<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Aniruddha Kulkarni</style></author><author><style face="normal" font="default" size="100%">Manoj Tare</style></author><author><style face="normal" font="default" size="100%">Meera Singh</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Mucuna Pruriens Seeds Extract Loaded Phytosomal Intranasal Gel for the Effective Treatment of Parkinson’s Disease</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Gel</style></keyword><keyword><style  face="normal" font="default" size="100%">L-Dopa extract</style></keyword><keyword><style  face="normal" font="default" size="100%">Mucuna pruriens</style></keyword><keyword><style  face="normal" font="default" size="100%">Nasal gel</style></keyword><keyword><style  face="normal" font="default" size="100%">Optimization</style></keyword><keyword><style  face="normal" font="default" size="100%">Phytosome</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2025</style></year><pub-dates><date><style  face="normal" font="default" size="100%">April 2025</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">17</style></volume><pages><style face="normal" font="default" size="100%">129-154</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;One phytoconstituent derived from Mucuna pruriens (legumes) is levodopa. This medication's oral usage is limited by its high first-pass metabolism and low absorption. The goal of the present research was to develop a phytosomal gel filled with levodopa extract for better delivery and brain targeting. Various techniques, including solvent evaporation, salting out anti-solvent precipitation, direct egg yolk, and egg lipids methods, were used to create phytosomal formulations. Scanning electron microscopy, particle size, x-ray diffraction, and other techniques were used to characterize phytosomes. And added into gel formation, the more successful batch was examined for several parameters. The final batch underwent a variety of animal tests, including pharmacokinetic analysis, irritation to the nasal cavity testing. The most effective phytosomes were those made via the antisolvent precipitation approach. In this investigation, a 3&lt;sup&gt;2&lt;/sup&gt;-randomized complete factorial design was employed. Batch F4 had an entrapment efficiency of 70%, a particle size of 15 (μg) and 60% CDR. The gel-formulated batch F4G3 demonstrated improved results in terms of extrudability (90.82), amount of drug (89.32%), viscosity (5421 cps at 100 rpm), and spreadability (25.18). Batch F4G3 of the Mucuna pruriens phytosome gel exhibited Higuchi's kinetics. According to the findings of the animal study, dopamine levels were significantly elevated. The pharmacokinetic and nasal irritation studies showed notable in vitro penetration of the nasal mucosa without resulting in skin irritation. For improving Parkinson's disease treatment, the phytosomal gel formulation delivered via the nasal route would be the ideal option.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">2</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">129</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p&gt;&lt;strong&gt;Aniruddha Kulkarni&lt;sup&gt;1*&lt;/sup&gt;, Manoj Tare&lt;sup&gt;2&lt;/sup&gt;, Meera Singh&lt;sup&gt;3&lt;/sup&gt; &lt;/strong&gt;&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Pharmaceutics Sinhgad Institute of Pharmaceutical Sciences, Lonavala, Pune, 410401 INDIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Pharmaceutics, Sitabai Thite College of Pharmacy (B. Pharm), Shirur, Pune Maharashtra, INDIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Pharmaceutics, Sinhgad College of Pharmacy, Vadgaon (Bk), Pune, M.S. INDIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Nguyen Van Long</style></author><author><style face="normal" font="default" size="100%">Bui Thi Thu Ha</style></author><author><style face="normal" font="default" size="100%">Anh Vu Tuan</style></author><author><style face="normal" font="default" size="100%">Hoang Van Luong</style></author><author><style face="normal" font="default" size="100%">Nguyen Tung Linh</style></author><author><style face="normal" font="default" size="100%">Thanh Chu Duc</style></author><author><style face="normal" font="default" size="100%">Phung Cao Dai</style></author><author><style face="normal" font="default" size="100%">Chul Soon Yong</style></author><author><style face="normal" font="default" size="100%">Chu Van Men</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Phytosomal Nanoparticles Preparation of Curcuminoids to Enhance Cellular Uptake of Curcuminoids on Breast Cancer Cell Line MCF-7</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Cellular uptake</style></keyword><keyword><style  face="normal" font="default" size="100%">Curcuminoids</style></keyword><keyword><style  face="normal" font="default" size="100%">FACS analysis</style></keyword><keyword><style  face="normal" font="default" size="100%">Nanoparticle</style></keyword><keyword><style  face="normal" font="default" size="100%">Phytosome</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2019</style></year><pub-dates><date><style  face="normal" font="default" size="100%">September 2019</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">11</style></volume><pages><style face="normal" font="default" size="100%">1037-1045</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Objective: &lt;/strong&gt;Curcuminoids, the bioactive compounds extracted from &lt;em&gt;Curcuma longa &lt;/em&gt;consisting of Curcumin (CUR), demethoxycurcumin (DMC) and bisdemethoxycurcumin (BDMC), have shown promising biological effects, including anticancer activity. This study sought to prepare a physically stable phytosomal nanoparticles of curcuminoids (Curs-Phyto) to facilitate uptake of curcuminoids on breast cancer cells line, and further increase the cytotoxicity against cancer cells. &lt;strong&gt;Methods: &lt;/strong&gt;The evaporation combined extrusion technique was employed to prepare phytosomal curcuminoids nanoparticles. The interaction between curcuminoids and phospholipid by a hydrogen bond was confirmed by differential scanning calorimetry (DSC), powder X-ray diffraction (XRD), fourier transform infrared (FT-IR), and &lt;sup&gt;1&lt;/sup&gt;H nuclear magnetic resonance (&lt;sup&gt;1&lt;/sup&gt;H-NMR). Their physicochemical characterizations and stability in simulated gastric and intestinal media were investigated. The effects of Curs-Phyto on MCF-7 cells were evaluated by flow cytometry, MTS assay and cell cycle analysis. &lt;strong&gt;Results:&lt;/strong&gt; We found that the Curs-Phyto were formed at a spherical shape with good size (~ 180 nm), a narrow size distribution (PDI &amp;lt; d0.2), high complexation rate (~ 87%, 95%, and 90% for BDMC, DMC, and CUR respectively) and high loading capacity of curcuminoids. More importantly, the Curs-Phyto showed the increased cellular uptake and enhanced cytotoxicity against MCF- 7 cancer cells, compared to free curcuminoids. &lt;strong&gt;Conclusion: &lt;/strong&gt;These results indicated that the phytosome could be a promising oral delivery system for curcuminoids for cancer treatment.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">1037</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Nguyen Van Long&lt;sup&gt;1,#&lt;/sup&gt;, Bui Thi Thu Ha&lt;sup&gt;1,#&lt;/sup&gt;, Anh Vu Tuan&lt;sup&gt;1&lt;/sup&gt;, Hoang Van Luong&lt;sup&gt;1&lt;/sup&gt;, Nguyen Tung Linh&lt;sup&gt;1&lt;/sup&gt;, Thanh Chu Duc&lt;sup&gt;1&lt;/sup&gt;, Phung Cao Dai&lt;sup&gt;2&lt;/sup&gt;, Chul Soon Yong&lt;sup&gt;2&lt;/sup&gt;, Chu Van Men&lt;sup&gt;1,#&lt;/sup&gt;,* &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Institute of Biomedicine and Pharmacy, Vietnam Military Medical University, 222-Phung Hung Street, Ha Dong District, Hanoi, VIETNAM.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Laboratory of Pharmaceutics, College of Pharmacy, Yeungnam University, 214-1 Dae-Dong, Gyeongsan 712-749, REPUBLIC OF KOREA. #These authors contributed equally to this work.&lt;/p&gt;
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