<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Judith M. Bocanegra-Nunez</style></author><author><style face="normal" font="default" size="100%">Deivy Y. Dionicio-Rosado</style></author><author><style face="normal" font="default" size="100%">Carmen R. Silva-Correa</style></author><author><style face="normal" font="default" size="100%">Víctor E. Villarreal-La Torre</style></author><author><style face="normal" font="default" size="100%">Julio A. Castañeda-Carranza</style></author><author><style face="normal" font="default" size="100%">Walter E. Janampa-Castillo</style></author><author><style face="normal" font="default" size="100%">Abhel A. Calderón-Peña</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Effect of a Cream Based on Hydroalcoholic Extract of Sebastiana Obtusifolia Leaves on Second-Degree Burns in Mice</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Burn healing</style></keyword><keyword><style  face="normal" font="default" size="100%">Cream</style></keyword><keyword><style  face="normal" font="default" size="100%">Sebastiana obtusifolia</style></keyword><keyword><style  face="normal" font="default" size="100%">Skin</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2026</style></year><pub-dates><date><style  face="normal" font="default" size="100%">October 2026</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">18</style></volume><pages><style face="normal" font="default" size="100%">216-220</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction: &lt;/strong&gt;&lt;em&gt;Sebastiana obtusifolia&lt;/em&gt; (Müll. Arg.), a species belonging to the Euphorbiaceae family, has traditionally been used for medicinal purposes by rural communities due to its medicinal properties. &lt;strong&gt;Objective:&lt;/strong&gt; Therefore, the objective of this study was to evaluate the effect of a cream based on &lt;em&gt;Sebastiana obtusifolia&lt;/em&gt; extract on burns induced in &lt;em&gt;Mus musculus&lt;/em&gt; Balb/c. &lt;strong&gt;Material and methods:&lt;/strong&gt; The experimental animals were divided into 6 groups with 5 specimens each. Forty-eight hours prior to the induction of second-degree burns, the hair was removed from the back area; Ketamine/xylazine 80 mg/kg/-10 mg/ kg was then administered intravenously, and a round metal rod with a diameter of 1.0 cm was placed on the depilated skin at a temperature of 100°C for 5 seconds. Group A received no treatment; Group B was treated with a 1% silver sulfadiazine healing ointment; Group C was treated with a base cream; and the other two groups, D, E, and F, were treated with a cream formulated with &lt;em&gt;Sebastiana obtusifolia&lt;/em&gt; at 0.5%, 1%, and 1.5%, respectively. The treatments were administered once a day for 21 days, measuring the burn area and taking the respective photographic controls throughout the experimental period. Euthanasia was then performed using sodium pentobarbital 185 mg/kg i.p. to obtain skin samples, which were preserved in 10% formalin and sent for histopathological analysis. &lt;strong&gt;Results:&lt;/strong&gt; There was a statistically significant difference between the groups, with a significance level of p&amp;lt;0.05 during the experiment. Histopathological sections showed that in groups D and F there was an abundance of collagen and fibroblasts in the direction of the dermis, attributable to the effect of the creams. &lt;strong&gt;Conclusion:&lt;/strong&gt; Creams based on hydroalcoholic extract of &lt;em&gt;Sebastiana obtusifolia&lt;/em&gt; “lloque blanco” have a healing effect on seconddegree burns induced in &lt;em&gt;Mus musculus&lt;/em&gt; Balb/c, with the greatest effect being observed with the 1.5% cream.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">216</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Judith M. Bocanegra-Núñez&lt;sup&gt;1&lt;/sup&gt;, Deivy Y. Dionicio-Rosado&lt;sup&gt;2&lt;/sup&gt;, Carmen R. Silva-Correa&lt;sup&gt;3&lt;/sup&gt;, Víctor E. Villarreal-La Torre&lt;sup&gt;3&lt;/sup&gt;, Julio A. Castañeda-Carranza&lt;sup&gt;4&lt;/sup&gt;, Walter E. Janampa-Castillo&lt;sup&gt;5&lt;/sup&gt;, Abhel A. Calderón-Peña&lt;sup&gt;6&lt;/sup&gt; &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Facultad de Ingeniería, Universidad Nacional Ciro Alegría, PERÚ.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Facultad de Gestión Empresarial, Universidad Nacional Ciro Alegría. PERÚ.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Facultad de Farmacia y Bioquímica, Universidad Nacional de Trujillo, PERÚ&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Facultad de Ciencias Físicas y Matemáticas, Universidad Nacional de Trujillo, PERÚ.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Facultad de Ciencias de la Educación y de la Comunicación, Universidad Nacional de Trujillo, PERÚ.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;6&lt;/sup&gt;Facultad de Ciencias Biológicas, Universidad Nacional de Trujillo, PERÚ.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Laurente-Pachamango Katherine G</style></author><author><style face="normal" font="default" size="100%">Cruzado-Razco José L</style></author><author><style face="normal" font="default" size="100%">Silva-Correa Carmen R</style></author><author><style face="normal" font="default" size="100%">Villarreal-La Torre Víctor E</style></author><author><style face="normal" font="default" size="100%">Sagástegui-Guarniz William Antonio</style></author><author><style face="normal" font="default" size="100%">Gamarra-Sánchez César D</style></author><author><style face="normal" font="default" size="100%">Ricardo M Gomez-Arce</style></author><author><style face="normal" font="default" size="100%">Deivy Y Dionicio-Rosado</style></author><author><style face="normal" font="default" size="100%">Julio A. Castañeda-Carranza</style></author><author><style face="normal" font="default" size="100%">Calderón-Peña Abhel A</style></author><author><style face="normal" font="default" size="100%">Aspajo-Villalaz Cinthya L</style></author><author><style face="normal" font="default" size="100%">Chávez- Flores Juana E</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Wound Healing Activity of an Essential Oil-Based Cream of Origanum vulgare L. on Mice</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Cream</style></keyword><keyword><style  face="normal" font="default" size="100%">Essential oil</style></keyword><keyword><style  face="normal" font="default" size="100%">Origanum vulgare</style></keyword><keyword><style  face="normal" font="default" size="100%">Skin</style></keyword><keyword><style  face="normal" font="default" size="100%">Wound Healing</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2024</style></year><pub-dates><date><style  face="normal" font="default" size="100%">April 2024</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">16</style></volume><pages><style face="normal" font="default" size="100%">292-295</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background and Aim:&lt;/strong&gt; The objective was to evaluate the effect of a cream based on the essential oil of Origanum vulgare on skin lesions induced in Mus musculus Balb/c.&lt;strong&gt; Materials and Methods:&lt;/strong&gt; The experimental animals were divided into four groups of 6 specimens each, in which skin lesions of approximately 1 cm in diameter were induced. Group I (Control) received no treatment, Group II (0.1% Origanum vulgare cream), Group III (0.5% Origanum vulgare cream), and Group IV (1% Origanum vulgare cream) received treatment for eight days. Skin lesions were measured on days 4 and 7. At the end of treatment, they were euthanized using sodium pentobarbital 60 m/kg v.ip. Skin samples were obtained and preserved in 10% formalin for histopathological analysis.&lt;strong&gt; Results: &lt;/strong&gt;When measuring the size of the skin lesions induced in the study groups, it was observed that in the control group, the decrease in the length of the lesions occurred on the fifth day; in group II, III, and IV, the lesions length decrease occurs on the second day. At the end of the experience, the measurements of the lesions were much smaller for the III and IV groups (0.33 and 0.41, respectively) compared to the control group (0.40 cm). On day seven, statistically significant difference was found on skin lesion measure between Group IV and the Control, with a significance level of p&amp;lt;0.05. &lt;strong&gt;Conclusion:&lt;/strong&gt; It is concluded that the 1% Origanum vulgare essential oil-based cream has a healing effect on dermal lesions induced in Mus musculus Balb/c.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">2</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">292</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Laurente-Pachamango Katherine G&lt;sup&gt;1&lt;/sup&gt;, Cruzado-Razco José L&lt;sup&gt;1&lt;/sup&gt;, Silva-Correa Carmen R&lt;sup&gt;1&lt;/sup&gt;, Villarreal-La Torre Víctor E&lt;sup&gt;1,*&lt;/sup&gt;, Sagástegui-Guarniz William Antonio&lt;sup&gt;1&lt;/sup&gt;, Gamarra-Sánchez César D&lt;sup&gt;1&lt;/sup&gt;, Ricardo M Gomez- Arce&lt;sup&gt;3&lt;/sup&gt;, Deivy Y Dionicio-Rosado&lt;sup&gt;3&lt;/sup&gt;, Julio A. Castañeda-Carranza&lt;sup&gt;3&lt;/sup&gt;, Calderón-Peña Abhel A&lt;sup&gt;2&lt;/sup&gt;, Aspajo- Villalaz Cinthya L&lt;sup&gt;2&lt;/sup&gt;, Chávez- Flores Juana E&lt;sup&gt;4&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Departamento de Farmacología, Facultad de Farmacia y Bioquímica, Universidad Nacional de Trujillo, PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Departamento de Química Biológica y Fisiología Animal, Facultad de Ciencias Biológicas, Universidad Nacional de Trujillo, PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Departamento de Estadística, Facultad de Ciencias Físicas y Matemática, Universidad Nacional de Trujillo, PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Facultad de Farmacia y Bioquímica, Universidad Norbert Wiener, PERU.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Madyawati Latief</style></author><author><style face="normal" font="default" size="100%">Muhaimin</style></author><author><style face="normal" font="default" size="100%">Heriyanti</style></author><author><style face="normal" font="default" size="100%">Indra Lasmana Tarigan</style></author><author><style face="normal" font="default" size="100%">Sutrisno</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Determination Antioxidant Activity of Coffea Arabica, Coffea Canephora, Coffea Liberica and Sunscreens Cream Formulation for Sun Protection Factor (SPF)</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Antioxidant</style></keyword><keyword><style  face="normal" font="default" size="100%">Coffee</style></keyword><keyword><style  face="normal" font="default" size="100%">Cream</style></keyword><keyword><style  face="normal" font="default" size="100%">SPF</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2022</style></year><pub-dates><date><style  face="normal" font="default" size="100%">April 2022</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">14</style></volume><pages><style face="normal" font="default" size="100%">335-342</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;Coffee is a highly consumed and popular beverage consumed in many countries. Its ingredients have a powerful antioxidant capacity and have the potential as sunscreen to protect the skin. This study aimed to examine the antioxidant activity of Arabica, robusta and liberica coffee extracts and the SPF activity of the coffee extract cream formulation. Coffee were macerated with three types of solvents with polarity gradients. The fraction of each coffee was analyzed for antioxidant activity using DPPH and formulated into the cream. Furthermore, the cream was analyzed for its SPF activity. The results of this study indicated that the methanol fraction of Robusta and Arabica coffee has the best antioxidant activity with IC50 values of 8.98 (ppm) and 13.13, respectively. Meanwhile, Liberica coffee has the best antioxidant in the ethyl acetate fraction, IC&lt;sub&gt;50&lt;/sub&gt; = 10.90 (ppm). In addition, the best SPF values for Robusta, Liberica and Arabica coffees were found in F3 cream with the category of Very Good Protection; 36.087 ± 0.0005; 35.007 ± 0.0005; 36,867 ± 0.0005 respectively.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">2</style></issue><work-type><style face="normal" font="default" size="100%">Research Article </style></work-type><section><style face="normal" font="default" size="100%">335</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Madyawati Latief&lt;sup&gt;1,2&lt;/sup&gt;, Muhaimin&lt;sup&gt;3&lt;/sup&gt;, Heriyanti&lt;sup&gt;1,2&lt;/sup&gt;, Indra Lasmana Tarigan&lt;sup&gt;1,2&lt;/sup&gt;, Sutrisno&lt;sup&gt;1,2&lt;/sup&gt;,&lt;sup&gt;*&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Chemistry, Faculty of Science and Technology, Universitas Jambi, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;The University Center of Excellence, E2- KOLIM, Universitas Jambi, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Biological Pharmacy, Faculty of Pharmacy, Universitas Padjajaran, Bandung, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Roger Ducos Youmsi Fokouo</style></author><author><style face="normal" font="default" size="100%">Patrick Valere Tsouh Fokou</style></author><author><style face="normal" font="default" size="100%">Cedric Derick Jiatsa Mbouna</style></author><author><style face="normal" font="default" size="100%">Elisabeth Zeuko’o Menkem</style></author><author><style face="normal" font="default" size="100%">Fabrice Fekam Boyom</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Formulation and Evaluation of Safety and Antifungal Efficacy of Syzigium Aromaticum-Base Cream on Guinea Pigs Infected with Trichophyton Mentagrophytes</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Antidermatophytes activity</style></keyword><keyword><style  face="normal" font="default" size="100%">Cream</style></keyword><keyword><style  face="normal" font="default" size="100%">Dermatophytes</style></keyword><keyword><style  face="normal" font="default" size="100%">Formulation</style></keyword><keyword><style  face="normal" font="default" size="100%">S. aromaticum</style></keyword><keyword><style  face="normal" font="default" size="100%">Toxicity</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2020</style></year><pub-dates><date><style  face="normal" font="default" size="100%">March 2020</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">12</style></volume><pages><style face="normal" font="default" size="100%">342-350</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background: &lt;/strong&gt;The increasing incidence of dermatophytoses in the world and the side effects of the current therapies encouraged the search of alternative drugs. Hence the objective of this work was to determine antidermatophytes activity of &lt;em&gt;Syzigium aromaticum&lt;/em&gt; formulate antidermatophytic cream. &lt;strong&gt;Materials and Methods:&lt;/strong&gt; The extracts were prepared by maceration of plant materials into methanol. Three formulations of creams were made, and the best was chosen according to its physicochemical stability and appearance. The acute dermal toxicity and antidermatophytic efficacy of the cream was performed on guinea-pig. &lt;strong&gt;Results: &lt;/strong&gt;The methanolic extract of &lt;em&gt;S. aromaticum &lt;/em&gt;was incorporated in the final cream formulation. The formulation containing shea-butter 58.5%, acetylic alcohol 2.5%, stearic acid 1.5%, bee-wax 10%, borax 1.5%, polysorbate 60 2.5%, 2 drops of lactic acid and water was chosen because of its good appearance and stability. The cream with methanolic extract of&lt;em&gt; S. aromaticum &lt;/em&gt;did not reveal any dermal toxic effect. The cream efficacy was dose-dependent. The treatment with cream at 5% methanolic extracts of &lt;em&gt;S. aromaticum&lt;/em&gt; revealed the best potency after 14 days of treatment. &lt;strong&gt;Conclusion:&lt;/strong&gt; These results show that the cream at 5% methanolic extract of &lt;em&gt;S. aromaticum&lt;/em&gt; seed is promising in the treatment of dermatophytoses and could be used as an alternative in the development of a new therapy.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">2</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">342</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Roger Ducos Youmsi Fokouo&lt;sup&gt;1,2&lt;/sup&gt;, Patrick Valere Tsouh Fokou&lt;sup&gt;1,2,3,&lt;/sup&gt;*, Cedric Derick Jiatsa Mbouna&lt;sup&gt;1&lt;/sup&gt;, Elisabeth Zeuko’o Menkem&lt;sup&gt;1,4&lt;/sup&gt;, Fabrice Fekam Boyom&lt;sup&gt;1,2 &lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Antimicrobial and Biocontrol Agents Unit, Laboratory for Phytobiochemistry and Medicinal Plants Study, Faculty of Science, University of Yaoundé 1, PO Box 812, Yaoundé, CAMEROON.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Drug Discovery and Development Unit, Laboratoire Roger Ducos, PO Box 20133, Yaounde, CAMEROON.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Biochemistry, Faculty of Sciences, University of Bamenda, PO Box 39, Bambili, CAMEROON.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Faculty of Health Sciences, University of Buea, PO Box 63, Buea, CAMEROON.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Anis Yohana Chaerunisaa</style></author><author><style face="normal" font="default" size="100%">Muhaimin Muhaimin</style></author><author><style face="normal" font="default" size="100%">Yasmiwar Susilawati</style></author><author><style face="normal" font="default" size="100%">Tiana Milanda</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Formulation of Creams Containing Active Fraction of Cassia fistula L. Barks and its Antibacterial Activity against Propionibacterium acnes and Pseudomonas aeruginosa</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Antibacteria</style></keyword><keyword><style  face="normal" font="default" size="100%">Cassia fistula</style></keyword><keyword><style  face="normal" font="default" size="100%">Cream</style></keyword><keyword><style  face="normal" font="default" size="100%">Propionibacterium Acnes</style></keyword><keyword><style  face="normal" font="default" size="100%">Pseudomonas aeruginosa</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2020</style></year><pub-dates><date><style  face="normal" font="default" size="100%">June 2020</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">12</style></volume><pages><style face="normal" font="default" size="100%">920-928</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background:&lt;/strong&gt; &lt;em&gt;Cassia fistula &lt;/em&gt;L. has been traditionally used to cure skin diseases. That disease can be caused by various bacteria, such as &lt;em&gt;Propionibacterium acnes &lt;/em&gt;and &lt;em&gt;Pseudomonas aerugniosa.&lt;/em&gt;&lt;strong&gt; Objective:&lt;/strong&gt; the objective of this research was to formulate cream containing active fraction of &lt;em&gt;Cassia fistula &lt;/em&gt;bark and to study the antibacterial activity as well as physical stability of the active substance after formulation. &lt;strong&gt;Materials and Methods:&lt;/strong&gt; The cream base were oilin- water (O/W) and water in oil (W/O) type. Antibacterial activity test had been performed by using agar diffusion method. Determination of Minimum Inhibitory Concentration (MIC) and Minimum Bactericidal Concentration (MBC) were conducted by microdilution method. The active fraction was formulated into creams with concentration of 4 -6x MIC. Physical evaluation of creams including organoleptic, pH, viscosity, TLC (Thin Layer Chromatography) profiling and antibacterial activity against both tested bacteria were evaluated during 28 days of storage. &lt;strong&gt;Results: &lt;/strong&gt;The results showed that ethyl acetate fraction was the most active, having MIC and MBC values of 175 and 350 ppm respectively against &lt;em&gt;P. acnes&lt;/em&gt;, while those against &lt;em&gt;P. aeruginosa&lt;/em&gt; were 400 and 800 ppm. Optimation on creams using different type of cream bases showed that either O/W or W/O creams remained stable during 28 days of storage in terms of organoleptic and pH. The viscosity increased in O/W and decreased in W/O type. Qualitative analysis by TLC profiling showed that the ethyl acetate fraction of &lt;em&gt;Cassia fistula&lt;/em&gt; as chemical compounds in creams was relatively stable as the profile remained the same after 28th day of storage. Result of antibacterial activity test on cream with O/W base was unchange after 28 day, while that with W/O revealed no activity which may due to poor diffusion within the cream base as media. &lt;strong&gt;Conclusion: &lt;/strong&gt;active fraction of &lt;em&gt;Cassia fistula&lt;/em&gt; can be formulated into cream with O/W cream base system.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">4</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">920</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Anis Yohana Chaerunisaa&lt;sup&gt;1,&lt;/sup&gt;*, Muhaimin Muhaimin&lt;sup&gt;2&lt;/sup&gt;, Yasmiwar Susilawati&lt;sup&gt;3&lt;/sup&gt;, Tiana Milanda&lt;sup&gt;3 &lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, Padjadjaran University, Jatinangor, Sumedang 45363, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Chemistry Education, Faculty of Education, University of Jambi, Jambi 36361, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Deparment of Pharmaceutical Biology, Faculty of Pharmacy, Padjadjaran University, Jatinangor, Sumedang 45363, INDONESIA.&lt;/p&gt;
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