<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Karnirius Harefa</style></author><author><style face="normal" font="default" size="100%">Delmi Sulastri</style></author><author><style face="normal" font="default" size="100%">Ellyza Nasrul</style></author><author><style face="normal" font="default" size="100%">Syafruddin Ilyas</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Analysis of Several Inflammatory Markers Expression in Obese Rats given Plectranthus amboinicus (Lour.) Spreng Ethanol Extract</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Enzyme-Linked Immunosorbent Assay</style></keyword><keyword><style  face="normal" font="default" size="100%">immunohistochemistry</style></keyword><keyword><style  face="normal" font="default" size="100%">Obese</style></keyword><keyword><style  face="normal" font="default" size="100%">Plant extract</style></keyword><keyword><style  face="normal" font="default" size="100%">Rats</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2021</style></year><pub-dates><date><style  face="normal" font="default" size="100%">January 2021</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">13</style></volume><pages><style face="normal" font="default" size="100%">172-178</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction: &lt;/strong&gt;Oxidative stress is one of the inflammatory events caused by obesity. This condition is characterized by an increase in various inflammatory markers, such as intercellular adhesion molecule 1 (ICAM-1), vascular cell adhesion molecule 1 (VCAM-1), and a cluster of differentiation 40 (CD40). This study aimed to analyze the effect of Plectranthus amboinicus (Lour.) Spreng ethanol extract on ICAM-1, VCAM-1, and CD40 in obese rats. &lt;strong&gt;Methods: &lt;/strong&gt;The study used a pure experimental method with a completely randomized design. There were 6 groups, namely, C− (negative control), C+ (positive control), CMC (soluble control), EE300 (P. amboinicus ethanol extract, 300 mg/kg body weight [BW]), EE600 (P. amboinicus ethanol extract, 600 mg/kg BW) and EE900 groups (P. amboinicus ethanol extract, 900 mg/kg BW). &lt;strong&gt;Results: &lt;/strong&gt;The results showed low levels of ICAM-1 and VCAM-1 in the blood plasma, especially in the EE900 group, but the difference was not substantial. The same trend also occurred in the expression of CD40 in the tunica intima layer of the rat aorta. &lt;strong&gt;Conclusions:&lt;/strong&gt; Thus, the administration of 900 mg/kg BW P. amboinicus ethanol extract for 45 days has the potential to treat obesity in rats through the suppression of oxidative stress and inflammatory markers (ICAM-1, VCAM-1 and CD40).&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">172</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Karnirius Harefa&lt;sup&gt;1&lt;/sup&gt;, Delmi Sulastri&lt;sup&gt;1&lt;/sup&gt;, Ellyza Nasrul&lt;sup&gt;1&lt;/sup&gt;, Syafruddin Ilyas&lt;sup&gt;2,&lt;/sup&gt;* &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Study Programme of Biomedic, Faculty of Medicine, Universitas Andalas, Padang, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Biology, Faculty of Mathematics and Natural Sciences,Universitas Sumatera Utara, Medan, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Kusmardi Kusmardi</style></author><author><style face="normal" font="default" size="100%">Aryo Tedjo</style></author><author><style face="normal" font="default" size="100%">Fadilah Fadilah</style></author><author><style face="normal" font="default" size="100%">Ade Arsianti</style></author><author><style face="normal" font="default" size="100%">Rafika Indah Paramita</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Identification by Docking Simulation and in vivo Effect of Essential Oil from Cinnamommum burmannii as Anti-obesity with Leptin Receptor in the Olfactory System of Mice Balb C</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Cinnamomum burmannii</style></keyword><keyword><style  face="normal" font="default" size="100%">docking simulation</style></keyword><keyword><style  face="normal" font="default" size="100%">immunohistochemistry</style></keyword><keyword><style  face="normal" font="default" size="100%">leptin receptors</style></keyword><keyword><style  face="normal" font="default" size="100%">olfactory system</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2018</style></year><pub-dates><date><style  face="normal" font="default" size="100%">August 2018</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">10</style></volume><pages><style face="normal" font="default" size="100%">875-879</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Aim:&lt;/strong&gt; This study examines the effect of inhalation of essential oil of cinnamon (&lt;em&gt;Cinnamomum burmannii&lt;/em&gt;) on the metabolic activity of hormone receptors olfactory system of mice Balb C. &lt;strong&gt;Methodology:&lt;/strong&gt; Effects of agonist or antagonist compounds in cinnamon essential oil on metabolic hormone receptors in the olfactory system are predicted using molecular docking simulation. Changes in the metabolic processes that occur views of changes in body weight, change in food intake, as well as lipid profile and blood glucose of mice. &lt;strong&gt;Result:&lt;/strong&gt; The results showed Expression of leptin receptors (Lep-R) in the brains of mice given either inhalation of essential oils derived from the leaves and stems, in contrast to the control group who did not get essential oils. Provision of essential oils through inhalation increased lep-R expression in the brain of mice. Both &lt;em&gt;in silico&lt;/em&gt; and &lt;em&gt;in vivo&lt;/em&gt; evidence that essential oils from cinnamon plants are extracted from &lt;em&gt;Cinnamommum burmannii&lt;/em&gt; and given by inhalation in Balb C mice are known to improve glucose and lipid metabolism by reducing the concentration of serum leptin concentrations and increased sensitivity to insulin.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">875</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Kusmardi Kusmardi&lt;sup&gt;1&lt;/sup&gt;, Aryo Tedjo&lt;sup&gt;2&lt;/sup&gt;, Fadilah Fadilah&lt;sup&gt;2&lt;/sup&gt;, Ade Arsianti&lt;sup&gt;2&lt;/sup&gt;, Rafika Indah Paramita&lt;sup&gt;2*&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Anatomical Pathology, Faculty of Medicine, University of Indonesia, Jakarta - 10430, INDONESIA.&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Medical Chemistry, Drug Development Research Center - IMERI, Faculty of Medicine, University of Indonesia, Jakarta - 10430, INDONESIA.&amp;nbsp;&lt;/p&gt;</style></auth-address></record></records></xml>