<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Tácuna-Calderón Ana Lucia</style></author><author><style face="normal" font="default" size="100%">Huaccho-Rojas Juan Jesus</style></author><author><style face="normal" font="default" size="100%">Zimic-Zare Carolina</style></author><author><style face="normal" font="default" size="100%">Pante-Medina Carlos</style></author><author><style face="normal" font="default" size="100%">Salazar-Granara Alberto</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Antidepressant and Antipsychotic-like Activity of the Ethanolic Extract of the Leaves of Maytenus macrocarpa</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Chuchuhuasi</style></keyword><keyword><style  face="normal" font="default" size="100%">Depression</style></keyword><keyword><style  face="normal" font="default" size="100%">Fluoxetine</style></keyword><keyword><style  face="normal" font="default" size="100%">Forced swim test</style></keyword><keyword><style  face="normal" font="default" size="100%">Haloperidol</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2018</style></year><pub-dates><date><style  face="normal" font="default" size="100%">November 2018</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">10</style></volume><pages><style face="normal" font="default" size="100%">s33-s37</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Introduction:&lt;/strong&gt; &lt;em&gt;Maytenus macrocarpa&lt;/em&gt; (Chuchuhuasi) is an Amazonian Peruvian traditional plant, traditionally used as anti-inflammatory, antipyretic, antihemorrhagic and antidiarrheic agent. Also, chuchuhuasi is known as a master plant, attributing to it properties in the central nervous system. In addition, depression is a disorder of the mood that cause disability to millions of people around the world. For this reason, the aim of this study was to determinate the antidepressant and antipsychotic-like activity of the ethanolic extract of Maytenus macrocarpa&lt;strong&gt;. Methods:&lt;/strong&gt; It was used the ethanolic extract of the leaves of &lt;em&gt;Maytenus macrocarpa&lt;/em&gt; (EELMM) in female mice at the experimental model of the Forced Swim Test described by Porsolt. As control, it was used distillate water, fluoxetine and haloperidol. &lt;strong&gt;Results:&lt;/strong&gt; The immobility time of the groups of EELMM has a mean of 38.26 &amp;plusmn; 21.57, 84.32 &amp;plusmn; 26.68 and 32.17 &amp;plusmn; 25.55 for the doses of 750, 1000 and 1250 mg/Kg respectively; and the immobility time had a median of 7.5 [4.07 &amp;ndash; 20.3] and 20.93 &amp;plusmn; [17.63 &amp;ndash; 23.75] for the doses of 500 mg/Kg and 1500 mg/Kg. It was seen a positive dose-response between the dose of 500 to 1000 mg/Kg (Pearson correlation of r=0.8339 and R=0.6954) and a negative dose-response between the dose of 1000 to 1500 mg/Kg. (Pearson correlation of r= -0.7590 and R= 0.5760). &lt;strong&gt;Conclusion:&lt;/strong&gt; It was demonstrated the antidepressant-like activity of the ethanolic extract of the leaves of &lt;em&gt;Maytenus macrocarpa&lt;/em&gt; with a dose of 500 mg/kg and an antipsychotic-like activity with a dose of 1000 mg/kg.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">6s</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">s33</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;T&amp;aacute;cuna-Calder&amp;oacute;n Ana Lucia&lt;sup&gt;1,2,3&lt;/sup&gt;, Huaccho-Rojas Juan Jesus&lt;sup&gt;1,2,3&lt;/sup&gt;, Zimic-Zare Carolina&lt;sup&gt;1,2&lt;/sup&gt;, Pante-Medina Carlos&lt;sup&gt;1&lt;/sup&gt;, Salazar-Granara Alberto&lt;sup&gt;1,2,3*&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt; 1&lt;/sup&gt;Universidad de San Martin de Porres, Facultad de Medicina Humana, Centro de Investigaci&amp;oacute;n de Medicina Tradicional y Farmacolog&amp;iacute;a, Lima, PERU.&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt; 2&lt;/sup&gt;Universidad Peruana Cayetano Heredia, Facultad de Ciencias y Filosof&amp;iacute;a, Secci&amp;oacute;n Bioqu&amp;iacute;mica, Biolog&amp;iacute;a molecular y Farmacolog&amp;iacute;a, Lima, PERU.&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt; 3&lt;/sup&gt;Sociedad Peruana de Farmacologia y Terap&amp;eacute;utica Experimental (SOPFARTEX), Lima, PERU.&lt;/p&gt;</style></auth-address></record></records></xml>