<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Amruth Kiran</style></author><author><style face="normal" font="default" size="100%">Praveen Kumar S E</style></author><author><style face="normal" font="default" size="100%">Tatiyana Mandal</style></author><author><style face="normal" font="default" size="100%">K Ganesh Shenoy</style></author><author><style face="normal" font="default" size="100%">Vasudev R Pai</style></author><author><style face="normal" font="default" size="100%">Swati Sharma</style></author><author><style face="normal" font="default" size="100%">Arul Amuthan</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Acute Toxicity Study of the Crude Aqueous Extract of Tribulus terrestris Dried Fruit with Potential Diuretic Effect</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">acute toxicity study</style></keyword><keyword><style  face="normal" font="default" size="100%">crude aqueous extract</style></keyword><keyword><style  face="normal" font="default" size="100%">Indian traditional medicine</style></keyword><keyword><style  face="normal" font="default" size="100%">Siddha system of medicine</style></keyword><keyword><style  face="normal" font="default" size="100%">Tribulus terrestris</style></keyword><keyword><style  face="normal" font="default" size="100%">Wistar Rats</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2025</style></year><pub-dates><date><style  face="normal" font="default" size="100%">September 2025</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">17</style></volume><pages><style face="normal" font="default" size="100%">566-576</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction:&lt;/strong&gt; &lt;em&gt;Tribulus terrestris&lt;/em&gt; is an important medicinal plant used in Indian traditional medicine, the crude aqueous extract of the plant is primarily used to induce diuresis for treating cardiovascular diseases and managing renal stones, etc... The safe dose and adverse effect profile of the extract was not explored adequately in preclinical studies. Hence, the present study was undertaken. &lt;strong&gt;Methods:&lt;/strong&gt; The acute toxicity was assessed based on the OECD guideline number 425: Acute Oral Toxicity – Up-and-Down-Procedure. A total of 11 animals were used in the study. Initially, one animal was administered with a dosage of 2000 mg/kg; and as the animal survived, four more animals were dosed and were observed for survival and other possible adverse drug reactions. The animals' body weight was measured before experimenting and at the end of the study. Biochemical and haematological examinations were done on normal control and test groups. Animals from the test group were sacrificed, and histopathological examinations of the vital organs were carried out. &lt;strong&gt;Results: &lt;/strong&gt;No signs of toxicity or changes in the behaviour were observed in the treatment group. As all the animals survived, it was decided that the LD&lt;sub&gt;50&lt;/sub&gt; was greater than 2000 mg/kg. However, the changes observed with platelets, total cholesterol and LDL were within the normal limits. Histological examination of the vital organs did not reveal any changes in the architecture of the organs. &lt;strong&gt;Conclusion:&lt;/strong&gt; Our study demonstrated that the crude aqueous extract of Tribulus terrestris dried fruit does not cause toxicity under the 2000 mg/kg dose limit.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">566</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Amruth Kiran&lt;sup&gt;1&lt;/sup&gt;, Praveen Kumar S E&lt;sup&gt;2&lt;/sup&gt;, Tatiyana Mandal&lt;sup&gt;1&lt;/sup&gt;, K Ganesh Shenoy&lt;sup&gt;1&lt;/sup&gt;, Vasudev R Pai&lt;sup&gt;3&lt;/sup&gt;, Swati Sharma&lt;sup&gt;4&lt;/sup&gt;, Arul Amuthan&lt;sup&gt;1,5,*&lt;/sup&gt; &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Division of Pharmacology, Department of Basic Medical Sciences, Manipal Academy of Higher Education, Manipal, India&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Pharmacology, Manipal Tata Medical College, Manipal Academy of Higher Education, Manipal, INDIA&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Pharmacognosy, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Manipal, INDIA&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Department of Pathology, Kasturba Medical College, Manipal Academy of Higher Education, Manipal, INDIA&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Division of Siddha, Centre for Integrative Medicine and Research (CIMR), Manipal Academy of Higher Education, Manipal, India&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Thanh Ha Tuan Nguyen</style></author><author><style face="normal" font="default" size="100%">Ngan Nguyen Hoang</style></author><author><style face="normal" font="default" size="100%">Xuan Thanh Nguyen</style></author><author><style face="normal" font="default" size="100%">Binh Nhu Do</style></author><author><style face="normal" font="default" size="100%">Son Trinh The</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Evaluate the Effect of Herbal Extract Remedy for Treatment of Liver Cirrhosis in in-vitro</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">CCl4</style></keyword><keyword><style  face="normal" font="default" size="100%">Liver cirrhosis</style></keyword><keyword><style  face="normal" font="default" size="100%">Silymarin</style></keyword><keyword><style  face="normal" font="default" size="100%">Wistar Rats</style></keyword><keyword><style  face="normal" font="default" size="100%">XGTQ herbal extract</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2021</style></year><pub-dates><date><style  face="normal" font="default" size="100%">January 2021</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">13</style></volume><pages><style face="normal" font="default" size="100%">189-195</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Objectives:&lt;/strong&gt; To evaluate the in-vitro effect of herbal extract recepies, namely XGTQ, in the treatment of liver cirrhosis that induced by Carbon tetrachloride (CCL4) in combination with alcohol and high-fat diet in rats. &lt;strong&gt;Materials and Methods: &lt;/strong&gt;Liver cirrhosis was induced by subcutaneously injecting CC14 (initial dose of 5,0ml/kg, followed by 1,2ml/kg twice a week in 10 weeks) in winstar rats. Then, fed with synthetic food, added 20% fat, and 0.05% cholesterol and iron oxalate. Rats were administered a day with fresh water and water mixed with 30% ethanol in another day. The rats were randomly divided into 5 groups and given distilled water (group 1 or control group and group 2 or cirrhosis group), silymarin (group 3 or reference group) or the herbal recipes, aka XGTQ, drug extract (group 4, 5) for 4 weeks. Blood was collected for biochemical test and livers were dissected to evaluate weight, morphology and quantified 4-hydroxyproline to evaluate fibrosis and collagen accumulation.&lt;strong&gt; Results: &lt;/strong&gt;In cirrhotic wistar rats, the XGTQ herbal drug at 19.6 g/kg/24h and 58.8 g/kg/24h showed the ability of reducing the level of enzymes AST, ALT in the blood (p&amp;lt;0.01), increasing plasma albumin and decreasing prothrobin time (p&amp;lt;0.05); improving physical condition, macroscopic and microscopic images of H&amp;amp;E-stained liver; decreasing the concentration of hydroxyproline in the liver and reducing the level of cirrhosis on the masson-stained templates. The effect of herbal recipes XGTQ increased dramatically with the dose, and was equivalent to silymarin at the dose of 70 mg/kg/24h. &lt;strong&gt;Conclusion: &lt;/strong&gt;The aqueous extract of XGTQ herbal remedy has have a good effect in treatment of liver cirrhosis in in-vitro and to be equivalent to that of silymarin at the dose of 70 mg/kg.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">189</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Thanh Ha Tuan Nguyen&lt;sup&gt;1,2,#&lt;/sup&gt;, Ngan Nguyen Hoang&lt;sup&gt;1,#&lt;/sup&gt;, Xuan Thanh Nguyen&lt;sup&gt;1,2&lt;/sup&gt;, Binh Nhu Do&lt;sup&gt;1,2&lt;/sup&gt;, Son Trinh The&lt;sup&gt;1,&lt;/sup&gt;* &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Vietnam Military Medical University, No.160 Phung Hung st, Phuc La, Ha dong, Ha noi, VIETNAM.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Military Hospital 103, No.261 Phung Hung st, Phuc La, Ha Dong, Ha Noi, VIETNAM.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;#&lt;/sup&gt;These authors contributed equally to this work and are co‐first authors&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Bhaskar Sharma</style></author><author><style face="normal" font="default" size="100%">Gaurav Sharma</style></author><author><style face="normal" font="default" size="100%">Suresh Chand Joshi</style></author><author><style face="normal" font="default" size="100%">Sunil Kumar Singh</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">To Evaluate the Antidiabetic and Rejuvenating Capability of Tissues on Alloxan Induced Diabetic Rats under the Effect of Ethanolic Leaf Extract of Coriandrum sativum: A Histopathological Study</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Alloxan</style></keyword><keyword><style  face="normal" font="default" size="100%">Coriandrum sativum.</style></keyword><keyword><style  face="normal" font="default" size="100%">Pancreas and Kidney Tissue</style></keyword><keyword><style  face="normal" font="default" size="100%">Wistar Rats</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2017</style></year><pub-dates><date><style  face="normal" font="default" size="100%">September 2017</style></date></pub-dates></dates><urls><web-urls><url><style face="normal" font="default" size="100%">http://fulltxt.org/article/177</style></url></web-urls></urls><volume><style face="normal" font="default" size="100%">9</style></volume><pages><style face="normal" font="default" size="100%">792-798</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Objective:&lt;/strong&gt; To evaluate the antidiabetic and rejuvenating capability of tissues on alloxan induced diabetic rats under the effect of ethanolic leaf extract of &lt;em&gt;Coriandrum sativum&lt;/em&gt;. &lt;strong&gt;Methods:&lt;/strong&gt; Diabetic model was prepared by administration of alloxan monohydrate (150 mg/ kg i.p). The ethanolic leaf extracts of &lt;em&gt;Coriandrum sativum&lt;/em&gt; at a dose of 200 and 400 mg/kg of body weight were administrated to diabetic induced groups for a period of 28 days. The effect of ethanolic leaf extract of &lt;em&gt;Coriandrum sativum&lt;/em&gt; leaf extract on serum blood glucose, insulin, lipase, &amp;alpha;- amylase and LDH as well as kidney function test [urea, uric acid, albumin, protein and creatinine] were measured in the alloxan induced diabetic rats. &lt;strong&gt;Results:&lt;/strong&gt; In the acute toxicity study, ethanolic leaf extract of &lt;em&gt;Coriandrum sativum&lt;/em&gt; leaf was non-toxic at 2 000 mg/kg in rats. The increased insulin level, albumin and protein level, decreased blood glucose and other biochemical parameters level were observed in diabetic rats treated with both doses of ethanol extract of &lt;em&gt;Coriandrum sativum&lt;/em&gt; leaf compared to diabetic control rats. In Histopathological study were revealed toward normal. &lt;strong&gt;Conclusion:&lt;/strong&gt; Ethanolic extract of &lt;em&gt;Coriandrum sativum&lt;/em&gt; leaf possesses significant antidiabetic and rejuvenating capability of tissues.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">792</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Bhaskar Sharma&lt;sup&gt;1&lt;/sup&gt;, Gaurav Sharma&lt;sup&gt;1*&lt;/sup&gt;, Suresh Chand Joshi&lt;sup&gt;2&lt;/sup&gt;, Sunil Kumar Singh&lt;sup&gt;3&lt;/sup&gt; &lt;/strong&gt;&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;School of Sciences , Suresh Gyan Vihar university, Mahal, Jagatpura, Jaipur--302017, Rajasthan, INDIA.&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Reproductive Toxicology Unit, Center for advanced studies, Department of Zoology, University of Rajasthan, Jaipur, INDIA.&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Pharmacognosy, United Institute of Pharmacy, Allahabad, Uttar Pradesh, INDIA.&lt;/p&gt;</style></auth-address></record></records></xml>