<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Aniruddha Kulkarni</style></author><author><style face="normal" font="default" size="100%">Manoj Tare</style></author><author><style face="normal" font="default" size="100%">Meera Singh</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Mucuna Pruriens Seeds Extract Loaded Phytosomal Intranasal Gel for the Effective Treatment of Parkinson’s Disease</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Gel</style></keyword><keyword><style  face="normal" font="default" size="100%">L-Dopa extract</style></keyword><keyword><style  face="normal" font="default" size="100%">Mucuna pruriens</style></keyword><keyword><style  face="normal" font="default" size="100%">Nasal gel</style></keyword><keyword><style  face="normal" font="default" size="100%">Optimization</style></keyword><keyword><style  face="normal" font="default" size="100%">Phytosome</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2025</style></year><pub-dates><date><style  face="normal" font="default" size="100%">April 2025</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">17</style></volume><pages><style face="normal" font="default" size="100%">129-154</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;One phytoconstituent derived from Mucuna pruriens (legumes) is levodopa. This medication's oral usage is limited by its high first-pass metabolism and low absorption. The goal of the present research was to develop a phytosomal gel filled with levodopa extract for better delivery and brain targeting. Various techniques, including solvent evaporation, salting out anti-solvent precipitation, direct egg yolk, and egg lipids methods, were used to create phytosomal formulations. Scanning electron microscopy, particle size, x-ray diffraction, and other techniques were used to characterize phytosomes. And added into gel formation, the more successful batch was examined for several parameters. The final batch underwent a variety of animal tests, including pharmacokinetic analysis, irritation to the nasal cavity testing. The most effective phytosomes were those made via the antisolvent precipitation approach. In this investigation, a 3&lt;sup&gt;2&lt;/sup&gt;-randomized complete factorial design was employed. Batch F4 had an entrapment efficiency of 70%, a particle size of 15 (μg) and 60% CDR. The gel-formulated batch F4G3 demonstrated improved results in terms of extrudability (90.82), amount of drug (89.32%), viscosity (5421 cps at 100 rpm), and spreadability (25.18). Batch F4G3 of the Mucuna pruriens phytosome gel exhibited Higuchi's kinetics. According to the findings of the animal study, dopamine levels were significantly elevated. The pharmacokinetic and nasal irritation studies showed notable in vitro penetration of the nasal mucosa without resulting in skin irritation. For improving Parkinson's disease treatment, the phytosomal gel formulation delivered via the nasal route would be the ideal option.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">2</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">129</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p&gt;&lt;strong&gt;Aniruddha Kulkarni&lt;sup&gt;1*&lt;/sup&gt;, Manoj Tare&lt;sup&gt;2&lt;/sup&gt;, Meera Singh&lt;sup&gt;3&lt;/sup&gt; &lt;/strong&gt;&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Pharmaceutics Sinhgad Institute of Pharmaceutical Sciences, Lonavala, Pune, 410401 INDIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Pharmaceutics, Sitabai Thite College of Pharmacy (B. Pharm), Shirur, Pune Maharashtra, INDIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Pharmaceutics, Sinhgad College of Pharmacy, Vadgaon (Bk), Pune, M.S. INDIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Afriwardi</style></author><author><style face="normal" font="default" size="100%">Rahmatul Nazmi</style></author><author><style face="normal" font="default" size="100%">Dwisari Dillasamola</style></author><author><style face="normal" font="default" size="100%">Elsa Badriyya</style></author><author><style face="normal" font="default" size="100%">Yufri Aldi</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Anti-inflammatory Activity of Pegagan Embun (Hydrocotyle sibthorpioides Lam.) Plant Extract on Topical Application</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Anti-inflammatory</style></keyword><keyword><style  face="normal" font="default" size="100%">Exudate</style></keyword><keyword><style  face="normal" font="default" size="100%">Gel</style></keyword><keyword><style  face="normal" font="default" size="100%">Hydrocotyle sibthorpioides Lam.</style></keyword><keyword><style  face="normal" font="default" size="100%">Ketoprofen</style></keyword><keyword><style  face="normal" font="default" size="100%">Leukocytes</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2021</style></year><pub-dates><date><style  face="normal" font="default" size="100%">March 2021</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">13</style></volume><pages><style face="normal" font="default" size="100%">411-417</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction:&lt;/strong&gt; Pegagan embun (&lt;em&gt;Hydrocotyle sibthorpioides&lt;/em&gt; Lam.) is traditionally known to have many benefits, including anti-inflammatory.&lt;strong&gt; Aims:&lt;/strong&gt; This study aimed to determine the activity of ethanol extract of Pegagan Embun as an anti-inflammatory using the granuloma pouch method. &lt;strong&gt;Methods:&lt;/strong&gt; This experiment used 25 male white mice and were divided into five groups, namely, the positive control group, &lt;em&gt;Hydrocotyle sibthorpioides &lt;/em&gt;Lam. extract group with concentration 0.5%; 1%; 2%, and the comparison group that given Kaltrofen® gel containing 2.5% ketoprofen. Experimental animals were given carrageenan 2% to induced the inflammation subcutaneously. The dosage form was given as much as 0.2 g topically for four days once a day. &lt;strong&gt;Results:&lt;/strong&gt; Based on the results of one-way ANOVA analysis and Duncan's test, there were significant differences in exudate volume and total leukocytes (p&amp;lt;0.05) in the positive control group, extract with concentration 0.5%, 1%, 2%, and the comparator. While the percentage of leukocyte cells showed that they were not significantly different (p&amp;gt;0.05), the number of neutrophil cells decreased. &lt;strong&gt;Conclusion:&lt;/strong&gt; From the overall data obtained, it can be concluded that the extract of &lt;em&gt;Hydrocotyle sibthorpioides&lt;/em&gt; Lam. at concentration 0.5 %; 1%; 2%, has an anti-inflammatory effect.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">2</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">411</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Afriwardi&lt;sup&gt;1,&lt;/sup&gt;*, Rahmatul Nazmi&lt;sup&gt;2&lt;/sup&gt;, Dwisari Dillasamola&lt;sup&gt;2&lt;/sup&gt;, Elsa Badriyya&lt;sup&gt;2&lt;/sup&gt;, Yufri Aldi&lt;sup&gt;2&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Faculty of Medicine, Andalas University, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Faculty of Pharmacy, Andalas University, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Arif Budiman</style></author><author><style face="normal" font="default" size="100%">Diah Lia Aulifa</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">A Study Comparing Antibacterial Activity of Ageratum Conyzoides L. Extract and Piper Betle L. Extract in Gel Dosage Forms Against Staphylococcus Aureus</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Ageratum conyzoides L. extract</style></keyword><keyword><style  face="normal" font="default" size="100%">Gel</style></keyword><keyword><style  face="normal" font="default" size="100%">Piper betle L. extract</style></keyword><keyword><style  face="normal" font="default" size="100%">Staphylococcus aureus</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2020</style></year><pub-dates><date><style  face="normal" font="default" size="100%">May 2020</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">12</style></volume><pages><style face="normal" font="default" size="100%">473-477</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background:&lt;/strong&gt; Microorganisms such as bacteria and viruses often infect humans in their living environments. &lt;em&gt;Staphylococcus aureus&lt;/em&gt; (SA) are gram-positive bacteria that are widely used in antibacterial activity experiments and cause infection in the body surface of mammals. &lt;em&gt;Ageratum conyzoides &lt;/em&gt;L. (AC) and Piper betle L. (PB)are the natural herbs which have antibacterial activity against SA. &lt;strong&gt;Objective: &lt;/strong&gt;This research was aimed to compare the antibacterial activity of AC with PB extracts in gel dosage form against SA. &lt;strong&gt;Methods:&lt;/strong&gt; The antibacterial activity of both extracts were determined by disc diffusion method and minimum inhibitory concentration (MIC) were evaluated by the microdilution method. These extracts were formulated into gel dosage form using sodium carboxymethyl cellulose (CMC) with various concentrations and then evaluated for pH, viscosity and antibacterial activity. &lt;strong&gt;Results: &lt;/strong&gt;The results show that both AC and PB extracts have antibacterial activity against SA with MIC value of 2 % and 5 %, respectively. Then, the gel containing 4 % sodium CMC showed the best physical stability, either containing AC or PB extract. The gel dosage forms of both extracts did not show any difference in organoleptic properties, pH and viscosity after 28 days storage. The gel dosage forms of AC and PB extracts have antibacterial activity with inhibition zone of 20.3 mm ± 1.3 mm and 15.21 ± 1.3 mm, respectively. &lt;strong&gt;Conclusion:&lt;/strong&gt; ,The antibacterial activity of AC extract was higher compared to that of PB extract in the gel dosage form.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">473</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Arif Budiman&lt;sup&gt;1,&lt;/sup&gt;*, Diah Lia Aulifa&lt;sup&gt;2 &lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, Universitas Padjadjaran, Jl. Raya Bandung-Sumedang Km. 21. INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Pharmaceutical Biology, Indonesian School of Pharmacy, Jl. Soekarno Hatta no.354, Bandung, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Elsa Badriyya</style></author><author><style face="normal" font="default" size="100%">Salman</style></author><author><style face="normal" font="default" size="100%">Amalia Refina Pratiwi</style></author><author><style face="normal" font="default" size="100%">Dwisari Dillasamola</style></author><author><style face="normal" font="default" size="100%">Yufri Aldi</style></author><author><style face="normal" font="default" size="100%">Elidahanum Husni</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Topical Anti-Inflammatory Activity of Bromelain</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Anti-inflammatory</style></keyword><keyword><style  face="normal" font="default" size="100%">Bromelain</style></keyword><keyword><style  face="normal" font="default" size="100%">Exudate</style></keyword><keyword><style  face="normal" font="default" size="100%">Gel</style></keyword><keyword><style  face="normal" font="default" size="100%">Granuloma</style></keyword><keyword><style  face="normal" font="default" size="100%">Leukocyte</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2020</style></year><pub-dates><date><style  face="normal" font="default" size="100%">November 2020</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">12</style></volume><pages><style face="normal" font="default" size="100%">1586-1593</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction:&lt;/strong&gt; Bromelain is a proteolytic enzyme found in pineapple plants. &lt;strong&gt;Aim:&lt;/strong&gt; This study conducted to determine the activity of bromelain enzyme as an anti-inflammatory using the Granuloma Pouch method. &lt;strong&gt;Methods: &lt;/strong&gt;The experimental animals were divided into five groups, namely the positive control group, the bromelain concentration group of 0.1%; 0.5%; 1%, and the comparison group. Experimental animals induced carrageenan 2% subcutaneously. The dosage form is given topically for 2, 4, and 6 days. The observation was made by measuring the volume of edema, the total number, and the percentage of leukocyte cells on days 2, 4, and 6. &lt;strong&gt;Results:&lt;/strong&gt; The observation results of a positive control group, bromelain concentration 0.1%, 0.5%, 1%, and the comparators, there was a significant decrease for the volume of exudate on days 2, 4, and 6 (p&amp;lt;0.05). The average total number of leukocytes also decreased significantly (p&amp;lt;0.05) in the positive control, the bromelain, and comparison group in day 2, 4, and 6. At the same time, the mean leucocyte percentage had no effect (p&amp;gt;0.05). &lt;strong&gt;Conclusion: &lt;/strong&gt;From the results of the study, it was concluded that the bromelain enzyme at concentration 0.1%, 0.5%, and 1% have an anti-inflammatory effect by suppressing the volume of exudate, and the total number of leucocyte.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6s</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">1586</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Elsa Badriyya, Salman, Amalia Refina Pratiwi, Dwisari Dillasamola, Yufri Aldi, Elidahanum Husni* &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;Faculty of Pharmacy, University Andalas, INDONESIA.&lt;/p&gt;
</style></auth-address></record></records></xml>