<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Arifia Safira</style></author><author><style face="normal" font="default" size="100%">Cinta Atsa Mahesa Rani</style></author><author><style face="normal" font="default" size="100%">Roro Ayu Puspitasari</style></author><author><style face="normal" font="default" size="100%">Anindyta Kirana Putri Ayuningtyas</style></author><author><style face="normal" font="default" size="100%">Yayang Amru Mahendra</style></author><author><style face="normal" font="default" size="100%">Agus Purnomo</style></author><author><style face="normal" font="default" size="100%">Faisal Fikri</style></author><author><style face="normal" font="default" size="100%">Shekhar Chhetri</style></author><author><style face="normal" font="default" size="100%">Muhammad Thohawi Elziyad Purnama</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Amino Acid and Proximate Analysis of Type-1 Collagen from Sea Cucumber and Tilapia-Skin and its Potential Application as Artificial Tendon</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">collagen</style></keyword><keyword><style  face="normal" font="default" size="100%">Key words: Artificial tendon</style></keyword><keyword><style  face="normal" font="default" size="100%">Marine biodiversity</style></keyword><keyword><style  face="normal" font="default" size="100%">Sea cucumber</style></keyword><keyword><style  face="normal" font="default" size="100%">Tilapia-skin</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2022</style></year><pub-dates><date><style  face="normal" font="default" size="100%">August 2022</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">14</style></volume><pages><style face="normal" font="default" size="100%">358-361</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;Tendon injury is a medical indication that requires surgical therapy and prolonged recovery. Collagen plays a crucial role in the wound healing process. Collagen maintains homeostasis, interacts with platelets, and enhances cellular components. Most living organisms consist of collagen components as fibrillar proteins. In this study, the potential properties of type-1 collagen from sea cucumber and Tilapia-skin were evaluated depend on proximate analysis, amino acid composition, and moisture-absorption ability. The result showed that Tilapia-skin has a higher protein and fat composition compared to the sea cucumber. In contrast, moisture, ash, and yield composition showed higher for sea cucumber compared to Tilapiaskin. Meanwhile, based on amino acid analysis was revealed that proline, alanine, methionine, isoleucine, leucine, phenylalanine, and lysine were lower on sea cucumber compared to Tilapia-skin. In conclusion, both type-1 collagen material from sea cucumber and Tilapia-skin might be developed as a biomaterial for tendon injury. It is crucial that further studies be carried out to emphasize the potential of biodegradable and bio-replaceable materials using the&lt;em&gt; in vivo &lt;/em&gt;model.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">4</style></issue><work-type><style face="normal" font="default" size="100%">Original Article </style></work-type><accession-num><style face="normal" font="default" size="100%">15</style></accession-num><section><style face="normal" font="default" size="100%">358</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Arifia Safira&lt;sup&gt;1,5&lt;/sup&gt;, Cinta Atsa Mahesa Rani&lt;sup&gt;1,5&lt;/sup&gt;, Roro Ayu Puspitasari&lt;sup&gt;1,5&lt;/sup&gt;, Anindyta Kirana Putri Ayuningtyas&lt;sup&gt;1,5&lt;/sup&gt;, Yayang Amru Mahendra&lt;sup&gt;1,5,&lt;/sup&gt; Agus Purnomo&lt;sup&gt;2&lt;/sup&gt;, Faisal Fikri&lt;sup&gt;3,5&lt;/sup&gt;, Shekhar Chhetri&lt;sup&gt;4&lt;/sup&gt;, Muhammad Thohawi Elziyad Purnama&lt;sup&gt;1,5,*&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Division of Veterinary Anatomy, Department of Veterinary Science, Faculty of Veterinary Medicine, Universitas Airlangga, Surabaya, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Veterinary Surgery and Radiology, Faculty of Veterinary Medicine, Universitas Gadjah Mada, Yogyakarta, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Division of Physiology and Pharmacology, Department of Veterinary Science, Faculty of Veterinary Medicine, Universitas Airlangga, Surabaya, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Department of Animal Science, College of Natural Resources, Royal University of Bhutan, Lobesa, Punakha, BHUTAN.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Department of Veterinary Science, School of Health and Life Sciences, Universitas Airlangga, Surabaya, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Muhammad Nursid</style></author><author><style face="normal" font="default" size="100%">Endar Marraskuranto</style></author><author><style face="normal" font="default" size="100%">Azizah Kuswardini</style></author><author><style face="normal" font="default" size="100%">Tjahyo Winanto</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Screening of Tyrosinase Inhibitor, Antioxidant and Cytotoxicity of Dried Sea Cucumber from Tomini Bay, Indonesia</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Antioxidant</style></keyword><keyword><style  face="normal" font="default" size="100%">Cytotoxicity</style></keyword><keyword><style  face="normal" font="default" size="100%">Screening</style></keyword><keyword><style  face="normal" font="default" size="100%">Sea cucumber</style></keyword><keyword><style  face="normal" font="default" size="100%">Tyrosinase inhibitor</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2019</style></year><pub-dates><date><style  face="normal" font="default" size="100%">May 2019</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">11</style></volume><pages><style face="normal" font="default" size="100%">555-558</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background:&lt;/strong&gt; Indonesia, as a tropical country, is one of the important producers of sea cucumbers (beche-de-mer). Sea cucumber is a marine invertebrate that contains attractive bioactive secondary metabolites and these metabolites can be used for health as well as cosmetics. &lt;strong&gt;Objective:&lt;/strong&gt; The aim of the study was to determine the activity of tyrosinase inhibitors, antioxidants, and cytotoxicity of sea cucumber methanolic extract. &lt;strong&gt;Methods:&lt;/strong&gt; Dried sea cucumber samples were taken from Boalemo waters, Tomini Bay, Indonesia. Tyrosinase inhibitor assay was carried out spectrophotometrically using tyrosinase enzymes and L-DOPA as a substrate and antioxidant tests were carried out by DPPH method. Cytotoxicity test against human breast cancer cell line (T47D) was conducted using the MTT assay. &lt;strong&gt;Results:&lt;/strong&gt; The study showed that &lt;em&gt;Bohadschia vitiensis&lt;/em&gt; had the best tyrosinase inhibitor activity with IC&lt;sub&gt;50&lt;/sub&gt; value of 0.28 mg/ml. The DPPH free radical scavenging testing showed that all sea cucumbers had weak antioxidant activity. On the other hand, cytotoxicity assay revealed that several sea cucumbers had good cytotoxicity against T47D cells, where &lt;em&gt;Holothuria atra&lt;/em&gt; and &lt;em&gt;Bohadschia marmorata &lt;/em&gt;showed strong cytotoxicities with IC&lt;sub&gt;50&lt;/sub&gt; values of 23.0 and 28.1 ug/mL, respectively. &lt;strong&gt;Conclusion:&lt;/strong&gt; Based on the study, it can be concluded that the dried sea cucumber from the Tomini bay region, Indonesia, has the potential to be developed as a source of tyrosinase inhibitors and cytotoxic agents.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">555</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Muhammad Nursid&lt;sup&gt;1,*&lt;/sup&gt;, Endar Marraskuranto&lt;sup&gt;1&lt;/sup&gt;, Azizah Kuswardini&lt;sup&gt;2&lt;/sup&gt;, Tjahyo Winanto&lt;sup&gt;2&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Research Center for Marine and Fisheries Product Processing and Biotechnology, Ministry of Marine and Fisheries Affairs, REPUBLIC OF INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Faculty of Marine and Fisheries Science, University of Jenderal Soedirman, Purwokerto, INDONESIA&lt;/p&gt;
</style></auth-address></record></records></xml>