<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Afaf E Abdel Ghani</style></author><author><style face="normal" font="default" size="100%">Sayed AA El-Toumy</style></author><author><style face="normal" font="default" size="100%">Wagdi IA El-Dougdoug</style></author><author><style face="normal" font="default" size="100%">Ahmed M Mansour</style></author><author><style face="normal" font="default" size="100%">Wafaa HB Hassan</style></author><author><style face="normal" font="default" size="100%">Hanaa M Hassan</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Chemical Profile and Hepatoprotective Activity of Ethyl Acetate Extracts of Euphorbia paralias and Euphorbia geniculata (Euphorbiaceae) from Egypt</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Euphorbia</style></keyword><keyword><style  face="normal" font="default" size="100%">Hepatoprotective</style></keyword><keyword><style  face="normal" font="default" size="100%">Polyphenolics</style></keyword><keyword><style  face="normal" font="default" size="100%">UPLC-ESI-MS/MS</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2020</style></year><pub-dates><date><style  face="normal" font="default" size="100%">June 2020</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">12</style></volume><pages><style face="normal" font="default" size="100%">762-770</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background:&lt;/strong&gt; Plants belonging to the genus Euphorbia were used traditionally to treat several health disorders and diseases. &lt;strong&gt;Objective:&lt;/strong&gt; the aim of this study is evaluation of secondary metabolites and hepatoprotective activity of the ethyl acetate fractions of the aerial parts of &lt;em&gt;Euphorbia paralias &lt;/em&gt;(&lt;em&gt;Ep&lt;/em&gt;) and &lt;em&gt;Euphorbia geniculata&lt;/em&gt; (&lt;em&gt;Eg&lt;/em&gt;). &lt;strong&gt;Materials and Methods: &lt;/strong&gt;UPLC-ESI-MS/ MS technique was used for identification of the secondary metabolites. The hepatoprotective potential of the two plants was evaluated for the first time in male rats with thioacetamide induced liver injury. &lt;strong&gt;Results: &lt;/strong&gt;A total of 32 secondary metabolites were identified in the ethyl acetate fractions of the aerial parts of both species. Ellagitannins such as tetragalloyl hexoside, ellagic acid, gallic acid, and flavonoids such as kaempferol-3-O-β-(6''-galloyl-Oglucopyranoside), quercetin glycosides (glucoside and arabinoside) were found to be the major components in &lt;em&gt;Ep &lt;/em&gt;whereas flavonoid glycosides including quercetin rutinoside, quercetin glycosides (glucoside, arabinoside and rhamnoside) and kaempeferol glycoside derivatives were highly abundant in &lt;em&gt;Eg. &lt;/em&gt;Administration of thioacetamide resulted in marked elevation in liver enzymes, elevation of lipid profile and alteration in oxidative stress parameters. While pretreatment of rats with &lt;em&gt;Ep&lt;/em&gt; and&lt;em&gt; Eg&lt;/em&gt; ethyl acetate fractions significantly attenuated the hepatic toxicity through reduction of liver biomarkers, improving the redox status of the tissue and so brought down the serum biochemical parameters and lipid profile nearly toward the normal levels. &lt;strong&gt;Conclusion: &lt;/strong&gt;The studied fractions show hepatoprotective potential with promising value as hepatoprotective drugs of natural origin in comparison with silymarin as the standard hepatoprotective drug.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">4</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">762</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Afaf E. Abdel Ghani&lt;sup&gt;1&lt;/sup&gt;, Sayed A. A. El-Toumy&lt;sup&gt;1&lt;/sup&gt;, Wagdi I. A. El-Dougdoug&lt;sup&gt;2&lt;/sup&gt;, Ahmed M. Mansour&lt;sup&gt;2&lt;/sup&gt;, Wafaa H. B. Hassan&lt;sup&gt;2&lt;/sup&gt;, Hanaa M. Hassan&lt;sup&gt;3,&lt;/sup&gt;* &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Pharmacognosy, Faculty of Pharmacy, Zagazig University, 44519 Zagazig, Egypt.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Chemistry of Tannins, National Research Center, El-Dokki- Cairo, 12622 Egypt.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Organic Chemistry, Faculty of Science, Benha University, 13518 Benha, Egypt.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Department of Pharmacology and Toxicology Faculty of Pharmacy, El-Alazhar University Cairo Egypt.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Department of Pharmacognosy Faculty of Pharmacy, Zagazig University,, Zagazig, Egypt.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;6&lt;/sup&gt;Pharmacy department Banha Educational Hospital, 13518 Banha, Banha, Egypt.&lt;/p&gt;
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