<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Nandkishor Ramdas Kotagale</style></author><author><style face="normal" font="default" size="100%">Ankit Kedia</style></author><author><style face="normal" font="default" size="100%">Rupali Gite</style></author><author><style face="normal" font="default" size="100%">Shubham Nilkanth Rahmatkar</style></author><author><style face="normal" font="default" size="100%">Dinesh Yugraj Gawande</style></author><author><style face="normal" font="default" size="100%">Milind Janraoji Umekar</style></author><author><style face="normal" font="default" size="100%">Brijesh Gulabrao Taksande</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Withaferin A attenuates Alcohol Abstinence Signs in Rats</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Anxiety</style></keyword><keyword><style  face="normal" font="default" size="100%">Corticosterone</style></keyword><keyword><style  face="normal" font="default" size="100%">Ethanol withdrawal</style></keyword><keyword><style  face="normal" font="default" size="100%">HPA axis</style></keyword><keyword><style  face="normal" font="default" size="100%">Withaferin A.</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2018</style></year><pub-dates><date><style  face="normal" font="default" size="100%">August 2018</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">10</style></volume><pages><style face="normal" font="default" size="100%">1190-1195</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Background:&lt;/strong&gt; &lt;em&gt;Withania somnifera&lt;/em&gt; (WS) have been reported to inhibit acquisition and expression conditioned place preference, self-administration and withdrawal anxiety of psychostimulants. In the present work, we have assessed the effect of withaferin A on somatic and affective symptoms of ethanol withdrawal syndrome in rats. &lt;strong&gt;Methods:&lt;/strong&gt; Animals had given free access to ethanol uninterrupted for 21 days through liquid diet. Withaferin A (5, 10 and 20 mg/kg) was injected (ip) either during the development of ethanol dependence phase (days 15 &amp;ndash; 21 or 30 min before ethanol withdrawal assessment. Withdrawal signs characterized by changes in somatic signs were measured in the open field followed by evaluation of anxiety parameters, locomotion, and depressive behavior. &lt;strong&gt;Results:&lt;/strong&gt; Withaferin A treatment 30 min before 24 h postethanol withdrawal assessment did not alter the scores of somatic behavioral signs in ethanol abstinence animals. However, withaferin A (10 and 20 mg/kg, ip) from day 15-21 prevented the ethanol withdrawal-induced elevated scores of somatic behaviors, hyperlocomotion, depressive behavior, and anxiety. Withaferin A treatment did not influence the blood ethanol levels in dependent and withdrawn animals. However, withaferin A administration attenuated the elevated plasma corticosterone and ACTH levels in ethanol-withdrawn rats, suggesting withaferin A induced anti-stress effect and stabilization of HPA axis activity could have facilitated the inhibitory effect of withaferin A on ethanol withdrawal syndrome. &lt;strong&gt;Conclusion:&lt;/strong&gt; The finding supports further investigation of withaferin A and other bioactive components of WS in alcohol addiction.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">1190</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Nandkishor Ramdas Kotagale, Ankit Kedia, Rupali Gite, Shubham Nilkanth Rahmatkar, Dinesh Yugraj Gawande, Milind Janraoji Umekar, Brijesh Gulabrao Taksande&lt;/strong&gt;&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;Department of Pharmacology, Division of Neuroscience, Shrimati Kishoritai Bhoyar College of Pharmacy, New Kamptee, Nagpur (M.S.), INDIA.&lt;/p&gt;</style></auth-address></record></records></xml>