<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Rini Prastiwi</style></author><author><style face="normal" font="default" size="100%">Ema Dewanti</style></author><author><style face="normal" font="default" size="100%">Inka Nurul Fadliani</style></author><author><style face="normal" font="default" size="100%">Nessa Aqilla</style></author><author><style face="normal" font="default" size="100%">Salwaa Salsabila</style></author><author><style face="normal" font="default" size="100%">Vera Ladeska</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">The Nephroprotective And Antioxidant Activity of Sterculia rubiginosa Zoll. Ex Miq. Leaves</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Antioxidant</style></keyword><keyword><style  face="normal" font="default" size="100%">Gentamicin</style></keyword><keyword><style  face="normal" font="default" size="100%">Nephroprotective</style></keyword><keyword><style  face="normal" font="default" size="100%">Sterculia rubiginosa Zoll Ex. Miq.</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2020</style></year><pub-dates><date><style  face="normal" font="default" size="100%">June 2020</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">12</style></volume><pages><style face="normal" font="default" size="100%">843-849</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background: &lt;/strong&gt;&lt;em&gt;Sterculia&lt;/em&gt; has an antioxidant activity. The &lt;em&gt;Sterculia &lt;/em&gt;genus has phenols and flavonoids content, and this chemical content may be have an nephroprotective activity. &lt;strong&gt;Objective: &lt;/strong&gt;The study was to investigate the &lt;em&gt;in vitro &lt;/em&gt;study of antioxidant activity with DPPH and FRAP study and nephroprotective activity of &lt;em&gt;Sterculia rubiginosa &lt;/em&gt;Zoll. Ex Miq. Leaves extract. &lt;strong&gt;Materials and Methods: &lt;/strong&gt;The leaves was extracted using ethanol. This extract was determined for antioxidant activity by &lt;em&gt;in vitro &lt;/em&gt;study with DPPH and FRAP methods, determined the content of total phenols, total flavonoids, and also identification of chemical content. Nephrotoxicity study done by induced gentamycin. The groups divided 6 group, consist: negative control, positive control, normal control, and the extract with dose 50 mg/kg, 100 mg/kg, and 200 mg/ kg. The parameter for nephroprotective activity was tubular necrosis, the presence of tubules casts and glomerular damage, creatinine serum, and urea. &lt;strong&gt;Results:&lt;/strong&gt; The ethanol extract has IC&lt;sub&gt;50 &lt;/sub&gt;162.34 μg/ml for DPPH scavenging activity and 18.65 ± 3.53 FeEAC (Mol/g) for FRAP. The secondary metabolite presence flavonoids, tannins, terpenes, alkaloids, and glycosides. The total phenols 462.36 ± 9.23 mg GAE/gr, total flavonoids content 59.44 ± 0.11 mg QE/gr extract. All the dose have an nephroprotective activity, but the best dose was 50 mg/kg. &lt;strong&gt;Conclusion: &lt;/strong&gt;The ethanol extract of &lt;em&gt;Sterculia rubiginosa&lt;/em&gt; showed antioxidant activity and nephroprotective activity.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">4</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">843</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Rini Prastiwi&lt;sup&gt;1,&lt;/sup&gt;*, Ema Dewanti&lt;sup&gt;1&lt;/sup&gt;, Inka Nurul Fadliani&lt;sup&gt;2&lt;/sup&gt;, Nessa Aqilla&lt;sup&gt;2&lt;/sup&gt;, Salwaa Salsabila&lt;sup&gt;2&lt;/sup&gt;, Vera Ladeska&lt;sup&gt;1&lt;/sup&gt; &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Pharmacognosy and Phytochemistry, Faculty of Pharmacy Universitas Muhammadiyah prof. Dr. HAMKA, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Pharmacology, Faculty of Pharmacy Universitas Muhammadiyah prof. Dr. HAMKA, INDONESIA.&lt;/p&gt;
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