<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Yayu Mulsiani Evary</style></author><author><style face="normal" font="default" size="100%">Amir Muhammad Nur</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Antioxidant and Antidiabetes Capacity of Hexane, Ethylacetate and Ethanol Extracts of Durio zibethinus Murr. Root</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Antioxidant</style></keyword><keyword><style  face="normal" font="default" size="100%">Durio Zibethinus Murr.</style></keyword><keyword><style  face="normal" font="default" size="100%">Extracts</style></keyword><keyword><style  face="normal" font="default" size="100%">roots</style></keyword><keyword><style  face="normal" font="default" size="100%">α-glucosidase inhibitor</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2018</style></year><pub-dates><date><style  face="normal" font="default" size="100%">August 2018</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">10</style></volume><pages><style face="normal" font="default" size="100%">937-940</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Introduction:&lt;/strong&gt; Active natural products from medicinal plants are good sources for the antioxidant and antidiabetic agent. Natural antioxidants protect human health against oxidative stress and free radicals which cause degenerative disease such as diabetes.&lt;strong&gt; Objectives:&lt;/strong&gt; This study was conduct to try one approach to treat diabetes that is to reduce gastrointestinal glucose absorption through the inhibition of the &amp;alpha;-glucosidase enzyme. &lt;strong&gt;Methods:&lt;/strong&gt; We make three different root extracts from &lt;em&gt;Durio zibethinus&lt;/em&gt; Murr. The extracts were examined for their DPPH radical scavenging activity, antioxidant activity using &amp;beta;-carotene-linoleic acid assay, and their &amp;alpha;-glucosidase inhibitory activity by a standard method. Additionally, we have also determined their total polyphenols and total flavonoids quantitatively using spectrophotometer UV-Vis. &lt;strong&gt;Results:&lt;/strong&gt; The root extracts&lt;em&gt; Durio zibethinus&lt;/em&gt; Murr. were effectively scavenged DPPH radicals in varied rate. The hexane (EHD), ethyl acetate (EEAD), and ethanol (EED) extracts revealed DPPH radical scavenging activity with IC&lt;sub&gt;50&lt;/sub&gt; of 541.28, 83.95 and 11.24 &amp;mu;g/ml respectively and their &amp;beta;-carotene-linoleic acid assay showed activity with IC&lt;sub&gt;50&lt;/sub&gt; of 273.58, 139.53, and 166.83 &amp;mu;g/ml, respectively. &lt;em&gt;In vitro&lt;/em&gt; assay of the &amp;alpha;-glucosidase inhibitory activity of the EHD, EEAD, and EED extracts showed an IC&lt;sub&gt;50&lt;/sub&gt; of 119.84, 23.69, and 3.35 &amp;mu;g/ml, respectively. &lt;strong&gt;Conclution:&lt;/strong&gt; In this present study, we found that ethanol extract revealed the most active antioxidant activity and the highest inhibitory activity against &amp;alpha;-glucosidase enzyme. The total phenolics and total flavonoids contents of the extracts were studied, where the ethanol extracts were found to have the highest than that of other extracts. This study proofs the medicinal potencies of &lt;em&gt;Durio zibethinus&lt;/em&gt; Murr. root extracts.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">937</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p&gt;&lt;strong&gt;Yayu Mulsiani Evary&lt;sup&gt;1&lt;/sup&gt;*, Amir Muhammad Nur&lt;sup&gt;2 &lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Pharmacognosy and Phytochemistry, Faculty of Pharmacy, Hasanuddin University, Makassar, INDONESIA.&lt;/p&gt;
&lt;p&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Pharmacology and Toxicology, Faculty of Pharmacy, Hasanuddin University, Makassar, INDONESIA.&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Mallikarjuna Rao Talluri</style></author><author><style face="normal" font="default" size="100%">Veda Priya Gummadi</style></author><author><style face="normal" font="default" size="100%">Ganga Rao Battu</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Chemical Composition and Hepatoprotective Activity of Saponaria officinalis on Paracetamol-Induced Liver Toxicity in Rats</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Liver</style></keyword><keyword><style  face="normal" font="default" size="100%">Paracetamol</style></keyword><keyword><style  face="normal" font="default" size="100%">roots</style></keyword><keyword><style  face="normal" font="default" size="100%">Saponaria officinalis</style></keyword><keyword><style  face="normal" font="default" size="100%">Toxicity</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2018</style></year><pub-dates><date><style  face="normal" font="default" size="100%">November 2018</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">10</style></volume><pages><style face="normal" font="default" size="100%">s129-s134</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Background:&lt;/strong&gt; The present day life style causing different illness including liver diseases and different health complications. So, there is a need to identify new chemical entities with more efficiency in the treatment of diseases and less side effects. There were many reports in recent times, about identifying new drugs from different medicinal plants and also precursors for synthesis new bioactive molecules for treating various diseases. &lt;strong&gt;Objective:&lt;/strong&gt; The present study was carried out on root parts (rhizomes) of &lt;em&gt;S. officinalis&lt;/em&gt; for phytochemical analysis and hepatoprotective activity on Paracetamol-induced liver toxicity. &lt;strong&gt;Materials and Methods:&lt;/strong&gt; The phytochemical analysis was carried out to know biological active compounds in different extracts of &lt;em&gt;S. officinalis&lt;/em&gt; using standard procedures and quantified the total alkaloid and phenolic contents. Hepatoprotective activity of the &lt;em&gt;S. officinalis&lt;/em&gt; extracts were carried out by using Paracetamol-induced hepatotoxicity in rats. &lt;strong&gt;Results:&lt;/strong&gt; The phytochemical analysis of &lt;em&gt;S. officinalis&lt;/em&gt; roots&amp;rsquo; extracts showed presence of sterols, terpenoids, glycosides, carbohydrates, proteins, flavanoids, alkaloids, phenols, tannins and absence of saponins and oils. The methanolic extract showed more phenolic and alkaloid contents on their quantification. The &lt;em&gt;S. officinalis&lt;/em&gt; roots extracts are found to be safe at 2000 mg/kg b. w. in acute toxicity study and showed dose dependent percentage protection on liver toxicity. Methanol extract showed more activity at 500mg/kg b. w. and is comparable with standard drug Liv 52 on altered liver biomarker enzymes AST (SGOT), ALT (SGPT), ALP, total bilirubin and total protein with percentage protection 56.17%, 54.53%, 61.55% 57.29% and 53.66%.&lt;strong&gt; Conclusion:&lt;/strong&gt; The present study results indicates that phytochemical constituent&amp;rsquo;s diversity in &lt;em&gt;S. officinalis&lt;/em&gt; and those extracts possess hepatoprotective activity. Further studies are needed and should involve the isolation of pure, biologically active compounds&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">6s</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">s129</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Mallikarjuna&lt;/strong&gt;&lt;strong&gt; Rao Talluri&lt;sup&gt;1&lt;/sup&gt;, Veda Priya Gummadi&lt;sup&gt;2,*&lt;/sup&gt;, Ganga Rao Battu&lt;sup&gt;2 &lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Anacipher Clinical Research Organization, Ramanthapur, Hyderabad, Telangana-500013, INDIA.&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;AU College of Pharmaceutical Science, Andhra University, Visakhapatnam, Andhra Pradesh-530003, INDIA.&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Mallikarjuna Rao Talluri</style></author><author><style face="normal" font="default" size="100%">Veda Priya Gummadi</style></author><author><style face="normal" font="default" size="100%">Ganga Rao Battu</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Chemical Composition and Hepatoprotective Activity of Saponaria officinalis on Paracetamol-induced Liver Toxicity in Rats</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Liver</style></keyword><keyword><style  face="normal" font="default" size="100%">Paracetamol</style></keyword><keyword><style  face="normal" font="default" size="100%">roots</style></keyword><keyword><style  face="normal" font="default" size="100%">Saponaria officinalis</style></keyword><keyword><style  face="normal" font="default" size="100%">Toxicity</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2018</style></year><pub-dates><date><style  face="normal" font="default" size="100%">August 2018</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">10</style></volume><pages><style face="normal" font="default" size="100%">1196-1201</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Background:&lt;/strong&gt; The present day life style causing different illness including liver diseases and different health complications. So, there is a need to identify new chemical entities with more efficiency in the treatment of diseases and less side effects. There were many reports in recent times, about identifying new drugs from different medicinal plants and also precursors for synthesis new bioactive molecules for treating various diseases. &lt;strong&gt;Objective:&lt;/strong&gt; The present study was carried out on root parts (rhizomes) of &lt;em&gt;S. officinalis&lt;/em&gt; for phytochemical analysis and hepatoprotective activity on paracetmol-induced liver toxicity. Materials and methods: The phytochemical analysis was carried out to know biological active compounds in different extracts of &lt;em&gt;S. officinalis&lt;/em&gt; using standard procedures and quantified the total alkaloid and phenolic contents. Hepatoprotective activity of the &lt;em&gt;S. officinalis&lt;/em&gt; extracts were carried out by using Paracetmol-induced hepatotoxicity in rats. &lt;strong&gt;Results:&lt;/strong&gt; The phytochemical analysis of &lt;em&gt;S. officinalis&lt;/em&gt; roots&amp;rsquo; extracts showed presence of sterols, terpenoids, glycosides, carbohydrates, proteins, flavanoids, alkaloids, phenols, tannins and absence of saponins and oils. The methanolic extract showed more phenolic and alkaloid contents on their quantification. The &lt;em&gt;S. officinalis&lt;/em&gt; roots extracts are found to be safe at 2000 mg/kg b. w. in acute toxicity study and showed dose dependent percentage protection on liver toxicity. Methanol extract showed more activity at 500mg/kg b. w. and is comparable with standard drug Liv 52 on altered liver biomarker enzymes AST (SGOT), ALT (SGPT), ALP, total bilirubin and total protein with percentage protection 66.67%,60.63%,65.93%,64.24% and 60.98%. &lt;strong&gt;Conclusion:&lt;/strong&gt; The present study results indicates that phytochemical constituent&amp;rsquo;s diversity in S. officinalis and those extracts possess hepatoprotective activity. Further studies are needed and should involve the isolation of pure, biologically active compounds.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">1196</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Mallikarjuna Rao Talluri&lt;sup&gt;1&lt;/sup&gt;, Veda Priya Gummadi&lt;sup&gt;2&lt;/sup&gt;,*, Ganga Rao Battu&lt;sup&gt;2&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;AnaCipher Clinical Research Organization, Ramanthapur, Hyderabad, Telangana-500013, INDIA.&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;AU College of Pharmaceutical Science, Andhra University, Visakhapatnam, Andhra Pradesh-530003, INDIA.&lt;/p&gt;</style></auth-address></record></records></xml>