<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Kusmardi Kusmardi</style></author><author><style face="normal" font="default" size="100%">Natasha Yemima Situmorang</style></author><author><style face="normal" font="default" size="100%">Endah Zuraidah</style></author><author><style face="normal" font="default" size="100%">Ari Estuningtyas</style></author><author><style face="normal" font="default" size="100%">Aryo Tedjo</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">The Effect of Mahkota Dewa (Phaleria macrocarpa) Leaf Extract on the Mucin 1 Expression in Mice Colonic Epithelial Cells Induced by Dextran Sodium Sulfate (DSS)</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Anti-inflammatory agent</style></keyword><keyword><style  face="normal" font="default" size="100%">Colon epithelial cell</style></keyword><keyword><style  face="normal" font="default" size="100%">Inflammatory bowel Disease</style></keyword><keyword><style  face="normal" font="default" size="100%">Mahkota Dewa (Phaleria macrocarpa)</style></keyword><keyword><style  face="normal" font="default" size="100%">MUC 1 expression</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2021</style></year><pub-dates><date><style  face="normal" font="default" size="100%">November 2021</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">13</style></volume><pages><style face="normal" font="default" size="100%">1509-1515</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background: &lt;/strong&gt;Inflammatory bowel disease is a chronic inflammation caused by the malignant inflammation response and if not treated, could lead to colorectal cancer. One of the researched treatment is mahkota dewa (&lt;em&gt;Phaleria macrocarpa&lt;/em&gt;) leaf extract that has flavonoid compound known to reduce inflammation. This study was aimed to prove that mahkota dewa leaf extract could reduce inflammation of mice colon induced with dextran sodium sulfate (DSS) and observe MUC1 expression from colon epithelial crypt of Lieberkuhn. &lt;strong&gt;Methods&lt;/strong&gt;: This was a laboratory experiment using biological material (paraffin block) taken from 28 mice and divided into 5 groups: normal, aspirin, low and high dose mahkota dewa, and negative control. They were processed into immunohistochemistry and stained microscopic slides. Afterwards, they were observed with 400x magnification and 5 field-of-view of mice colon crypt of lieberkuhn. Then MUC1 expression was counted using ImageJ to obtain mean immunohistochemistry score and analyzed with SPSS. &lt;strong&gt;Results:&lt;/strong&gt; There were significant reduction of MUC1 expressions from normal, aspirin, and high dose mahkota dewa groups compared to the negative control group. The result shown MUC1 expression from high dose mahkota dewa (M=149.90,SD=3.81) and aspirin (M=158.92,SD=5.28) were closer to normal group (M=148.02,SD=5.28). There were no significant results between negative (M=175.39,SD=14.30) and low dose mahkota dewa group (M=149.90,SD=5.02).&lt;strong&gt; Conclusion:&lt;/strong&gt; There was a reduction of MUC1 expression in DSS-induced mice colonic epithelial cells for high dose mahkota dewa group. This shown that high dosage mahkota dewa leaf extract could reduce inflammation like aspirin.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">1509</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Kusmardi Kusmardi&lt;sup&gt;1-3,*&lt;/sup&gt;, Natasha Yemima Situmorang&lt;sup&gt;4&lt;/sup&gt;, Endah Zuraidah&lt;sup&gt;5&lt;/sup&gt;, Ari Estuningtyas&lt;sup&gt;6&lt;/sup&gt;, Aryo Tedjo&lt;sup&gt;2,7&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Anatomic Pathology, Faculty of Medicine – Universitas Indonesia, Jakarta, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Drug Development Research Center, Indonesia Medical Education and Resesarch Institute (IMERI), Universitas Indonesia, Jakarta, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Human Cancer Research Center, IMERI, Universitas Indonesia, Jakarta, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Faculty of Medicine, Universitas Indonesia, Jakarta, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Department of Anatomic Pathology, Faculty of Medicine – Universitas Indonesia, Jakarta, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;6&lt;/sup&gt;Department of Pharmacology and Therapeutic, Faculty of Medicine, Universitas Indonesia, Jakarta, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;7&lt;/sup&gt;Department of Medical Chemistry, Faculty of Medicine, Universitas Indonesia, Jakarta, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Nilesh Balasaheb Chougule</style></author><author><style face="normal" font="default" size="100%">Sachin Annasaheb Nitve</style></author><author><style face="normal" font="default" size="100%">Kailasam Koumaravelou</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Phytochemical Investigation and Screening for Inflammatory Bowel Disease Activity of Ethanolic Extract of Kariyat</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Indomithacin.</style></keyword><keyword><style  face="normal" font="default" size="100%">Inflammatory bowel Disease</style></keyword><keyword><style  face="normal" font="default" size="100%">Kariyat</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2018</style></year><pub-dates><date><style  face="normal" font="default" size="100%">April 2018</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">10</style></volume><pages><style face="normal" font="default" size="100%">602-610</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Objectives:&lt;/strong&gt; The present study investigates the protective effect of Kariyat against Indomethacin and Acetic Acid induced Inflammatory Bowel Disease in male wistar rats. &lt;strong&gt;Material Method:&lt;/strong&gt; HPTLC and GC-MS investigations indicated presence of steroid, phenols, terpenoid, alkaloids, saponine, flavonoids. IBD was induced by administration of Indomethacin (7.5mg/kg b.w. S.c.), Acetic Acid (4% v/v). Two different models used to induce IBD named Indomethacin induces enter colitis and Acetic Acid induces enter colitis in case of Indomethacin induces enter colitis the compromises 5 groups (n=6), normal, control, standard treated (Prednisolone 2mg/kg p.o.), KEE treated (100 mg/kg b.w.), KEE treated (200 mg/kg b.w.) in case of Acetic Acid induces colitis the compromises 5 groups (n=6), normal, control, standard treated (Prednisolone 2mg/kg p.o.), KEE treated (100mg/kg b.w.), KEE treated(200mg/kg b.w.). After treatment of 7 days animals were sacrificed and colon was isolated for macroscopic and microscopic studies. Quantification of inflammation was done by using myeloperoxidase assay (MPO), Lactate dehydrogenase (LDH), Lipid peroxidase (LPO). &lt;strong&gt;Result:&lt;/strong&gt; Evaluation based on macroscopic features showed significantly lower score values for drug treated and standard drug treated groups compared to the disease control groups. Histological examination of disease control group showed massive necrosis of the mucosa and sub mucosa. Drug treated group showed mild lesions, regeneration and inflammatory reaction. The Prednisolone treated group showed suppressed inflammatory reaction. The results observed from MPO, LDH and LPO assays showed significant improvement of disease with extract treated groups compared to disease control group. Histopathological examination of Kariyat treated group revealed less damage compared to Indomethacin and Acetic Acid Induced group. &lt;strong&gt;Conclusion:&lt;/strong&gt; Kariyat have shown to be effective in Indomethacin and Acetic Acid induced colitis in rats, which has protected the animals against experimentally induced disease because of its antioxidant and anti-inflammatory activity.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">602</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p&gt;&lt;strong&gt;Nilesh Balasaheb Chougule&lt;sup&gt;1, 2&lt;/sup&gt;, Sachin Annasaheb Nitve&lt;sup&gt;1,3&lt;/sup&gt;, Kailasam Koumaravelou&lt;sup&gt;1&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;&lt;sup&gt;1&lt;/sup&gt;Centre for Research and Development, PRIST University, Vallam, Thanjavur 613 403, Tamil Nadu, INDIA.&lt;/p&gt;
&lt;p&gt;&lt;sup&gt;2&lt;/sup&gt;Annasaheb Dange College of D. Pharmacy, Ashta, Sangli, Maharashtra, INDIA.&lt;/p&gt;
&lt;p&gt;&lt;sup&gt;3&lt;/sup&gt;Anil Alias Pintu Magdum College of D. Pharmacy, Dharnggutti, Kolhapur, Maharashtra, INDIA.&lt;/p&gt;</style></auth-address></record></records></xml>