<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Herman Herman</style></author><author><style face="normal" font="default" size="100%">Arsyik Ibrahim</style></author><author><style face="normal" font="default" size="100%">Junaidin Junaidin</style></author><author><style face="normal" font="default" size="100%">M. Arifuddin</style></author><author><style face="normal" font="default" size="100%">Baso Didik Hikmawan</style></author><author><style face="normal" font="default" size="100%">Siska Siska</style></author><author><style face="normal" font="default" size="100%">Tahyatul Bariroh</style></author><author><style face="normal" font="default" size="100%">Reza Yuridian Purwoko</style></author><author><style face="normal" font="default" size="100%">Lizma Febrina</style></author><author><style face="normal" font="default" size="100%">Muhammad Faisal</style></author><author><style face="normal" font="default" size="100%">Iswahyudi Iswahyudi</style></author><author><style face="normal" font="default" size="100%">Marissa Angelina</style></author><author><style face="normal" font="default" size="100%">Erwin Samsul</style></author><author><style face="normal" font="default" size="100%">Laode Rijai</style></author><author><style face="normal" font="default" size="100%">Islamudin Ahmad</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Pharmacognostic Profile and Antidiabetic Activity of Eleutherine bulbosa Mills. Bulbs from East Kalimantan, Indonesia</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Antidiabetic activity</style></keyword><keyword><style  face="normal" font="default" size="100%">Bawang Dayak</style></keyword><keyword><style  face="normal" font="default" size="100%">contaminant levels evaluation</style></keyword><keyword><style  face="normal" font="default" size="100%">Eleutherine bulbosa (Mill.) Urb</style></keyword><keyword><style  face="normal" font="default" size="100%">pharmacognostic profile</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2024</style></year><pub-dates><date><style  face="normal" font="default" size="100%">February 2024</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">16</style></volume><pages><style face="normal" font="default" size="100%">118-125</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background: &lt;/strong&gt;Eleutherine bulbosa (Mill.) Urb., known as Bawang Dayak, is commonly found growing in Kalimantan, Indonesia. The characteristics of the environment in which the plant grows greatly influence the characteristics of the plant and its biological activity. Objective: This study aimed to determine the pharmacognostic profile and evaluate the antidiabetic activity of E. bulbosa bulb extract obtained from Kota Bangun, Kutai Kertanegara, Indonesia. &lt;strong&gt;Methods:&lt;/strong&gt; The dried powdered of E. bulbosa bulbs was extracted using two different methods (maceration and microwave-assisted extraction). The evaluation of the sample fluorescence and non-specific parameters was done. The antidiabetic activity of the extracts was conducted using streptozocin-induced mice and histopathology analysis. &lt;strong&gt;Results:&lt;/strong&gt; The fluorescence evaluation indicated various secondary metabolites contained in E. bulbosa simplicia. Non-specific parameters include drying loss (8.83±0.2611%), water content in simplicia (8.04±0.7481%), specific gravity (1.04±0.0058%), total ash content (20.3±0.1583%), acid insoluble ash content (1.70±0.0608%), ethanol content in extract (0.99±0.0017%), lead content (0.010 mg/g), cadmium (0.091 mg/g), Arsenic (0.0003 mg/g), aflatoxin (not detected), and mold/yeast (0.8 × 105 colonies/g) meet the established regulations. Meanwhile, the antidiabetic assay showed that both extracts decreased the blood glucose levels in mice during the 14 days of treatments in a dose-dependent manner. This activity is correlated with the increased repair of pancreatic beta cells as observed by histopathological analysis. &lt;strong&gt;Conclusion:&lt;/strong&gt; The dried bulbs of E. bulbosa obtained from Kota Bangun, Kutai Kertanegara, East Kalimantan, Indonesia meet the standards set as raw materials for antidiabetic herbal medicines.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">118</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Herman Herman&lt;sup&gt;1&lt;/sup&gt;, Arsyik Ibrahim&lt;sup&gt;1&lt;/sup&gt;, Junaidin Junaidin&lt;sup&gt;1&lt;/sup&gt;, M. Arifuddin&lt;sup&gt;1&lt;/sup&gt;, Baso Didik Hikmawan&lt;sup&gt;1&lt;/sup&gt;, Siska Siska&lt;sup&gt;3&lt;/sup&gt;, Tahyatul Bariroh&lt;sup&gt;4&lt;/sup&gt;, Reza Yuridian Purwoko&lt;sup&gt;5&lt;/sup&gt;, Lizma Febrina&lt;sup&gt;1&lt;/sup&gt;, Muhammad Faisal&lt;sup&gt;1&lt;/sup&gt;, Iswahyudi Iswahyudi&lt;sup&gt;2&lt;/sup&gt;, Marissa Angelina&lt;sup&gt;6&lt;/sup&gt;, Erwin Samsul&lt;sup&gt;1&lt;/sup&gt;, Laode Rijai&lt;sup&gt;1&lt;/sup&gt;, Islamudin Ahmad&lt;sup&gt;1,2&lt;/sup&gt;*&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Pharmaceutical Research and Development Laboratory of FARMAKA TROPIS, Faculty of Pharmacy, Universitas Mulawarman, Samarinda, East Kalimantan, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Pharmaceutical Sciences, Faculty of Pharmacy, Universitas Mulawarman, Samarinda, East Kalimantan, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Pharmacology, Faculty of Pharmacy and Sciences, Universitas Muhammadiyah Prof. Dr. Hamka, East Jakarta, Jakarta, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Department of Pharmaceutical Biology, Faculty of Pharmacy and Sciences, Universitas Muhammadiyah Prof. Dr. Hamka, East Jakarta, Jakarta, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Research Center for Pre-Clinical and Clinical Medicine, National Research and Innovation Agency (BRIN), Cibinong, West Java, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;6&lt;/sup&gt;Research Centre for Pharmaceutical Ingredients and Traditional Medicine, National Research and Innovation Agency (BRIN), Kompleks Puspitek Serpong, South Tangerang and 15416, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Maulana Yusuf Alkandahri</style></author><author><style face="normal" font="default" size="100%">Dani Sujana</style></author><author><style face="normal" font="default" size="100%">Dadang Muhammad Hasyim</style></author><author><style face="normal" font="default" size="100%">Mareetha Zahra Shafirany</style></author><author><style face="normal" font="default" size="100%">Lela Sulastri</style></author><author><style face="normal" font="default" size="100%">Maya Arfania</style></author><author><style face="normal" font="default" size="100%">Dedy Frianto</style></author><author><style face="normal" font="default" size="100%">Farhamzah</style></author><author><style face="normal" font="default" size="100%">Anggun Hari Kusumawati</style></author><author><style face="normal" font="default" size="100%">Nia Yuniarsih</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Antidiabetic Activity of Extract and Fractions of Castanopsis costata Leaves on Alloxan-induced Diabetic Mice</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Antidiabetic activity</style></keyword><keyword><style  face="normal" font="default" size="100%">Castanopsis costata</style></keyword><keyword><style  face="normal" font="default" size="100%">Diabetes mellitus</style></keyword><keyword><style  face="normal" font="default" size="100%">North Sumatra.</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2021</style></year><pub-dates><date><style  face="normal" font="default" size="100%">December 2021</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">13</style></volume><pages><style face="normal" font="default" size="100%">1589-1593</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background: &lt;/strong&gt;In North Sumatra, Castanopsis costata is commonly used by traditional practitioners for the treatment of diabetes mellitus, however, no studies have been carried out to substantiate this practice. Therefore, this study aims to evaluate the anti-diabetic activity of extract and fractions of C. costata leaves in mice with alloxan-induced diabetes. &lt;strong&gt;Methods:&lt;/strong&gt; Swiss albino mice with alloxan-induced diabetes, were acquired and subjected to the experimental evaluations. Subsequently, the fasting blood glucose levels of the diabetic mice groups treated with glibenclamid, extract and fractions, as well as the untreated group, were evaluated after two weeks of therapy. &lt;strong&gt;Results: &lt;/strong&gt;Based on the results, the ethanolic extract of C. costata considerably reduced the mice’s blood glucose levels in a dose-dependent manner, at dosages of 25, 50, 100, and 200 mg/kgBW (% DBGL: 21.10%, 46.36%, 58.94%, and 60.93%, respectively). In addition, the water fraction of C. costata leaves produced a greater reduction in blood glucose levels (% DBGL: 78.93%), compared to the ethyl acetate and n-hexane fractions (% DBGL: 67.06% and 58.83%), respectively. Meanwhile, treatment with the antidiabetic drug, glibenclamide (5 mg/kgBW) produced a 50.75% reduction in blood glucose levels. &lt;strong&gt;Conclusion: &lt;/strong&gt;Based on the findings, the extract and fractions of C. costata leaves were concluded to exhibit significant anti-diabetic activity. This supported the claim that traditional practitioners in North Sumatra use the plant extract for diabetes treatment.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6s</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">1589</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Maulana Yusuf Alkandahri&lt;sup&gt;1&lt;/sup&gt;,&lt;sup&gt;*&lt;/sup&gt;, Dani Sujana&lt;sup&gt;2&lt;/sup&gt;, Dadang Muhammad Hasyim&lt;sup&gt;2&lt;/sup&gt;, Mareetha Zahra Shafirany&lt;sup&gt;3&lt;/sup&gt;, Lela Sulastri&lt;sup&gt;4&lt;/sup&gt;, Maya Arfania&lt;sup&gt;1&lt;/sup&gt;, Dedy Frianto&lt;sup&gt;1&lt;/sup&gt;, Farhamzah&lt;sup&gt;1&lt;/sup&gt;, Anggun Hari Kusumawati&lt;sup&gt;1&lt;/sup&gt;, Nia Yuniarsih&lt;sup&gt;1&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Faculty of Pharmacy, Buana Perjuangan Karawang University, Karawang, West Java, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Diploma Program of Pharmacy, Karsa Husada Garut College of Health Sciences, Garut, West Java, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Pharmaceutical Biology, School of Pharmacy Muhammadiyah Cirebon, Cirebon, West Java, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Department of Pharmaceutics and Pharmaceutical Technology, School of Pharmacy Muhammadiyah Cirebon, Cirebon, West Java, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Ruqiah Ganda Putri Panjaitan</style></author><author><style face="normal" font="default" size="100%">Novitasari</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Anti-diabetic Activity of the Red Dragon Fruit Peel (Hylocereus polyrhizus) in Ethanol Extract against Diabetic Rats</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Antidiabetic activity</style></keyword><keyword><style  face="normal" font="default" size="100%">Diabetic rats</style></keyword><keyword><style  face="normal" font="default" size="100%">Hylocereus polyrhizus</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2021</style></year><pub-dates><date><style  face="normal" font="default" size="100%">September 2021</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">13</style></volume><pages><style face="normal" font="default" size="100%">1079-1085</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background:&lt;/strong&gt; The red dragon fruit peel, which is rarely used in general, contains higher antioxidant properties compared to the flesh parts and has various secondary metabolites utilised in medicines. &lt;strong&gt;Objectives:&lt;/strong&gt; This study was aimed to determine the effects of ethanol extract administration of the red dragon fruit peel (&lt;em&gt;Hylocereus polyrhizus&lt;/em&gt;) against the decline of blood glucose levels in diabetes mellitus rats. &lt;strong&gt;Methods:&lt;/strong&gt; In this study, the total of 24 male white Wistar rats (&lt;em&gt;Rattus novergicus&lt;/em&gt;) were divided into 4 groups. All experimental animals were induced to diabetic conditions by the administration of streptozotocin and nicotinamide dosages at 45 mg/kg body weight and 110 mg/kg body weight, respectively. For 14 days, each group was treated accordingly. The first group or negative control (NC) was treated with the administration of CMC-Na 0.5% dose 2 ml/200 g body weight; the second group or positive control (PC) was administrated with glibenclamide dose 0.09 mg/200 g body weight; the third (E1) and fourth (E2) groups were administered with the ethanol extracts of the red dragon fruit peels at dosages of 37.44 mg/200 g body weight and 74.88 mg/200 g body weight, respectively. &lt;strong&gt;Results:&lt;/strong&gt; After the 14-day trial, the average levels of blood glucose on the negative control group (382.92 mg/dl) experienced no decline, and the blood glucose levels amongst groups were statistically different (&lt;em&gt;p&lt;/em&gt;&amp;lt;0.05). Conclusion: The anti-diabetic activity of the red dragon fruit peel in the ethanol extract dose 74.88 mg/200 g body weight is statistically equal to the glibenclamide dose 0.09 mg/200 g body weight.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">1079</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Ruqiah Ganda Putri Panjaitan*, Novitasari&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;Department of Biology Education, Faculty of Teacher Training and Education, Tanjungpura University. Jl. Prof. Dr. H. Hadari Nawawi, Bansir Laut, Kec. Pontianak Tenggara, Kota Pontianak, West Kalimantan 78124, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Neeraj Choudhary</style></author><author><style face="normal" font="default" size="100%">Pranav Kumar Prabhakar</style></author><author><style face="normal" font="default" size="100%">Gopal L Khatik</style></author><author><style face="normal" font="default" size="100%">Subba Rao Chamakuri</style></author><author><style face="normal" font="default" size="100%">Devesh Tewari</style></author><author><style face="normal" font="default" size="100%">Ashish Suttee</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Evaluation of Acute toxicity, In-vitro, In-vivo Antidiabetic Potential of the Flavonoid Fraction of the plant Chenopodium album L</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Acute toxicity</style></keyword><keyword><style  face="normal" font="default" size="100%">Alpha-amylase</style></keyword><keyword><style  face="normal" font="default" size="100%">Antidiabetic activity</style></keyword><keyword><style  face="normal" font="default" size="100%">Chenopodium album</style></keyword><keyword><style  face="normal" font="default" size="100%">Lc-Ms</style></keyword><keyword><style  face="normal" font="default" size="100%">Molecular docking</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2021</style></year><pub-dates><date><style  face="normal" font="default" size="100%">May 2021</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">13</style></volume><pages><style face="normal" font="default" size="100%">765-779</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background: &lt;/strong&gt;The &lt;em&gt;Chenopodium album &lt;/em&gt;L. commonly recognized as Bathua, is widely distributed globally and contains various phytoconstituents that help treat several diseases. However, until now, aerial parts' antidiabetic potential and the plant's acute toxicity at fraction level have never been established. &lt;strong&gt;Objectives: &lt;/strong&gt;To investigate the acute toxicity, the&lt;em&gt; in-vitro&lt;/em&gt;,&lt;em&gt; in-vivo&lt;/em&gt; antidiabetic potential of the plant at fraction level. &lt;strong&gt;Materials and Methods: &lt;/strong&gt;The aerial parts of the plant were fractionated into different fractions, i.e., flavonoid fraction (CAFF), tannin fraction (CATF), alkaloid fraction (CAAF), saponin fraction (CASF), and were analyzed for&lt;em&gt; in-vitro &lt;/em&gt;alpha-amylase inhibition assay. The CAFF, CATF, and CAAF were selected based on&lt;em&gt; in-vitro &lt;/em&gt;alpha-amylase inhibition assay results and were further screened for its acute toxicity and&lt;em&gt; in vivo &lt;/em&gt;antidiabetic activity using a high-fat diet and streptozotocin-induced diabetes model. The CAFF was characterized by LC-MS, and a molecular docking study was carried out. &lt;strong&gt;Results:&lt;/strong&gt; The &lt;em&gt;in-vitro &lt;/em&gt;alpha-amylase inhibition assay revealed that CAFF was found to be more potent than standard Acarbose having IC&lt;sub&gt;50&lt;/sub&gt; values 122.18 ± 1.15 and 812.83± 1.07 μg/ml, respectively. The CAFF fraction was found to possess potent antidiabetic activity in a dose-dependent manner in both in vitro and &lt;em&gt;in vivo &lt;/em&gt;diabetic models and did not produce any sign of severe toxicity. Furthermore, the bioactive CAFF fraction was characterized by LC-MS, showed the presence of quercetin 3-O-(2’’,6’’-di-O-rhamnosyl) glucoside (QRG) or quercetin 3-O-(2’’,6’’-di-Orhamnosyl) galactoside (QRGa) and quercetin 3-O-rutinoside (rutin) (QR). It is predicted from the molecular docking study that the CAFF fraction primarily acts as an alphaamylase inhibitor. &lt;strong&gt;Conclusion:&lt;/strong&gt; The CAFF fraction was found to poses dose-dependent potent antidiabetic activity and did not produce any sign of severe toxicity and primarily act as an alpha-amylase inhibitor.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">765</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Neeraj Choudhary&lt;sup&gt;1,2&lt;/sup&gt;, Pranav Kumar Prabhakar&lt;sup&gt;1&lt;/sup&gt;, Gopal L. Khatik&lt;sup&gt;1&lt;/sup&gt;, Subba Rao Chamakuri&lt;sup&gt;1&lt;/sup&gt;, Devesh Tewari&lt;sup&gt;1&lt;/sup&gt;, Ashish Suttee&lt;sup&gt;1,&lt;/sup&gt;*&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;School of Pharmaceutical Sciences, Lovely Professional University, Punjab, INDIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Faculty of Pharmaceutical Sciences, PCTE Group of Institutes, Ludhiana, Punjab, INDIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Ana L Agüero-Hernández</style></author><author><style face="normal" font="default" size="100%">Catalina Rosales-López</style></author><author><style face="normal" font="default" size="100%">Cristina Herrera</style></author><author><style face="normal" font="default" size="100%">Andrés Vargas-Picado</style></author><author><style face="normal" font="default" size="100%">Rodrigo Muñoz</style></author><author><style face="normal" font="default" size="100%">Ana Abdelnour-Esquivel</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Hypoglycemic Effect of Kalanchoe pinnata (Lam) Pers. Leaf Extract</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Antidiabetic activity</style></keyword><keyword><style  face="normal" font="default" size="100%">Diabetic</style></keyword><keyword><style  face="normal" font="default" size="100%">Extract</style></keyword><keyword><style  face="normal" font="default" size="100%">Kalanchoe pinnata</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2020</style></year><pub-dates><date><style  face="normal" font="default" size="100%">May 2020</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">12</style></volume><pages><style face="normal" font="default" size="100%">557-561</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction:&lt;/strong&gt; &lt;em&gt;Kalanchoe pinnata &lt;/em&gt;(Lam) Pers (Crasulaceae) is a succulent ornamental plant. In Costa Rica, the leaves are used as a coadjuvant treatment for &lt;em&gt;Diabetes Mellitus&lt;/em&gt; based on traditional knowledge of natural remedies. Moreover, there are some studies mentioning its use for &lt;em&gt;Diabetes Mellitus&lt;/em&gt; as medicinal plant in several countries. This research aimed to demonstrate the antidiabetic properties of hydroalcoholic extracts of &lt;em&gt;K. pinnata&lt;/em&gt; leaves through phytochemical screening, alpha amylase inhibition and rodent models. &lt;strong&gt;Methods: &lt;/strong&gt;Crude extracts of &lt;em&gt;K. pinnata&lt;/em&gt; leaves were prepared by infusion and decoction using water:ethanol (70:30) as a solvent. The extracts prepared by decoction (LAED, lyophilized-water:ethanoldecoction) and by infusion (LAEI, lyophilized-water:ethanol-infusion) were analyzed by FolinCiocalteu, HPLC and capacity of inhibition of α-amylase activity. To determine hypoglycemic activity in rats, extracts were administered orally at doses of 250, 500 and 750 mg/Kg and blood sugar levels were monitored over a four hours period using a glucometer. &lt;strong&gt;Results:&lt;/strong&gt; A significant reduction (p &amp;lt; 0.05) in blood glucose was observed after one hour in rats treated with 500 mg/Kg of LAED extract. Treatment with 750 mg/Kg LAEI induced a statistically significant reduction in blood sugar at 90, 180 and 240 min, showing that the glucose-lowering effect of this extract was greater at a higher concentration. &lt;strong&gt;Conclusions: &lt;/strong&gt;This study confirmed the hypoglycemic effect of &lt;em&gt;K. pinnata&lt;/em&gt; extracts in the acute phase in rats and supports the use of this Crassulaceae as a home remedy.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">557</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Ana L. Agüero-Hernández&lt;sup&gt;1,&lt;/sup&gt;*, Catalina Rosales-López&lt;sup&gt;1&lt;/sup&gt;, Cristina Herrera&lt;sup&gt;2&lt;/sup&gt;, Andrés Vargas-Picado&lt;sup&gt;3&lt;/sup&gt;, Rodrigo Muñoz&lt;sup&gt;3&lt;/sup&gt;&lt;sup&gt;&amp;nbsp;&lt;/sup&gt;and Ana Abdelnour-Esquivel&lt;sup&gt;1&lt;/sup&gt; &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Centro de Investigación en Biotecnología (CIB), del Instituto Tecnológico de Costa Rica, Cartago, COSTA RICA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Instituto de Investigaciones Farmacéuticas (INIFAR), Facultad de Farmacia, Universidad de Costa Rica, San José, COSTA RICA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Centro Nacional de Innovaciones Biotecnológicas (CENIBiot), San José, COSTA RICA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Sangeetha DN</style></author><author><style face="normal" font="default" size="100%">S. Rajamani</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">In vitro Antidiabetic Activity of Methanolic Leaf Extract of Indianthus virgatus (Roxb.) Suksathan and Borchs by Glucose Uptake Method</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Antidiabetic activity</style></keyword><keyword><style  face="normal" font="default" size="100%">In vitro cytotoxicity</style></keyword><keyword><style  face="normal" font="default" size="100%">Indianthus virgatus (Roxb.) Suksathan and Borchs</style></keyword><keyword><style  face="normal" font="default" size="100%">L-6 cell line</style></keyword><keyword><style  face="normal" font="default" size="100%">Methanolic leaf extract</style></keyword><keyword><style  face="normal" font="default" size="100%">MTT Assay</style></keyword><keyword><style  face="normal" font="default" size="100%">Skeletal muscle Cell Lines</style></keyword><keyword><style  face="normal" font="default" size="100%">Therapeutic agents</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2019</style></year><pub-dates><date><style  face="normal" font="default" size="100%">July 2019</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">11</style></volume><pages><style face="normal" font="default" size="100%">674-677</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;Medicinal plants play a key role to cure many diseases from time immemorial. The usage of medicinal plants in traditional medicinal system is the vital process of India. Diabetes Mellitus is a systemic metabolic disease characterized by hyperglycemia, abnormal elevated levels of lipid and fat in blood and hypoinsulinaemia. The current epidemic of diabetes indicates the need of proper and effective medications that are limited in their potency to have many side effects. Thus, introduction of alternative and complementary medicine is now in picture. &lt;strong&gt;Objective:&lt;/strong&gt; The main objective of this work is to evaluate the &lt;em&gt;in vitro&lt;/em&gt; anti diabetic activity of methanolic extracts of &lt;em&gt;Indianthus virgatus&lt;/em&gt; (Roxb.) Suksathan and Borchs in skeletal muscle cell line. &lt;strong&gt;Methods:&lt;/strong&gt; The &lt;em&gt;in vitro &lt;/em&gt;cytotoxicity was performed for leaf extract (Methanol) on L-6 (Rat skeletal muscle) cell line to find toxic concentration of the leaf extract by MTT assay. Glucose uptake activity of test substance was determined in differentiated L-6 cells. &lt;strong&gt;Results:&lt;/strong&gt; In Glucose uptake assay, Methanol Extract exhibited moderate toxicity to skeletal muscle cell line and glucose uptake assay it shows dose dependent glucose uptake. Glucose uptake rate increased with the increasing concentration of the leaf extract. &lt;strong&gt;Conclusion:&lt;/strong&gt; The results of the current study clearly demonstrated the antidiabetic potency of methanolic leaf extract obtained from &lt;em&gt;Indianthus virgatus &lt;/em&gt;(Roxb.) Suksathan and Borchs. under &lt;em&gt;in vitro &lt;/em&gt;model.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">4</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">674</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Sangeetha DN&lt;sup&gt;1,&lt;/sup&gt;*, S. Rajamani&lt;sup&gt;2&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Research Scholar, Bharathiar University, Coimbatore, Tamil Nadu, INDIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Associate Professor, Department of Botany, St. Josephs’ Post Graduate and Research Centre, Bengaluru, Karnataka, INDIA.&lt;/p&gt;
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