<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Makhele Thapelo Simon</style></author><author><style face="normal" font="default" size="100%">Makhoahle Pakiso Moses</style></author><author><style face="normal" font="default" size="100%">Mashele Sitheni Samson</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Anti-Neoplastic and Cytotoxicity Potency Measuring of Five Medicago sativa L. (Alfalfa) Leaf Extracts Towards Melanoma (UACC62), Breast (MCF7), Prostate (PC3), and Colon (HCT116) Cancer Cells</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">AICR (American Institute for Cancer Research)</style></keyword><keyword><style  face="normal" font="default" size="100%">Cancer (malignancy</style></keyword><keyword><style  face="normal" font="default" size="100%">Carcinoma</style></keyword><keyword><style  face="normal" font="default" size="100%">CSIR (The Council for Scientific and Industrial Research</style></keyword><keyword><style  face="normal" font="default" size="100%">ECACC (European Collection of Authenticated Cell Cultures</style></keyword><keyword><style  face="normal" font="default" size="100%">International Agency for Research on Cancer (IARC)</style></keyword><keyword><style  face="normal" font="default" size="100%">Leukemia</style></keyword><keyword><style  face="normal" font="default" size="100%">lymphoma)</style></keyword><keyword><style  face="normal" font="default" size="100%">Medicago sativa L. (Alfalfa)</style></keyword><keyword><style  face="normal" font="default" size="100%">NCI (National Cancer Institute</style></keyword><keyword><style  face="normal" font="default" size="100%">neoplasm</style></keyword><keyword><style  face="normal" font="default" size="100%">sarcoma</style></keyword><keyword><style  face="normal" font="default" size="100%">South Africa)</style></keyword><keyword><style  face="normal" font="default" size="100%">Sulforhodamine B Assay (SRB)</style></keyword><keyword><style  face="normal" font="default" size="100%">THC (delta-9 tetrahydrocannabinol). Rick Simpson oil (RSO).</style></keyword><keyword><style  face="normal" font="default" size="100%">Tumour</style></keyword><keyword><style  face="normal" font="default" size="100%">U.S Department of Health and Human Services)</style></keyword><keyword><style  face="normal" font="default" size="100%">UK)</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2023</style></year><pub-dates><date><style  face="normal" font="default" size="100%">October 2023</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">15</style></volume><pages><style face="normal" font="default" size="100%">768-776</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;The National Cancer Registry of the National Department of Health of South Africa confirms that in females, the highest incidence of cancers diagnosed in the year 2019 was breast (10 172 cases), cervical (6 945 cases) and colorectal (1 952 cases) cancers, while in males the most diagnosed cancers were prostate, lung, and colorectal neoplasms. The risk factors that promote cancer development, and metastasis or spreading includes excessive alcohol and narcotic usage, carcinogenic infections (oncoviruses) and genetical predispositions. The global incidence of cancer is much likely to increase because of the increased exposure to risk factors (processed fast foods, industrial toxins in air and water) that promote oxidative stress, low grade chronic inflammation, diabetes mellitus, hyperglycemia, and insulin resistance. Because the ancient healer or doctor relied on plants and other natural resources for therapeutic compounds, we wanted to measure the anti-cancer actions induced by our Alfac-facah leaf extracts towards four major cancer cells. The growth inhibitory and cytotoxicity activity that was induced by our extracts was measured using the reliable Sulforhodamine B Assay as per the collaborative research program between the CSIR’s Biosciences Pharmacology Group and the NCI. Our Alfac-facah leaf test material was extracted using five solvents: Ethanol, Methanol, Diethyl-ether, Acetone, and Water. Medicinal Plants persist to play a key role in medicine, whereby they not only help with treating or preventing diseases, but they also contribute to the general wellbeing of the patient. For this reason, natural resources remain a pivotal ingredient of novel drug development compounds&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">768</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Makhele Thapelo Simon, Makhoahle Pakiso Moses*, Mashele Sitheni Samson&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;Faculty of Health and Environmental Sciences, Central University of Technology, Free State Province, 20 President Brand Street, Bloemfontein, SOUTH AFRICA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Chethankumara Ganadhal Puttaramaiah</style></author><author><style face="normal" font="default" size="100%">Krishna Venkatarangaiah</style></author><author><style face="normal" font="default" size="100%">Nagaraj Kakanahalli</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Screening In vitro Anticancer Activity of Alseodaphne semecarpifolia Nees Stem Bark Extracts against some Cancer Cell lines</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Alseodaphne semecarpifolia</style></keyword><keyword><style  face="normal" font="default" size="100%">Carcinoma</style></keyword><keyword><style  face="normal" font="default" size="100%">Cell lines</style></keyword><keyword><style  face="normal" font="default" size="100%">Cell viability</style></keyword><keyword><style  face="normal" font="default" size="100%">Cytotoxicity</style></keyword><keyword><style  face="normal" font="default" size="100%">Lymphoma</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2019</style></year><pub-dates><date><style  face="normal" font="default" size="100%">September 2019</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">11</style></volume><pages><style face="normal" font="default" size="100%">884-888</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction:&lt;/strong&gt; Cancer is considered as the prime lethal disease that affects different organs of the body. Even with the rapid developments in the medical sciences, there are no proper medicines to cure specific kind of cancer without side effects. The inhibition of tumour cell growth without side effects either by the use herbal or synthetic drugs is considered as an important target in cancer therapy. In traditional medicinal system &lt;em&gt;A. semecarpifolia&lt;/em&gt; stem bark is the prime source of herbal drug to treat lymphatic and skin cancers. &lt;strong&gt;Objective:&lt;/strong&gt; The purpose of this study is to evaluate the anticancer potential of &lt;em&gt;A. semecarpifolia&lt;/em&gt; stem bark extracts against some cancer cell lines. &lt;strong&gt;Methods:&lt;/strong&gt; The&lt;em&gt; in vitro&lt;/em&gt; anticancer activity was evaluated against DLA, EAC, HeLa, HepG2 and L929 cell lines by trypan blue dye exclusion assay and SRB assay. &lt;strong&gt;Results:&lt;/strong&gt; The results of the anticancer activity revealed that, when compared to standard drug Cyclophosphamide, SBPEE and SBCE of A. semecarpifolia showed significant anticancer activity against DLA and EAC cell lines, without causing any toxicity to the normal mouse fibroblast cells L929. Whereas, none of the three extracts showed cytotoxicity against HeLa, HepG2 and L929 cell lines. &lt;strong&gt;Conclusion: &lt;/strong&gt;The present study suggested that, SBPEE and SBCE possesses significant cytotoxic activity against DLA and EAC cell lines, which confirms the traditional medicinal claim of &lt;em&gt;A. semecarpifolia&lt;/em&gt; as a potent anticancer plant against lymphatic and skin cancer.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">884</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p&gt;&lt;strong&gt;Chethankumara Ganadhal Puttaramaiah&lt;sup&gt;1&lt;/sup&gt;, Krishna Venkatarangaiah&lt;sup&gt;2&lt;/sup&gt;, Nagaraj Kakanahalli&lt;sup&gt;3,&lt;/sup&gt;*&lt;/strong&gt;&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;1&lt;/sup&gt;Research Scholar, Department of PG Studies and Research in Applied Zoology, Kuvempu University, Shivamogga, Karnataka, INDIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;2&lt;/sup&gt;Professor, Department of PG Studies and Research in Biotechnology, Kuvempu University, Shivamogga, Karnataka, INDIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;3&lt;/sup&gt;Professor, Department of PG Studies and Research in Applied Zoology, Kuvempu University, Shivamogga, Karnataka, INDIA.&lt;/p&gt;
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