<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">I Gde Rurus Suryawan</style></author><author><style face="normal" font="default" size="100%">Andrianto</style></author><author><style face="normal" font="default" size="100%">Ratna Dewi Cahyaningtias</style></author><author><style face="normal" font="default" size="100%">Makhyan Jibril Al-Farabi</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Hypoxic Preconditioning Decrease ROS and Increase SOD Expression in Adipose-Derived Mesenchymal Cell</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Antioxidant</style></keyword><keyword><style  face="normal" font="default" size="100%">Hypoxia</style></keyword><keyword><style  face="normal" font="default" size="100%">Oxidative stress</style></keyword><keyword><style  face="normal" font="default" size="100%">Stem Cells</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2020</style></year><pub-dates><date><style  face="normal" font="default" size="100%">May 2020</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">12</style></volume><pages><style face="normal" font="default" size="100%">430-435</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;Adipose-derived Mesenchymal Stem Cells (AMSCs) have promising ability to differentiate into a cardiomyocyte. However, post-transplantation survival of AMSCs is relatively low due to lethal cellular hypoxia. Hypoxic preconditioning is a sublethal hypoxia condition which may improve AMSCs survival. This research evaluates the effect of hypoxic preconditioning on the expression of reactive oxygen species (ROS) and superoxide dismutase (SOD) of AMSCs. Isolated human AMSCs was cultured to the 4&lt;sup&gt;th&lt;/sup&gt; passage and confirmed with CD45, CD90 and CD105 expression. Cells were divided into control group (normoxia with 21% O&lt;sub&gt;2&lt;/sub&gt;) and hypoxic preconditioning group (with 1% O&lt;sub&gt;2&lt;/sub&gt;). ROS and SOD were evaluated using immunofluorescence and analyzed using SPSS 25. AMSCs was characterized by the CD105 and CD90 without expression of CD44 and CD45. ROS expression is significantly lower in hypoxia group than in controlled group (253,13 ± 67,795 vs 342,13 ± 116,447; p &amp;lt; 0.05) and SOD expression is significantly higher in hypoxia group than in controlled group (340,25 ± 96,476 vs 234,56 ± 38,238; p &amp;lt;0.05). In conclusion, hypoxic preconditioning in human AMSCs induce lower expression of intracellular ROS and higher expression of intracellular SOD.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">430</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p&gt;&lt;strong&gt;I Gde Rurus Suryawan&lt;sup&gt;1,&lt;/sup&gt;*, Andrianto&lt;sup&gt;1&lt;/sup&gt;, Ratna Dewi Cahyaningtias&lt;sup&gt;1&lt;/sup&gt;, Makhyan Jibril Al-Farabi&lt;sup&gt;1,2 &lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Cardiology and Vascular Medicine, Soetomo General Hospital, Airlangga University, Mayjend. Prof. Dr. Moestopo Street No.6-8, Surabaya, INDONESIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;2&lt;/sup&gt;School of Health Management, University College London, Gower St, Bloomsbury, London WC1E 6BT, UK.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Manish Kumar,</style></author><author><style face="normal" font="default" size="100%">Milind Parle</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Pharmacological Evaluation of Cucumber for Cognition Enhancing Effect on Brain of Mice</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Acetylcholinesterase</style></keyword><keyword><style  face="normal" font="default" size="100%">Cholesterol</style></keyword><keyword><style  face="normal" font="default" size="100%">Dementia</style></keyword><keyword><style  face="normal" font="default" size="100%">Glucose</style></keyword><keyword><style  face="normal" font="default" size="100%">Hypoxia</style></keyword><keyword><style  face="normal" font="default" size="100%">object recognition task</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2014</style></year><pub-dates><date><style  face="normal" font="default" size="100%">8th April 2014</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">6</style></volume><pages><style face="normal" font="default" size="100%">100-107</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Introduction:&lt;/strong&gt; Cucumber is fruit of &lt;em&gt;Cucumis sativus&lt;/em&gt; var. &lt;em&gt;sativus&lt;/em&gt; L. which has been used traditionally in gastrointestinal problems, skin problems and as coolant in salad for body and brain. Cucumber is a great folk medicine used to reduce heat and inflammation. Cognitive effects of cucumber are assessed in this study.&lt;strong&gt; Methods:&lt;/strong&gt; Fresh fruits of &lt;em&gt;Cucumis sativus&lt;/em&gt; L. were ground and a paste was prepared which consisted of different concentrations of cucumber (10, 20, 30 % w/w). The three doses were given ad &lt;em&gt;libitum&lt;/em&gt; to mice for 15 successive days. Animal models utilized were sodium nitrite induced hypoxia and object recognition task. Biochemical analysis employed estimation of acetylcholinesterase activity in brain, serum glucose levels, cholesterol levels, brain lipid peroxidation (MDA) levels and reduced glutathione levels in brain of mice.&lt;strong&gt; Results:&lt;/strong&gt; 6g/kg and 9g/kg doses of cucumber significantly (&lt;em&gt;P&lt;/em&gt;&amp;lt; 0.05, &lt;em&gt;P&lt;/em&gt;&amp;lt; 0.01) increased frequency of entry, number of entry and duration of entry in small compartment in sodium nitrite induced hypoxia model and depicted significantly (&lt;em&gt;P&lt;/em&gt;&amp;lt; 0.05, &lt;em&gt;P&lt;/em&gt;&amp;lt; 0.001) enhanced exploratory activity in object recognition task model. Further, biochemical analysis indicated good potential of cucumber in cognition enhancement. 9 g/kg dose (&lt;em&gt;P&lt;/em&gt;&amp;lt; 0.001) reduced brain &lt;strong&gt;AchE&lt;/strong&gt; activity along with blood glucose and serum cholesterol levels. 6 g/kg dose (&lt;em&gt;P&lt;/em&gt;&amp;lt; 0.01) replenished brain GSH levels and reduced lipid peroxides. &lt;strong&gt;Conclusion:&lt;/strong&gt; Cucumber increased cognition in rodents.&lt;/p&gt;&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Key words: &lt;/strong&gt;Hypoxia, object recognition task, acetylcholinesterase, glucose, cholesterol, dementia.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Manish Kumar&lt;sup&gt;a,&lt;/sup&gt;&lt;sup&gt;*&lt;/sup&gt; and Milind Parle&lt;/strong&gt;&lt;sup&gt;&lt;strong&gt;b &lt;/strong&gt;&lt;/sup&gt;&lt;/p&gt;&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;a&lt;/sup&gt;Keshav College of Pharmacy, Salwan, Karnal 132046, India&lt;sup&gt;&lt;/sup&gt;&lt;/p&gt;&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;b&lt;/sup&gt;Department of Pharmaceutical Sciences, Guru Jambheshwar University of Science and Technology, Hisar, Haryana 125001, India.&lt;/p&gt;</style></auth-address></record></records></xml>