<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Mandla Hlongwane</style></author><author><style face="normal" font="default" size="100%">Siphamandla Lamula</style></author><author><style face="normal" font="default" size="100%">Lisa Buwa-Komoreng</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Phytochemical Analysis and Antimicrobial Activity of Medicinal Plants Commonly Used in the Treatment of Tuberculosis in the Eastern Free State, South Africa</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Dicoma anomala</style></keyword><keyword><style  face="normal" font="default" size="100%">Drimia depressa</style></keyword><keyword><style  face="normal" font="default" size="100%">Eucomis autumnalis</style></keyword><keyword><style  face="normal" font="default" size="100%">Hermannia depressa</style></keyword><keyword><style  face="normal" font="default" size="100%">Lotononis lanceolata</style></keyword><keyword><style  face="normal" font="default" size="100%">Senecio harveianus</style></keyword><keyword><style  face="normal" font="default" size="100%">Thesium angulosum</style></keyword><keyword><style  face="normal" font="default" size="100%">Xysmalobium undulatum</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2025</style></year><pub-dates><date><style  face="normal" font="default" size="100%">April 2025</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">17</style></volume><pages><style face="normal" font="default" size="100%">155-163</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background: &lt;/strong&gt;Tuberculosis (TB), an airborne infectious disease that mainly infects the lungs, caused by&lt;em&gt; Mycobacterium tuberculosis.&lt;/em&gt; South Africa is one of the countries with the highest TB and multi-drugresistant TB burden.&lt;strong&gt; Objective: &lt;/strong&gt;This study aimed at screening eight medicinal plants that are frequently used by herbalists and traditional healers of the eastern Free State for the treatment of TB. &lt;strong&gt;Methods:&lt;/strong&gt; Thirty-two plant extracts were screened for the presence of phytochemicals, antibacterial, antifungal and antimycobacterial activities using standard methods. &lt;strong&gt;Results:&lt;/strong&gt; Extracts prepared from &lt;em&gt;Hermannia depressa&lt;/em&gt; and &lt;em&gt;Senecio harveianus &lt;/em&gt;displayed the best antibacterial activity against all test microorganisms ranging between 0.098 and 0.781 mg/ml while &lt;em&gt;Drimia depressa&lt;/em&gt; and &lt;em&gt;Lotononis lanceolata &lt;/em&gt;extracts displayed the best antifungal activity between 0.049 and 0.781 mg/ml. The good antimycobacterial activity was observed with organic extracts prepared from&lt;em&gt; Dicoma anomala,&lt;/em&gt; &lt;em&gt;H. depressa, L. lanceolata &lt;/em&gt;and &lt;em&gt;S. harveianus &lt;/em&gt;between 0.195 and 0.781 mg/ml. &lt;strong&gt;Discussion:&lt;/strong&gt; All plants displayed the presence of tannins and saponins and the absence of alkaloids, anthraquinones and steroids. Plants under this study demonstrated significant antibacterial, antifungal and antimycobacterial activities, with extracts prepared from &lt;em&gt;H. depressa &lt;/em&gt;and &lt;em&gt;S. harveianus &lt;/em&gt;displaying the best activity against all the test microorganisms with MIC values ranging between 0.098 and 0.781 mg/ml, respectively. &lt;strong&gt;Conclusion:&lt;/strong&gt; The selected medicinal plants that are used in the treatment of TB and related respiratory ailments in the eastern Free State revealed the presence of phytochemicals and significant antimicrobial activities, which explain and justify their frequent use by traditional healers.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">2</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">155</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Mandla Hlongwane&lt;sup&gt;1&lt;/sup&gt;, Siphamandla Lamula&lt;sup&gt;2&lt;/sup&gt;, Lisa Buwa-Komoreng&lt;sup&gt;2*&lt;/sup&gt; &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Research Directorate, Mangosuthu University of Technology, Durban, SOUTH AFRICA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Botany Department, Faculty of Science and Agriculture, University of Fort Hare, Alice, SOUTH AFRICA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">G Ayeni</style></author><author><style face="normal" font="default" size="100%">OJ Pooe</style></author><author><style face="normal" font="default" size="100%">M Singh</style></author><author><style face="normal" font="default" size="100%">N Nundkumar</style></author><author><style face="normal" font="default" size="100%">MBC Simelane</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Cytotoxic and Antioxidant Activities of Selected South African Medicinal Plants</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Antioxidants</style></keyword><keyword><style  face="normal" font="default" size="100%">DNA</style></keyword><keyword><style  face="normal" font="default" size="100%">Eucomis autumnalis</style></keyword><keyword><style  face="normal" font="default" size="100%">Warburgia salutaris</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2019</style></year><pub-dates><date><style  face="normal" font="default" size="100%">November 2019</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">11</style></volume><pages><style face="normal" font="default" size="100%">1532-1539</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction: &lt;/strong&gt;Indigenous plants are known to play a pivotal role in the well-being of Africa’s native societies. These plants are believed to be endowed with healing effects against various ailments rooting from oxidative stress. However, most of these plants including &lt;em&gt;Ziziphus mucronata, Warburgia salutaris &lt;/em&gt;and&lt;em&gt; Eucomis autumnalis &lt;/em&gt;lack scientific reports validating their medicinal properties. Thus, the current study, aimed to investigate the cytotoxic and antioxidant activities of selected South African medicinal plants. &lt;strong&gt;Methods:&lt;/strong&gt; Scavenging activity of the extracts were evaluated on 2,2-diphenyl-1-picrylhydrazyl (DPPH), superoxide anion (O&lt;sub&gt;2 &lt;/sub&gt;-) nitric oxide (NO-), hydroxyl anion (-OH) radicals and lipid peroxide (LP) values at varying concentration (20 - 100 μg/mL). Cytotoxic evaluation using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) was conducted on HEK293 cells. Reducing power and metal chelating ability of the extracts were assessed. In the same vein, protective index of DNA plasmid (pET151/D TOPO plasmid) induced free radical by incubating with Fenton’s reagents were tested, &lt;em&gt;in vitro.&lt;/em&gt; Reducing and metal chelating ability of the extracts were evaluated in this study. &lt;strong&gt;Results: &lt;/strong&gt;The crude extracts displayed radical scavenging activity and limit peroxidation process. The extracts showed potent ferric reducing power and chelating effects. Cytotoxic effects of the extracts analyzed using the MTT assay displayed low toxicity levels. Furthermore, the extracts were able to protect pET151/D-TOPO plasmid DNA nicking induced by hydroxyl radicals in a Fenton’s reaction mixture. &lt;strong&gt;Conclusion: &lt;/strong&gt;It is evident in this study that the plant extracts are potential antioxidant therapeutics and justify inclusion of indigenous herbs as a complementary agents in the treatment regimen.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6s</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">1532</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;G Ayeni&lt;sup&gt;1,&lt;/sup&gt;*, OJ Pooe&lt;sup&gt;1&lt;/sup&gt;, M Singh&lt;sup&gt;1&lt;/sup&gt;, N Nundkumar&lt;sup&gt;1&lt;/sup&gt;, MBC Simelane&lt;sup&gt;2&lt;/sup&gt; &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Discipline of Biochemistry, School of Life Science, University of KwaZulu-Natal, Durban, SOUTH AFRICA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Biochemistry, University of Johannesburg, Auckland Park, SOUTH AFRICA.&lt;/p&gt;
</style></auth-address></record></records></xml>