<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Selvaraj Jayaraman</style></author><author><style face="normal" font="default" size="100%">Ponnulakshmi Rajagopal</style></author><author><style face="normal" font="default" size="100%">Vishnupriya Veeraraghavan</style></author><author><style face="normal" font="default" size="100%">Poonguzhali Sivagnanam</style></author><author><style face="normal" font="default" size="100%">Divya Ravikumar</style></author><author><style face="normal" font="default" size="100%">Sumetha Suga Deiva Suga</style></author><author><style face="normal" font="default" size="100%">Kavin Mozhi James</style></author><author><style face="normal" font="default" size="100%">Surapaneni Krishna Mohan</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Black Horehound (Ballota nigra Linn) Induces Apoptosis in Prostate Cancer Cells (PC-3) Through Intrinsic Signalling Cascade</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Apoptosis</style></keyword><keyword><style  face="normal" font="default" size="100%">Ballota nigra</style></keyword><keyword><style  face="normal" font="default" size="100%">Intrinsic pathway</style></keyword><keyword><style  face="normal" font="default" size="100%">PC3</style></keyword><keyword><style  face="normal" font="default" size="100%">Prostate cancer</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2020</style></year><pub-dates><date><style  face="normal" font="default" size="100%">September 2020</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">12</style></volume><pages><style face="normal" font="default" size="100%">1377-1382</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background: &lt;/strong&gt;Prostate cancer is the most commonly diagnosed cancer among men. The disease varies widely in its clinical aggressiveness.&lt;em&gt; Ballota nigra &lt;/em&gt;Linn (Black horehound) is a three-foot, perennial herb of the family Lamiaceae and it has been shown to have various pharmacological properties such as antioxidant, hypoglycemic, neuro-sedative, antibacterial, insecticidal and anticholinesterase activities. However, the elucidation of &lt;em&gt;B.nigra&lt;/em&gt; for its anticancer activity in prostate cancer has not been studied so far. &lt;strong&gt;Methodology: &lt;/strong&gt;Prostate cancer PC3 cells were treated with different concentrations of &lt;em&gt;B.nigra&lt;/em&gt; (50, 100, 200 &amp;amp; 400μg/ml) for the analysis of Bcl-2, Phosphorylation of Bcl2 (p-Bcl2) and tumor suppressor protein p53, Case pase-3 and caspase-9 in PC3 cells. &lt;strong&gt;Results:&lt;/strong&gt; The &lt;em&gt;B.nigra&lt;/em&gt; ethanolic leaf extract reduced the levels of anti apoptotic proteins (Bcl-2, p-Bcl2) and increased the level of tumor suppressor protein p53, caspase-3 and 9 significantly (p&amp;lt;0.05). &lt;strong&gt;Conclusion:&lt;/strong&gt; Results of the study show that &lt;em&gt;B.nigra&lt;/em&gt; has potential anticancer activity by modulating intrinsic activity of apoptotic signaling in PC-3 cells. Thus, &lt;em&gt;B.nigra &lt;/em&gt;may have a potential therapeutic option for the treatment of prostate cancer.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">1377</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Selvaraj Jayaraman&lt;sup&gt;1,&lt;/sup&gt;*, Ponnulakshmi Rajagopal&lt;sup&gt;2&lt;/sup&gt;, Vishnupriya Veeraraghavan&lt;sup&gt;1&lt;/sup&gt;, Poonguzhali Sivagnanam&lt;sup&gt;3&lt;/sup&gt;, Divya Ravikumar&lt;sup&gt;4&lt;/sup&gt;, Sumetha Suga Deiva Suga&lt;sup&gt;5&lt;/sup&gt;, Kavin Mozhi James&lt;sup&gt;3&lt;/sup&gt;, Surapaneni Krishna Mohan&lt;sup&gt;6&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Biochemistry, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai - 600 077, INDIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Central Research Laboratory, Meenakshi Academy of Higher Education and Research (Deemed to be University), West K. K. Nagar, Chennai-600 078, INDIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Medical Surgical Nursing, Panimalar College of Nursing, Varadharajapuram, Poonamallee, Chennai - 600 123, INDIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Department of Obstetrics and Gynaecology, Panimalar Medical College Hospital &amp;amp; Research Institute, Varadharajapuram, Poonamallee, Chennai - 600 123, INDIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Department of Microbiology, Panimalar Medical College Hospital &amp;amp; Research Institute, Varadharajapuram, Poonamallee, Chennai - 600 123, INDIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;6&lt;/sup&gt;Department of Biochemistry, Panimalar Medical College Hospital &amp;amp; Research Institute, Varadharajapuram, Poonamallee, Chennai - 600 123, INDIA.&lt;/p&gt;
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