<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Horacio Larqué</style></author><author><style face="normal" font="default" size="100%">Abelardo Chávez Montes</style></author><author><style face="normal" font="default" size="100%">Jaime Zamora-Chimal</style></author><author><style face="normal" font="default" size="100%">Moises Looh-Hernández</style></author><author><style face="normal" font="default" size="100%">Joel H. Elizondo Luevano</style></author><author><style face="normal" font="default" size="100%">Esther del Olmo</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Bioguided Assay of Polyphenols Isolated from Medicinal Mayan Species and its Activity Against Leishmania mexicana.</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Coumarins</style></keyword><keyword><style  face="normal" font="default" size="100%">Flavonoids</style></keyword><keyword><style  face="normal" font="default" size="100%">Leishmania mexicana</style></keyword><keyword><style  face="normal" font="default" size="100%">NMR structural determination</style></keyword><keyword><style  face="normal" font="default" size="100%">Polyphenols</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2024</style></year><pub-dates><date><style  face="normal" font="default" size="100%">February 2024</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">16</style></volume><pages><style face="normal" font="default" size="100%">174-180</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Objective: &lt;/strong&gt;This study underlines the in vitro leishmanicidal activity of the methanol extracts (MeOH), fractions of n-hexane (n-Hex), chloroform (TCM) and ethyl acetate (EtOAc), and compounds isolated from plant species used in the Mayan traditional medicine. &lt;strong&gt;Materials and Methods: &lt;/strong&gt;Extracts of medicinal species collected in the Mayan Peninsula such as Hylocerus undatus, Bauhinia divaricate, Euphorbia hirta, Ruellia nudiflora and Cedrela odorata, were tasted in a bio guided assays against amastigotes of Leishmania mexicana. Different chromatographic techniques were applied in order to isolated the most active compounds. Additionally, spectroscopic experiments 1H-NMR, 13C-NMR, LC-MS and FT-IR were stablished to determine the chemical structure of the chemical compounds. &lt;strong&gt;Results: &lt;/strong&gt;Euphorbia hirta and Cedrella odorata, showed good bioactivity with 14.81 ± 2.63 g/mL and IC50 = 18.39 ± 0.88 μg/mL respectively, meanwhile Bauhinia divaricata not show activity and Ruellia nudiflora showed poor activity with IC50 = 92.18 ± 3.64 μg/mL, followed by Hylocerus undatus with IC50 = 122.5 ± 20.99 μg/mL, when tasted against amastigotes of Leishmania mexicana. Spectroscopic data confirmed the presence of quercetin, myricetin, kempherol and scopoletin, with IC50 = 2.92 ± 0.42 μM, 12.30 ± 0.57 μM, 20.22 ± 4.66 μM and 4.05 ± 0.68 μM respectively. &lt;strong&gt;Conclusion:&lt;/strong&gt; The bioguided assays guided us, to the purification and isolation of four different metabolites, mainly flavonoids and structurally related compounds, some of them show good activity, however, their low bioavailability indicates the need for detailed structural relation activity studies, together with the development of formulations and delivery systems.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">174</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Horacio Larqué&lt;sup&gt;1,2&lt;/sup&gt;,*, Abelardo Chávez Montes&lt;sup&gt;2&lt;/sup&gt;, Jaime Zamora-Chimal&lt;sup&gt;3&lt;/sup&gt;, Moises Looh- Hernández&lt;sup&gt;3&lt;/sup&gt;, Joel H. Elizondo Luevano&lt;sup&gt;2&lt;/sup&gt;, Esther del Olmo&lt;sup&gt;1&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Departamento de Química Farmacéutica, Facultad de Farmacia, Universidad de Salamanca (USAL), Campus Miguel de Unamuno s/n, 37007, Salamanca, SPAIN.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Departamento de Química, Facultad de Ciencias Biológicas, Universidad Autónoma de Nuevo León (UANL), Av. de los Rectores s/n, Cd. Universitaria, 66450, San Nicolás de los Garza, Nuevo León, MÉXICO.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Unidad de Investigación en Medicina Experimental, Facultad de Medicina, Universidad Nacional Autónoma de México, Ciudad de México, MÉXICO.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Quírico A Castillo</style></author><author><style face="normal" font="default" size="100%">José M. Padrón</style></author><author><style face="normal" font="default" size="100%">Anastacio Emiliano</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Secondary Metabolites from Pterocaulon alopecuroides and their Antiproliferative Activities</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">4´-dihydroxy-7-(γ</style></keyword><keyword><style  face="normal" font="default" size="100%">5</style></keyword><keyword><style  face="normal" font="default" size="100%">Antiproliferative activities</style></keyword><keyword><style  face="normal" font="default" size="100%">Coumarins</style></keyword><keyword><style  face="normal" font="default" size="100%">Flavonoids</style></keyword><keyword><style  face="normal" font="default" size="100%">Pterocaulon alopecuroides</style></keyword><keyword><style  face="normal" font="default" size="100%">γ-dimethylallyloxy)dihydroflavonol</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2019</style></year><pub-dates><date><style  face="normal" font="default" size="100%">May 2019</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">11</style></volume><pages><style face="normal" font="default" size="100%">493-495</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Objective:&lt;/strong&gt; To isolate secondary metabolites from the aerial parts of &lt;em&gt;Pterocaulon alopecuroides&lt;/em&gt;, elucidate their structures and evaluate their antiproliferative activities on selected human cancer cell lines. &lt;strong&gt;Materials and Methods:&lt;/strong&gt; The ethanolic extract of &lt;em&gt;P. alopecuroides&lt;/em&gt; afforded five compounds, which were characterized using spectroscopic techniques and by comparison with data from the literature. Antiproliferative activities of all isolates were evaluated. &lt;strong&gt;Results:&lt;/strong&gt; The compounds 7-(2,3-dihydroxy-3-methylbutoxy)-6-methoxycoumarin (&lt;strong&gt;1&lt;/strong&gt;), 5,6-methylenedioxy- 7-(2,3-dihydroxy-3-methylbutoxy) coumarin (&lt;strong&gt;2&lt;/strong&gt;), Dihydrokaempferol (&lt;strong&gt;3&lt;/strong&gt;), 5,7,4´-trihydroxy- 6-(α,α-dimethylallyl)dihydroflavonol (&lt;strong&gt;4&lt;/strong&gt;) and 5,4´-dihydroxy-7-(γ,γ-dimethylallyloxy)dihydroflavonol (&lt;strong&gt;5&lt;/strong&gt;) were isolated. The antiproliferative activity of all compounds was evaluated in a panel of six human solid tumor cell lines showing GI&lt;sub&gt;50 &lt;/sub&gt;values for the most active compounds in the low micromolar range. &lt;strong&gt;Conclusion:&lt;/strong&gt; Compound &lt;strong&gt;2&lt;/strong&gt; is reported for first time from &lt;em&gt;P. alopecuroides&lt;/em&gt;. Isolated coumarins show no antiproliferative activity, whilst among flavonoids compound &lt;strong&gt;5&lt;/strong&gt; showed the best antiproliferative activity.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">493</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Quírico A Castillo&lt;sup&gt;1,*&lt;/sup&gt;, José M. Padrón&lt;sup&gt;2&lt;/sup&gt;, Anastacio Emiliano&lt;sup&gt;3&lt;/sup&gt; &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Escuela de Química and Instituto de Química, Universidad Autónoma de Santo Domingo (UASD), Facultad de Ciencias, Ciudad Universitaria, Santo Domingo, D.N., DOMINICAN REPUBLIC.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;BioLab, Instituto Universitario de Bio-Orgánica “Antonio González” (IUBO-AG), Centro de Investigaciones Biomédicas de Canarias (CIBICAN), Universidad de La Laguna, 38206, La Laguna, SPAIN.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Universidad Ana G. Méndez at Gurabo, PO Box 3030, Gurabo, PR 00778, PUERTO RICO.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Ponnam Devendar</style></author><author><style face="normal" font="default" size="100%">K.V.N. Satya Srinivas</style></author><author><style face="normal" font="default" size="100%">J. Kotesh Kumar</style></author><author><style face="normal" font="default" size="100%">T. Sandeep Kumar</style></author><author><style face="normal" font="default" size="100%">Savita Bhagel</style></author><author><style face="normal" font="default" size="100%">K.P. Sastry</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Phytochemical Investigation, Antioxidant and Antifungal Activities of Rhizomes of Euphorbia Fusiformis</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Antifungal activity</style></keyword><keyword><style  face="normal" font="default" size="100%">antioxidant activity</style></keyword><keyword><style  face="normal" font="default" size="100%">Coumarins</style></keyword><keyword><style  face="normal" font="default" size="100%">Euphorbia fusiformis</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2014</style></year><pub-dates><date><style  face="normal" font="default" size="100%">26th May 2014</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">6</style></volume><pages><style face="normal" font="default" size="100%">78-82</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Objective:&lt;/strong&gt; Isolation of compounds from &lt;em&gt;Euphorbia fusiformis&lt;/em&gt; rhizomes and evaluation of extracts and each isolates for its antioxidant and antifungal activities.&lt;strong&gt; Results:&lt;/strong&gt; Five compounds were isolated including Euphol 1, &amp;beta;-Sitosterol 2, Caudicifolin 3, Scoparone 4 and Scopoletin 5. The occurrence of the compounds 2, 4 and 5 in the herb reported here for the first time. The ethyl acetate extract showed significant antioxidant activity (IC&lt;sub&gt;50&lt;/sub&gt; = 2.781 mg/ml) and its yielded compound 3 showed moderate antioxidant activity (IC&lt;sub&gt;50&lt;/sub&gt; = 3.25 mg/ml) using DPPH method. The ethyl acetate extract showed better antifungal activity against &lt;em&gt;Aspergillus niger&lt;/em&gt; and &lt;em&gt;Candida albican&lt;/em&gt;s. &lt;strong&gt;Conclusion:&lt;/strong&gt; Compounds&lt;strong&gt; 2, 4, 5 &lt;/strong&gt;were isolated first time from this plant. The ethyl acetate extract showed significant antioxidant and antifungal activity against&lt;em&gt; A. nigar&lt;/em&gt; and &lt;em&gt;C. Albicans&lt;/em&gt;. Thus, this study concludes by demonstrating the isolation, characterization, antioxidant and antifungal properties of &lt;em&gt;E. fusiformis&lt;/em&gt;, which may have further therapeutic value.&lt;/p&gt;&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Key Words:&lt;/strong&gt;&lt;em&gt;Euphorbia fusiformis&lt;/em&gt;, coumarins, antioxidant activity, antifungal activity.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">4</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Ponnam Devendar, K V N Satya Srinivas, J Kotesh Kumar,&lt;sup&gt;*&lt;/sup&gt; T Sandeep Kumar, Savita Bhagel and K P Sastry &lt;/strong&gt;&lt;/p&gt;&lt;p style=&quot;text-align: justify;&quot;&gt;CSIR-Central Institute of Medicinal and Aromatic Plants-Research Centre, Boduppal, Hyderabad-500092, Telangana State, India.&lt;/p&gt;</style></auth-address></record></records></xml>