<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Rashmi Kaup Shiva</style></author><author><style face="normal" font="default" size="100%">Ganaraja Bolumbu</style></author><author><style face="normal" font="default" size="100%">Santosh Mayannavar</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Role of Catecholamine Pathways in Action of Orexin B Induced Open Field Activity by Nucleus Accumbens in Wistar Rats</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Dopamine</style></keyword><keyword><style  face="normal" font="default" size="100%">Noradrenaline</style></keyword><keyword><style  face="normal" font="default" size="100%">Nucleus Accumbens</style></keyword><keyword><style  face="normal" font="default" size="100%">Orexin B</style></keyword><keyword><style  face="normal" font="default" size="100%">TCSOX2- 29</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2018</style></year><pub-dates><date><style  face="normal" font="default" size="100%">June 2018</style></date></pub-dates></dates><urls><web-urls><url><style face="normal" font="default" size="100%">http://fulltxt.org/article/641</style></url></web-urls></urls><volume><style face="normal" font="default" size="100%">10</style></volume><pages><style face="normal" font="default" size="100%">628-632</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Aims:&lt;/strong&gt; To elucidate whether exploratory behaviour changes following Orexin B infusion in NAc is mediated through catecholamines in male Wistar rats. &lt;strong&gt;Methods:&lt;/strong&gt; Inbred male Wistar rats (n= 24) were divided into three groups. Control, Treated 1 (Orexin B) and Treated 2 (Orexin B antagonist) groups. Using stereotaxic method, guide cannula was set in place bilaterally to reach Nucleus Accumbens. Orexin B and its antagonist, TCS-OX2-29 were infused in separate groups of overnight fasted rats. Following open field activity, catecholamines (Dopamine, Adrenaline, and Noradrenaline) were estimated in brain tissue homogenate by ELISA. Data were expressed as mean&amp;plusmn;SEM (ANOVA; Student-Newman Keuls test,).p&amp;lt;0.05 were considered as statistically significant. &lt;strong&gt;Results:&lt;/strong&gt; Orexin B infusion significantly increased noradrenaline levels in Nucleus accumbens when compared to controls. TCS-OX2-29 significantly decreased noradrenaline in Nucleus accumbens during open field exploration activity. Adrenaline was not altered significantly during open field activity. &lt;strong&gt;Conclusion:&lt;/strong&gt; These results suggest that Orexin B, which plays a role in the regulation of motor and exploratory behaviour when infused in NAc mediates these actions through noradrenergic neurotransmission in Nucleus Accumbens.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">4</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">628</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Rashmi Kaup Shiva&lt;sup&gt;1&lt;/sup&gt;, Ganaraja Bolambu&lt;sup&gt;2&lt;/sup&gt;*, Santosh Mayannavar&lt;sup&gt;3 &lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Physiology, Centre for Basic Sciences, Kasturba Medical College (A unit of Manipal Academy of Higher Education (MAHE), Manipal), Mangalore, Karnataka, INDIA.&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Physiology, Karwar Institute of Medical Sciences, Karwar, Karnataka, INDIA.&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Oral and Maxillofacial Surgery, Manipal College of Dental Sciences, Mangaluru, Karnataka, INDIA.&lt;/p&gt;</style></auth-address></record></records></xml>