<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Ranjini HS</style></author><author><style face="normal" font="default" size="100%">Kadmad Abdul Hameed Mohamed Azar</style></author><author><style face="normal" font="default" size="100%">S Fayazul Haq</style></author><author><style face="normal" font="default" size="100%">Prashanthkumar Goudappala</style></author><author><style face="normal" font="default" size="100%">Vinodakumar HR</style></author><author><style face="normal" font="default" size="100%">Akash A</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Acute Oral Toxicity Evaluation of Hydroalcoholic Extract of Salvia Officinalis Roots in Wistar Rats as per OECD 423 TG</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Acute toxicity</style></keyword><keyword><style  face="normal" font="default" size="100%">Haematology</style></keyword><keyword><style  face="normal" font="default" size="100%">heart</style></keyword><keyword><style  face="normal" font="default" size="100%">Kidney</style></keyword><keyword><style  face="normal" font="default" size="100%">Liver</style></keyword><keyword><style  face="normal" font="default" size="100%">Salvia officinalis</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2025</style></year><pub-dates><date><style  face="normal" font="default" size="100%">September 2025</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">17</style></volume><pages><style face="normal" font="default" size="100%">577-582</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background: &lt;/strong&gt;In this study, we assessed the hydroalcoholic root extract of &lt;em&gt;Salvia officinalis &lt;/em&gt;oral acute toxicity investigation using an animal model. &lt;strong&gt;Methods: &lt;/strong&gt;The investigation of acute oral toxicity was conducted using OECD 423 guidelines. The Institutional Animal Ethics Committee approved the study (IAEC). A single oral dose of &lt;em&gt;Salvia officinalis&lt;/em&gt; hydroalcoholic root extract (800, 1600, and 3200 mg/kg) was administered, and the subjects were monitored for 14 days. Animals were sacrificed on the fifteenth day, and body weight, haematological, and serum hepatic biochemical parameters were assessed and compared to the standard group. &lt;strong&gt;Results:&lt;/strong&gt;Groups treated with &lt;em&gt;Salvia officinalis&lt;/em&gt; showed no mortality or discernible alterations. The findings show that Wistar rats did not experience appreciable harmful effects from administering hydroalcoholic root extract from the &lt;em&gt;Salvia officinalis&lt;/em&gt; plant. &lt;strong&gt;Conclusions:&lt;/strong&gt; The extract can be utilized safely for therapeutic use in pharmaceutical formulations.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">577</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Ranjini HS&lt;sup&gt;1&lt;/sup&gt;, Kadmad Abdul Hameed Mohamed Azar&lt;sup&gt;2&lt;/sup&gt;, S Fayazul Haq&lt;sup&gt;3&lt;/sup&gt;, Prashanthkumar Goudappala&lt;sup&gt;4*&lt;/sup&gt;, Vinodakumar H R&lt;sup&gt;5&lt;/sup&gt;, Akash&lt;sup&gt;5&lt;/sup&gt; &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Assistant professor, Department of Biochemistry, BGSMCH, Nagarur, Bengaluru North, Karnataka, INDIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Assistant Professor, Department of Pharmacology, Srinivas Institute of Medical Sciences and Research Centre, Mangalore, Karnataka, INDIA .&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Assistant Professor, Department of Biochemistry, Sri Siddhartha Institute of Medical Sciences, Sri Siddhartha Academy of Higher Education, T Begur, INDIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Associate Professor, Department of Biochemistry, Sri Siddhartha Medical College, Sri Siddhartha Academy of Higher Education, Tumkur, INDIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Assistant Professor, 6Tutor, Department of Biochemistry, Sri Siddhartha Medical College, Sri Siddhartha Academy of Higher Education, Tumkur, INDIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Mokhtaria Yasmina BOUFADI</style></author><author><style face="normal" font="default" size="100%">Soumia KEDDARI</style></author><author><style face="normal" font="default" size="100%">Faiza MOULAI-HACENE</style></author><author><style face="normal" font="default" size="100%">Sara CHAA</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Chemical Composition, Antioxidant and Anti-Inflammatory Properties of Salvia Officinalis Extract from Algeria</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Biomarkers of inflammation</style></keyword><keyword><style  face="normal" font="default" size="100%">HPLC/UV</style></keyword><keyword><style  face="normal" font="default" size="100%">Lipoperoxydation</style></keyword><keyword><style  face="normal" font="default" size="100%">Oxydative stress</style></keyword><keyword><style  face="normal" font="default" size="100%">Salvia officinalis</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2021</style></year><pub-dates><date><style  face="normal" font="default" size="100%">March 2021</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">13</style></volume><pages><style face="normal" font="default" size="100%">506-515</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background:&lt;/strong&gt; Due to its flavoring and seasoning properties, &lt;em&gt;Salvia officinalis &lt;/em&gt;has been widely used in the preparation of many foods. In folk medicine in Asia and Latin America, it has been used for the treatment of various types of disorders, including seizures, ulcers, rheumatism, inflammation, dizziness, and high blood sugar. &lt;strong&gt;Objective: &lt;/strong&gt;The purpose of this study is to determine the chemical composition by HPLC/UV, antioxidant activity and lipid peroxidation; thus the, the anti-inflammatory effect of the ethanolic extract of &lt;em&gt;Salvia officinalis &lt;/em&gt;(EES) on certain homeostatic parameters, inflammatory biomarkers and antioxidant status in Wistar rats subjected to inflammation induced by carrageenan. &lt;strong&gt;Method:&lt;/strong&gt; Male rats (&lt;em&gt;n&lt;/em&gt; = 24) were exposed to inflammation of the peritoneal by carrageenan (200 μL: 2%) and treated for 5 days with ethanolic extract of &lt;em&gt;Salvia officinalis&lt;/em&gt; (EES) in order to repair the damage caused by inflammation on homeostasis, TNF-α and PGE2. &lt;strong&gt;Results:&lt;/strong&gt; The results of scavenging of DPPH and lipoperoxidation of the extract, showed an IC&lt;sub&gt;50 &lt;/sub&gt;of 29.69 ± 1.32 and 46.17 ± 1.51 μg/mL, respectively. The identification of EEC by HPLC shows the presence of polyphenolic acids (salvianolic acid, rosmarinic acid, caffeic acid, ferulic acid) and many flavonoids (Cirsimaritin, Catechin, Acacetin, kaempferol, pinocembrine, quercetin). Salvia extract contains 221.08 ± 2.36 mg EAG/g and 80.54 ± 1.3 mg EQ/g dry extract. Compared to the control group, carrageenan induced a substantial decrease (P&amp;lt;0.05) in antioxidant enzymes and a highly significant increase (P&amp;lt;0.05) in homeostatic parameters (blood sugar, CRP and fibrinogen), biomarkers of inflammation (TNF-α and PGE2) and malondialdehyde levels. &lt;strong&gt;Conclusion:&lt;/strong&gt; The administration of Salvia extract corrects this perturbation where there is an improvement in antioxidant enzymes and a decrease in biomarkers of inflammation. &lt;em&gt;Salvia officinalis&lt;/em&gt; has been able to repair carrageenin-induced perturbations homeostasis and inflammation markers in Wistar rats.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">2</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">506</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Mokhtaria Yasmina BOUFADI&lt;sup&gt;1,2,&lt;/sup&gt;*, Soumia KEDDARI&lt;sup&gt;1&lt;/sup&gt;, Faiza MOULAIHACENE&lt;sup&gt;1&lt;/sup&gt;, Sara CHAA&lt;sup&gt;1&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Laboratory of Beneficial Microorganisms, Functional Food and Health (LMBAFS). Faculty of Natural Sciences and Life. Abdelhamid Ibn Badis University, Mostaganem, ALGERIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Laboratory of Pharmaceutical Chemistry, Faculty of Pharmacy, Libre University, Brussels, BELGIUM.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Amel CHOUABIA</style></author><author><style face="normal" font="default" size="100%">Samir DJEMLI</style></author><author><style face="normal" font="default" size="100%">Cherif ABDENNOUR</style></author><author><style face="normal" font="default" size="100%">Leila MALLEM</style></author><author><style face="normal" font="default" size="100%">Labiba KAHALERRAS</style></author><author><style face="normal" font="default" size="100%">Fatma Zohra ARKOUB</style></author><author><style face="normal" font="default" size="100%">Narimene BOUABDALLAH</style></author><author><style face="normal" font="default" size="100%">Abdelkrim TAHRAOUI</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Protective effect of Salvia officinalis against cypermethrininduced reprotoxicity in male Wistar rats</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Cypermethrin</style></keyword><keyword><style  face="normal" font="default" size="100%">Histology</style></keyword><keyword><style  face="normal" font="default" size="100%">Rats</style></keyword><keyword><style  face="normal" font="default" size="100%">Salvia officinalis</style></keyword><keyword><style  face="normal" font="default" size="100%">Spermatozoa</style></keyword><keyword><style  face="normal" font="default" size="100%">Toxicity</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2021</style></year><pub-dates><date><style  face="normal" font="default" size="100%">November 2021</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">13</style></volume><pages><style face="normal" font="default" size="100%">1413-1421</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background:&lt;/strong&gt; Medicinal plants are a reservoir of biologically active compounds with therapeutic properties that, over time, have been used for the treatment of various diseases. This study aims to evaluate the protective effect of the aqueous extract of the leaves of&lt;em&gt; Salvia officinalis &lt;/em&gt;against cypermethrin-induced toxicity. &lt;strong&gt;Methods: &lt;/strong&gt;30 male rats weighing approximately 240 g were divided into equal six groups; the control group received tap water, the positive control received the aqueous extract of sage leaves (SLE) at a dose of (0.5g/kg bw), the groups treated with cypermethrin (Cyp1) at 8.33 mg/kg bw and (Cyp2) at 25 mg/kg bw, and the groups treated by cypermethrin combined with aqueous extract of sage SLE+Cyp1 (0.5g/kg bw+8.33 mg/kg bw) and SLE+Cyp2 (0.5g/kg bw+25 mg/kg bw) for four days/week. After 4 weeks of oral administration, epididymal seminal fluid was analyzed via the CASA system, in addition to the histological study testis and epididymis. &lt;strong&gt;Results: &lt;/strong&gt;The obtained results showed a decrease in the absolute weight of the reproductive organs, with a significant decrease in sperm concentration, motility and speed in the cypermethrin-treated group compared to the control. Histological study of the testes and epididymis indicates an alteration in the stages of spermatogenesis in groups Cyp1 and Cyp2 compared to the control. However, the above-mentioned parameters were maintained almost normal in the groups that received the aqueous extract of sage with both doses of cypermethrin. &lt;strong&gt;Conclusion:&lt;/strong&gt; it can be demonstrated that SLE has been shown to protect rats from cypermethrin-induced reprotoxicity.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">1413</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Amel CHOUABIA&lt;sup&gt;1&lt;/sup&gt;, Samir DJEMLI&lt;sup&gt;2&lt;/sup&gt;,*, Cherif ABDENNOUR&lt;sup&gt;1&lt;/sup&gt;, Leila MALLEM&lt;sup&gt;1&lt;/sup&gt;, Labiba KAHALERRAS&lt;sup&gt;1&lt;/sup&gt;, Fatma Zohra ARKOUB&lt;sup&gt;1&lt;/sup&gt;, Narimene BOUABDALLAH&lt;sup&gt;1&lt;/sup&gt;, Abdelkrim TAHRAOUI&lt;sup&gt;2&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Faculty of Sciences, Animal Ecophysiology Laboratory, Department of Biology, Badji Mokhtar University, Annaba, ALGERIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Faculty of Sciences, Applied Neuroendocrinology Laboratory, Department of Biology, Badji Mokhtar University, Annaba, ALGERIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Sanjana Datta</style></author><author><style face="normal" font="default" size="100%">Shailendra Patil</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Evaluation of Traditional Herb Extract Salvia officinalis in Treatment of Alzheimers Disease</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Alzheimer’s disease</style></keyword><keyword><style  face="normal" font="default" size="100%">Histopathological assessment</style></keyword><keyword><style  face="normal" font="default" size="100%">Locomotor activity</style></keyword><keyword><style  face="normal" font="default" size="100%">Salvia officinalis</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2020</style></year><pub-dates><date><style  face="normal" font="default" size="100%">February  2020</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">12</style></volume><pages><style face="normal" font="default" size="100%">131-143</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Aim and Objective: &lt;/strong&gt;Alzheimer’s disease is progressive neurodegenerative disorder which affects older individuals. It is the most common cause of dementia and it is associated with the presence of senile plaques which are deposition of beta- amyloidal protein in the hippocampus area of the brain. Medicinal plants have played vital role in world health. In spite of the great advances observed in modern medicine in recent decades, plants still make an important contribution to health care. The present study is done to evaluate &lt;em&gt;Salvia officinalis,&lt;/em&gt; for &lt;em&gt;in vivo &lt;/em&gt;study on Alzheimer’s disease induced mice. &lt;strong&gt;Materials and Methodology: &lt;/strong&gt;Memory Enhancing Activity, Conditioned avoidance test, Y-maze spontaneous alternation test, Elevated Plus Maze, Morris Water Maze, Measurement of Locomotor Activity were done to assess memory and cognitive functioning. The isolated brain homogenate is estimated for reduced glutathione content, Acetyl cholinesterase Activity, Superoxide dismutase assay (SOD), Lipid peroxidation assay (TBARS), Glutathione peroxidase assay (GSH-Px) and Histopathology examination of brain was performed and analyzed. &lt;strong&gt;Results and Discussion: &lt;/strong&gt;The elevated level of enzymes and decreased level of tissue antioxidant markers were observed in treatment comparative to piracetam treatment group. While 300 mg/kg extract significantly reduced the elevated levels of the enzymes and also significantly increased the tissue antioxidant levels, while decreased the glutathione levels when compared with the control. &lt;strong&gt;Conclusion: &lt;/strong&gt;The histopathological study confirmed the recovery. The herbal extract (150 and 300 mg/kg) has shown effectiveness against Alzheimer’s disease.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">131</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Sanjana Datta*, Shailendra Patil&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;SVN Institute of Pharmaceutical Sciences, Swami Vivekanand University, Sagar (MP) 470228, INDIA.&lt;/p&gt;
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