<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Phimkun Aiyarakanchanakun</style></author><author><style face="normal" font="default" size="100%">Chanida Palanuvej</style></author><author><style face="normal" font="default" size="100%">Nijsiri Ruangrungsi</style></author><author><style face="normal" font="default" size="100%">Anuchit Phanumartwiwath</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Pharmacognostic Specifications, RP-HPLC Analysis of Chlorogenic Acid Content and Antioxidant Activity of Morus alba Linn. Leaves in Thailand</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">antioxidant activity</style></keyword><keyword><style  face="normal" font="default" size="100%">Chlorogenic acid</style></keyword><keyword><style  face="normal" font="default" size="100%">Morus alba</style></keyword><keyword><style  face="normal" font="default" size="100%">Pharmacognostic specification</style></keyword><keyword><style  face="normal" font="default" size="100%">Quality control</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2021</style></year><pub-dates><date><style  face="normal" font="default" size="100%">September 2021</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">13</style></volume><pages><style face="normal" font="default" size="100%">1186-1194</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background:&lt;/strong&gt; Morus alba Linn. leaves have been widely used as herbal medicine with therapeutics and contain chlorogenic acid as a bioactive phenolic compound. &lt;strong&gt;Objective:&lt;/strong&gt; The present study aimed to conduct the pharmacognostic specifications of M. alba leaves and the method validation for quantification of chlorogenic acid content. &lt;strong&gt;Materials and Methods: &lt;/strong&gt;Macroscopic- and microscopic characteristics, physicochemical parameters combined with quantification of chlorogenic acid in &lt;em&gt;M. alba &lt;/em&gt;leaves collected from 15 sources throughout Thailand and their antioxidant activity were reported in this study. &lt;strong&gt;Results: &lt;/strong&gt;The physicochemical parameters of&lt;em&gt; M. alba&lt;/em&gt; leaves were determined by indicating water content (7.97 ± 0.35%), loss on drying (4.55 ± 0.21%), total ash (14.38 ± 0.25%), acid-insoluble ash (6.21 ± 0.37%), water-extractive value (16.14 ± 0.50%) and ethanol-extractive value (8.61 ± 0.39%). In addition, the chlorogenic acid contents in &lt;em&gt;M. alba&lt;/em&gt; leaves were found to be 0.4159 ± 0.1958 g/100g dry weight. The ethanolic leaf extracts exhibited their antioxidant activity with half-maximal inhibitory concentration (IC&lt;sub&gt;50&lt;/sub&gt;) values (326.09–467.55 μg/mL). &lt;strong&gt;Conclusion: &lt;/strong&gt;This study showed the establishment of pharmacognostic study of&lt;em&gt; M. alba&lt;/em&gt; leaves and validation of the reversed-phase high-performance liquid chromatography (RPHPLC) quantitative analysis of their chlorogenic acid contents, which are applicable to be a reference for quality control and standardization of &lt;em&gt;M. alba&lt;/em&gt; leaves.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">1186</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Phimkun Aiyarakanchanakun&lt;sup&gt;1&lt;/sup&gt;, Chanida Palanuvej&lt;sup&gt;1&lt;/sup&gt;, Nijsiri Ruangrungsi&lt;sup&gt;1,2&lt;/sup&gt;, Anuchit Phanumartwiwath&lt;sup&gt;1,&lt;/sup&gt;*&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;College of Public Health Sciences, Chulalongkorn University, Bangkok, THAILAND.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Pharmacognosy, College of Pharmacy, Rangsit University, Pathum Thani, THAILAND.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Muhajri Agusfina</style></author><author><style face="normal" font="default" size="100%">Fadlina Chany Saputri</style></author><author><style face="normal" font="default" size="100%">Aditya Sindu Sakti</style></author><author><style face="normal" font="default" size="100%">Abdul Mun’im</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Difference of Acidic Adding Effect in Ethanol Extraction of White Mulberry Stem Bark (Morus alba) and DPP-4 Inhibiting Activity Screening for Identifying its Antidiabetic Potential</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Apigenin</style></keyword><keyword><style  face="normal" font="default" size="100%">DPP IV</style></keyword><keyword><style  face="normal" font="default" size="100%">Morus alba</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2019</style></year><pub-dates><date><style  face="normal" font="default" size="100%">July 2019</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">11</style></volume><pages><style face="normal" font="default" size="100%">790-795</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Objective:&lt;/strong&gt; Murberry (&lt;em&gt;Morus alba&lt;/em&gt;) is one of the plants that can be used to treat diabetes and bioactive compounds that play a role are apigenin. Apigenin compounds have been reported to have an antidiabetic effect and are found in the form of glycosides. To separate apigenin from its glycosides, it takes the process of hydrolysis using acid. This study aims to look at the differences between ethanol extracts without hydrolysis with acids and ethanol extracts which are hydrolyzed by acid and determine their activity as dipeptidyl peptidase-4 (DPP-4) inhibitors&lt;em&gt; in vitro&lt;/em&gt;. &lt;strong&gt;Methods: &lt;/strong&gt;&lt;em&gt;Morus alba&lt;/em&gt; stem bark dry powder was extracted MAE using 96% ethanol with acid hydrolysis using HCl 2 N and extracted without acid hydrolysis then apigenin levels can be measured by each extraction process using HPLC. DPP-4 activity was evaluated using glycyl-prolyl-7-amino-4-methyl coumarin (Gly-Pro-AMC) substrate then the inhibitory effect of extracts was determined based on the number of free AMCs by measuring fluorescence at excitation wavelengths of 350-360 nm and emission wavelengths of 450-465 nm using micro-plate readers. Sitagliptin is used as a positive control of DPP-4 inhibition in this test. &lt;strong&gt;Results:&lt;/strong&gt; The ethanol extraction method with acid hydrolysis can attract more apigenin compounds than the ethanol extraction method without acid hydrolysis. The level of apigenin in the sample of ethanol extract with acid hydrolysis was 0.16%, and in the ethanol extract without acid hydrolysis was 0.04%. The amount of inhibitory activity of DPP-4 &lt;em&gt;Morus alba &lt;/em&gt;stem bark extract was 23%, which is 0.33 times the inhibition of sitagliptin activity. &lt;strong&gt;Conclusion: &lt;/strong&gt;Extraction methods with acid hydrolysis are more effective in attracting apigenin compounds than without acid hydrolysis. &lt;em&gt;Morus alba&lt;/em&gt; stem bark extract has an anti-diabetic effect through the mechanism of action of DPP-4 inhibitors can be used as a reference for therapy of diabetes mellitus from natural ingredients.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">4</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">790</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Muhajri Agusfina&lt;sup&gt;1&lt;/sup&gt;, Fadlina Chany Saputri&lt;sup&gt;3&lt;/sup&gt;, Aditya Sindu Sakti&lt;sup&gt;4&lt;/sup&gt;, Abdul Mun’im&lt;sup&gt;2,&lt;/sup&gt;*&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Graduate Programme of Herbal Medicine, Faculty of Pharmacy, Universitas Indonesia, Depok, 16424, West Java, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Pharmacognosy- Phytochemistry, Faculty of Pharmacy, Universitas Indonesia, Depok, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Pharmacology-Toxicology, Faculty of Pharmacy, Universitas Indonesia, 16424, Depok, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Faculty of Pharmacy, Universitas Indonesia, 16424, Depok, INDONESIA.&lt;/p&gt;
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