<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Prajna R H</style></author><author><style face="normal" font="default" size="100%">Shivananda Nayak</style></author><author><style face="normal" font="default" size="100%">Priya V</style></author><author><style face="normal" font="default" size="100%">Shruthi Rai P</style></author><author><style face="normal" font="default" size="100%">Shivaraja shankara Y M</style></author><author><style face="normal" font="default" size="100%">Prashanthkumar Goudappala</style></author><author><style face="normal" font="default" size="100%">Dinesh PV</style></author><author><style face="normal" font="default" size="100%">Namratha KG</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">The role of TNF-Alpha, IL-6, Adiponectin, and Leptin in Inflammation and Metabolic Dysregulation in Type 2 Diabetes Mellitus</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Adiponectin</style></keyword><keyword><style  face="normal" font="default" size="100%">IL-6</style></keyword><keyword><style  face="normal" font="default" size="100%">Inflammation</style></keyword><keyword><style  face="normal" font="default" size="100%">Leptin</style></keyword><keyword><style  face="normal" font="default" size="100%">Metabolic Dysregulation</style></keyword><keyword><style  face="normal" font="default" size="100%">TNF-Alpha</style></keyword><keyword><style  face="normal" font="default" size="100%">Type 2 diabetes mellitus</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2025</style></year><pub-dates><date><style  face="normal" font="default" size="100%">December 2025</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">17</style></volume><pages><style face="normal" font="default" size="100%">699-702</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background: &lt;/strong&gt;Type 2 Diabetes Mellitus (T2DM) is characterized by chronic inflammation and metabolic dysregulation. The present study investigates the role of inflammatory markers, including TNF-alpha and IL-6, and metabolic hormones such as adiponectin and leptin, in individuals with T2DM. &lt;strong&gt;Methods:&lt;/strong&gt; A total of 147 participants diagnosed with T2DM were included in the study. Clinical and biochemical parameters, including fasting blood sugar (FBS), glycated hemoglobin (HbA1C), adiponectin, leptin, TNF-alpha, and IL-6, were measured. Descriptive statistics and correlation analysis were performed to determine associations between inflammatory markers and metabolic dysregulation.&lt;strong&gt; Results: &lt;/strong&gt;The mean age of participants was &lt;strong&gt;42.63 ± 6.38 &lt;/strong&gt;years, and the average BMI was &lt;strong&gt;28.38 ± 2.25 kg/m²&lt;/strong&gt;. FBS and HbA1C levels were &lt;strong&gt;175.72 ± 61.61 mg/dL&lt;/strong&gt; and &lt;strong&gt;7.26 ± 0.94%,&lt;/strong&gt; respectively. The mean adiponectin and leptin levels were &lt;strong&gt;4.71 ± 1.75 μg/mL&lt;/strong&gt; and &lt;strong&gt;20.58 ± 5.19 ng/mL&lt;/strong&gt;, respectively. TNF-alpha and IL-6 levels averaged &lt;strong&gt;132.00 ± 9.45 pg/mL&lt;/strong&gt; and &lt;strong&gt;33.52 ± 14.55 pg/mL&lt;/strong&gt;, respectively. Correlation analysis indicated an inverse relationship between adiponectin and BMI, while leptin was positively correlated with BMI and insulin levels. Elevated TNFalpha and IL-6 levels were associated with increased HbA1C and fasting blood glucose. &lt;strong&gt;Conclusion: &lt;/strong&gt;This study highlights the significant role of inflammatory markers in metabolic dysregulation among T2DM patients. Elevated TNF-alpha and IL-6 levels reinforce the link between chronic inflammation and impaired glucose metabolism. These findings underscore the need for anti-inflammatory strategies in diabetes management.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">699</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Prajna R H&lt;sup&gt;1,2&lt;/sup&gt;, Shivananda Nayak&lt;sup&gt;3&lt;/sup&gt;, Priya V&lt;sup&gt;4*&lt;/sup&gt;, Shruthi Rai P&lt;sup&gt;5&lt;/sup&gt;, Shivaraja shankara Y M&lt;sup&gt;6&lt;/sup&gt;, Prashanthkumar Goudappala&lt;sup&gt;7&lt;/sup&gt;, Dinesh PV&lt;sup&gt;8&lt;/sup&gt;, Namratha KG&lt;sup&gt;9&lt;/sup&gt; &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Research scholar, SaveethaResearch Center, Saveetha Institute of Medical and Technical Sciences(SIMATS), Chennai, INDIA,600077&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Assistant Professor, Department of Biochemistry, KVG Medical College and Hospital, Sullia, INDIA, 574327&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Professor, Department of Biochemistry, Subbaiah Institute of Medical Science, Shivamogga, INDIA,577222&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Professor, Center of Molecular Medicine and Diagnostics (COMManD), Department of Biochemistry, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University Chennai, INDIA,600077&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Professor, Department of Biochemistry, KVG Medical College and Hospital, Sullia, INDIA, 574327&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;6&lt;/sup&gt;Professor, Department of Biochemistry, KVG Medical College and Hospital, Sullia, INDIA, 574327&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;7&lt;/sup&gt;Associate Professor, Department of Biochemistry, Sri Siddhartha Medical College, Sri Siddhartha Academy of Higher Education, Tumkur, INDIA ,572107&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;8&lt;/sup&gt;Professor, Department of Community medicine, KVG Medical College and Hospital, Sullia, INDIA, 574327&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;9&lt;/sup&gt;Professor, Department of Microbiology, KVG Medical College and Hospital,Sullia , INDIA, 574327.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Teguh Triyono</style></author><author><style face="normal" font="default" size="100%">Bambang Hendriawan Prasaja Jati</style></author><author><style face="normal" font="default" size="100%">Usi Sukorini</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Increased Risk of Tumor Necrosis Factor-Alpha Levels in Adult Patients with Malignancy Receiving Non-Leucodepleted Packed Red Cells Transfusion</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Malignancy</style></keyword><keyword><style  face="normal" font="default" size="100%">Non-leucodepleted</style></keyword><keyword><style  face="normal" font="default" size="100%">PRC transfusion</style></keyword><keyword><style  face="normal" font="default" size="100%">Relative risk</style></keyword><keyword><style  face="normal" font="default" size="100%">TNF-Alpha</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2022</style></year><pub-dates><date><style  face="normal" font="default" size="100%">December 2022</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">14</style></volume><pages><style face="normal" font="default" size="100%">778-781</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background and Objectives:&lt;/strong&gt; Blood transfusion in patients with malignancy may evoke transfusion reactions. Leukocyte, as a major producer of cytokines, including Tumor Necrosis Factor-alpha (TNF-alpha), is considered to correlate to transfusion reactions. This study aims to determine the risk of increased TNFalpha in adult patients with malignancy who received non-leucodepleted (nLD) erythrocyte transfusion compared to those receiving leucodepleted (LD) Packed Red Cells (PRC) transfusion. &lt;strong&gt;Materials and Methods&lt;/strong&gt;: This quasi-experimental study was conducted on adult patients with malignancy who required PRC transfusion and underwent outpatient treatment. The patients were divided without randomization into nLD and LD groups, and then their pre-transfusion TNF-alpha levels and the post-transfusion changes were examined.&lt;strong&gt; Results: &lt;/strong&gt;This study included thirty-one patients fulfilling the inclusion criteria. The TNFalpha levels in nLD and LD groups after transfusion increased significantly (p &amp;lt; 0.05), i.e., from 0.81 (0.2 - 4.2) pg/mL and 1.7 (0.15 - 6.3) pg/mL to 10.1 (1.4 - 28.9) and 5.9 (0.95 - 12.9) pg/mL. There was no significant difference in the pre-transfusion median TNF-alpha levels between the nLD and LD groups (p = 0.122). However, the post-transfusion median TNF-alpha levels of the nLD group were significantly higher (p = 0.024). It indicated that the increase in TNF-alpha levels is associated with nLD blood products transfused. The Relative Risk of the increased TNF-alpha levels in nLD-PRC transfusion was 2.01 (95% Confidence Interval: 1,153-3,502). &lt;strong&gt;Conclusion: &lt;/strong&gt;nLD-PRC transfusion poses a 2.01 times risk for increased TNF-alpha levels compared to LD-PRC transfusion.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Original Article </style></work-type><section><style face="normal" font="default" size="100%">778</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p&gt;&lt;strong&gt;Teguh Triyono&lt;sup&gt;1&lt;/sup&gt;, Bambang Hendriawan Prasaja Jati&lt;sup&gt;2&lt;/sup&gt;, Usi Sukorini&lt;sup&gt;3,*&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Clinical Pathology and Laboratory Medicine, Faculty of Medicine, Universitas Gadjah Mada, INDONESIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;2&lt;/sup&gt;Clinical Laboratory, Baa Regional Public Hospital, INDONESIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Clinical Pathology and Laboratory Medicine, Faculty of Medicine, Universitas Gadjah Mada, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Sreelakshmi Bada Venkatappa Gari</style></author><author><style face="normal" font="default" size="100%">Ramalingam Peraman</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Tinospora Sinensis (Lour.) Merr. Stem Modulate The TNF-Alpha Expression In HCT- 116 Tumour Cell, Besides the Inhibitory Effect on Cervical, Colon and Breast Cancer Cell Lines and Mycobacterium Tuberculosis H37Rv</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Anticancer</style></keyword><keyword><style  face="normal" font="default" size="100%">Antitubercular</style></keyword><keyword><style  face="normal" font="default" size="100%">HCT-116</style></keyword><keyword><style  face="normal" font="default" size="100%">Immunomodulatory</style></keyword><keyword><style  face="normal" font="default" size="100%">Tinospora sinensis</style></keyword><keyword><style  face="normal" font="default" size="100%">TNF-Alpha</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2021</style></year><pub-dates><date><style  face="normal" font="default" size="100%">January 2021</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">13</style></volume><pages><style face="normal" font="default" size="100%">8-16</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background: &lt;/strong&gt;The present study was designed to evaluate TNF-Alpha experession, anticancer and antitubercular properties for the stem extracts of &lt;em&gt;Tinospora sinensis&lt;/em&gt; (TS). &lt;strong&gt;Objective: &lt;/strong&gt;natural product research is widely used for identifying hit molecules for life threatening diseases including cancer, tuberculosis and drug resistant infections. &lt;strong&gt;Materials and Methods:&lt;/strong&gt; There were three polarity dependant solvent extracts obtained through cold maceration process using ethanol (ELTS), ethyl acetate (EATS) and n-hexane (NHTS), respectively. The extracts were subjected to MTT assay for their anticancer potential against HeLa (cervical cancer), MCF-7 (breast cancer) and HCT116 (colon cancer) cell lines, and based on the results, NHTS was subjected to flow cytometry for TNF-Alpha expression in HCT-116 cells. The antitubercular activity for the extracts was performed against &lt;em&gt;Mycobacterium tuberculosis&lt;/em&gt; H&lt;sub&gt;37&lt;/sub&gt;Rv (Mtb) by luciferase reporter phage (LPS) assay method.&lt;strong&gt; Results:&lt;/strong&gt; The result of anticancer screening revealed that n-hexane extracts showed the significant inhibition (&lt;em&gt;p&lt;/em&gt;&amp;lt;0.05) on HCT-116 cells with the IC&lt;sub&gt;50&lt;/sub&gt; of 177.4 μg/ml, whereas EATS and ELTS were equally active on HeLa with the respective IC&lt;sub&gt;50&lt;/sub&gt; of 236 and 277 μg/ml. The NHTS was significantly effective on decreasing (&lt;em&gt;P&lt;/em&gt;&amp;lt;0.05) TNF-Alpha expression (31.27 MFU) in HCT-116 cells and is closely active with standard simvastatin (26.7 MFU) against the control (7.06 MFU). The antitubercular activity results revealed the equi-potency of both NHTS and EATS on Mtb with growth inhibition of 84 % at 100μg/ml. The GC-MS analyses of NHTS confirmed the presence of Berberine, palmatine, tembertarine, magniflorine, choline and tinosporin. &lt;strong&gt;Conclusion: &lt;/strong&gt;Overall, we scientifically support the traditional use&lt;em&gt; Tinospora sinensis&lt;/em&gt; stem in the treatment of cancer and immune diseases.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">8</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Sreelakshmi Bada Venkatappa Gari&lt;sup&gt;1,&lt;/sup&gt;*, Ramalingam Peraman&lt;sup&gt;2&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Research Scholar, Faculty of Pharmaceutical Sciences, Jawaharlal Nehru Technological University Anantapur (JNTUA), Anantapur, Andhra Pradesh 515002, INDIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Professor of Pharmaceutical and Medicinal chemistry RERDS-Centre for Pharmaceutical Research, Raghavendra Institute of Pharmaceutical Education and Research (RIPER)-Autonomous, Anantapur, Andhra Pradesh 515721, INDIA.&lt;/p&gt;
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