<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Puneshwar Keshari</style></author><author><style face="normal" font="default" size="100%">Pradeep</style></author><author><style face="normal" font="default" size="100%">Sudhakar Bhat</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Evaluation of Hepatoprotective Potential of Rhododendron arboreum Sm. Stem Bark as Abhava Pratinidhi Dravya (Substitute) of Rohitaka (Tecomella undulata (Sm.) Seem.) Against Paracetamol Induced Hepatotoxicity in Experimental Rats</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Abhava Pratinidhi Dravya</style></keyword><keyword><style  face="normal" font="default" size="100%">Choorna</style></keyword><keyword><style  face="normal" font="default" size="100%">Hepatoprotective</style></keyword><keyword><style  face="normal" font="default" size="100%">Kwatha</style></keyword><keyword><style  face="normal" font="default" size="100%">Rhododendron arboreum</style></keyword><keyword><style  face="normal" font="default" size="100%">Rohitaka</style></keyword><keyword><style  face="normal" font="default" size="100%">Substitute</style></keyword><keyword><style  face="normal" font="default" size="100%">Tecomella undulata</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2019</style></year><pub-dates><date><style  face="normal" font="default" size="100%">September 2019</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">11</style></volume><pages><style face="normal" font="default" size="100%">1148-1154</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background:&lt;/strong&gt; Rohitaka (&lt;em&gt;Tecomella undulata&lt;/em&gt; (Sm.) Seem.) has been considered as threatened and listed as rare at international level (IUCN, 2000). In Ayurveda classics, Rohitaka is described as Yakritpleehgulmodarhara (useful in liver and spleenic disorders). &lt;em&gt;Rhododendron arboreum&lt;/em&gt; Sm. is used by folklore practitioners for treatment of Jaundice and marketed as Rohitaka in Nepal. &lt;strong&gt;Aim: &lt;/strong&gt;To evaluate &lt;em&gt;Rhododendron arboreum&lt;/em&gt; Sm. as an effective pratinidhi dravya (substitute) in abhava (absence) of Rohitaka (&lt;em&gt;Tecomella undulata&lt;/em&gt; (Sm.) Seem.) with special reference to hepatoprotective activity in paracetamol induced hepatotoxicity in rats. &lt;strong&gt;Materials and Methods:&lt;/strong&gt; In the present study, hepatoprotective effect of Choorna (powder) and Kwatha (decoction) of &lt;em&gt;Rhododendron arboreum&lt;/em&gt; Sm. and &lt;em&gt;Tecomella undulata&lt;/em&gt; (Sm.) Seem. (Choorna-0.54 g/kg body wt. and Kwatha- 4.32 ml/kg body wt. p. o. for 10 days along with paracetamol toxicant 3 g/kg body wt. p. o. on 6&lt;sup&gt;th&lt;/sup&gt; and 8&lt;sup&gt;th &lt;/sup&gt;day) were investigated against paracetamol induced hepatotoxicity. Silymarin (100 mg/kg body wt.) was used as standard hepatoprotective reference drug. &lt;strong&gt;Statistical Analysis Used:&lt;/strong&gt; The obtained data were analyzed by ANOVA with Dunnet's multiple ‘t’ test and level of p&amp;lt;0.05 was considered as statistically significant. &lt;strong&gt;Results: &lt;/strong&gt;Paracetamol treatment led to elevated levels of liver marker enzymes and disorientation in histological observations which were significantly reversed by treatment with &lt;em&gt;Rhododendron arboreum&lt;/em&gt; Sm. and &lt;em&gt;Tecomella undulata&lt;/em&gt; (Sm.) Seem. dependent on dosage forms. &lt;strong&gt;Conclusion: &lt;/strong&gt;The study revealed that both the drugs have similar hepatoprotective effect and thus &lt;em&gt;Rhododendron arboreum&lt;/em&gt; Sm. as “Abhava Pratinidhi Dravya” for &lt;em&gt;Tecomella undulata&lt;/em&gt; (Sm.) Seem. with special reference to hepatoprotective activity is justified.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">1148</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Puneshwar Keshari*, Pradeep, Sudhakar Bhat &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;Department of Dravyaguna, SDM College of Ayurveda and Hospital, Hassan- 573201, Karnataka, INDIA.&lt;/p&gt;
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