<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Nguyen Van Long</style></author><author><style face="normal" font="default" size="100%">Bui Thi Thu Ha</style></author><author><style face="normal" font="default" size="100%">Anh Vu Tuan</style></author><author><style face="normal" font="default" size="100%">Hoang Van Luong</style></author><author><style face="normal" font="default" size="100%">Nguyen Tung Linh</style></author><author><style face="normal" font="default" size="100%">Thanh Chu Duc</style></author><author><style face="normal" font="default" size="100%">Phung Cao Dai</style></author><author><style face="normal" font="default" size="100%">Chul Soon Yong</style></author><author><style face="normal" font="default" size="100%">Chu Van Men</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Phytosomal Nanoparticles Preparation of Curcuminoids to Enhance Cellular Uptake of Curcuminoids on Breast Cancer Cell Line MCF-7</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Cellular uptake</style></keyword><keyword><style  face="normal" font="default" size="100%">Curcuminoids</style></keyword><keyword><style  face="normal" font="default" size="100%">FACS analysis</style></keyword><keyword><style  face="normal" font="default" size="100%">Nanoparticle</style></keyword><keyword><style  face="normal" font="default" size="100%">Phytosome</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2019</style></year><pub-dates><date><style  face="normal" font="default" size="100%">September 2019</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">11</style></volume><pages><style face="normal" font="default" size="100%">1037-1045</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Objective: &lt;/strong&gt;Curcuminoids, the bioactive compounds extracted from &lt;em&gt;Curcuma longa &lt;/em&gt;consisting of Curcumin (CUR), demethoxycurcumin (DMC) and bisdemethoxycurcumin (BDMC), have shown promising biological effects, including anticancer activity. This study sought to prepare a physically stable phytosomal nanoparticles of curcuminoids (Curs-Phyto) to facilitate uptake of curcuminoids on breast cancer cells line, and further increase the cytotoxicity against cancer cells. &lt;strong&gt;Methods: &lt;/strong&gt;The evaporation combined extrusion technique was employed to prepare phytosomal curcuminoids nanoparticles. The interaction between curcuminoids and phospholipid by a hydrogen bond was confirmed by differential scanning calorimetry (DSC), powder X-ray diffraction (XRD), fourier transform infrared (FT-IR), and &lt;sup&gt;1&lt;/sup&gt;H nuclear magnetic resonance (&lt;sup&gt;1&lt;/sup&gt;H-NMR). Their physicochemical characterizations and stability in simulated gastric and intestinal media were investigated. The effects of Curs-Phyto on MCF-7 cells were evaluated by flow cytometry, MTS assay and cell cycle analysis. &lt;strong&gt;Results:&lt;/strong&gt; We found that the Curs-Phyto were formed at a spherical shape with good size (~ 180 nm), a narrow size distribution (PDI &amp;lt; d0.2), high complexation rate (~ 87%, 95%, and 90% for BDMC, DMC, and CUR respectively) and high loading capacity of curcuminoids. More importantly, the Curs-Phyto showed the increased cellular uptake and enhanced cytotoxicity against MCF- 7 cancer cells, compared to free curcuminoids. &lt;strong&gt;Conclusion: &lt;/strong&gt;These results indicated that the phytosome could be a promising oral delivery system for curcuminoids for cancer treatment.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">1037</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Nguyen Van Long&lt;sup&gt;1,#&lt;/sup&gt;, Bui Thi Thu Ha&lt;sup&gt;1,#&lt;/sup&gt;, Anh Vu Tuan&lt;sup&gt;1&lt;/sup&gt;, Hoang Van Luong&lt;sup&gt;1&lt;/sup&gt;, Nguyen Tung Linh&lt;sup&gt;1&lt;/sup&gt;, Thanh Chu Duc&lt;sup&gt;1&lt;/sup&gt;, Phung Cao Dai&lt;sup&gt;2&lt;/sup&gt;, Chul Soon Yong&lt;sup&gt;2&lt;/sup&gt;, Chu Van Men&lt;sup&gt;1,#&lt;/sup&gt;,* &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Institute of Biomedicine and Pharmacy, Vietnam Military Medical University, 222-Phung Hung Street, Ha Dong District, Hanoi, VIETNAM.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Laboratory of Pharmaceutics, College of Pharmacy, Yeungnam University, 214-1 Dae-Dong, Gyeongsan 712-749, REPUBLIC OF KOREA. #These authors contributed equally to this work.&lt;/p&gt;
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