<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">M Janib Achmad</style></author><author><style face="normal" font="default" size="100%">Alim Isnansetyo</style></author><author><style face="normal" font="default" size="100%">Noer Kasanah</style></author><author><style face="normal" font="default" size="100%">Ustadi</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Macrophage Immunomodulatory Activity of Unsaturated Fatty Acid Isolated from the Crown-of-thorns Star Fish (acanthaster planci)</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Acanthaster planci</style></keyword><keyword><style  face="normal" font="default" size="100%">Immunomodulatory</style></keyword><keyword><style  face="normal" font="default" size="100%">North moluccas</style></keyword><keyword><style  face="normal" font="default" size="100%">Phagocytic capacity</style></keyword><keyword><style  face="normal" font="default" size="100%">Phagocytic index</style></keyword><keyword><style  face="normal" font="default" size="100%">Ternate island</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2018</style></year><pub-dates><date><style  face="normal" font="default" size="100%">August 2018</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">10</style></volume><pages><style face="normal" font="default" size="100%">951-957</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Introduction:&lt;/strong&gt; Immunomodulator are chemical compounds that can improve the body&amp;rsquo;s defense mechanisms both specific and non-specific, and non-specific induction of both cellular and humoral defense mechanisms.&lt;strong&gt; Objectives:&lt;/strong&gt; The objectives of this study were to investigate immunomodulator activity and to identify the chemical constituents of active fractions from star fish&lt;em&gt; Acanthaster planci&lt;/em&gt;, based on bioassay guided isolation.&lt;strong&gt; Materials and Methods:&lt;/strong&gt; &lt;em&gt;A. planci&lt;/em&gt; was collected from Ternate Island, North Moluccas, extracted with distilled methanol, partitioned with gradient chloroform-hexane-water and fractionated in column chromatography using silica gel and gradient hexane-ethyl acetate. Profiling chemical constituent was done by thin layer chromatograpahy and GC-MS. The immunomodulator activity was measured based on percentage of phagocytic capacity (PC) and phagocytic index (PI). &lt;strong&gt;Results:&lt;/strong&gt; The result showed that 3 partition fractions exhibited immunomodulator activity. Data analysis exhibited that the best fraction was hexane fraction, and the best dosesmost effective doses of PC and PI were at 0.5 mg/kg body weight (BW) and 0.7 mg/kg BW, respectively. Data analysis of the 3 hexane fractions exhibited that the best fraction was fraction 3 and the best doses of PC was at 0.5 mg/kg BW and that of PI was at 0.7 mg/kg BW. Metabolites analysis using GC-MS yielded a number of chemical constituents of fraction 2 dan fraction 3 that dominated by unsaturated fatty acid. The study concluded that star fish &lt;em&gt;A. planci&lt;/em&gt; from Ternate Island has a potential source of immunomodulator.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">951</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;M Janib Achmad&lt;sup&gt;1&lt;/sup&gt;, Alim Isnansetyo&lt;sup&gt;2&lt;/sup&gt;, Noer Hasanah&lt;sup&gt;2&lt;/sup&gt;,Ustadi&lt;sup&gt;2 &lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Faculty of Fisheries and Marine Science, University of Khairun Ternate Jl.Pertamina Kampus 2, Kel. Gambesi Ternate Selatan, INDONESIA. &lt;sup&gt;2&lt;/sup&gt;Department of Fisheries, University of Gadjah Mada Jl Flora Buluksumur, Yogyakarta, INDONESIA.&lt;/p&gt;</style></auth-address></record></records></xml>