<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Neeraj Choudhary</style></author><author><style face="normal" font="default" size="100%">Pranav Kumar Prabhakar</style></author><author><style face="normal" font="default" size="100%">Gopal L Khatik</style></author><author><style face="normal" font="default" size="100%">Subba Rao Chamakuri</style></author><author><style face="normal" font="default" size="100%">Devesh Tewari</style></author><author><style face="normal" font="default" size="100%">Ashish Suttee</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Evaluation of Acute toxicity, In-vitro, In-vivo Antidiabetic Potential of the Flavonoid Fraction of the plant Chenopodium album L</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Acute toxicity</style></keyword><keyword><style  face="normal" font="default" size="100%">Alpha-amylase</style></keyword><keyword><style  face="normal" font="default" size="100%">Antidiabetic activity</style></keyword><keyword><style  face="normal" font="default" size="100%">Chenopodium album</style></keyword><keyword><style  face="normal" font="default" size="100%">Lc-Ms</style></keyword><keyword><style  face="normal" font="default" size="100%">Molecular docking</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2021</style></year><pub-dates><date><style  face="normal" font="default" size="100%">May 2021</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">13</style></volume><pages><style face="normal" font="default" size="100%">765-779</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background: &lt;/strong&gt;The &lt;em&gt;Chenopodium album &lt;/em&gt;L. commonly recognized as Bathua, is widely distributed globally and contains various phytoconstituents that help treat several diseases. However, until now, aerial parts' antidiabetic potential and the plant's acute toxicity at fraction level have never been established. &lt;strong&gt;Objectives: &lt;/strong&gt;To investigate the acute toxicity, the&lt;em&gt; in-vitro&lt;/em&gt;,&lt;em&gt; in-vivo&lt;/em&gt; antidiabetic potential of the plant at fraction level. &lt;strong&gt;Materials and Methods: &lt;/strong&gt;The aerial parts of the plant were fractionated into different fractions, i.e., flavonoid fraction (CAFF), tannin fraction (CATF), alkaloid fraction (CAAF), saponin fraction (CASF), and were analyzed for&lt;em&gt; in-vitro &lt;/em&gt;alpha-amylase inhibition assay. The CAFF, CATF, and CAAF were selected based on&lt;em&gt; in-vitro &lt;/em&gt;alpha-amylase inhibition assay results and were further screened for its acute toxicity and&lt;em&gt; in vivo &lt;/em&gt;antidiabetic activity using a high-fat diet and streptozotocin-induced diabetes model. The CAFF was characterized by LC-MS, and a molecular docking study was carried out. &lt;strong&gt;Results:&lt;/strong&gt; The &lt;em&gt;in-vitro &lt;/em&gt;alpha-amylase inhibition assay revealed that CAFF was found to be more potent than standard Acarbose having IC&lt;sub&gt;50&lt;/sub&gt; values 122.18 ± 1.15 and 812.83± 1.07 μg/ml, respectively. The CAFF fraction was found to possess potent antidiabetic activity in a dose-dependent manner in both in vitro and &lt;em&gt;in vivo &lt;/em&gt;diabetic models and did not produce any sign of severe toxicity. Furthermore, the bioactive CAFF fraction was characterized by LC-MS, showed the presence of quercetin 3-O-(2’’,6’’-di-O-rhamnosyl) glucoside (QRG) or quercetin 3-O-(2’’,6’’-di-Orhamnosyl) galactoside (QRGa) and quercetin 3-O-rutinoside (rutin) (QR). It is predicted from the molecular docking study that the CAFF fraction primarily acts as an alphaamylase inhibitor. &lt;strong&gt;Conclusion:&lt;/strong&gt; The CAFF fraction was found to poses dose-dependent potent antidiabetic activity and did not produce any sign of severe toxicity and primarily act as an alpha-amylase inhibitor.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">765</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Neeraj Choudhary&lt;sup&gt;1,2&lt;/sup&gt;, Pranav Kumar Prabhakar&lt;sup&gt;1&lt;/sup&gt;, Gopal L. Khatik&lt;sup&gt;1&lt;/sup&gt;, Subba Rao Chamakuri&lt;sup&gt;1&lt;/sup&gt;, Devesh Tewari&lt;sup&gt;1&lt;/sup&gt;, Ashish Suttee&lt;sup&gt;1,&lt;/sup&gt;*&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;School of Pharmaceutical Sciences, Lovely Professional University, Punjab, INDIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Faculty of Pharmaceutical Sciences, PCTE Group of Institutes, Ludhiana, Punjab, INDIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Ayan Kumar Naskar</style></author><author><style face="normal" font="default" size="100%">Souradut Ray</style></author><author><style face="normal" font="default" size="100%">Sanjukta Mondal Parui</style></author><author><style face="normal" font="default" size="100%">Amal Kumar Mondal</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Studies on an in-vitro Investigation of Anti Diabetic Property of a Hemiparasitic Taxa Dendrophthoe falcata (L.f.) Ettingsh (Loranthaceae)</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Alpha-amylase</style></keyword><keyword><style  face="normal" font="default" size="100%">Dendrophthoe falcata</style></keyword><keyword><style  face="normal" font="default" size="100%">Loranthaceae</style></keyword><keyword><style  face="normal" font="default" size="100%">Medicinal value</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2019</style></year><pub-dates><date><style  face="normal" font="default" size="100%">July 2019</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">11</style></volume><pages><style face="normal" font="default" size="100%">699-704</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;em&gt;Dendrophthoe falcata&lt;/em&gt; (L.f.) Ettingsh, belong to the family Loranthaceae an unique hemiparasitic taxon, spreads almost all the entire forest in South West Bengal. It is generally stem hemi parasitic taxa and habitat mostly on aerial part of host plant having strong in spite of common root system. It is depend on the host plant for mainly water and to some extend carbon. It synthesizes its own food. The haustoria have penetrated to the vascular bundle mainly in the xylem tissue of the host plants. It has numerous medicinal values with a long history of its use in Chinese traditional medicines. &lt;strong&gt;Objectives:&lt;/strong&gt; The present work deals with the anti-diabetic property medicinal aspect. &lt;strong&gt;Methods:&lt;/strong&gt; The leaves extract mixed with the amylase enzyme then add the starch solution and allow the reaction for few minutes after that the reaction mixture interrupted with DNS. &lt;strong&gt;Results: &lt;/strong&gt;The responsible enzyme i.e. Alpha-amylase breaks the large starch molecules which produces free glucose and simultaneously increases the blood sugar level and as a result hyperglycemia occurs. In this experiment increase the concentration of leaves extract which has decreased the activity of this potent enzyme.&lt;strong&gt; Conclusions:&lt;/strong&gt; This study also reveals that, the plant’s leaves extracts have inhibitory activity on this key enzyme viz. alpha amylase which is very crucial data for drug preparation and other research purposes.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">4</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">699</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Ayan Kumar Naskar&lt;sup&gt;1&lt;/sup&gt;, Souradut Ray&lt;sup&gt;1&lt;/sup&gt;, Sanjukta Mondal Parui&lt;sup&gt;2&lt;/sup&gt;,&amp;nbsp; Amal Kumar Mondal&lt;sup&gt;1,&lt;/sup&gt;*&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Plant Taxonomy, Biosystematics and Molecular Taxonomy laboratory, UGCDRS- SAP, DBT-BOOST-WB Supported Department, Department of Botany and Forestry, Vidyasagar University, Midnapore-721102, West Bengal, INDIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Post Graduate Department of Zoology, Lady Brabourne College, Kolkata-700017, West Bengal, INDIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Thangavelu Lakshmi</style></author><author><style face="normal" font="default" size="100%">Rajendran Ramasamy</style></author><author><style face="normal" font="default" size="100%">Rathinam Thirumalaikumaran</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Preliminary Phytochemical analysis and In vitro Antioxidant, FTIR Spectroscopy, Anti-diabetic activity of Acacia catechu ethanolic seed extract</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Acacia catechu seed</style></keyword><keyword><style  face="normal" font="default" size="100%">Alpha glucosidase</style></keyword><keyword><style  face="normal" font="default" size="100%">Alpha-amylase</style></keyword><keyword><style  face="normal" font="default" size="100%">Antidiabetic</style></keyword><keyword><style  face="normal" font="default" size="100%">Antioxidant</style></keyword><keyword><style  face="normal" font="default" size="100%">FTIR Spectroscopy</style></keyword><keyword><style  face="normal" font="default" size="100%">Phytochemical</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2015</style></year><pub-dates><date><style  face="normal" font="default" size="100%">Nov-Dec 2015</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">7</style></volume><pages><style face="normal" font="default" size="100%">356-362</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Objective:&lt;/strong&gt; To evaluate the preliminary phytochemical analysis and in vitro antioxidant activity, anti-diabetic effect of ethanolic seed extract of Acacia catechu against the alpha amylase and alpha glucosidase digestive enzymes in the pancreas and small intestine. &lt;strong&gt;Methods:&lt;/strong&gt; Preliminary phytochemical analysis was done by adopting the method of Evans. Antioxidant assay is performed by DPPH, ABTS and FRAP assay, Anti diabetic activity was determined by modified method of miller, the extract at different concentrations was tested for mammalian alpha amylase and alpha glucosidase enzyme inhibitory assay under the controlled experimental conditions and subjected to determination of absorbance. &lt;strong&gt;Results: &lt;/strong&gt;The present study reveals the presence of few secondary metabolites and the extract exhibits potent Antioxidant activity and a concentration dependent inhibition of Alpha amylase and Alpha glucosidase.&lt;strong&gt; Conclusion:&lt;/strong&gt; From the present study it can be concluded that ethanolic seed extract of Acacia catechu possessed marked in vitro antioxidant and anti-diabetic effect. The effect was plausibly due to the presence of phenolic contents of Acacia catechu&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">356</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Thangavelu Lakshmi&lt;sup&gt;*1&lt;/sup&gt;, Rajendran Ramasamy&lt;sup&gt;2&lt;/sup&gt; and Rathinam Thirumalaikumaran&lt;sup&gt;3&lt;/sup&gt; &lt;/strong&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Pharmacology, Saveetha Dental College and Hospitals, Chennai, India. 2Department of R and D, Green Chem Herbal Extracts and Formulations, Bangalore, India. 3Department of Pharmacognosy, Faculty of Pharmacy, Sree Ramachandra Medical College and Research Institute, chennai, India.&lt;/p&gt;</style></auth-address></record></records></xml>