<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Afriwardi</style></author><author><style face="normal" font="default" size="100%">Rahmad Abdillah</style></author><author><style face="normal" font="default" size="100%">Elidahanum Husni</style></author><author><style face="normal" font="default" size="100%">Hafifah Hardini</style></author><author><style face="normal" font="default" size="100%">Khalila Tri Syahbani Zuler</style></author><author><style face="normal" font="default" size="100%">Aditya Alqamal Alianta</style></author><author><style face="normal" font="default" size="100%">Yufri Aldi</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Subacute Toxicity Test of Hydrocotyle Sibthorpioides Lam. Extract on Histopathological Images of Liver and Kidney of White Male Mice</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Histopathology</style></keyword><keyword><style  face="normal" font="default" size="100%">Hydrocotyle sibthorpioides Lam.</style></keyword><keyword><style  face="normal" font="default" size="100%">Kidney</style></keyword><keyword><style  face="normal" font="default" size="100%">LD50</style></keyword><keyword><style  face="normal" font="default" size="100%">Liver</style></keyword><keyword><style  face="normal" font="default" size="100%">Subacute.</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2022</style></year><pub-dates><date><style  face="normal" font="default" size="100%">October 2022</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">14</style></volume><pages><style face="normal" font="default" size="100%">619-626</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction:&lt;/strong&gt;&lt;em&gt; Hydrocotyle sibthorpioides&lt;/em&gt; Lam. in Indonesia known as pegagan embun. It has been used to increase the immune system and has been shown to have immunostimulating, anti-inflammatory and hematopoietic effects. However, there is no scientific evidence that shows this plant is safe for long-term use. Based on that circumstance, this study aimed to measure the safety of Pegagan Embun (&lt;em&gt;Hydrocotyle sibthorpioides&lt;/em&gt; Lam.) ethanol extract activities on liver and kidney histopathology. &lt;strong&gt;Aim:&lt;/strong&gt; The study aimed to measure the safety of Pegagan Embun (&lt;em&gt;Hydrocotyle sibthorpioides &lt;/em&gt;Lam.) ethanol extract activities on liver and kidney histopathology. &lt;strong&gt;Material and Method&lt;/strong&gt;: Ethanol extract used because all the active compounds in plants extracted as a whole, and it cheaper and more efficient in the extraction process. Determine as many thirty-six white male mice as test animals and separate them into eight treatment groups. The administrated ethanol extract of Pegagan Embun (&lt;em&gt;Hydrocotyle sibthorpioides&lt;/em&gt; Lam.) at doses of 7, 35, and 150 mg/kg BW for 7, 14, and 21 days. On days 8&lt;sup&gt;th&lt;/sup&gt;, 15&lt;sup&gt;th&lt;/sup&gt;, and 22&lt;sup&gt;nd&lt;/sup&gt;, three white male mice collected from each treatment group and collected their liver and kidney. The data analysed used a T-test with IBM SPSS type 24. &lt;strong&gt;Result: &lt;/strong&gt;LD50 of ethanol extract of &lt;em&gt;Hydrocotyle sibthorpioides&lt;/em&gt; Lam. &amp;gt; 15,000 mg/kg means practically not toxic. The results showed that the administration of extract &lt;em&gt;Hydrocotyle sibthorpioides &lt;/em&gt;Lam. for 7, 14, and 21 days showed a non-significant effect on any histological damage to the liver of male white mice at doses of 7 and 35 mg/kg BW (normal histology). The non-significant effect also occurs at150 mg/kg BW for 7 days; however, it caused mild damage at a dose of 150 mg/kg BW for 14 days and moderate damage at 150 mg/kg BW for 21 days. In renal histopathology, doses of 7 mg/kg BW. for 7, 14, and 21 days showed normal histology and doses of 35 mg/kg BW for 7, 14, and 21 days showed minimal damage. The administration at doses of 150 mg/kg BW for 7 days showed mild damage, while a dose of 150 mg/kg BW for 14 and 21 days showed moderate damage. &lt;strong&gt;Conclusion:&lt;/strong&gt; It concluded that the administration of extract of &lt;em&gt;Hydrocotyle sibthorpioides&lt;/em&gt; Lam. did not cause severe damage to the histology of the liver and kidneys of white male mice.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">619</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Afriwardi&lt;sup&gt;1&lt;/sup&gt;, Rahmad Abdillah&lt;sup&gt;2&lt;/sup&gt;, Elidahanum Husni&lt;sup&gt;3&lt;/sup&gt;, Hafifah Hardini&lt;sup&gt;4&lt;/sup&gt;, Khalila Tri Syahbani Zuler&lt;sup&gt;4&lt;/sup&gt;, Aditya Alqamal Alianta&lt;sup&gt;5&lt;/sup&gt;, Yufri Aldi&lt;sup&gt;6,*&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;lecturer in the Department of Physiology also as the Dean of Faculty of Medicine Universitas Andalas, Dean at the Faculty of Dentistry of Universitas Andalas, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;lecturer in Department of Pharmacology, Faculty of Pharmacy, Universitas Andalas, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;lecturer in Department of Biology of Pharmacy, Faculty of Pharmacy, Universitas Andalas, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Profession student in Pharmacist Program at Faculty of Pharmacy, Universitas Andalas, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;lecturer in Department on Socio-economic Animal Science, Faculty of Animal Science, Universitas Andalas, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;6&lt;/sup&gt;lecturer in Department of Pharmacology, Faculty of Pharmacy, Universitas Andalas, INDONESIA&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Tanuja Singh</style></author><author><style face="normal" font="default" size="100%">Ruchi</style></author><author><style face="normal" font="default" size="100%">Anjali singh</style></author><author><style face="normal" font="default" size="100%">Ravish Kumar</style></author><author><style face="normal" font="default" size="100%">Jitendra Kumar Singh</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Acute toxicity study of Phyllanthus niruri and its effect on the cyto-architectural structure of nephrocytes in Swiss albino mice Mus-musculus</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Biochemical</style></keyword><keyword><style  face="normal" font="default" size="100%">Histological analysis</style></keyword><keyword><style  face="normal" font="default" size="100%">Kidney</style></keyword><keyword><style  face="normal" font="default" size="100%">LD50</style></keyword><keyword><style  face="normal" font="default" size="100%">P. niruri.</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2016</style></year><pub-dates><date><style  face="normal" font="default" size="100%">09/2015</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">8</style></volume><pages><style face="normal" font="default" size="100%">77-80</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align:justify&quot;&gt;&lt;strong&gt;Background:&lt;/strong&gt; In the era of herbal renaissance, world is moving towards the medicinal plant that repairs and strengthening the body system without any toxic side effects. Popular medicinal plant &lt;em&gt;Phyllanthus niruri&lt;/em&gt; contains various bioactive molecules, the present study aimed to observe the biochemical and cyto-architectural alterations in kidney associated with acute oral toxicity (LD&lt;sub&gt;50&lt;/sub&gt;) of aqueous extract of &lt;em&gt;P.niruri&lt;/em&gt; in Swiss albino mice. However, limited data is available about the toxicity of herbal remedies used for medication, which is a critical constrain. &lt;strong&gt;Materials and Methods:&lt;/strong&gt; For the acute oral toxicity study, the animals were divided into six groups of 6 mice each. Group&amp;ndash;I was named control group and the treatment groups were administered aqueous leaf extract of &lt;em&gt;P.niruri&lt;/em&gt; orally at different doses of 500 mg/Kg bw (Group-II), 1000 mg/Kg bw (Group-III), 2000 mg/Kg bw (Group-IV), 2500 mg/Kg bw (Group-V) and 3000 mg/Kg bw (Group-VI) for 15 consecutive days. The mice were sacrificed on and serum was collected for the biochemical analysis. The kidney was dissected and processed for histological analysis. &lt;strong&gt;Results:&lt;/strong&gt; The LD&lt;sub&gt;50&lt;/sub&gt; dose of &lt;em&gt;P.niruri &lt;/em&gt;was found to be 2590.984 mg/Kg bw in Swiss albino mice model in laboratory condition. The result showed the elevated serum level of urea in treated group of mice at higher doses which was found to be statistically significant as compared to the control (Group&amp;ndash;I). There were no any significant increase in serum creatinine has been observed. Histological alteration were observed at higher dose more than 2500 mg/Kg bw (Group-VI). &lt;strong&gt;Conclusion:&lt;/strong&gt; It is evident from our study that &lt;em&gt;P. niruri &lt;/em&gt;may have toxic effect at high doses. Therefore, it should be ingested with precautions.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">77</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Tanuja Singh&lt;sup&gt;1&lt;/sup&gt;, Ruchi&lt;sup&gt;2&lt;/sup&gt;, Anjali Singh&lt;sup&gt;3&lt;/sup&gt;, Ravish Kumar&lt;sup&gt;3&lt;/sup&gt; and Jitendra Kumar Singh&lt;sup&gt;4&lt;/sup&gt; &lt;/strong&gt;&lt;/p&gt;

&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Botany, Thakur Prasad Singh, College, Magadh University, Patna.&lt;/p&gt;

&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Botany, Braj Mohan Das College, Dayalpur, Babasaheb Bhimrao Ambedkar, Bihar University, Bihar, India&amp;ndash;844502.&lt;/p&gt;

&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Research Centre, Mahavir Cancer Sansthan, Phulwarisharif, Patna, India.&lt;/p&gt;

&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Department of Research, S.S. Hospital and Research Institute, Patna, India.&lt;/p&gt;</style></auth-address></record></records></xml>