<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Paola Raunelli</style></author><author><style face="normal" font="default" size="100%">Danae Liviac</style></author><author><style face="normal" font="default" size="100%">Rafael Alvis</style></author><author><style face="normal" font="default" size="100%">Silvio Puente</style></author><author><style face="normal" font="default" size="100%">Ivan Best</style></author><author><style face="normal" font="default" size="100%">Oscar Reategui</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Cytoprotective Effect of the Eryngium foetidum &quot;Sacha Culantro&quot; Methanolic Leaf Extract Versus Sodium Fluoride Exposed Mice using the Micronucleus Test and the Comet Assay</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Comet assay</style></keyword><keyword><style  face="normal" font="default" size="100%">Cytoprotective</style></keyword><keyword><style  face="normal" font="default" size="100%">Eryngium foetidum</style></keyword><keyword><style  face="normal" font="default" size="100%">Genotoxicity</style></keyword><keyword><style  face="normal" font="default" size="100%">Micronucleus test</style></keyword><keyword><style  face="normal" font="default" size="100%">Toxicity</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2019</style></year><pub-dates><date><style  face="normal" font="default" size="100%">May 2019</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">11</style></volume><pages><style face="normal" font="default" size="100%">461-465</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction: &lt;/strong&gt;&lt;em&gt;Eryngium foetidum&lt;/em&gt;, commonly known as sacha culantro, is a plant that grows in the Peruvian Amazonian jungle, studied for its high concentration of antioxidant substances and various ethnopharmacological properties. The main goal of the study is to observe the cytoprotective and antioxidant effect of the extract from its leafs in &lt;em&gt;Mus musculus&lt;/em&gt; previously administered with Sodium fluoride (NaF) using the Micronucleus test and the Comet assay. &lt;strong&gt;Methods: &lt;/strong&gt;The extract was administrated orally in four different concentrations: 180, 360, 720, 1440 mg/Kg for ten days, at the 11&lt;sup&gt;th&lt;/sup&gt; day a single dose of NaF was administrated via intraperitoneal at 20 mg/Kg. The genotoxicity study was made with mice from the strain BALB/c, using the Micronucleus test on bone marrow and the Comet assay on peripheral blood according the OECD guides 474 and 489 respectively. The statistical analysis was made by the media’s analysis with ANOVA. &lt;strong&gt;Results: &lt;/strong&gt;Significant differences were found in Micronucleus frequency between the highest concentrations of &lt;em&gt;Eryngium foetidum&lt;/em&gt; and NaF. The Comet assay showed significant reduction in NaF induced damage according to different concentrations of the extract. &lt;strong&gt;Conclusion:&lt;/strong&gt; The &lt;em&gt;Eryngium foetidum&lt;/em&gt; extract has cytoprotective activity against oxidant substances such as NaF.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">461</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Paola Raunelli&lt;sup&gt;1,2&lt;/sup&gt;, Danae Liviac&lt;sup&gt;3&lt;/sup&gt;, Rafael Alvis&lt;sup&gt;3&lt;/sup&gt;, Silvio Puente&lt;sup&gt;4&lt;/sup&gt;, Ivan Best&lt;sup&gt;1,5,6&lt;/sup&gt; Oscar Reátegui&lt;sup&gt;1,7,*&lt;/sup&gt; &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Universidad Científica del Sur, Panamericana Sur Km 19, Lima, PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Medical School, Universidad Científica del Sur, Lima, PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Laboratory of Cellular and Molecular Biology, Universidad Científica del Sur, Lima, PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Nutrition and Dietetic School, Universidad Científica del Sur, Lima, PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Hersil S. A. Laboratorios Industriales Farmacéuticos, Lima, PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;6&lt;/sup&gt;Grupo de Ciencia, Tecnología e Innovación en Alimentos, Universidad San Ignacio de Loyola, Lima, PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;7&lt;/sup&gt;Agroforestry Engineering School, Universidad Científica del Sur, Lima, PERU.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Oscar Herrera-Calderon</style></author><author><style face="normal" font="default" size="100%">Jorge Luis Arroyo-Acevedo</style></author><author><style face="normal" font="default" size="100%">Roberto Chávez-Asmat</style></author><author><style face="normal" font="default" size="100%">Juan Pedro Rojas-Armas</style></author><author><style face="normal" font="default" size="100%">Edwin Enciso-Roca</style></author><author><style face="normal" font="default" size="100%">Victor Chumpitaz Cerrate</style></author><author><style face="normal" font="default" size="100%">César Franco-Quino</style></author><author><style face="normal" font="default" size="100%">Luz Chacaltana-Ramos</style></author><author><style face="normal" font="default" size="100%">Ricardo Ángel Yuli-Posadas</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Effect of Sacha Inchi Oil (Plukenetia volubilis L.) on Genotoxicity in Mice (Mus musculus) and Subchronic Toxicity in Goldfish (Carassius auratus)</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Genotoxicity</style></keyword><keyword><style  face="normal" font="default" size="100%">Plukenetia Volubilis</style></keyword><keyword><style  face="normal" font="default" size="100%">Sacha Inchi Oil</style></keyword><keyword><style  face="normal" font="default" size="100%">Subchronic Toxicity</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2019</style></year><pub-dates><date><style  face="normal" font="default" size="100%">November 2019</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">11</style></volume><pages><style face="normal" font="default" size="100%">1549-1557</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction:&lt;/strong&gt;&lt;em&gt; Plukenetia volubilis&lt;/em&gt; is known as Sacha Inchi (SI) is originary from the peruvian amazone and it has been cultivated and consumed since the pre and Inca's time. &lt;strong&gt;Objective: &lt;/strong&gt;Sacha inchi oil was assessed for genotoxicity in Balb C albino mice and subchronic toxicity in goldfish (&lt;em&gt;Carassius auratus&lt;/em&gt;). &lt;strong&gt;Material and Methods:&lt;/strong&gt; The genotoxicity was assessed in Mus musculus Balb C (&lt;em&gt;n&lt;/em&gt; = 25) separated into five groups randomly selected of twenty-five each one. Groups were 10 mL / kg normal saline (NS), 40 mg / kg cyclophosphamide group (CP) and the three other groups received cyclophosphamide and sacha inchi oil of concentrations 10, 100 and 1000 mg / kg respectively. The substances were administered three times during 24 hours. The genotoxicity in mice was evaluated determining micronucleus levels in blood and bone marrow. The subchronic toxicity was assessed in goldfish (&lt;em&gt;Carassius auratus&lt;/em&gt;) (&lt;em&gt;n &lt;/em&gt;= 48) separated into four groups randomly selected of six each: normal saline group (control) and three groups that received doses of 10, 100 and 1000 μg sacha inchi oil per litre of water respectively for 45 days. &lt;strong&gt;Results:&lt;/strong&gt; The values of weight, length, growth rate, condition factor (K) and number of survivors were recorded. CP group showed higher micronuclei levels in blood and bone marrow compared with sacha inchi oil 10, 100 and 1000 mg / kg groups (ANOVA Test &lt;em&gt;p&lt;/em&gt; &amp;lt;0.01 Scheffe´s Post Hoc &lt;em&gt;p &lt;/em&gt;&amp;lt;0.05, &lt;em&gt;p &lt;/em&gt;&amp;lt;0.01 and &lt;em&gt;p&lt;/em&gt; &amp;lt;0.001 respectively). The subchronic toxicity assessment in goldfish showed isometric growth, a decline in &quot;K&quot; and a similar specific percentage growth rate per day in all groups (ANOVA test &lt;em&gt;p&lt;/em&gt;&amp;gt; 0.05). &lt;strong&gt;Conclusion: &lt;/strong&gt;Sacha inchi oil was not toxic under experimental conditions.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6s</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">1549</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Oscar Herrera-Calderon&lt;sup&gt;1,&lt;/sup&gt;*, Jorge Luis Arroyo-Acevedo&lt;sup&gt;2&lt;/sup&gt;, Roberto Chávez-Asmat&lt;sup&gt;3&lt;/sup&gt;, Juan Pedro Rojas-Armas&lt;sup&gt;2&lt;/sup&gt;, Edwin Enciso-Roca&lt;sup&gt;4&lt;/sup&gt;, Victor Chumpitaz Cerrate&lt;sup&gt;5&lt;/sup&gt;, Cesar Franco-Quino&lt;sup&gt;6&lt;/sup&gt;, Luz Chacaltana-Ramos&lt;sup&gt;7&lt;/sup&gt;, Ricardo Ángel Yuli-Posadas&lt;sup&gt;8 &lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Faculty of Pharmacy and Biochemistry, Universidad Nacional Mayor de San Marcos, Lima 15001, PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Faculty of Medicine, Universidad Nacional Mayor de San Marcos, Lima 15001, PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Association for the Development of Student Research in Health Sciences (ADIECS), Faculty of Medicine, Universidad Nacional Mayor de San Marcos, Lima 15001, PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Faculty of Health Sciences, Universidad Nacional de San Cristóbal de Huamanga, Ayacucho 05001, PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Laboratory of Pharmacology, Universidad Cientifica del Sur, Lima 15001, PERU&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;6&lt;/sup&gt;School of Public Health and Administration, Universidad Peruana Cayetano Heredia, Lima 15001, Peru.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;7&lt;/sup&gt;Faculty of Pharmacy and Biochemistry, Universidad Nacional San Luis Gonzaga, Ica 11001, PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;8&lt;/sup&gt;Universidad Continental, Huancayo 12002, PERU.&lt;/p&gt;
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