<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Paul Alan Arkin Alvarado-García</style></author><author><style face="normal" font="default" size="100%">Marilú Roxana Soto-Vásquez</style></author><author><style face="normal" font="default" size="100%">Demetrio Rafael Jara-Aguilar</style></author><author><style face="normal" font="default" size="100%">José Gilberto Gavidia-Valencia</style></author><author><style face="normal" font="default" size="100%">Natalia Mavila Guzmán-Rodríguez</style></author><author><style face="normal" font="default" size="100%">Elda Maritza Rodrigo-Villanueva</style></author><author><style face="normal" font="default" size="100%">Iris Melina Alfaro- Beltrán</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Antidepressant, Anxiolytic, and Antioxidant Properties of Piper Aduncum Essential Oil from Northern Peru</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Antidepressant</style></keyword><keyword><style  face="normal" font="default" size="100%">Antioxidant</style></keyword><keyword><style  face="normal" font="default" size="100%">Anxiolytic</style></keyword><keyword><style  face="normal" font="default" size="100%">Essential oil</style></keyword><keyword><style  face="normal" font="default" size="100%">Piper aduncum</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2024</style></year><pub-dates><date><style  face="normal" font="default" size="100%">December 2024</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">16</style></volume><pages><style face="normal" font="default" size="100%">1252-1258</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;This investigation aimed to evaluate the antidepressant, anxiolytic, and antioxidant effects of &lt;em&gt;Piper aduncum&lt;/em&gt; essential oil from northern Peru. The essential oils were obtained through hydro-distillation using a modified Clevenger-type apparatus. The chromatography-mass spectrometry (GC-MS) was used to assess the chemical composition. Behavioral assays in mice were used to evaluate the antidepressant and anxiolytic effects. In addition, the antioxidant capacity was performed through DPPH, ABTS, and FRAP assays. The GC-MS analysis revealed that linalool (29.16%), bicyclogermacrene (13.32%), nerolidol (12.38%), and β-caryophyllene (10.76%) were the principal components. The results demonstrated significant antidepressant and anxiolytic effects comparable to fluoxetine and diazepam, with statistical differences between all groups (p&amp;lt;0.005). The IC50 values for the DPPH, ABTS, and FRAP assays were 5.9±0.08, 0.20±0.06, and 109.5±1.3, respectively. Consequently, &lt;em&gt;Piper aduncum&lt;/em&gt; essential oil exhibits antidepressant and anxiolytic-like effects and modest antioxidant properties compared to the controls.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">1252</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Paul Alan Arkin Alvarado- García&lt;sup&gt;1*&lt;/sup&gt;, Marilú Roxana Soto- Vásquez&lt;sup&gt;2&lt;/sup&gt;, Demetrio Rafael Jara-Aguilar&lt;sup&gt;2&lt;/sup&gt;, José Gilberto Gavidia-Valencia&lt;sup&gt;2&lt;/sup&gt;, Natalia Mavila Guzmán-Rodríguez&lt;sup&gt;1,3&lt;/sup&gt;, Elda Maritza Rodrigo-Villanueva&lt;sup&gt;2&lt;/sup&gt;, Iris Melina Alfaro-Beltrán&lt;sup&gt;4&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Grupo de investigación en Salud Mental y Medicina Integrativa, Escuela de Medicina, Universidad César Vallejo, Trujillo, PERÚ.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Grupo de investigación de Productos Naturales y Sustancias Bioactivas. Facultad de Farmacia y Bioquímica. Universidad Nacional de Trujillo, Trujillo, PERÚ.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Escuela de Psicología, Universidad César Vallejo, Trujillo, PERÚ&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Facultad de Farmacia y Bioquímica, Universidad Nacional de Trujillo, Trujillo, PERÚ.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Paul Alan Arkin Alvarado-García</style></author><author><style face="normal" font="default" size="100%">Marilú Roxana Soto-Vásquez</style></author><author><style face="normal" font="default" size="100%">Taniht Lisseth Cubas Romero</style></author><author><style face="normal" font="default" size="100%">Santiago M. Benites</style></author><author><style face="normal" font="default" size="100%">Anthony Derlis Auris-López</style></author><author><style face="normal" font="default" size="100%">Gerardo Manuel Del Pino-Aliaga</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Exploring the Calming Potential of Peppermint: Anxiolytic Effects of Mentha piperita Essential Oil on State and Trait Anxiety</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Anxiety</style></keyword><keyword><style  face="normal" font="default" size="100%">Essential oil</style></keyword><keyword><style  face="normal" font="default" size="100%">Mentha piperita</style></keyword><keyword><style  face="normal" font="default" size="100%">State anxiety</style></keyword><keyword><style  face="normal" font="default" size="100%">Trait anxiety</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2024</style></year><pub-dates><date><style  face="normal" font="default" size="100%">December 2024</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">16</style></volume><pages><style face="normal" font="default" size="100%">1290-1296</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction: &lt;/strong&gt;This study aimed to evaluate the anxiolytic effect of &lt;em&gt;Mentha piperita&lt;/em&gt; essential oil on state and trait anxiety. &lt;strong&gt;Methods:&lt;/strong&gt; The essential oil was extracted by hydrodistillation, and its chemical composition was analyzed using Gas Chromatography-Mass Spectrometry (GC-MS). A total of 93 participants were divided into a control group (CG) and an experimental group (EG), with 47 participants in the EG receiving MPEO aromatherapy and 46 in the CG. Anxiety levels were measured using the State-Trait Anxiety Inventory (STAI) at pretest and posttest phases. Results: GC-MS analysis showed that menthol had the highest concentration (42.56%), followed by menthone (19.24%) and linalool (11.68%). Mixed model analysis revealed that group assignment (EG vs. CG) was a significant predictor of posttest state anxiety (F=16.508, p=0.001) and trait anxiety (F=9.091, p=0.003), independent of pretest scores, supporting the intervention’s effect on reducing anxiety. Posttest results showed a significant reduction in state anxiety in the EG compared to the CG (p=0.001) with a large effect size (r=0.508), while trait anxiety showed a moderate reduction (p=0.001, r=0.342).&lt;strong&gt; Conclusion: &lt;/strong&gt;These findings suggest that &lt;em&gt;Mentha piperita&lt;/em&gt; essential oil may effectively reduce state and trait anxiety, with a more pronounced impact on state anxiety.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">1290</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Paul Alan Arkin Alvarado- García&lt;sup&gt;1&lt;/sup&gt;, Marilú Roxana Soto- Vásquez&lt;sup&gt;2&lt;/sup&gt;, Taniht Lisseth Cubas Romero&lt;sup&gt;1&lt;/sup&gt;, Santiago M. Benites&lt;sup&gt;3&lt;/sup&gt;, Anthony Derlis Auris-López&lt;sup&gt;1&lt;/sup&gt;, Gerardo Manuel Del Pino- Aliaga&lt;sup&gt;1&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Escuela de Psicología. Universidad Autónoma del Perú. Lima, PERÚ.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Facultad de Farmacia y Bioquímica. Universidad Nacional de Trujillo, Trujillo, PERÚ.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Universidad Autónoma del Perú. Lima, PERÚ.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Laurente-Pachamango Katherine G</style></author><author><style face="normal" font="default" size="100%">Cruzado-Razco José L</style></author><author><style face="normal" font="default" size="100%">Silva-Correa Carmen R</style></author><author><style face="normal" font="default" size="100%">Villarreal-La Torre Víctor E</style></author><author><style face="normal" font="default" size="100%">Sagástegui-Guarniz William Antonio</style></author><author><style face="normal" font="default" size="100%">Gamarra-Sánchez César D</style></author><author><style face="normal" font="default" size="100%">Ricardo M Gomez-Arce</style></author><author><style face="normal" font="default" size="100%">Deivy Y Dionicio-Rosado</style></author><author><style face="normal" font="default" size="100%">Julio A. Castañeda-Carranza</style></author><author><style face="normal" font="default" size="100%">Calderón-Peña Abhel A</style></author><author><style face="normal" font="default" size="100%">Aspajo-Villalaz Cinthya L</style></author><author><style face="normal" font="default" size="100%">Chávez- Flores Juana E</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Wound Healing Activity of an Essential Oil-Based Cream of Origanum vulgare L. on Mice</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Cream</style></keyword><keyword><style  face="normal" font="default" size="100%">Essential oil</style></keyword><keyword><style  face="normal" font="default" size="100%">Origanum vulgare</style></keyword><keyword><style  face="normal" font="default" size="100%">Skin</style></keyword><keyword><style  face="normal" font="default" size="100%">Wound Healing</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2024</style></year><pub-dates><date><style  face="normal" font="default" size="100%">April 2024</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">16</style></volume><pages><style face="normal" font="default" size="100%">292-295</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background and Aim:&lt;/strong&gt; The objective was to evaluate the effect of a cream based on the essential oil of Origanum vulgare on skin lesions induced in Mus musculus Balb/c.&lt;strong&gt; Materials and Methods:&lt;/strong&gt; The experimental animals were divided into four groups of 6 specimens each, in which skin lesions of approximately 1 cm in diameter were induced. Group I (Control) received no treatment, Group II (0.1% Origanum vulgare cream), Group III (0.5% Origanum vulgare cream), and Group IV (1% Origanum vulgare cream) received treatment for eight days. Skin lesions were measured on days 4 and 7. At the end of treatment, they were euthanized using sodium pentobarbital 60 m/kg v.ip. Skin samples were obtained and preserved in 10% formalin for histopathological analysis.&lt;strong&gt; Results: &lt;/strong&gt;When measuring the size of the skin lesions induced in the study groups, it was observed that in the control group, the decrease in the length of the lesions occurred on the fifth day; in group II, III, and IV, the lesions length decrease occurs on the second day. At the end of the experience, the measurements of the lesions were much smaller for the III and IV groups (0.33 and 0.41, respectively) compared to the control group (0.40 cm). On day seven, statistically significant difference was found on skin lesion measure between Group IV and the Control, with a significance level of p&amp;lt;0.05. &lt;strong&gt;Conclusion:&lt;/strong&gt; It is concluded that the 1% Origanum vulgare essential oil-based cream has a healing effect on dermal lesions induced in Mus musculus Balb/c.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">2</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">292</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Laurente-Pachamango Katherine G&lt;sup&gt;1&lt;/sup&gt;, Cruzado-Razco José L&lt;sup&gt;1&lt;/sup&gt;, Silva-Correa Carmen R&lt;sup&gt;1&lt;/sup&gt;, Villarreal-La Torre Víctor E&lt;sup&gt;1,*&lt;/sup&gt;, Sagástegui-Guarniz William Antonio&lt;sup&gt;1&lt;/sup&gt;, Gamarra-Sánchez César D&lt;sup&gt;1&lt;/sup&gt;, Ricardo M Gomez- Arce&lt;sup&gt;3&lt;/sup&gt;, Deivy Y Dionicio-Rosado&lt;sup&gt;3&lt;/sup&gt;, Julio A. Castañeda-Carranza&lt;sup&gt;3&lt;/sup&gt;, Calderón-Peña Abhel A&lt;sup&gt;2&lt;/sup&gt;, Aspajo- Villalaz Cinthya L&lt;sup&gt;2&lt;/sup&gt;, Chávez- Flores Juana E&lt;sup&gt;4&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Departamento de Farmacología, Facultad de Farmacia y Bioquímica, Universidad Nacional de Trujillo, PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Departamento de Química Biológica y Fisiología Animal, Facultad de Ciencias Biológicas, Universidad Nacional de Trujillo, PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Departamento de Estadística, Facultad de Ciencias Físicas y Matemática, Universidad Nacional de Trujillo, PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Facultad de Farmacia y Bioquímica, Universidad Norbert Wiener, PERU.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Paul Alan Arkin Alvarado-García</style></author><author><style face="normal" font="default" size="100%">Marilú Roxana Soto-Vásquez</style></author><author><style face="normal" font="default" size="100%">Luis Enrique Rosales-Cerquin</style></author><author><style face="normal" font="default" size="100%">Santiago M. Benites</style></author><author><style face="normal" font="default" size="100%">Taniht Lisseth Cubas-Romero</style></author><author><style face="normal" font="default" size="100%">Emilio German Ramírez-Roca</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Anxiolytic-Like Effect of Cymbopogon Citratus (Lemongrass) Essential Oil</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Anxiety</style></keyword><keyword><style  face="normal" font="default" size="100%">Cymbopogon citratus.</style></keyword><keyword><style  face="normal" font="default" size="100%">Essential oil</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2023</style></year><pub-dates><date><style  face="normal" font="default" size="100%">August 2023</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">15</style></volume><pages><style face="normal" font="default" size="100%">674-679</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction: &lt;/strong&gt;Essential oils are complex substances that are widely utilized in the practices of aromatherapy. Certain essential oils are recognized for their potential to alleviate anxiety symptoms. This research was conducted to evaluate the effects of &lt;em&gt;Cymbopogon citratus &lt;/em&gt;essential oil on anxiety. &lt;strong&gt;Methods: &lt;/strong&gt;The chemical composition of the extracted essential oil was analyzed using Gas chromatography with flame-ionization detection (GC-FID) and Gas chromatography-mass spectrometry (GC–MS). In addition, an experimental study with measures at pretest-posttest was conducted, where 128 participants were divided into two groups, a waiting-list (WL) control group, and an experimental group (EG)treated with aromatherapy based on &lt;em&gt;Cymbopogon citratus&lt;/em&gt; essential oil. The anxiety index was evaluated by Zung Self- Rating Anxiety Scale (SAS).&lt;strong&gt; Results: &lt;/strong&gt;The chemical analysis identified geranial (52,1%) and neral (35,2%) as the principal constituents. Anxiety levels decreased in the experimental group during the posttest phase (p&amp;lt;0.05). Besides a large effect size was found for anxiety (d = 0.962; Δ= 0.988) with 1-β=0.999 a percentage of change of -10.99%. &lt;strong&gt;Conclusion:&lt;/strong&gt; &lt;em&gt;Cymbopogon citratus&lt;/em&gt; essential oil inhalation showed to be effective in decreasing scores anxiety. Therefore, it has the potential to serve as a supplementary treatment for anxiety.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">4</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">674</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Paul Alan Arkin Alvarado-García&lt;sup&gt;1,*&lt;/sup&gt;, Marilú Roxana Soto-Vásquez&lt;sup&gt;2&lt;/sup&gt;, Luis Enrique Rosales-Cerquin&lt;sup&gt;3&lt;/sup&gt;, Santiago M. Benites&lt;sup&gt;4&lt;/sup&gt;, Taniht Lisseth Cubas- Romero&lt;sup&gt;1&lt;/sup&gt;, Emilio German Ramírez- Roca&lt;sup&gt;5&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Escuela de Psicología. Universidad Autónoma del Perú. Lima, PERÚ.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Facultad de Farmacia y Bioquímica. Universidad Nacional de Trujillo, Trujillo, PERÚ.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Hospital de Apoyo Chepén, Chepén, PERÚ.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Universidad Autónoma del Perú. Lima, PERÚ. 5Escuela de Farmacia y Bioquímica. Universidad Nacional de San Cristóbal de Huamanga, PERÚ.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Paul Alan Arkin Alvarado-García</style></author><author><style face="normal" font="default" size="100%">Marilú Roxana Soto-Vásquez</style></author><author><style face="normal" font="default" size="100%">Francisco Mercedes Infantes Gomez</style></author><author><style face="normal" font="default" size="100%">Natalia Mavila Guzmán Rodríguez</style></author><author><style face="normal" font="default" size="100%">Yolanda Elizabeth Rodríguez de Guzmán</style></author><author><style face="normal" font="default" size="100%">Demetrio Rafael Jara-Aguilar</style></author><author><style face="normal" font="default" size="100%">Roger Antonio Rengifo-Penadillos</style></author><author><style face="normal" font="default" size="100%">José Gilberto Gavidia-Valencia</style></author><author><style face="normal" font="default" size="100%">Iris Melina Alfaro-Beltrán</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Effects of Melissa officinalis essential oil on state and trait anxiety</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Essential oil</style></keyword><keyword><style  face="normal" font="default" size="100%">Melissa officinalis.</style></keyword><keyword><style  face="normal" font="default" size="100%">State anxiety</style></keyword><keyword><style  face="normal" font="default" size="100%">Trait anxiety</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2023</style></year><pub-dates><date><style  face="normal" font="default" size="100%">June 2023</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">15</style></volume><pages><style face="normal" font="default" size="100%">454-460</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction:&lt;/strong&gt; Essential oils are complex substances used extensively in aromatherapy and phytotherapy, some of them as anxiety and stress-relieving agents. In order to evaluate the effects of &lt;em&gt;Melissa officinalis&lt;/em&gt; essential oil on state and trait anxiety, this study was conducted. &lt;strong&gt;Methods: &lt;/strong&gt;The essential oil was extracted by steam distillation and the chemical composition was investigated by Gas chromatographymass spectrometry (GC–MS). In addition, a Quasi experimental study with measures at pretest-posttest was conducted, where 58 participants were divided into two groups, a waiting-list (WL) control group, and an experimental group (EG)treated with aromatherapy based on &lt;em&gt;Melissa officinalis&lt;/em&gt; essential oil. The anxiety index was evaluated by State-Trait Anxiety Inventory (STAI). Measures were taken at two times: pretest and posttest. &lt;strong&gt;Results&lt;/strong&gt;: The chemical analysis showed that β-cubebene (26.3%), β-caryophyllene (25.4%) and geranial (12.5%) were de main components. Both state and trait anxiety levels decreased in the experimental group during the posttest phase; however, only state anxiety demonstrated statistically significant differences (p&amp;lt;0.05). A moderate size effect was found for state anxiety (d = 0.799; g= 0.797) with 1-β=0.803; but none for trait anxiety. &lt;strong&gt;Conclusion:&lt;/strong&gt; &lt;em&gt;Melissa officinalis&lt;/em&gt; essential oil was moderately effective on state anxiety but has no effect on trait anxiety.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">454</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Paul Alan Arkin Alvarado- García&lt;sup&gt;1,*&lt;/sup&gt;, Marilú Roxana Soto- Vásquez&lt;sup&gt;2&lt;/sup&gt;, Francisco Mercedes Infantes Gomez&lt;sup&gt;1&lt;/sup&gt;, Natalia Mavila Guzmán Rodríguez&lt;sup&gt;3&lt;/sup&gt;, Yolanda Elizabeth Rodríguez de Guzmán&lt;sup&gt;4&lt;/sup&gt;, Demetrio Rafael Jara- Aguilar&lt;sup&gt;2&lt;/sup&gt;, Roger Antonio Rengifo- Penadillos&lt;sup&gt;2&lt;/sup&gt;, José Gilberto Gavidia-Valencia&lt;sup&gt;2&lt;/sup&gt;, Iris Melina Alfaro-Beltrán&lt;sup&gt;5&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Escuela de Medicina. Universidad César Vallejo, Trujillo, PERÚ.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Facultad de Farmacia y Bioquímica. Universidad Nacional de Trujillo, Trujillo, PERÚ.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Escuela de Psicología. Universidad César Vallejo, Trujillo, PERÚ.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Facultad de Enfermería. Universidad Nacional de Trujillo, Trujillo, PERÚ.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Instituto Pablo Casals, Trujillo, PERÚ.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Julio Luis Díaz-Uribe</style></author><author><style face="normal" font="default" size="100%">María Elena Salazar-Salvatierra</style></author><author><style face="normal" font="default" size="100%">Julio Reynaldo Ruiz-Quiroz</style></author><author><style face="normal" font="default" size="100%">Oscar Herrera- Calderon</style></author><author><style face="normal" font="default" size="100%">Eddie Loyola-Gonzales</style></author><author><style face="normal" font="default" size="100%">Freddy Emilio Tataje-Napuri</style></author><author><style face="normal" font="default" size="100%">José Francisco Kong-Chirinos</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Phytochemical Profile, Antioxidant and Antibacterial Activity of the Essential Oil of Luma Chequen (Molina) A. Gray from Peru</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Antibacterial.</style></keyword><keyword><style  face="normal" font="default" size="100%">Antioxidant</style></keyword><keyword><style  face="normal" font="default" size="100%">Aromatic plant</style></keyword><keyword><style  face="normal" font="default" size="100%">Essential oil</style></keyword><keyword><style  face="normal" font="default" size="100%">Luma chequeen</style></keyword><keyword><style  face="normal" font="default" size="100%">Medicinal plant</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2023</style></year><pub-dates><date><style  face="normal" font="default" size="100%">October 2023</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">15</style></volume><pages><style face="normal" font="default" size="100%">777-780</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background&lt;/strong&gt;: Luma chequen belongs to Myrtaceae family and it is known as “arrayan”. In the traditional medicine from Peru, L chequen is used as aromatic plant, anti-inflammatory and hypocholesterolemic. Objective: To determine the phytochemical profile, evaluate the antioxidant and the antibacterial activity of &lt;em&gt;L. chequen&lt;/em&gt; essential oil. &lt;strong&gt;Material and Methods&lt;/strong&gt;: In the analysis of the volatile components a Gas Chromatography coupled to Mass Spectrometry (GC-MS) was used to identify the content of terpenes and sesquiterpenes. 2,2-diphenyl-1-picrylhydrazyl (DPPH) was the method used to determine the antioxidant activity and obtain the half inhibitory concentration (IC&lt;sub&gt;50&lt;/sub&gt;). For the antibacterial activity, a colorimetric macrodilution method was carried out to evaluate the effect of the essential oil of &lt;em&gt;L. chequen&lt;/em&gt; against &lt;em&gt;Staphylococcus aureus&lt;/em&gt; ATCC 25923 and Escherichia coli ATCC 25922. &lt;strong&gt;Results:&lt;/strong&gt; The analysis by GC-MS showed two major components alpha-pinene (62.89%) followed by 1,8-cineole (11.94%), and propanoic acid, 2-methyl-, 2-methylpropyl ester with 8.67%. In the antioxidant activity against DPPH radical, the essential oil of &lt;em&gt;L. chequen&lt;/em&gt; showed an IC&lt;sub&gt;50&lt;/sub&gt; equivalent to124.60 ± 2.0 μg/mL. In the antibacterial activity, &lt;em&gt;L. chequen&lt;/em&gt; had an MIC (minimum inhibitory concentration) for &lt;em&gt;Staphylococcus aureus &lt;/em&gt;ATCC 25923 and Escherichia coli ATCC 25922 of 4.35 ± 0 μg/mL and 8.71 ± 0 μg/mL respectively. &lt;strong&gt;Conclusion&lt;/strong&gt;: &lt;em&gt;L. chequen &lt;/em&gt;presented monoterpene compounds as main phytoconstituents as well as antioxidant and antibacterial activity in vitro. The essential oil might be used as antimicrobial agent in the future overall against S. aureus.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">777</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;Julio Luis Díaz-Uribe&lt;sup&gt;1&lt;/sup&gt;, María Elena Salazar-Salvatierra&lt;sup&gt;2&lt;/sup&gt;, Julio Reynaldo Ruiz-Quiroz&lt;sup&gt;2&lt;/sup&gt;, Oscar Herrera-Calderon&lt;sup&gt;3,*&lt;/sup&gt;, Eddie Loyola- Gonzales&lt;sup&gt;4&lt;/sup&gt;, Freddy Emilio Tataje- Napuri&lt;sup&gt;5&lt;/sup&gt;, José Francisco Kong- Chirinos&lt;sup&gt;6&lt;/sup&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Basic and Applied Chemistry Department, Faculty of Pharmacy and Biochemistry, Universidad Nacional Mayor de San Marcos, Lima 15001, PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Institute for Research in Biological Chemistry, Microbiology and Biotechnology “Marco Antonio Garrido Malo”, Faculty of Pharmacy and Biochemistry, Universidad Nacional Mayor de San Marcos, Lima 15001, PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Pharmacology, Bromatology and Toxicology, Faculty of Pharmacy and Biochemistry, Universidad Nacional Mayor de San Marcos, Lima, PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Department of Pharmaceutical Science, Faculty of Pharmacy and Biochemistry, Universidad Nacional San Luis Gonzaga, Ica 11001, PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Departamento de Ciencias Comunitarias, Facultad de Odontología, Universidad Nacional San Luis Gonzaga, Ica 11001, PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;6&lt;/sup&gt;Department of Surgical Clinical Sciences, Faculty of Human Medicine, Universidad Nacional San Luis Gonzaga, Ica 11001, PERU.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Yelfi Anwar</style></author><author><style face="normal" font="default" size="100%">Gunawan Pasaribu</style></author><author><style face="normal" font="default" size="100%">M. Nazari V</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Review on Bioactive Potential of Indonesian Forest Essential Oils</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Bioactivity</style></keyword><keyword><style  face="normal" font="default" size="100%">Chemical compound</style></keyword><keyword><style  face="normal" font="default" size="100%">Essential oil</style></keyword><keyword><style  face="normal" font="default" size="100%">Indonesian forest</style></keyword><keyword><style  face="normal" font="default" size="100%">Pharmaceutics</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2022</style></year><pub-dates><date><style  face="normal" font="default" size="100%">December 2022</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">14</style></volume><pages><style face="normal" font="default" size="100%">873-879</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;Essential oils are composed of some natural, volatile, as well as aromatic compounds extracted from plants. In recent years, several studies have shown that some of their benefits can be attributed to their antimicrobial, antioxidant, anti-inflammatory, and also immunomodulatory properties. So, essential oils have been proposed as a common elective to anti-microbials or for utilize in combination with other antimicrobials against multidrug-resistant microscopic organisms. Most of the potential data about essential oils were obtained with in vitro and in vivo studies. Several types of essential oils are available in Indonesia which are reported to have biological activity such as antioxidants and antiaging are essential oils of pine (&lt;em&gt;Pinus merkusii&lt;/em&gt;), kilemo (Litsea cubeba), agarwood (&lt;em&gt;Aquilaria &lt;/em&gt;spp), eucalyptus (&lt;em&gt;Eucalyptus citriodora&lt;/em&gt;), and cinnamon (&lt;em&gt;Cinnamomum burmanii&lt;/em&gt;). The major chemical compound of pine oil is alpha pinene. Kilemo oil contains geranial. chemical marker compound of agarwood is chromone and sesquiterpenes. Eucalyptus contains citronella. The chemical component of cinnamon oil is cinnamaldehyde. Some essential oils have shown remarkable antioxidant activities when used at specific concentrations which can be due to their richness in phenolic compounds. However, toxicological studies are needed before any recommendation for application can be given. Preformulating and formulation studies will be needed to develop suitable dosage forms in order to introduce optimized pharmaceuticals (high active, low toxic) as alternative of current pharmaceutical dosage forms&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Review Article</style></work-type><section><style face="normal" font="default" size="100%">873</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Yelfi Anwar&lt;sup&gt;1,*&lt;/sup&gt;, Gunawan Pasaribu&lt;sup&gt;2&lt;/sup&gt;, M. Nazari V&lt;sup&gt;1&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;School of Pharmacy, University August 17, 1945, Jakarta, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Research Center for Biomass and Bioproducts, National Research and Innovation Agency, Jakarta, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Paul Alan Arkin Alvarado-García</style></author><author><style face="normal" font="default" size="100%">Marilú Roxana Soto-Vásquez</style></author><author><style face="normal" font="default" size="100%">Luis Enrique Rosales-Cerquin</style></author><author><style face="normal" font="default" size="100%">Demetrio Rafael Jara-Aguilar</style></author><author><style face="normal" font="default" size="100%">Santiago M. Benites</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Anxiolytic-like Effect of Luma chequen Essential Oil: A Pilot Study</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Anxiety</style></keyword><keyword><style  face="normal" font="default" size="100%">Essential oil</style></keyword><keyword><style  face="normal" font="default" size="100%">Luma chequeen.</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2021</style></year><pub-dates><date><style  face="normal" font="default" size="100%">December 2021</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">13</style></volume><pages><style face="normal" font="default" size="100%">1607-1613</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction: &lt;/strong&gt;Essential oils are complex substances used widely extended in the form of aromatherapy or phytotherapy, some of them as agents to relieve anxiety and stress. In this sense this study was conducted to examine the anxiolytic-like effect of Luma chequen essential oil. &lt;strong&gt;Methods: &lt;/strong&gt;The essential oil was extracted by steam distillation and the chemical composition was investigated by Gas chromatography with flame-ionization detection (GC-FID) and Gas chromatography-mass spectrometry (GC–MS). Moreover, a randomized, double blind, placebo-controlled trial was conducted, where 48 participants were divided into two groups, comprising a control group (CG) treated with placebo, and an experimental group (EG) treated with aromatherapy based on Luma chequen essential oil. The anxiety index was evaluated by State-Trait Anxiety Inventory (STAI). Measures were taken at two times: pretest and posttest.&lt;strong&gt; Results:&lt;/strong&gt; The chemical analysis showed that α-pinene was the main component (56.5%). State and Trait anxiety scores showed a decrease in posttest study phase in comparison with pretest in experimental group compared to placebo (p&amp;lt;0.005 for state anxiety and p&amp;lt;0.05 for trait anxiety). Cohen`s d score was 0.84 in State anxiety, while it was 0.52 for Trait anxiety. Percentages of change showed reductions of anxiety variable ranging between 14.94% for State anxiety and 13.60% for Trait anxiety. &lt;strong&gt;Conclusions: &lt;/strong&gt;These results suggest that aromatherapy based on essential oil of Luma chequen was moderately effective in improving anxiety.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6s</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">1607</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Paul Alan Arkin Alvarado-García&lt;sup&gt;1&lt;/sup&gt;,*, Marilú Roxana Soto-Vásquez&lt;sup&gt;2&lt;/sup&gt;, Luis Enrique Rosales-Cerquin&lt;sup&gt;3&lt;/sup&gt;, Demetrio Rafael Jara-Aguilar&lt;sup&gt;2&lt;/sup&gt;, Santiago M. Benites&lt;sup&gt;4&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Universidad Autónoma del Perú. Escuela de Psicología. Lima, Perú.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Facultad de Farmacia y Bioquímica. Universidad Nacional de Trujillo, Trujillo, PERÚ.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Escuela de Medicina. Universidad César Vallejo, Trujillo, PERÚ. 4Universidad Autónoma del Perú. Lima, PERÚ&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">NK Shaboyan</style></author><author><style face="normal" font="default" size="100%">AV Moghrovyan</style></author><author><style face="normal" font="default" size="100%">KH Dumanyan</style></author><author><style face="normal" font="default" size="100%">NH Ghukasyan</style></author><author><style face="normal" font="default" size="100%">AA Altunyan</style></author><author><style face="normal" font="default" size="100%">NI Arshakyan</style></author><author><style face="normal" font="default" size="100%">AM Ghazaryan</style></author><author><style face="normal" font="default" size="100%">GR Ulikhanyan</style></author><author><style face="normal" font="default" size="100%">AL Ginosyan</style></author><author><style face="normal" font="default" size="100%">AS Dadayan</style></author><author><style face="normal" font="default" size="100%">NB Chichoyan</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Phytochemical Analysis and Antioxidant Activity of Cotinus coggygria Scop. from Armenian Flora</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Antiradical activity</style></keyword><keyword><style  face="normal" font="default" size="100%">Cotinus coggygria Scop.</style></keyword><keyword><style  face="normal" font="default" size="100%">DPPH</style></keyword><keyword><style  face="normal" font="default" size="100%">Essential oil</style></keyword><keyword><style  face="normal" font="default" size="100%">Ethanol Extract</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2021</style></year><pub-dates><date><style  face="normal" font="default" size="100%">July 2021</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">13</style></volume><pages><style face="normal" font="default" size="100%">933-941</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;Armenian flora is stood out by the variety of its medicinal and edible plants. Here small plants as well as trees and shrubs are met. &lt;em&gt;Cotinus coggygria &lt;/em&gt;of Armenian flora is used in folk medicine. The aim of this investigation was to determine the chemical composition of Armenian flora’s smoke trees leaves’ essential oil and antiradical activity of ethanol extract of leaves and branches of smoke tree. &lt;strong&gt;Methods:&lt;/strong&gt; The aerial parts were extracted by hydrodistillation method, and the composition was analyzed by gas chromatograph interfaced to a mass spectrometer. Antiradical activity of essential oil from leaves and branches was determined by using appropriate methods. &lt;strong&gt;Results:&lt;/strong&gt; The total amount of flavonoids has been determined in the leaves of the smoke tree by miricetin. This analysis revealed that the flavonoid amount in ethanol extract of&lt;em&gt; C. coggygria&lt;/em&gt;, growing in Armenia, was 0,94%. In volatile oil of Smoke tree leaves 22 compounds were determined. The results demonstrated that in the essential oil of leaves of Cotinus from Armenian flora predominated Germacrene D, Linalool, formate, ά –Terpineol sesquiterpenes and diterpene alcohol Thunbergol. Ethanol extracts of leaves and branches of Smoke tree showed antioxidant activity. &lt;strong&gt;Conclusion: &lt;/strong&gt;From the results, it is evident that &lt;em&gt;C. coggygria&lt;/em&gt; from Armenia flora contains various bioactive compounds and the extracts of leaves pronounced higher antioxidant activity and recommended as a plant of phytopharmaceutical importance.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">4</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">933</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;N.K. Shaboyan&lt;sup&gt;1&lt;/sup&gt;, A.V. Moghrovyan&lt;sup&gt;2&lt;/sup&gt;, K.H. Dumanyan&lt;sup&gt;2&lt;/sup&gt;, N.H. Ghukasyan&lt;sup&gt;2&lt;/sup&gt;, A.A. Altunyan&lt;sup&gt;2&lt;/sup&gt;, N.I. Arshakyan&lt;sup&gt;2&lt;/sup&gt;, A.M. Ghazaryan&lt;sup&gt;2&lt;/sup&gt;, G.R. Ulikhanyan&lt;sup&gt;2&lt;/sup&gt;, A.L. Ginosyan&lt;sup&gt;3&lt;/sup&gt;, A.S. Dadayan&lt;sup&gt;4&lt;/sup&gt;, N.B. Chichoyan&lt;sup&gt;2,&lt;/sup&gt;*&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Institute of Pharmacy YSU, 0025,1 Alek Manukyan st, Yerevan, RA, ARMENIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Yerevan State Medical University after M.Heratsi, Department of Pharmacognosy, 0025, 2 Koryun st., Yerevan, RA, ARMENIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Analytical laboratory after Academician Emil Gabrielyan&quot;, branch of &quot;Scientific center of drug and medical technology expertise&quot; CJSC, 0051, Komitas Ave., 49/4, Yerevan, RA, ARMENIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;4Scientific and Production Center «Armbiotechnology» of National Academy of Sciences RA, 0056, 14 Gyurjyan Str., Yerevan, RA, ARMENIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Carmen R. Silva-Correa</style></author><author><style face="normal" font="default" size="100%">Jorge L. Campos-Reyna</style></author><author><style face="normal" font="default" size="100%">Víctor E. Villarreal-La Torre</style></author><author><style face="normal" font="default" size="100%">Abhel A. Calderón-Peña</style></author><author><style face="normal" font="default" size="100%">William Antonio Sagástegui-Guarniz</style></author><author><style face="normal" font="default" size="100%">Luz M. Guerrero-Espino</style></author><author><style face="normal" font="default" size="100%">Anabel D González-Siccha</style></author><author><style face="normal" font="default" size="100%">Cinthya L. Aspajo-Villalaz</style></author><author><style face="normal" font="default" size="100%">María V. González-Blas</style></author><author><style face="normal" font="default" size="100%">José L. Cruzado-Razco</style></author><author><style face="normal" font="default" size="100%">Julio Hilario-Vargas</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Potential Neuroprotective Activity of Essential Oils in Memory and Learning Impairment</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Alzheimer disease</style></keyword><keyword><style  face="normal" font="default" size="100%">Animal model</style></keyword><keyword><style  face="normal" font="default" size="100%">Essential oil</style></keyword><keyword><style  face="normal" font="default" size="100%">Learning</style></keyword><keyword><style  face="normal" font="default" size="100%">Memory</style></keyword><keyword><style  face="normal" font="default" size="100%">Neurodegenerative diseases</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2021</style></year><pub-dates><date><style  face="normal" font="default" size="100%">September 2021</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">13</style></volume><pages><style face="normal" font="default" size="100%">1312-1322</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;Memory and learning is negatively affected by many factors. Alzheimer's disease is a progressive and irreversible neurological disorder that occurs gradually, a sickness that is increasingly common, and multiple scientific articles suggest that essential oils improve memory and learning and are useful in the treatment of various neurodegenerative diseases, including Alzheimer's disease. This review aims to conduct a critical collection of current information on research into both memory and learning impairment, as well as essential oils that are able to avoid this neurodegenerative disease. Currently, different animal models have been useful for the study of neurodegenerative problems that alter memory and learning, experimental pharmacological, genetic and toxicological models that can simulate specific cognitive deficit syndromes. In addition, research in this review show several essential oil compounds that present positive results in animal studies, but still lack human clinical trials. Therefore, the assessment of the safety and efficacy of these phytochemical compounds in diseases that cause memory impairment and learning, remain a promising area for future research.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><work-type><style face="normal" font="default" size="100%">Review article</style></work-type><section><style face="normal" font="default" size="100%">1312</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Carmen R. Silva-Correa&lt;sup&gt;1,&lt;/sup&gt;*, Jorge L. Campos-Reyna&lt;sup&gt;2&lt;/sup&gt;, Víctor E. Villarreal-La Torre&lt;sup&gt;1&lt;/sup&gt;, Abhel A. Calderón-Peña&lt;sup&gt;3&lt;/sup&gt;, William Antonio Sagástegui-Guarniz&lt;sup&gt;1&lt;/sup&gt;, Luz M. Guerrero-Espino&lt;sup&gt;2&lt;/sup&gt;, Anabel D. González-Siccha&lt;sup&gt;1&lt;/sup&gt;, Cinthya L. Aspajo-Villalaz&lt;sup&gt;3&lt;/sup&gt;, María V. González-Blas&lt;sup&gt;1&lt;/sup&gt;, José L. Cruzado- Razco&lt;sup&gt;1&lt;/sup&gt;, Julio Hilario-Vargas&lt;sup&gt;2&lt;/sup&gt; &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Facultad de Farmacia y Bioquímica, Universidad Nacional de Trujillo, PERÚ.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Facultad de Medicina, Universidad Nacional de Trujillo, PERÚ.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Facultad de Ciencias Biológicas, Universidad Nacional de Trujillo, PERÚ.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Iman Mansi</style></author><author><style face="normal" font="default" size="100%">Nasser A. Awadh Ali</style></author><author><style face="normal" font="default" size="100%">Nizar M. Mhaidat</style></author><author><style face="normal" font="default" size="100%">Khaled Hussain</style></author><author><style face="normal" font="default" size="100%">Ali G. Al-kaf</style></author><author><style face="normal" font="default" size="100%">Sirajudheen Anwar</style></author><author><style face="normal" font="default" size="100%">William N. Setzer</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Chemical Composition and Biological Activity of the Essential Oil Isolated from the Leaves of Achillea fragrantissima Growing Wild in Yemen</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Achillea fragrantissima</style></keyword><keyword><style  face="normal" font="default" size="100%">Artemisia ketone</style></keyword><keyword><style  face="normal" font="default" size="100%">Cytotoxicity</style></keyword><keyword><style  face="normal" font="default" size="100%">Essential oil</style></keyword><keyword><style  face="normal" font="default" size="100%">GC-MS</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2019</style></year><pub-dates><date><style  face="normal" font="default" size="100%">September 2019</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">11</style></volume><pages><style face="normal" font="default" size="100%">1077-1081</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background:&lt;/strong&gt; Yemen is diverse in its geography and rich in its natural flora. &lt;em&gt;Achillea fragrantissima&lt;/em&gt; grown wild in Yemen is widely used in folkloric medicine. &lt;strong&gt;Objectives:&lt;/strong&gt; To investigate the chemical composition, cytotoxicity, xanthine oxidase inhibitory and tyrosinase inhibitory activities of the essential oil isolated form the leaves of &lt;em&gt;Achillea fragrantissima&lt;/em&gt; (Forssk.) Sch. Bip. growing wild in Yemen. &lt;strong&gt;Materials and Methods:&lt;/strong&gt; The oil was collected after hydrodistillation for 3 h, the oil composition was analyzed by GC-MS and assayed for biological activities. Results: Artemisia ketone (49.53%), camphor (14.73%), α-bisabolol (11.20%), α-bisabolol oxide B (2.62%) were the main components of the oil. The MTT assay of the oil on two human colorectal cancer cell lines (SW480 and HCT-116) showed IC&lt;sub&gt;50&lt;/sub&gt; values of 110.1 and 134.6 μg ml⁻¹, respectively. Xanthine oxidase inhibitory and tyrosinase inhibitory activity assays were performed but exhibited only marginal activities. &lt;strong&gt;Conclusion: &lt;/strong&gt;the components of the essential oil could be excellent anticancer drugs for treatment of colon cancer.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">1077</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p&gt;&lt;strong&gt;Iman Mansi&lt;sup&gt;1,&lt;/sup&gt;*, Nasser A. Awadh Ali&lt;sup&gt;2,3&lt;/sup&gt;, Nizar M. Mhaidat&lt;sup&gt;4&lt;/sup&gt;, Khaled Hussain&lt;sup&gt;5&lt;/sup&gt;, Ali G. Al-kaf&lt;sup&gt;3&lt;/sup&gt;, Sirajudheen Anwar&lt;sup&gt;6&lt;/sup&gt;, William N. Setzer&lt;sup&gt;7,8&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Clinical pharmacy and Pharmacy Practice, Faculty of Pharmaceutical sciences, The Hashemite University, P.O. Box 330127, Zarqa 13133, JORDAN.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;2&lt;/sup&gt;Pharmacognosy Department, Faculty of Clinical Pharmacy, Albaha University, Al Baha, SAUDI ARABIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;3&lt;/sup&gt;Pharmacognosy &amp;amp; Medicinal Chemistry Department, Faculty of Pharmacy, Sana’a University, Sana’a, YEMEN.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;4&lt;/sup&gt;Department of clinical pharmacy and Pharmacy practice, Faculty of Pharmacy, Jordan University of Science and Technology, Irbid-JORDAN.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;5&lt;/sup&gt;Chemistry Department, Faculty of Sciences, Sana’a University, YEMEN.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;6&lt;/sup&gt;Pharmacology &amp;amp; Toxicology Department, Faculty of Clinical Pharmacy,Hail University, Hail, KSA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;7&lt;/sup&gt;Department of Chemistry, University of Alabama in Huntsville, Huntsville, AL 35899, USA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;8&lt;/sup&gt;Aromatic Plant Research Center, 230 N 1200 E, Suite 100, Lehi, UT 84043, USA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Tsakhkhaeva Zuhra Sarmanovna</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Phytochemical Study of Odorous Celery Root (Apium graveolens L.) Grown in the North Caucasus</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Carotenoids</style></keyword><keyword><style  face="normal" font="default" size="100%">Essential oil</style></keyword><keyword><style  face="normal" font="default" size="100%">Flavonoids</style></keyword><keyword><style  face="normal" font="default" size="100%">Free organic acids</style></keyword><keyword><style  face="normal" font="default" size="100%">Polysaccharides</style></keyword><keyword><style  face="normal" font="default" size="100%">Tannins</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2019</style></year><pub-dates><date><style  face="normal" font="default" size="100%">May 2019</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">11</style></volume><pages><style face="normal" font="default" size="100%">527-530</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Context:&lt;/strong&gt; Flavoring celery (&lt;em&gt;Apium graveolens&lt;/em&gt; L.) from the umbrella family (Apiaceae) is a common food plant, its use as a spice has been known since Ancient Greece. Stems, leaves and root are widely used in cooking in various dishes: soups, salads and side dishes. Celery fragrant has mild laxative, diuretic, antiseptic, anti-allergic, anti-inflammatory, enveloping and wound healing properties. &lt;strong&gt;Aims:&lt;/strong&gt; The aim of our research was the phytochemical study of celery root odorous, quantitative definition of flavonoid, carotenoid, polysaccharides, tannin, free organic acids, essential oils and lipid. &lt;strong&gt;Methods and Material:&lt;/strong&gt; The research material was dried and chopped celery fragrant root passing through a 3 mm sieve. We carried out quantitative determination of biologically active substances in the celery root odorous by the following methods: flavonoids (In terms of rutin) by the spectrophotometric method; carotenoids by the photocolorimetric method; essential oil, polysaccharides, lipophilic substances by the gravimetric method; free organic acids and tannins by the titrimetric method. &lt;strong&gt;Statistical analysis used:&lt;/strong&gt; The results of the studies are given in the table. Statistical data processing was performed according to the method “Statistical processing of the results of a chemical experiment and biological tests” presented in State Pharmacopoeia XI [1]. The sample size (&lt;em&gt;n&lt;/em&gt;)&lt;em&gt; &lt;/em&gt;is 6, the confidence level (&lt;em&gt;P&lt;/em&gt;) is 95%, the student criterion (&lt;em&gt;t&lt;/em&gt; (&lt;em&gt;P&lt;/em&gt;, f) is 2.57). &lt;strong&gt;Results:&lt;/strong&gt; For the first time, we carried out a quantitative assessment of the content of seven groups of biologically active compounds of celery root odorous, grown in the North Caucasus: essential oil - 2.04 ± 0.01%, flavonoids - 1.44 ± 0.01,% lipophilic substances - 4, 05 ± 0.01%, carotenoids - 3.03 ± 0.02%, free organic acids - 2.38 ± 0.02%, tannins - 8.06 ± 0.01%, water-soluble polysaccharides - 8, 33 ± 0.01%, pectin substances - 3.45 ± 0.01%, hemicellulose A - 1.54 ± 0.01%, hemicellulose B - 1.47 ± 0.01%. &lt;strong&gt;Conclusion: &lt;/strong&gt;Celery root odorous grown in the North Caucasus is a source of biologically active compounds.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">527</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Tsakhkhaeva Zuhra Sarmanovna* &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;Department of Pharmacy, Medical Faculty, FSBEI of HE (Federal State Budgetary Educational Institution of Higher Education) “Kabardino-Balkaria State University- 360004, RUSSIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Olga Trifonova</style></author><author><style face="normal" font="default" size="100%">Olga Evdokimova</style></author><author><style face="normal" font="default" size="100%">Vera Prokofieva</style></author><author><style face="normal" font="default" size="100%">Alexey Matyushin</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Rationale for Manufacturing of Cut-Pressed Granules from Herbal Raw Material Rich in Essential Oil: An Example of Chamomile Flowers and Sweet Flag Rhizome</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Chamomile</style></keyword><keyword><style  face="normal" font="default" size="100%">Cut-pressed granules</style></keyword><keyword><style  face="normal" font="default" size="100%">Dosage form</style></keyword><keyword><style  face="normal" font="default" size="100%">Essential oil</style></keyword><keyword><style  face="normal" font="default" size="100%">Herbal drugs</style></keyword><keyword><style  face="normal" font="default" size="100%">Sweet flag</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2019</style></year><pub-dates><date><style  face="normal" font="default" size="100%">October 2019</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">11</style></volume><pages><style face="normal" font="default" size="100%">1285-1289</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background: &lt;/strong&gt;Currently, there are at least 43 different dosage forms present on the Russian Federation pharmaceutical market. A novel, unique dosage form – cut-pressed granules (CPG) – was developed in order to improve manufacturing characteristics and, therefore, quality of herbal drug products released in tea bags. However, treatment conditions may result in decreased levels of active substances in some of the plants, especially those containing essential oil, which is prone to degradation. The aim of this study was to assess feasibility of CPG manufacturing from herbal raw material rich in essential oil. &lt;strong&gt;Materials and Methods: &lt;/strong&gt;Different morphological groups of raw material from two commonly used medicinal plants, chamomile (&lt;em&gt;Matricaria recutita&lt;/em&gt; L.) flowers and sweet flag (&lt;em&gt;Acorus calamus&lt;/em&gt; L.) rhizome, were chosen as the objects of the study. Qualitative composition of lipophilic constituents in herbal raw materials and CPG was assessed using thin-layer chromatography. Essential oil content was determined by steam distillation.&lt;strong&gt; Results:&lt;/strong&gt; The results confirmed equivalence of chromatographic profiles for the analyzed raw materials and CPG; thus, granulation didn’t affect qualitative composition of lipophilic components in chamomile flowers and sweet flag rhizome. The study also showed that the granulation process, in fact, promoted stability of the dosage form: during long-term storage the content of essential oil in all of the assessed cut-pressed granules was equivalent or higher than in corresponding herbal raw material. &lt;strong&gt;Conclusions:&lt;/strong&gt; It can be concluded that &lt;em&gt;Matricaria recutita &lt;/em&gt;L. flowers and &lt;em&gt;Acorus calamus&lt;/em&gt; L. rhizome can be used as herbal raw material for CPG manufacturing.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">1285</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Olga Trifonova&lt;sup&gt;1,2&lt;/sup&gt;, Olga Evdokimova&lt;sup&gt;3&lt;/sup&gt;, Vera Prokofieva&lt;sup&gt;4&lt;/sup&gt;, Alexey Matyushin&lt;sup&gt;5&lt;/sup&gt;,* &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Pharmacy, Sechenov First Moscow State Medical University, Moscow, RUSSIAN FEDERATION.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;JSC “Krasnogorskleksredstva”, Krasnogorsk, RUSSIAN FEDERATION.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Federal State Budgetary Institution Scientific Centre for Expert Evaluation of Medicinal Products of the Ministry of Health of the Russian Federation, Moscow, RUSSIAN FEDERATION.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;A.P. Arzamastsev Department of Pharmaceutical and Toxicological Chemistry, Sechenov First Moscow State Medical University, Moscow, RUSSIAN FEDERATION.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Department of Analytical and Forensic Toxicology, Sechenov First Moscow State Medical University, Moscow, RUSSIAN FEDERATION.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Ghazi Faisal Najmuldeen</style></author><author><style face="normal" font="default" size="100%">Kamalanathan  Narayanan</style></author><author><style face="normal" font="default" size="100%">Deeveeya A/P Kirubananthan</style></author><author><style face="normal" font="default" size="100%">Ghasak Ghazi Faisal</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Comparison of Tongkat Ali Root Chemical Composition Extracted by Soxhlet, Conventional Steam and Microwave Assisted Extraction Techniques</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Conventional Steam Extraction (CSE)</style></keyword><keyword><style  face="normal" font="default" size="100%">Essential oil</style></keyword><keyword><style  face="normal" font="default" size="100%">Eurycoma longifolia Jack</style></keyword><keyword><style  face="normal" font="default" size="100%">Microwave assisted extraction</style></keyword><keyword><style  face="normal" font="default" size="100%">Soxhlet Extraction</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2018</style></year><pub-dates><date><style  face="normal" font="default" size="100%">August 2018</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">10</style></volume><pages><style face="normal" font="default" size="100%">916-920</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;Eurycoma longifolia Jack (Tongkat Ali) roots are used in traditional medicines for its wide range of biological effects. The process of extracting out this essential oil from the plant requires a delicate and efficient method. In this research the extract of the essential oil of &lt;em&gt;Eurycoma longifolia&amp;rsquo;s&lt;/em&gt; root using Microwave Assisted Extraction (MAE), Soxhlet Extraction and Conventional Steam Extraction (CSE) methods, is characterized to identify the components of essential oil extracted and then to compare the yield percentage and components of the extracts from both methods. The extract obtained was characterized using gas chromatography mass spectroscopy (GC-MS) by comparing the compositions of components present in commercial Tongkat Ali oil stored in the GC-MS library. The findings showed that the MAE gives a maximum yield percentage of 5% with six chemical components extracted in 20 min while SE and CSE gives high yield percentage of 28.3% in 3 h and 2.5 % in 6 h respectively with only three chemical components extracted. Therefore, MAE is the optimum method for extracting essential oil from Tongkat Ali with a high quality.&lt;/p&gt;
&lt;p&gt;&amp;nbsp;&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">916</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p&gt;&lt;strong&gt;Ghazi Faisal Najmuldeen&lt;sup&gt;1&lt;/sup&gt;, Kamalanathan  Narayanan&lt;sup&gt;1&lt;/sup&gt;, Deeveeya A/P Kirubananthan&lt;sup&gt;1&lt;/sup&gt;, Ghasak Ghazi Faisal&lt;sup&gt;2&lt;/sup&gt;* &lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;&lt;sup&gt;1&lt;/sup&gt;Faculty of Chemical and Natural Resources Engineering, University Malaysia Pahang, 26300 Gambang, Pahang, MALAYSIA.&lt;/p&gt;
&lt;p&gt;&lt;sup&gt; 2&lt;/sup&gt;Department of Fundamental Dental and Medical Sciences, Kulliyya of Dentistry, International Islamic University, MALAYSIA.&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">María C. Flechas</style></author><author><style face="normal" font="default" size="100%">Raquel E. Ocazionez</style></author><author><style face="normal" font="default" size="100%">Elena E. Stashenko</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Evaluation of in vitro Antiviral Activity of Essential Oil Compounds Against Dengue Virus</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Antiviral</style></keyword><keyword><style  face="normal" font="default" size="100%">Dengue</style></keyword><keyword><style  face="normal" font="default" size="100%">Essential oil</style></keyword><keyword><style  face="normal" font="default" size="100%">Flavivirus</style></keyword><keyword><style  face="normal" font="default" size="100%">Terpene</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2018</style></year><pub-dates><date><style  face="normal" font="default" size="100%">December 2017</style></date></pub-dates></dates><urls><web-urls><url><style face="normal" font="default" size="100%">http://fulltxt.org/article/366</style></url></web-urls></urls><volume><style face="normal" font="default" size="100%">10</style></volume><pages><style face="normal" font="default" size="100%">55-59</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Introduction:&lt;/strong&gt; There are not effective drugs available for treatment of dengue fever despite intensive research on synthetic inhibitors. The search for active phytochemicals could serve for the discovery of new drugs. This study aims to evaluate the antiviral activity&lt;em&gt; in vitro&lt;/em&gt; of compounds found in essential oils from medicinal plants. &lt;strong&gt;Materials and Methods:&lt;/strong&gt; Nine synthetic-derived essential oil compounds were evaluated. Antiviral effect was screened measuring the reduction of viral NS1 and E proteins in HepG-2 and Vero cells. Results: &amp;beta;-Caryophyllene was identified as the most active compound, it reduced the virus serotype-2 replication in HepG-2 cells at IC&lt;sub&gt;50&lt;/sub&gt; of 22 &amp;plusmn; 5.6 &amp;mu;M, and blocked replication of all four serotypes in Vero cells at IC&lt;sub&gt;50&lt;/sub&gt; between 8.0 &amp;mu;M and 15.0 &amp;mu;M. The selectivity indexes were between 5.3 and 10. According to results from time-in-addition assays, the antiviral effect of &amp;beta;-caryophyllene appears to be associated with interruption of early steps of the virus life cycle. Citral revealed modest antiviral effect, it reduced the virus serotype-2 (IC&lt;sub&gt;50&lt;/sub&gt; of 31 &amp;plusmn; 4.5 &amp;mu;M) replication but not the other three serotypes. Seven terpenes did not reveal antiviral activity at maximum concentration of 30 &amp;mu;M. &lt;strong&gt;Conclusion:&lt;/strong&gt; Research on compounds found in essential oils can contribute to the drug discovery effort for dengue. &amp;beta;-Caryophyllene could serve as a starting point.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">55</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p&gt;&lt;strong&gt;Mar&amp;iacute;a C. Flechas, Raquel E. Ocazionez*, Elena E. Stashenko &lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;Centro de Investigaciones en Enfermedades Tropicales (CINTROP) and Centro de Investigaci&amp;oacute;n en Biomol&amp;eacute;culas (CIBIMOL), Universidad Industrial de Santander, Bucaramanga, COLOMBIA.&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Sara Al Ayoubi, Karim Raafat</style></author><author><style face="normal" font="default" size="100%">Abdalla El-Lakany</style></author><author><style face="normal" font="default" size="100%">Maha Aboul-Ela</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Phytochemical Investigation of Psoralea bituminosa L. and its Anti-Diabetic Potentials</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Antidiabetic</style></keyword><keyword><style  face="normal" font="default" size="100%">Antioxidant</style></keyword><keyword><style  face="normal" font="default" size="100%">Diabetic neuropathy</style></keyword><keyword><style  face="normal" font="default" size="100%">Essential oil</style></keyword><keyword><style  face="normal" font="default" size="100%">Psoralea bituminosa</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2018</style></year><pub-dates><date><style  face="normal" font="default" size="100%">August 2018</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">10</style></volume><pages><style face="normal" font="default" size="100%">841-853</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Introduction:&lt;/strong&gt; &lt;em&gt;Psoralea bituminosa&lt;/em&gt; L. (Fabaceae), is a very important medicinal plant, used in traditional medicine in Europe, Asia, and America, and in Africa for, its antiseptic, antihyperglycemic and anti-oxidative potentials. The objective of this study is to investigate the potential of &lt;em&gt;Psoralea bituminosa&lt;/em&gt; (&lt;em&gt;Pbt&lt;/em&gt;.) in the management of diabetes and diabetic &amp;ndash; induced thermal hyperalgesia. Moreover, this study aimed also to investigate the volatile oil constituents of Pbt. growing in Lebanon utilizing GC-MS method. &lt;strong&gt;Methods:&lt;/strong&gt; Blood glucose level (BGL) was measured using gluco-meter while diabetic-induced thermal hyperplasia of Pbt. growing in Lebanon was measured using tail flick and hot plate methods. Antioxidant was measured using DPPH free radicals method. Volatile oil of fresh and dried aerial parts of &lt;em&gt;Pbt&lt;/em&gt;. was analyzed using GC-MS.&lt;strong&gt; Results:&lt;/strong&gt; The result of study conducted on Lebanese &lt;em&gt;Pbt&lt;/em&gt;. revealed that acute anti-diabetic activity of &lt;em&gt;Pbt.&lt;/em&gt; in the 3 extracts subjected a decrease in BGL ranging between 34% to 38.5%. In subchronic anti-diabetic activity of Pbt. BGL dropped in range 19% to 44%. Moreover, Pbt. extract showed 1.7% to 13.6%increase in body weight at all doses with respect to 8&lt;sup&gt;th&lt;/sup&gt; day. On the other hand, alloxan diabetic induced mice reported melioration by 63.8% to 86.3% on the 8th week alloxan after injection in diabetic &amp;ndash; induced thermal hyperalgesia hotplate latency method. Nevertheless, a marked improvement in tail flick latency on the 8&lt;em&gt;th&lt;/em&gt; week after alloxan injection by 22.7 % to 48.6 %. &lt;em&gt;Pbt.&lt;/em&gt; extract revealed DPPH radical decreases at 82.6% at concentration of 100 mg/mL, respectively. Total flavonoid content measured of Pbt. was 135.83 mg/g while total phenolic content showed 217.48 mg/g. &lt;strong&gt;Conclusion:&lt;/strong&gt;&amp;nbsp;&lt;em&gt;Psoralea &lt;/em&gt;&lt;em&gt;bituminosa&amp;nbsp;&lt;/em&gt; showed a significant effect in the management of diabetes and neuropathic pain conditions and limiting expected side-effects, which might be used as a future antidiabetic therapy.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">841</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Sara Al Ayoubi, Karim Raafat&lt;sup&gt;*&lt;/sup&gt;,&amp;nbsp;Abdalla El- Lakany,&amp;nbsp;Maha Aboul-Ela &lt;/strong&gt;&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;Department of Pharmaceutical Sciences, Faculty of Pharmacy, Beirut Arab University, Beirut, LEBANON.&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Pradeep Kumar Sharma</style></author><author><style face="normal" font="default" size="100%">Vijender Singh</style></author><author><style face="normal" font="default" size="100%">Mohammed Ali</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Chemical Composition and Antimicrobial Activity of Fresh Rhizome Essential Oil of Zingiber Officinale Roscoe</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal,</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Antimicrobial activity</style></keyword><keyword><style  face="normal" font="default" size="100%">Chemical composition</style></keyword><keyword><style  face="normal" font="default" size="100%">Essential oil</style></keyword><keyword><style  face="normal" font="default" size="100%">GC-MS analysis</style></keyword><keyword><style  face="normal" font="default" size="100%">Zingiber officinale.</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2016</style></year><pub-dates><date><style  face="normal" font="default" size="100%">February 2016</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">8</style></volume><pages><style face="normal" font="default" size="100%">185-190</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Background: &lt;/strong&gt;&lt;em&gt;Zingiber officinale &lt;/em&gt;Roscoe (Zingiberaceae) is a rhizomatous perennial herb found in tropical Asia. It is extensively used worldwide as a spice, flavoring agent and herbal remedy for cold, throat and chest&amp;nbsp;infections and cough. The present study was carried out to analyse an essential oil from the fresh rhizomes of &lt;em&gt;Z. officinale &lt;/em&gt;of Ghaziabad region and to evaluate its antimicrobial activity. &lt;strong&gt;Materials and Methods: &lt;/strong&gt;The fresh rhizomes were hydrodistilled to get the essential oil which was analysed by GC and GC-MS techniques. The oil was evaluated for antimicrobial activity by disc diffusion method. &lt;strong&gt;Results and Discussion: &lt;/strong&gt;The essential oil was characterized by high percentage of sesquiterpenes (66.66%), monoterpenes (17.28%) and aliphatic compounds (13.58%). The predominant sesquiterpene was zingiberene (46.71%) followed by valencene (7.61%), &amp;beta;-funebrene (3.09%) and selina-4(14),7(11)-diene (1.03%). The major monoterpenes were characterized as citronellyl &lt;em&gt;n&lt;/em&gt;-butyrate (19.34%), &amp;beta;-phellandrene (3.70%), camphene (2.59%) and &amp;alpha;-pinene (1.09%). The essential oil exhibited significant antimicrobial activity against &lt;em&gt;Bacillus subtilis, Staphylococcus aureus&lt;/em&gt;, &lt;em&gt;Escherichia&lt;/em&gt; &lt;em&gt;coli, Pseudomonas aeruginosa&lt;/em&gt;, &lt;em&gt;Candida albicans &lt;/em&gt;and &lt;em&gt;Aspergillus niger&lt;/em&gt;. &lt;strong&gt;Conclusion: &lt;/strong&gt;The essential oil mainly contained a large number of sesquiterpenes and monoterpenes and exhibited significant antimicrobial activity against pathogenic microorganisms.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">185</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align:justify&quot;&gt;&lt;strong&gt;Pradeep Kumar Sharma&lt;sup&gt;1&lt;/sup&gt;*, Vijender Singh&lt;sup&gt;2&lt;/sup&gt;, Mohammed Ali&lt;sup&gt;3 &lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p style=&quot;text-align:justify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Pharmacy, R V Northland Institute, Greater Noida, G B Nagar, U.P. 203207, INDIA.&lt;/p&gt;

&lt;p style=&quot;text-align:justify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;B B S College of Pharmacy, Greater Noida, G B Nagar, U.P. 201306, INDIA.&lt;/p&gt;

&lt;p style=&quot;text-align:justify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Phytochemistry Research Laboratory, Faculty of Pharmacy, Jamia Hamdard, Hamdard Nagar, New Delhi 110062, INDIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Ramaraj Thirugnanasampandan</style></author><author><style face="normal" font="default" size="100%">Gunasekar Ramya</style></author><author><style face="normal" font="default" size="100%">Madhusudhanan Gogulramnath</style></author><author><style face="normal" font="default" size="100%">Rajarajeswaran Jayakumar</style></author><author><style face="normal" font="default" size="100%">M.S. Kanthimathi</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Evaluation of cytotoxic, DNA protecting and LPS induced MMP-9 down regulation activities of Plectranthus amboinicus (Lour) Spreng. essential oil</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Antigenotoxicity</style></keyword><keyword><style  face="normal" font="default" size="100%">Cytotoxicity</style></keyword><keyword><style  face="normal" font="default" size="100%">Essential oil</style></keyword><keyword><style  face="normal" font="default" size="100%">RT- PCR.</style></keyword><keyword><style  face="normal" font="default" size="100%">Zymogram</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2015</style></year><pub-dates><date><style  face="normal" font="default" size="100%">01/2015</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">7</style></volume><pages><style face="normal" font="default" size="100%">32-36</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Introduction:&lt;/strong&gt; &lt;em&gt;Plectranthus amboinicus&lt;/em&gt; (Lour) Spreng is a known medicinal plant used in Siddha and Ayurveda medicines in India. It has enormous medicinal potential to treat various diseases. &lt;strong&gt;Methods:&lt;/strong&gt; The present study focused on the use of essential oil obtained from the leaves of Plectranthusamboinicusto test cytotoxicity against breast (MCF-7) and colorectal (HT-29) cancer cell lines, to protect DNA from H&lt;sub&gt;2&lt;/sub&gt;O&lt;sub&gt;2&lt;/sub&gt; induced genotoxicity through comet assay and to treat inflammation in lipopolysaccharide (LPS) induced over expression of matrix metalloproteinase-9 (MMP-9) in human peripheral blood mononuclear cells (PBMCs) by gelatin zymogram and inhibition at transcriptional level confirmed using RT-PCR (reverse transcriptase polymerase chain reaction). &lt;strong&gt;Results:&lt;/strong&gt; Cytotoxicity of essential oil against MCF-7 and HT-29 cancer cell lines revealed the IC&lt;sub&gt;50&lt;/sub&gt; values of 53 &amp;plusmn; 0.01 and 87 &amp;plusmn; 0.01 &amp;mu;g/mL respectively. At 200 &amp;mu;g/mL essential oil protected against 75% of DNA damage in 3T3-L1 fibroblast cells. Essential oil showed significant reduction in production of MMP-9 in a concentration dependent manner. &lt;strong&gt;Conclusion:&lt;/strong&gt; Overall, the results showed that essential oil of &lt;em&gt;P. amboinicus&lt;/em&gt; is a potent bioactive substance and it could be used in herbal medicine preparations.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">32</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Ramaraj Thirugnanasampandan&lt;sup&gt;a,*&lt;/sup&gt;, Gunasekar Ramya&lt;sup&gt;a&lt;/sup&gt;, Madhusudhanan Gogulramnath&lt;sup&gt;a&lt;/sup&gt;, Rajarajeswaran Jayakumar&lt;sup&gt;b&lt;/sup&gt;, M.S. Kanthimathi&lt;sup&gt;b&lt;/sup&gt; &lt;/strong&gt;&lt;/p&gt;

&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;a&lt;/sup&gt;Laboratory of Plant Tissue Culture and Molecular Bioprospection, PG and Research Department of Biotechnology, Kongunadu Arts and Science College, GN Mills, Coimbatore, Tamil Nadu, India.&lt;/p&gt;

&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;b&lt;/sup&gt;Department of Molecular Medicine, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia.&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Ramaraj Thirugnanasampandan</style></author><author><style face="normal" font="default" size="100%">Gunasekar Ramya</style></author><author><style face="normal" font="default" size="100%">Madhusudhanan Gogulramnath</style></author><author><style face="normal" font="default" size="100%">Rajarajeswaran Jayakumar</style></author><author><style face="normal" font="default" size="100%">M.S. Kanthimathi</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Evaluation of cytotoxic, DNA protecting and LPS induced MMP-9 down regulation activities of Plectranthus amboinicus (Lour) Spreng. essential oil.</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Antigenotoxicity</style></keyword><keyword><style  face="normal" font="default" size="100%">Cytotoxicity</style></keyword><keyword><style  face="normal" font="default" size="100%">Essential oil</style></keyword><keyword><style  face="normal" font="default" size="100%">RT- PCR</style></keyword><keyword><style  face="normal" font="default" size="100%">Zymogram</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2015</style></year><pub-dates><date><style  face="normal" font="default" size="100%">27th Nov, 2014</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">7</style></volume><pages><style face="normal" font="default" size="100%">32-36</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Introduction:&lt;/strong&gt;&lt;em&gt;Plectranthus amboinicus&lt;/em&gt; (Lour) Spreng is a known medicinal plant used in Siddha and Ayurveda medicines in India. It has enormous medicinal potential to treat various diseases. &lt;strong&gt;Methods:&lt;/strong&gt; The present study focused on the use of essential oil obtained from the leaves of &lt;em&gt;Plectranthus amboinicus&lt;/em&gt; to test cytotoxicity against breast (MCF-7) and colorectal (HT-29) cancer cell lines, to protect DNA from H&lt;sub&gt;2&lt;/sub&gt;O&lt;sub&gt;2&lt;/sub&gt; induced genotoxicity through comet assay and to treat inflammation in lipopolysaccharide (LPS) induced over expression of matrix metalloproteinase-9 (MMP-9) in human peripheral blood mononuclear cells (PBMCs) by gelatin zymogram and inhibition at transcriptional level confirmed using RT-PCR (reverse transcriptase polymerase chain reaction). &lt;strong&gt;Results:&lt;/strong&gt; Cytotoxicity of essential oil against MCF-7 and HT-29 cancer cell lines revealed the IC50 values of 53 &amp;plusmn; 0.01 and 87 &amp;plusmn; 0.01&amp;mu;g/mL respectively. At 200 &amp;mu;g/mL essential oil protected against 75% of DNA damage in 3T3-L1 fibroblast cells. Essential oil showed significant reduction in production of MMP-9 in a concentration dependent manner. &lt;strong&gt;Conclusion:&lt;/strong&gt; Overall, the results showed that essential oil of &lt;em&gt;P. amboinicus&lt;/em&gt; is a potent bioactive substance and it could be used in herbal medicine preparations.&lt;br /&gt;&lt;strong&gt;Key words:&lt;/strong&gt;&lt;em&gt; Essential oil , Cytotoxicity , Antigenotoxicity, Zymogram, RT- PCR.&lt;/em&gt;&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><custom1><style face="normal" font="default" size="100%">Ramaraj Thirugnanasampandan, Gunasekar Ramya, Madhusudhanan Gogulramnath, Rajarajeswaran Jayakumar, M.S. Kanthimathi</style></custom1><section><style face="normal" font="default" size="100%">32</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Ramaraj Thirugnanasampandan&lt;sup&gt;a,*&lt;/sup&gt;, Gunasekar Ramya&lt;sup&gt;a&lt;/sup&gt;, Madhusudhanan Gogulramnath&lt;sup&gt;a&lt;/sup&gt;, Rajarajeswaran Jayakumar&lt;sup&gt;b&lt;/sup&gt;, M.S. Kanthimathi&lt;/strong&gt;&lt;sup&gt;&lt;strong&gt;b&lt;/strong&gt;&lt;/sup&gt;&lt;/p&gt;&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;a&lt;/sup&gt;Laboratory of Plant Tissue Culture and Molecular Bioprospection, PG and Research Department of Biotechnology, Kongunadu Arts and Science College, GN Mills, Coimbatore, Tamil Nadu, India&lt;/p&gt;&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;b&lt;/sup&gt;Department of Molecular Medicine, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia.&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Ramdan Btissam</style></author><author><style face="normal" font="default" size="100%">Ramdan Raja</style></author><author><style face="normal" font="default" size="100%">Amakran Amina</style></author><author><style face="normal" font="default" size="100%">Vannier Brigitte</style></author><author><style face="normal" font="default" size="100%">NHIRI Mohamed</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">In vitro study of anti-glycation and radical scavenging activities of the essential oils of three plants from Morocco: Origanum compactum, Rosmarinus officinalis and Pelargonium asperum</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Aging</style></keyword><keyword><style  face="normal" font="default" size="100%">Antiglycation</style></keyword><keyword><style  face="normal" font="default" size="100%">Antioxidant</style></keyword><keyword><style  face="normal" font="default" size="100%">Diabetes</style></keyword><keyword><style  face="normal" font="default" size="100%">Essential oil</style></keyword><keyword><style  face="normal" font="default" size="100%">radical scavenger.</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2015</style></year><pub-dates><date><style  face="normal" font="default" size="100%">8th Jan, 2015</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">7</style></volume><pages><style face="normal" font="default" size="100%">124-135</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align:justify&quot;&gt;&lt;strong&gt;Introduction:&lt;/strong&gt; We have carried out our study on the chemical composition; anti-glycation andradical scavenging activities of &lt;em&gt;Origanum compactum&lt;/em&gt;, &lt;em&gt;Rosmarinus officinalis&lt;/em&gt; and &lt;em&gt;Pelargonium asperum&lt;/em&gt; essential oils (EO) that were harvested in the northeast of Morocco. These plants have been traditionally used in medicine as a chief ingredient of many polyherbal formulations for the treatment of several pathologies. &lt;strong&gt;Method:&lt;/strong&gt; The phytochemical study was revealed by GC-MS. The protein glycation inhibitory activity of EO extracted from these plant tissues was evaluated &lt;em&gt;in vitro&lt;/em&gt; using the model system of bovine serum albumin and methylglyoxal. The measure of DPPH&amp;bull; radical reducing power was used to evaluate the antiradical activity. To test each fraction, we used the IC50 value previously obtained for the crude oils. &lt;strong&gt;Results:&lt;/strong&gt; The phytochemical study of these essential oils showed that p-Thymol, Eucalyptol and Citronellal were respectively the major components in the three investigated EO of&lt;em&gt; O.compactum&lt;/em&gt;, &lt;em&gt;R. officinal&lt;/em&gt; is and &lt;em&gt;P. asperum&lt;/em&gt;. More than 90% of the total components were detected. The extracts and fractions with glycation inhibitory activity also showed antiradical activity when the DPPH&amp;bull; radical reducing power was measured. &lt;strong&gt;Conclusion:&lt;/strong&gt; The glycation inhibitory activity was correlated with the antiradical potency of the extracts. Thus, the positive glycation inhibitory and antiradical activities of these plants might suggest a possible role in targeting aging and diabetic complications.The presence of various bioactive compounds confirms the application of these plants for various diseases by traditional practitioners. However, isolation of individual phytochemical constituents may proceed to find a novel drug.&lt;/p&gt;&lt;p style=&quot;text-align:justify&quot;&gt;&lt;strong&gt;Key words: &lt;/strong&gt;Aging, Antioxidant, Antiglycation, Diabetes, Essential oil, Radical scavenger.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">2</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">124</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Ramdan Btissam&lt;sup&gt;1,*&lt;/sup&gt;, Ramdan Rajae&lt;sup&gt;2&lt;/sup&gt;, Amakran Amina&lt;sup&gt;1&lt;/sup&gt;, Vannier Brigitte&lt;sup&gt;3&lt;/sup&gt; and NHIRI Mohamed&lt;sup&gt;1 &lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Biology, Laboratory of Biochemistry and Molecular Genetics, Faculty of Science and Technology, University Abdelmalek Essaadi, BP 416, Tangier, 90000, Morocco.&lt;/p&gt;&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Biology, L.G.B, University IbnTofail, Faculty of Science, K&amp;eacute;nitra, Morocco.&lt;/p&gt;&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Cell Biology &amp;quot;Receivers Regulations Tumor Cells&amp;quot;, University of Poitiers, Faculty of Science, Biology-Health Division, B&amp;acirc;t B36,1, rue Georges Bonnet TSA51106, 86073-Poitiers cedex 09, France.&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Ramdan Btissam</style></author><author><style face="normal" font="default" size="100%">Amakran Amina</style></author><author><style face="normal" font="default" size="100%">NHIRI Mohamed</style></author></authors><secondary-authors><author><style face="normal" font="default" size="100%">Ramdan Rajae</style></author></secondary-authors><tertiary-authors><author><style face="normal" font="default" size="100%">Vannier Brigitte</style></author></tertiary-authors></contributors><titles><title><style face="normal" font="default" size="100%">In vitro study of anti-glycation and radical scavenging activities of the essential oils of three plants from Morocco: Origanum compactum, Rosmarinus officinalis and Pelargonium asperum</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Aging</style></keyword><keyword><style  face="normal" font="default" size="100%">Antiglycation</style></keyword><keyword><style  face="normal" font="default" size="100%">Antioxidant</style></keyword><keyword><style  face="normal" font="default" size="100%">Diabetes</style></keyword><keyword><style  face="normal" font="default" size="100%">Essential oil</style></keyword><keyword><style  face="normal" font="default" size="100%">Radical scavenger</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2015</style></year><pub-dates><date><style  face="normal" font="default" size="100%">Mar-Apr 2015</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">7</style></volume><pages><style face="normal" font="default" size="100%">124-135</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;&lt;strong&gt;Introduction:&lt;/strong&gt; We have carried out our study on the chemical composition; anti-glycation andradical scavenging activities of Origanum compactum, Rosmarinus officinalis and Pelargonium asperum essential oils (EO) that were harvested in the northeast of Morocco. These plants have been traditionally used in medicine as a chief ingredient of many polyherbal formulations for the treatment of several pathologies. &lt;strong&gt;Method: &lt;/strong&gt;The phytochemical study was revealed by GC-MS. The protein glycation inhibitory activity of EO extracted from these plant tissues was evaluated in vitro using the model system of bovine serum albumin and methylglyoxal. The measure of DPPH&amp;bull; radical reducing power was used to evaluate the antiradical activity. To test each fraction, we used the IC50 value previously obtained for the crude oils. &lt;strong&gt;Results:&lt;/strong&gt; The phytochemical study of these essential oils showed that p-Thymol, Eucalyptol and Citronellal were respectively the major components in the three investigated EO of O.compactum, R. officinal is and P. asperum. More than 90% of the total components were detected. The extracts and fractions with glycation inhibitory activity also showed antiradical activity when the DPPH&amp;bull; radical reducing power was measured.&lt;strong&gt; Conclusion:&lt;/strong&gt; The glycation inhibitory activity was correlated with the antiradical potency of the extracts. Thus, the positive glycation inhibitory and antiradical activities of these plants might suggest a possible role in targeting aging and diabetic complications.The presence of various bioactive compounds confirms the application of these plants for various diseases by traditional practitioners. However, isolation of individual phytochemical constituents may proceed to find a novel drug.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">2</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">124</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p&gt;&lt;strong&gt;Ramdan Btissam&lt;sup&gt;1,*&lt;/sup&gt;, Ramdan Rajae&lt;sup&gt;2&lt;/sup&gt;, Amakran Amina&lt;sup&gt;1&lt;/sup&gt;, Vannier Brigitte&lt;sup&gt;3 &lt;/sup&gt;and NHIRI Mohamed&lt;sup&gt;1&lt;/sup&gt;&lt;/strong&gt; &lt;sup&gt;1&lt;/sup&gt;Department of Biology, Laboratory of Biochemistry and Molecular Genetics, Faculty of Science and Technology, University Abdelmalek Essaadi, BP 416, Tangier, 90000, Morocco. 2Department of Biology, L.G.B, University IbnTofail, Faculty of Science, K&amp;eacute;nitra, Morocco. 3Department of Cell Biology &amp;quot;Receivers Regulations Tumor Cells&amp;quot;, University of Poitiers, Faculty of Science, Biology-Health Division, B&amp;acirc;t B36,1, rue Georges Bonnet TSA51106, 86073-Poitiers cedex 09, France&lt;/p&gt;</style></auth-address></record></records></xml>