<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Ismael Leon-Rivera</style></author><author><style face="normal" font="default" size="100%">Juana Villeda-Hernandez</style></author><author><style face="normal" font="default" size="100%">Elizur Montiel-Arcos</style></author><author><style face="normal" font="default" size="100%">Isaac Tello</style></author><author><style face="normal" font="default" size="100%">Maria Yolanda Rios</style></author><author><style face="normal" font="default" size="100%">Samuel Estrada-Soto</style></author><author><style face="normal" font="default" size="100%">Angelica Berenice Aguilar</style></author><author><style face="normal" font="default" size="100%">Veronica Nunez-Urquiza</style></author><author><style face="normal" font="default" size="100%">Jazmin Mendez-Miron</style></author><author><style face="normal" font="default" size="100%">Victoria Campos-Pena</style></author><author><style face="normal" font="default" size="100%">Sergio Hidalgo-Figueroa</style></author><author><style face="normal" font="default" size="100%">Eva Hernandez</style></author><author><style face="normal" font="default" size="100%">Gerardo Hurtado</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Neuroprotective Effects of Ganoderma curtisii Polysaccharides After Kainic Acid-Seizure Induced</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Anti-inflammatory</style></keyword><keyword><style  face="normal" font="default" size="100%">Anticonvulsant</style></keyword><keyword><style  face="normal" font="default" size="100%">Ganoderma curtisii</style></keyword><keyword><style  face="normal" font="default" size="100%">Neuroprotective</style></keyword><keyword><style  face="normal" font="default" size="100%">β-glucan</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2019</style></year><pub-dates><date><style  face="normal" font="default" size="100%">September 2019</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">11</style></volume><pages><style face="normal" font="default" size="100%">1046-1054</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background:&lt;/strong&gt; Epilepsy is one of the major neurological disorders affecting world population. Although, some &lt;em&gt;Ganoderma&lt;/em&gt; species have shown neuroprotective activities, the effects of polysaccharides isolated from &lt;em&gt;Ganoderma curtisii&lt;/em&gt; on epileptic seizures have not been reported. &lt;strong&gt;Objective:&lt;/strong&gt; The aims of the present study were to determine whether treatment with a polysaccharide fraction (GCPS-2) from a Mexican &lt;em&gt;Ganoderma curtisii &lt;/em&gt;strain can reduce seizures, and the increases in the levels of apoptotic molecules and inflammatory cytokines in kainic acid-induced seizure mouse model. &lt;strong&gt;Materials and Methods:&lt;/strong&gt; Rats were separated in groups: Control group received 2.5% Tween 20 solution; GCPS-2 groups were administered GCPS-2 (10, 40, or 80 mg/kg); KA group received KA 10 mg/kg; GCPS-2+KA received GCPS- 2 and 30 min later KA. Pathological changes in neuronal morphology, expression of B-cell lymphoma-2, and pro-inflammatory cytokines (interleukin1-β and tumor necrosis factor-α) in the rat hippocampus and cortex were determined by immunohistochemistry.&lt;strong&gt; Results: &lt;/strong&gt;&lt;em&gt;Ganoderma curtisii&lt;/em&gt; soluble polysaccharides (GCPS-2) inhibited convulsions in rats. Moreover, treatment with GCPS-2 reduced the increased levels of apoptotic signaling molecules (Bcl-2) and proinflammatory mediators (in the kainic acid-treated hippocampus and cortex). &lt;strong&gt;Conclusion:&lt;/strong&gt; &lt;em&gt;Ganoderma curtisii&lt;/em&gt; soluble polysaccharides have a neuroprotective potential against epilepsy, partially through its ability to inhibit neurotoxic events in the &lt;em&gt;in vivo&lt;/em&gt; hippocampus and cortex.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">1046</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Ismael León-Rivera&lt;sup&gt;1&lt;/sup&gt;*, Juana Villeda-Hernández&lt;sup&gt;2&lt;/sup&gt;, Elizur Montiel-Arcos&lt;sup&gt;3&lt;/sup&gt;, Isaac Tello&lt;sup&gt;3&lt;/sup&gt;, María Yolanda Rios&lt;sup&gt;1&lt;/sup&gt;, Samuel Estrada-Soto&lt;sup&gt;4&lt;/sup&gt;, Angélica Berenice Aguilar&lt;sup&gt;1&lt;/sup&gt;, Verónica Núñez-Urquiza&lt;sup&gt;1&lt;/sup&gt;, Jazmín Méndez-Mirón&lt;sup&gt;5&lt;/sup&gt;, Victoria Campos-Peña&lt;sup&gt;2&lt;/sup&gt;, Sergio Hidalgo-Figueroa&lt;sup&gt;6&lt;/sup&gt;, Eva Hernández&lt;sup&gt;7&lt;/sup&gt;, Gerardo Hurtado&lt;sup&gt;7&lt;/sup&gt; &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Centro de Investigaciones Químicas, IICBA, Universidad Autónoma del Estado de Morelos, Avenida Universidad 1001, Col. Chamilpa 62209 Cuernavaca, Morelos, ESTADOS UNIDOS MEXICANOS.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Instituto Nacional de Neurología y Neurocirugía Manuel Velasco Suárez. Avenida Insurgentes Sur No. 3877 Col. La Fama Tlalpan, Ciudad de México, ESTADOS UNIDOS MEXICANOS.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Centro de Investigaciones Biológicas, Universidad Autónoma del Estado de Morelos, Avenida Universidad 1001, Col. Chamilpa 62209 Cuernavaca, Morelos, ESTADOS UNIDOS MEXICANOS.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Facultad de Farmacia, Universidad Autónoma del Estado de Morelos, Avenida Universidad 1001, Col. Chamilpa 62209 Cuernavaca, Morelos, ESTADOS UNIDOS MEXICANOS.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Facultad de Ciencias Biológicas, Universidad Autónoma del Estado de Morelos, Avenida Universidad 1001, Col. Chamilpa 62209 Cuernavaca, Morelos, ESTADOS UNIDOS MEXICANOS.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;6&lt;/sup&gt;CONACYT-IPICYT Consorcio de Investigación, Innovación y Desarrollo para las Zonas Áridas, 78216 San Luis Potosí, ESTADOS UNIDOS MEXICANOS.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;7&lt;/sup&gt;Instituto Nacional de Salud Pública. Avenida Universidad 565, Col. Santa María Ahuacatitla Cuernavaca, Morelos, ESTADOS UNIDOS MEXICANOS.&lt;/p&gt;
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