<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Nisa Naspiah</style></author><author><style face="normal" font="default" size="100%">Mohammad Rizki Fadhil Pratama</style></author><author><style face="normal" font="default" size="100%">Sukardiman</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Xanthine Oxidase Inhibition Activity and ADMET Properties of Terap (Artocarpus odoratissimus Blanco) Leaves Metabolites: Phytochemical Screening and in silico Studies</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Artocarpus odoratissimus</style></keyword><keyword><style  face="normal" font="default" size="100%">Molecular docking</style></keyword><keyword><style  face="normal" font="default" size="100%">Xanthin Oxidase</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2021</style></year><pub-dates><date><style  face="normal" font="default" size="100%">September 2021</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">13</style></volume><pages><style face="normal" font="default" size="100%">1150-1160</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;Indonesia, with its biodiversity, is overgrown by various kinds of plants that have medicinal potential, including Terap (&lt;em&gt;Artocarpus odoratissimus&lt;/em&gt; Blanco). The leaves of &lt;em&gt;A. odoratissimus &lt;/em&gt;are empirically used by local people of Borneo Island to treat gout. The purpose of this study was to determine the antigout activity of the active compound from&lt;em&gt; A. odoratissimus&lt;/em&gt; leaves through xanthine oxidase inhibition using the molecular docking method and to determine the ADMET properties of these compounds. Phytochemical screening showed that &lt;em&gt;A. odoratissimus&lt;/em&gt; leaf extract contained alkaloids, flavonoids, steroids/triterpenoids, and phenolics. The results of TLC showed that &lt;em&gt;A. odoratissimus &lt;/em&gt;leaf extract contained steroid and flavonoid compounds in the form of stigmasterol and rutin. The results of molecular docking showed that flavan-3-ol provided the lowest bond-free energy against xanthine oxidase with a ΔG value of -8.3 kcal/mol, lower than allopurinol and hypoxanthine as reference ligands. Flavan-3-ol interacts with xanthine oxidase through hydrogen bonding with amino acid residues in the form of Arginine 912 and Lysine 1045. The prediction of ADMET properties from flavan-3-ol shows that the compound can be absorbed and has good permeability. Overall, the flavan-3-ol found in&lt;em&gt; A. odoratissimus&lt;/em&gt; leaves shows the potential to be developed as a xanthine oxidase inhibitor for use in gout therapy.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">1150</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Nisa Naspiah&lt;sup&gt;1&lt;/sup&gt;, Mohammad Rizki Fadhil Pratama&lt;sup&gt;1&lt;/sup&gt;, Sukardiman&lt;sup&gt;2,&lt;/sup&gt;*&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Doctoral Program of Pharmaceutical Science, Faculty of Pharmacy, Universitas Airlangga, Jl Dr Ir H Soekarno Mulyorejo, Surabaya, East Java, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Pharmacognosy and Phytochemical, Faculty of Pharmacy, Universitas Airlangga, Jl Dr Ir H Soekarno Mulyorejo, Surabaya, East Java, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Nurlina Ibrahim</style></author><author><style face="normal" font="default" size="100%">Siti Nuryanti</style></author><author><style face="normal" font="default" size="100%">Asriani Hasanuddin</style></author><author><style face="normal" font="default" size="100%">Muhammad Sulaiman Zubair</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Phytochemical Analysis and Antihyperuricemic Activity of Ethanolic Extract of Moringa oleifera Seeds</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Antihyperuricemic</style></keyword><keyword><style  face="normal" font="default" size="100%">Moringa oleifera</style></keyword><keyword><style  face="normal" font="default" size="100%">Quercetin</style></keyword><keyword><style  face="normal" font="default" size="100%">Total flavonoids</style></keyword><keyword><style  face="normal" font="default" size="100%">Xanthin Oxidase</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2020</style></year><pub-dates><date><style  face="normal" font="default" size="100%">November 2020</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">12</style></volume><pages><style face="normal" font="default" size="100%">1698-1704</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background: &lt;/strong&gt;&lt;em&gt;Moringa oleifera &lt;/em&gt;is a popular plant that has been known to have several importance biological activities.&lt;strong&gt; Objectives: &lt;/strong&gt;To perform phytochemical analysis, to in vivo evaluate the antihyperuricemic activity and to measure the inhibition of ethanolic extract of &lt;em&gt;Moringa oleifera&lt;/em&gt; seed on xanthine oxidase enzyme.&lt;strong&gt; Materials and Methods:&lt;/strong&gt; The seed were collected from Sigi regency, Central Sulawesi, Indonesia. Extraction was performed by maceration method with ethanol 96% as a solvent. Thin layer chromatography (TLC), high performance liquid chromatography (HPLC) and spectrophotometric UV-Vis were used to determine the phytochemical contents. The antihyperuricemic activity was evaluated by using in vivo model of rat induced by potassium oxonate. The xanthin oxidase inhibitory activity was also determined by spectroscopic method by measuring the catalytic rate of xanthin oxidase enzyme. &lt;strong&gt;Results:&lt;/strong&gt; Phytochemical analysis confirmed the presence of alkaloids, terpenoids, flavonoids, phenolics, saponin and tannin. Quantitative determination of total flavonoids and quercetin concentration found the values of 82.17 ± 0.684 mg QE/g and 0.5131 ± 0.0022 mg/g dried extract, respectively. Ethanolic extract of &lt;em&gt;Moringa oleifera&lt;/em&gt; seed have potential antihyperuricemic activity in which it can significantly reduce the serum uric acid level on potassium oxonate-induced hyperuricemic rat model with the effective dose of 125 mg/ kg BW. Xanthin oxidase inhibitory activity showed the moderate activity with IC&lt;sub&gt;50 &lt;/sub&gt;of 88.39 μg/ml. &lt;strong&gt;Conclusion:&lt;/strong&gt; This study confirmed the potential of&lt;em&gt; Moringa oleifera&lt;/em&gt; seed ethanolic extract, growing in Sigi, Central Sulawesi to be developed as herbal medicinal source for antihyperuricemic drug.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6s</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">1698</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Nurlina Ibrahim&lt;sup&gt;1&lt;/sup&gt;, Siti Nuryanti&lt;sup&gt;2&lt;/sup&gt;, Asriani Hasanuddin&lt;sup&gt;3&lt;/sup&gt;, Muhammad Sulaiman Zubair&lt;sup&gt;1,&lt;/sup&gt;* &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Pharmacy, Faculty of Sciences, Tadulako University, Kampus Bumi Tadulako, 94118, Palu, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Chemistry, Faculty of Teacher Training and Education, Tadulako University, Kampus Bumi Tadulako, 94118, Palu, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Animal Husbandry, Faculty of Animal Husbandry and Fisheries, Tadulako University, Kampus Bumi Tadulako, 94118, Palu, INDONESIA.&lt;/p&gt;
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