Universidad Nacional de Trujillo, PERÚ.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">G Tharun</style></author><author><style face="normal" font="default" size="100%">S Sivakrishnan</style></author><author><style face="normal" font="default" size="100%">JVC Sharma</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Toxicity Assessment, Evaluation of Antioxidant and Hepatoprotective Activity on Cordia obliqua Fruit Extracts</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Cordia obliqua</style></keyword><keyword><style  face="normal" font="default" size="100%">Hepatotoxicity</style></keyword><keyword><style  face="normal" font="default" size="100%">Paracetamol</style></keyword><keyword><style  face="normal" font="default" size="100%">Silymarin</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2020</style></year><pub-dates><date><style  face="normal" font="default" size="100%">August 2020</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">12</style></volume><pages><style face="normal" font="default" size="100%">1005-1011</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background: &lt;/strong&gt;&lt;em&gt;Cordia obliqua &lt;/em&gt;Willd plant is a genus of flowering plants in the borage family, Boraginaceae. It is also known as clammy cherry. Very little research was carried out for identification of its medicinal importance when compared to other Cordia species&lt;strong&gt; Objective: &lt;/strong&gt;To determine the safe dose and to explore the in vivo antioxidant and hepatoprotective activity of &lt;em&gt;Cordia obliqua &lt;/em&gt;fruits &lt;strong&gt;Methods:&lt;/strong&gt; As per our previous study the ethanolic and aqueous extracts were rich in phytoconstituents and exhibited good in vitro antioxidant effect. So the ethanolic and aqueous extracts were used for evaluation of activity. Acute toxicity study (LD&lt;sub&gt;50&lt;/sub&gt;) was conducted according to OECD guidelines. For hepatoprotective activity paracetamol induced hepatotoxicity was studied using standard drug like Silymarin. The antioxidant potential] of the plant extracts were tested using three tests viz, Reduced GSH, Catalase and SOD activity &lt;strong&gt;Results: &lt;/strong&gt;Acute toxicity studies showed the non-toxic nature of &lt;em&gt;Cordia obliqua&lt;/em&gt; fruit extract upto dose of 3000mg/kg body weight. Administration of Paracetamol to rats increased the levels of marker enzymes like ALT, AST and ALP. Increase in the levels of these enzymes in serum indicates damage to the liver cells. Pretreatment with aqueous and ethanolic extracts of &lt;em&gt;Cordia obliqua &lt;/em&gt;decreased the levels of ALT, AST, ALP and increased levels of total protein, total bilirubin, direct bilirubin and comparisons histology of cells of extract which are an indication for the hepatoprotective activity. &lt;strong&gt;Conclusion: &lt;/strong&gt;The fruits of &lt;em&gt;Cordia obliqua&lt;/em&gt; are safe and effective in treatment of hepatic disorders and prevent oxidation of cells.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">1005</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;G Tharun&lt;sup&gt;1,&lt;/sup&gt;*, S Sivakrishnan&lt;sup&gt;2&lt;/sup&gt;, JVC Sharma&lt;sup&gt;3&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;PhD Research Scholar of Department of Pharmacy, Annamalai University, Chidambaram and Asst. Professor, University College of Pharmaceutical Sciences, Palamuru University, Mahabubnagar, Telangana, INDIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Assistant Professor, Department of Pharmacy, FEAT, Annamalai University, Annamalai Nagar, Chidambaram, Tamilnadu, INDIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Professor and Principal, Joginpally B.R Pharmacy College, Yenkapally, Moinabad, R.R. Dist. Telangana, INDIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Mallikarjuna Rao Talluri</style></author><author><style face="normal" font="default" size="100%">Veda Priya Gummadi</style></author><author><style face="normal" font="default" size="100%">Ganga Rao Battu</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Chemical Composition and Hepatoprotective Activity of Saponaria officinalis on Paracetamol-induced Liver Toxicity in Rats</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Liver</style></keyword><keyword><style  face="normal" font="default" size="100%">Paracetamol</style></keyword><keyword><style  face="normal" font="default" size="100%">roots</style></keyword><keyword><style  face="normal" font="default" size="100%">Saponaria officinalis</style></keyword><keyword><style  face="normal" font="default" size="100%">Toxicity</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2018</style></year><pub-dates><date><style  face="normal" font="default" size="100%">August 2018</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">10</style></volume><pages><style face="normal" font="default" size="100%">1196-1201</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Background:&lt;/strong&gt; The present day life style causing different illness including liver diseases and different health complications. So, there is a need to identify new chemical entities with more efficiency in the treatment of diseases and less side effects. There were many reports in recent times, about identifying new drugs from different medicinal plants and also precursors for synthesis new bioactive molecules for treating various diseases. &lt;strong&gt;Objective:&lt;/strong&gt; The present study was carried out on root parts (rhizomes) of &lt;em&gt;S. officinalis&lt;/em&gt; for phytochemical analysis and hepatoprotective activity on paracetmol-induced liver toxicity. Materials and methods: The phytochemical analysis was carried out to know biological active compounds in different extracts of &lt;em&gt;S. officinalis&lt;/em&gt; using standard procedures and quantified the total alkaloid and phenolic contents. Hepatoprotective activity of the &lt;em&gt;S. officinalis&lt;/em&gt; extracts were carried out by using Paracetmol-induced hepatotoxicity in rats. &lt;strong&gt;Results:&lt;/strong&gt; The phytochemical analysis of &lt;em&gt;S. officinalis&lt;/em&gt; roots&amp;rsquo; extracts showed presence of sterols, terpenoids, glycosides, carbohydrates, proteins, flavanoids, alkaloids, phenols, tannins and absence of saponins and oils. The methanolic extract showed more phenolic and alkaloid contents on their quantification. The &lt;em&gt;S. officinalis&lt;/em&gt; roots extracts are found to be safe at 2000 mg/kg b. w. in acute toxicity study and showed dose dependent percentage protection on liver toxicity. Methanol extract showed more activity at 500mg/kg b. w. and is comparable with standard drug Liv 52 on altered liver biomarker enzymes AST (SGOT), ALT (SGPT), ALP, total bilirubin and total protein with percentage protection 66.67%,60.63%,65.93%,64.24% and 60.98%. &lt;strong&gt;Conclusion:&lt;/strong&gt; The present study results indicates that phytochemical constituent&amp;rsquo;s diversity in S. officinalis and those extracts possess hepatoprotective activity. Further studies are needed and should involve the isolation of pure, biologically active compounds.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">1196</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Mallikarjuna Rao Talluri&lt;sup&gt;1&lt;/sup&gt;, Veda Priya Gummadi&lt;sup&gt;2&lt;/sup&gt;,*, Ganga Rao Battu&lt;sup&gt;2&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;AnaCipher Clinical Research Organization, Ramanthapur, Hyderabad, Telangana-500013, INDIA.&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;AU College of Pharmaceutical Science, Andhra University, Visakhapatnam, Andhra Pradesh-530003, INDIA.&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Mallikarjuna Rao Talluri</style></author><author><style face="normal" font="default" size="100%">Veda Priya Gummadi</style></author><author><style face="normal" font="default" size="100%">Ganga Rao Battu</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Chemical Composition and Hepatoprotective Activity of Saponaria officinalis on Paracetamol-Induced Liver Toxicity in Rats</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Liver</style></keyword><keyword><style  face="normal" font="default" size="100%">Paracetamol</style></keyword><keyword><style  face="normal" font="default" size="100%">roots</style></keyword><keyword><style  face="normal" font="default" size="100%">Saponaria officinalis</style></keyword><keyword><style  face="normal" font="default" size="100%">Toxicity</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2018</style></year><pub-dates><date><style  face="normal" font="default" size="100%">November 2018</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">10</style></volume><pages><style face="normal" font="default" size="100%">s129-s134</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Background:&lt;/strong&gt; The present day life style causing different illness including liver diseases and different health complications. So, there is a need to identify new chemical entities with more efficiency in the treatment of diseases and less side effects. There were many reports in recent times, about identifying new drugs from different medicinal plants and also precursors for synthesis new bioactive molecules for treating various diseases. &lt;strong&gt;Objective:&lt;/strong&gt; The present study was carried out on root parts (rhizomes) of &lt;em&gt;S. officinalis&lt;/em&gt; for phytochemical analysis and hepatoprotective activity on Paracetamol-induced liver toxicity. &lt;strong&gt;Materials and Methods:&lt;/strong&gt; The phytochemical analysis was carried out to know biological active compounds in different extracts of &lt;em&gt;S. officinalis&lt;/em&gt; using standard procedures and quantified the total alkaloid and phenolic contents. Hepatoprotective activity of the &lt;em&gt;S. officinalis&lt;/em&gt; extracts were carried out by using Paracetamol-induced hepatotoxicity in rats. &lt;strong&gt;Results:&lt;/strong&gt; The phytochemical analysis of &lt;em&gt;S. officinalis&lt;/em&gt; roots&amp;rsquo; extracts showed presence of sterols, terpenoids, glycosides, carbohydrates, proteins, flavanoids, alkaloids, phenols, tannins and absence of saponins and oils. The methanolic extract showed more phenolic and alkaloid contents on their quantification. The &lt;em&gt;S. officinalis&lt;/em&gt; roots extracts are found to be safe at 2000 mg/kg b. w. in acute toxicity study and showed dose dependent percentage protection on liver toxicity. Methanol extract showed more activity at 500mg/kg b. w. and is comparable with standard drug Liv 52 on altered liver biomarker enzymes AST (SGOT), ALT (SGPT), ALP, total bilirubin and total protein with percentage protection 56.17%, 54.53%, 61.55% 57.29% and 53.66%.&lt;strong&gt; Conclusion:&lt;/strong&gt; The present study results indicates that phytochemical constituent&amp;rsquo;s diversity in &lt;em&gt;S. officinalis&lt;/em&gt; and those extracts possess hepatoprotective activity. Further studies are needed and should involve the isolation of pure, biologically active compounds&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">6s</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">s129</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Mallikarjuna&lt;/strong&gt;&lt;strong&gt; Rao Talluri&lt;sup&gt;1&lt;/sup&gt;, Veda Priya Gummadi&lt;sup&gt;2,*&lt;/sup&gt;, Ganga Rao Battu&lt;sup&gt;2 &lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Anacipher Clinical Research Organization, Ramanthapur, Hyderabad, Telangana-500013, INDIA.&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;AU College of Pharmaceutical Science, Andhra University, Visakhapatnam, Andhra Pradesh-530003, INDIA.&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Varsha Raj</style></author><author><style face="normal" font="default" size="100%">Arun Kumar Mishra</style></author><author><style face="normal" font="default" size="100%">Amrita Mishra</style></author><author><style face="normal" font="default" size="100%">Najam Ali Khan</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Hepatoprotective effect of Prunus armeniaca L. (Apricot) leaf extracts on Paracetamol induced liver damage in Wistar rats</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Apricot</style></keyword><keyword><style  face="normal" font="default" size="100%">Hepatotoxicity</style></keyword><keyword><style  face="normal" font="default" size="100%">Liver toxicity.</style></keyword><keyword><style  face="normal" font="default" size="100%">Paracetamol</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2016</style></year><pub-dates><date><style  face="normal" font="default" size="100%">December 2015</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">8</style></volume><pages><style face="normal" font="default" size="100%">154-158</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align:justify&quot;&gt;&lt;strong&gt;Objective&lt;/strong&gt;: To evaluate the hepatoprotective effect of &lt;em&gt;Prunus armeniaca&lt;/em&gt; L. (Apricot) leaf on paracetamol induced liver toxicity in rats. &lt;strong&gt;Method: &lt;/strong&gt;Phytochemical investigation was performed to find active constituents of the plant extracts by the different phytochemical tests. After induction of liver toxicity, the biochemical parameters such as serum glutamic pyruvic transaminase (sGPT), serum glutamic oxaloacetic transaminase (sGOT), serum alkaline phosphatase (sALP), serum bilirubin (SB), thiobarbituric acid reactive substances (TBARS), &amp;gamma;-glutamyl transferase (GGT), lactate dehydrogenase (LDH), total protein (TP), albumin. The physical parameters including liver weight, body weight and histopathological changes in the liver were studied with Ursodeoxycholic acid as standard hepatoprotective agents.&lt;strong&gt; Results: &lt;/strong&gt;The phytochemical investigation of the extracts showed the presence of Alkaloids, volatile oil, saponin glycosides, condensed tanins, terpenoids, steroids and flavonoids. Methanol and aqueous extract before the paracetamol administration caused a significant reduction in the values of sGOT, sGPT, sALP, TBARS, GGT, LDH TP, Albumin and sB (P&amp;lt;0.01) almost comparable to the Ursodeoxycholic acid. The hepatoprotective activity was confirmed by histopathological examination of the liver tissue of control and treated animals. &lt;strong&gt;Conclusions:&lt;/strong&gt; The result concludes that &lt;em&gt;Prunus armeniaca&lt;/em&gt; L. possesses the hepatoprotective effect against paracetamol induced liver toxicity in rats.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">2</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">154</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align:justify&quot;&gt;&lt;strong&gt;Varsha Raj*, Arun Kumar Mishra, Amrita Mishra, Najam Ali Khan&lt;/strong&gt;&lt;/p&gt;

&lt;p style=&quot;text-align:justify&quot;&gt;Department of Pharmacy, Pharmacology Research Lab, IFTM University, Moradabad, 244102, INDIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Shaik Aminabee</style></author><author><style face="normal" font="default" size="100%">Atmakuri Lakshmana Rao</style></author><author><style face="normal" font="default" size="100%">Maram Chinna Eswaraiah</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Hepatoprotective Activity of Michelia nilagirica against Paracetamol Induced Hepatic Injury in Rats</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Albino rats</style></keyword><keyword><style  face="normal" font="default" size="100%">Hepatoprotective</style></keyword><keyword><style  face="normal" font="default" size="100%">Michelia nilagirica</style></keyword><keyword><style  face="normal" font="default" size="100%">Paracetamol</style></keyword><keyword><style  face="normal" font="default" size="100%">Screening.</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2015</style></year><pub-dates><date><style  face="normal" font="default" size="100%">29th Apr, 2015</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">7</style></volume><pages><style face="normal" font="default" size="100%">228-235</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Background:&lt;/strong&gt;&lt;em&gt;Michelia nilagirica&lt;/em&gt; belonging to the family &lt;em&gt;Mangoliaceae&lt;/em&gt; is commonly used by many traditional healers in most of the herbal preparations for diabetes and kidney diseases. &lt;strong&gt;Objective:&lt;/strong&gt; Different fractions isolated from ethanolic extract of whole plant of Michelia nilagirica is investigated for hepatoprotective activity in wistar albino rats against paracetamol induced hepatic injury. &lt;strong&gt;Materials &amp;amp; Methods: &lt;/strong&gt;Rats were divided into eight groups. Each group contains six animals. Hepatic injury was achieved by injecting paracetamol at a dose of 2 mg/kg p.o. &lt;strong&gt;Results: &lt;/strong&gt;The hepatoprotective action is seen with fraction A by reduction in serum marker enzymes like Aspartate transaminase (AST), Alanine transaminase (ALT). It also reduced the elevated levels of Alkaline phosphotase (ALP) &amp;amp; Serum bilirubin. &lt;strong&gt;Conclusion:&lt;/strong&gt; Histopathological studies further confined the hepatoprotective activity of fraction A against paracetamol treated group. The results obtained were compared with silymarin (100 mg/kg, orally), a standard drug.&lt;/p&gt;&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Key words: &lt;/strong&gt;Albino rats, Hepatoprotective, &lt;em&gt;Michelia nilagirica&lt;/em&gt;, Paracetamol, Screening.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">4</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">228</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Shaik Aminabee&lt;sup&gt;1&lt;/sup&gt;, Atmakuri Lakshmana Rao&lt;sup&gt;*1&lt;/sup&gt; and Maram Chinna Eswaraiah&lt;sup&gt;2 &lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Pharmacology, V. V. Institute of Pharmaceutical Sciences, Gudlavalleru, Andhra Pradesh, INDIA&lt;/p&gt;&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Pharmacognosy, Anurag College of Pharmacy, Kodad, Telangana, INDIA.&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Shaik Aminabee</style></author><author><style face="normal" font="default" size="100%">Atmakuri Lakshmana Rao</style></author></authors><secondary-authors><author><style face="normal" font="default" size="100%">Maram Chinna Eswaraiah</style></author></secondary-authors></contributors><titles><title><style face="normal" font="default" size="100%">Hepatoprotective Activity of Michelia nilagirica against Paracetamol Induced Hepatic Injury in Rats</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Albino rats</style></keyword><keyword><style  face="normal" font="default" size="100%">Hepatoprotective</style></keyword><keyword><style  face="normal" font="default" size="100%">Michelia nilagirica</style></keyword><keyword><style  face="normal" font="default" size="100%">Paracetamol</style></keyword><keyword><style  face="normal" font="default" size="100%">Screening</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2015</style></year><pub-dates><date><style  face="normal" font="default" size="100%">Jul-Aug 2015</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">7</style></volume><pages><style face="normal" font="default" size="100%">228-235</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;&lt;strong&gt;Background:&lt;/strong&gt; Michelia nilagirica belonging to the family Mangoliaceae is commonly used by many traditional healers in most of the herbal preparations for diabetes and kidney diseases. &lt;strong&gt;Objective: &lt;/strong&gt;Different fractions isolated from ethanolic extract of whole plant of Michelia nilagirica is investigated for hepatoprotective activity in wistar albino rats against paracetamol induced hepatic injury. &lt;strong&gt;Materials &amp;amp; Methods:&lt;/strong&gt; Rats were divided into eight groups. Each group contains six animals. Hepatic injury was achieved by injecting paracetamol at a dose of 2 mg/kg p.o. &lt;strong&gt;Results:&lt;/strong&gt; The hepatoprotective action is seen with fraction A by reduction in serum marker enzymes like Aspartate transaminase (AST), Alanine transaminase (ALT). It also reduced the elevated levels of Alkaline phosphotase (ALP) &amp;amp; Serum bilirubin. &lt;strong&gt;Conclusion:&lt;/strong&gt; Histopathological studies further confined the hepatoprotective activity of fraction A against paracetamol treated group. The results obtained were compared with silymarin (100 mg/kg, orally), a standard drug.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">4</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">228</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p&gt;&lt;strong&gt;Shaik Aminabee&lt;sup&gt;1&lt;/sup&gt;, Atmakuri Lakshmana Rao&lt;sup&gt;*1&lt;/sup&gt; and Maram Chinna Eswaraiah&lt;sup&gt;2 1&lt;/sup&gt;&lt;/strong&gt;Department of Pharmacology, V. V. Institute of Pharmaceutical Sciences, Gudlavalleru, Andhra Pradesh, INDIA 2Department of Pharmacognosy, Anurag College of Pharmacy, Kodad, Telangana, INDIA.&lt;/p&gt;
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