<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Hareg Zewdu Alehegn</style></author><author><style face="normal" font="default" size="100%">Abiodun A. Adeyemi</style></author><author><style face="normal" font="default" size="100%">Abayomi Mayowa Ajayi</style></author><author><style face="normal" font="default" size="100%">Foluke A. Fasola</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Evaluation of Phytochemical, Antioxidant, Anti-sickling, and Membrane Stabilization Properties of Justicia carnea Leaves and Stems Extracts</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">erythrocytes</style></keyword><keyword><style  face="normal" font="default" size="100%">Hemoglobin</style></keyword><keyword><style  face="normal" font="default" size="100%">Medicinal plants</style></keyword><keyword><style  face="normal" font="default" size="100%">Sickle Cell Disease</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2026</style></year><pub-dates><date><style  face="normal" font="default" size="100%">April 2026</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">18</style></volume><pages><style face="normal" font="default" size="100%">1-7</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction:&lt;/strong&gt; Sickle cell disease (SCD) is an autosomal recessive inherited genetic blood disorder resulting from the aberrant structure of hemoglobin (Hb) that results in the production of hemoglobin S (Hb S). Objective: This study aimed to investigate the phytochemical profiles, antioxidant, anti-sickling, and membrane stabilizing activities of crude extracts of &lt;em&gt;Justicia carnea &lt;/em&gt;leaves and stems that used to treat SCD in Nigeria. &lt;strong&gt;Methods:&lt;/strong&gt; The 70 % ethanol crude extracts of the dried, powdered leaves and stems of &lt;em&gt;J. carnea&lt;/em&gt; were prepared by maceration. Reversal and inhibition activity of the plant materials were evaluated by using sodium-metabisulphite-sickled HB SS blood cells from two patients not in crisis. The membrane stabilization assays on rats' red blood cells (RBCs) and human sickled RBCs and antioxidant assays were determined following standard methods. Results were presented as Mean ± SEM. Data analysis and graph plotting were carried out using GraphPad Prism® version 8.01.&lt;strong&gt; Results:&lt;/strong&gt; The antioxidant assays indicated that &lt;em&gt;J. carnea&lt;/em&gt; leaves (JCL) had stronger DPPH activity (IC₅₀ = 245.031 ± 0.228 μg/mL). While, the stems (JCS) exhibited higher NO scavenging (84.123 ± 0.497 μg/mL). The highest reversal and inhibition percentages observed at 60, 90, and 120-minute time points. At 60th minutes reading, JCL 20 mg/mL (78.9±0.13%) demonstrated the highest reversal activity, while JCL 10 mg/mL (66.9±0.82 %) revealed the strongest inhibition effect. The extracts showed dose-dependent membrane stabilization activity. &lt;strong&gt;Conclusions: &lt;/strong&gt;The extracts demonstrated remarkable antioxidant, anti-sickling, and membrane stabilizing activities. The use of this plant could be a promising natural therapy for SCD.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">1</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Hareg Zewdu Alehegn&lt;sup&gt;1,2*&lt;/sup&gt;, Abiodun A. Adeyemi&lt;sup&gt;3&lt;/sup&gt;, Abayomi Mayowa Ajayi&lt;sup&gt;4&lt;/sup&gt;, Foluke A. Fasola&lt;sup&gt;5&lt;/sup&gt; &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;M.Sc. Candidate, Medicinal Plants Research and Drug Development, Pan African University, Life and Earth Sciences Institute (Including Health and Agriculture), Ibadan, NIGERIA&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Pharmacognosy, School of Pharmacy, College of Medicine and Health Sciences, University of Gondar, Gondar, ETHIOPIA&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Senior Lecturer, Department of Pharmacognosy, Faculty of Pharmacy, University of Ibadan, Ibadan, NIGERIA&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Senior Lecturer, Department of Pharmacology and Therapeutics, Faculty of Basic Medical Sciences, University of Ibadan, Ibadan, NIGERIA&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Reader/Consultant Haematologist Department of Haematology, College of Medicine, University of Ibadan/University College Hospital, Ibadan, NIGERIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Meti Megawati</style></author><author><style face="normal" font="default" size="100%">Toto Sudargo</style></author><author><style face="normal" font="default" size="100%">And Susetyowati</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">The Effect of Jelly Candy Snake Fruit and Banana With Ferrous  Fumarat Fortified using Nano Technology in Adolescent Female  at Junior High School</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Adolescent female</style></keyword><keyword><style  face="normal" font="default" size="100%">Anemia</style></keyword><keyword><style  face="normal" font="default" size="100%">Fortified</style></keyword><keyword><style  face="normal" font="default" size="100%">Hemoglobin</style></keyword><keyword><style  face="normal" font="default" size="100%">Jelly Candy</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2023</style></year><pub-dates><date><style  face="normal" font="default" size="100%">December 2023</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">15</style></volume><pages><style face="normal" font="default" size="100%">1150-1155</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Aim:&lt;/strong&gt; Adolescent Female are a population at risk for anemia. Nutritional factors such as calories, protein, iron, dietary fiber, and folic acid induce this disease. Furthermore, fishy odor and nausea are two factors that contribute to adolescent females’ lack of iron consumption. Jelly candy formulations of snake and banana fruit with ferrous fumarate fortification using nanotechnology also decrease these diseases as an alternative to food consumption. Young adolescents ought to embrace this jelly formulation, considering its reasonable pricing. Therefore, this study aims to determine the effect of jelly candy formulations of snake and banana fruit with ferrous fumarate fortification using nanotechnology on the increase in hemoglobin levels. &lt;strong&gt;Materials And Methods:&lt;/strong&gt; A quasi-experimental approach was adopted with a Pretest-Posttest Control Group design. The study included a cohort of 150 adolescent girls hailing from Tamansari District, Tasikmalaya City, within the age range of 12 to 18 years. Additionally, the subjects were divided into three distinct groups, namely the treatments (involving jelly, snack fruit, banana, and ferrous fumarate supplementation, abbreviated as JEPISA), control group 1 (comprising jelly and ferrous fumarate supplementation, denoted as JFumarate), and control group 2 (receiving iron and folic acid supplementation as part of the Programme), each consisting of 50 participants. The sample selection process employed the purposive sampling technique and the collected data were subjected to analysis using T-Test, Chi-square and Multiple Logistic Regression methods. &lt;strong&gt;Results:&lt;/strong&gt; The results of the T-Test analysis showed that the mean rise in hemoglobin after lean period of 13 week after giving treatments increased hemoglobin levels by 0.65 ± 0.39 g/dl (95% CI 0.53-0.75 g/dl), significantly (p-value=0,000). Their mean post intervention haemoglobin of three group was 12.10 ± 0.80 g/dl, 12.42 ± 0.70 g/dl and 11.73 ± 0.90 g/dl respectively. The results of statistical test were obtained, the treatment and control group 1 (p=0,044) and the treatment and control group 2 (p=0,33). The result of the multivariate analysis showed that complaince (p=0,000), nutritional status (p=0,000) and menstrual duration (p=0,000) variable were confounding variables for the incidence of anemia (Exp(B)=17,769). &lt;strong&gt;Conclusion: &lt;/strong&gt;There were differences in Hb levels before and after administering the treatment. However, there was statistically significant difference between treatment with controls 1 and 2. Weekly supplementation of treatment’s in Iron Deficiency Anemia patients is as good as weekly supplementation of control 1 and but higher than control 2. Adolescent female who did not adhere to consuming iron had a chance of experiencing anemia 17,769 times compared to obedient adolescents after controlling for the variable nutritional status and length of menstruation.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">1150</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Meti Megawati&lt;sup&gt;1,&lt;/sup&gt;*, Toto Sudargo&lt;sup&gt;2&lt;/sup&gt; , And Susetyowati&lt;sup&gt;2&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;1&lt;/sup&gt;Doctoral Program in Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada, Yogyakarta, 55281, INDONESIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;2&lt;/sup&gt;Department Nutrition and Health, Faculty of Medicine, Public Health and Nursing of Program Faculty of Medicine, Public Health And Nursing of Universitas Gadjah Mada, Yogyakarta, 55281, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Prawesty Diah Utami</style></author><author><style face="normal" font="default" size="100%">Herin Setianingsih</style></author><author><style face="normal" font="default" size="100%">Indira Firdha Syafitri</style></author><author><style face="normal" font="default" size="100%">Rico Pratama Wiyono</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">The Anti-Malarial Effect of Thespesia populnea (L.) Soland ex Correa Extract Using Malaria Mice Model Infected with P. berghei</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">BALB/C</style></keyword><keyword><style  face="normal" font="default" size="100%">Hemoglobin</style></keyword><keyword><style  face="normal" font="default" size="100%">Malaria</style></keyword><keyword><style  face="normal" font="default" size="100%">Parasitemia</style></keyword><keyword><style  face="normal" font="default" size="100%">Thespesia populnea extract</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2021</style></year><pub-dates><date><style  face="normal" font="default" size="100%">March 2021</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">13</style></volume><pages><style face="normal" font="default" size="100%">585-590</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction:&lt;/strong&gt; Malaria is a re-emerging disease that still causes high morbidity and mortality rates. Reports of malaria therapy, encouraging studies to find new therapies based on plants and adjuvant in malaria infection. &lt;em&gt;Thespesia populnea&lt;/em&gt; or portia tree leaf extract is a plant that has been shown to have anti-inflammatory, antibacterial and antifungal effects. The aim of this study was to analyze the effect of &lt;em&gt;Thespesia populnea&lt;/em&gt; leaf extract as antimalarial levels, and and its effect on hemoglobin levels in BALB/C mice infected with&lt;em&gt; Plasmodium berghei &lt;/em&gt;ANKA (PbA).&lt;strong&gt; Methods: &lt;/strong&gt;The study was true experimental laboratories using post-test only group design. Using 27 mice were randomly divided into 3 groups: Group with aquades (G1), Group received Chloroquine (G2), and Group with 200 mg/kg bw of &lt;em&gt;Thespesia populnea&lt;/em&gt; (L.) Soland ex Correa extract and Chloroquine (G3). The degree of parasitemia was observed serially from the first day to the fourth day. Observation of the number of leukocytes and hemoglobin on the fourth day after the mice were terminated. &lt;strong&gt;Results:&lt;/strong&gt; The results of statistical analysis showed that the administration of &lt;em&gt;Thespesia populnea&lt;/em&gt; leef extract 200 mg/kg bw with chloroquine had the effect of decreasing the degree of parasitemia and increasing hemoglobin significantly than G1 group, but there was no significant difference with G2 group, although descriptively there were differences. &lt;strong&gt;Conclusion: &lt;/strong&gt;Based on the results of this study, it can be concluded that &lt;em&gt;Thespesia populnea&lt;/em&gt; or portia tree leaf extract has an anti-malarial effect and can also significantly prevent anemia.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">2</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">585</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Prawesty Diah Utami*, Herin Setianingsih, Indira Firdha Syafitri, Rico Pratama Wiyono&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;Faculty of Medicine, Universitas Hang Tuah, Surabaya, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Elidahanum Husni</style></author><author><style face="normal" font="default" size="100%">Dwisari Dillasamola</style></author><author><style face="normal" font="default" size="100%">Elsa Badriyya</style></author><author><style face="normal" font="default" size="100%">Resta Angelia</style></author><author><style face="normal" font="default" size="100%">Yufri Aldi</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Ethanol Extract Activity of Pegagan Embun (Hydrocotyle sibthorpioides L.) Against Hematopoietic on Anemic Male White Mice</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">erythrocytes</style></keyword><keyword><style  face="normal" font="default" size="100%">Extract of Hydrocotyle sibthorpioides L.</style></keyword><keyword><style  face="normal" font="default" size="100%">Hematocrit</style></keyword><keyword><style  face="normal" font="default" size="100%">Hemoglobin</style></keyword><keyword><style  face="normal" font="default" size="100%">Reticulocytes</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2021</style></year><pub-dates><date><style  face="normal" font="default" size="100%">July 2021</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">13</style></volume><pages><style face="normal" font="default" size="100%">866-873</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction: &lt;/strong&gt;Pegagan embun (&lt;em&gt;Hydrocotyle sibthorpioides&lt;/em&gt; L.) is known to have many benefits, including as a blood booster. This study aims to determine the activity of pegagan embun (&lt;em&gt;Hydrocotyle sibthorpioides&lt;/em&gt; L.) on the formation of red blood cells. The parameters include the number of erythrocytes, reticulocytes, hemoglobin levels, and hematocrit values in anemic male white mice induced by chloramphenicol 130 mg/kg for 14 days. &lt;strong&gt;Methods:&lt;/strong&gt; Anemic mice consisted of 4 groups, namely the first group was given physiological NaCl, the second, third, and fourth groups were given ethanol extract of pegagan embun (&lt;em&gt;Hydrocotyle sibthorpioides&lt;/em&gt; L.) at a dose of 10, 50 and 100 mg/kgper oral every day, for 14 days. Observations were made on days 0, 14, 21, and 28. &lt;strong&gt;Results:&lt;/strong&gt; The results showed that administration of pegagan embun extracts at a dose of 10, 50, and 100 mg/kgto anemic male white mice significantly increase the number of erythrocyte cells, the number of reticulocytes, the hemoglobin levels, and the hematocrit values (p &amp;lt;0.05). Increasing the dose and duration of pegagan embun extract administration could provide a more significant increase in the hematopoietic parameters (p &amp;lt;0.05). &lt;strong&gt;Conclusion:&lt;/strong&gt;It can be concluded that the extract of pegagan embun (&lt;em&gt;Hydrocotyle sibthorpioides&lt;/em&gt; L.) can be used to treat anemia in male white mice.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">4</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">866</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Elidahanum Husni*, Dwisari Dillasamola, Elsa Badriyya, Resta Angelia, Yufri Aldi&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;Faculty of Pharmacy, University Andalas, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Anupam Jaiswal</style></author><author><style face="normal" font="default" size="100%">Aditya Ganeshpurkar</style></author><author><style face="normal" font="default" size="100%">Ankita Awasthi</style></author><author><style face="normal" font="default" size="100%">Divya Bansal</style></author><author><style face="normal" font="default" size="100%">Nazneen Dubey</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Protective Effects of Beetroot Extract against Phenyl Hydrazine Induced Anemia in Rats</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Beta vulgaris</style></keyword><keyword><style  face="normal" font="default" size="100%">erythrocytes</style></keyword><keyword><style  face="normal" font="default" size="100%">Hemoglobin</style></keyword><keyword><style  face="normal" font="default" size="100%">phenyl hydrazine</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2014</style></year><pub-dates><date><style  face="normal" font="default" size="100%">2nd July 2014</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">6</style></volume><pages><style face="normal" font="default" size="100%">1-4</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Background:&lt;/strong&gt; Anemia can be regarded as one of the oldest blood malformation known over a century. Megaloblastic anemia arises due to curtailed formation of erythrocytes, which leads to formation of a large number of underdeveloped erythrocytes. Proper nutritional supplementation may be useful in such condition. &lt;em&gt;Beta vulgaris&lt;/em&gt; or beetroot is one of the important vegetables consumed worldwide. The aim of the present work was to evaluate anti-anemic potential of beetroot. &lt;strong&gt;Methods:&lt;/strong&gt; Beetroot was extracted with ethanol. Phytochemical and phytoanalytical studies were performed on extract. Anemia was induced by phenyl-hydrazine. Animals were treated with extract throughout the study for 24 days. The red blood cell (RBC) number and hemoglobin concentration were determined every 3 days for 24 days. &lt;strong&gt;Results:&lt;/strong&gt; Extract was found to be rich in folic acid, ascorbic acid, and iron. Following the induction of anemia, the number of erythrocytes and the hemoglobin concentration decreased by 62.51% and 69.64%, respectively. Administration of standard hematinic preparation and extract (200 mg/kg) resulted in signifi cant increase (&lt;em&gt;P&lt;/em&gt;&amp;lt; 0.001; &lt;em&gt;P&lt;/em&gt;&amp;lt; 0.01) in the number of RBCs as well as hemoglobin concentration when compared to the untreated phenyl hydrazine-induced anemic rats. &lt;strong&gt;Conclusion:&lt;/strong&gt; Extract effectively raised the level of hemoglobin and erythrocyte count at dose 200 mg/kg. Vitamin and minerals found in beetroot are most likely active ingredients responsible for its hematinic effects. Still, methodical studies are obligatory to derive its effects on humans.&lt;/p&gt;&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Key words:&lt;/strong&gt;&lt;em&gt;Beta vulgaris&lt;/em&gt;, erythrocytes, hemoglobin, phenyl hydrazine.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Anupam Jaiswal&lt;sup&gt;1&lt;/sup&gt;, Aditya Ganeshpurkar&lt;sup&gt;1*&lt;/sup&gt;, Ankita Awasthi&lt;sup&gt;1&lt;/sup&gt;, Divya Bansal&lt;sup&gt;2&lt;/sup&gt;, Nazneen Dubey&lt;/strong&gt;&lt;sup&gt;&lt;strong&gt;1&lt;/strong&gt;&lt;/sup&gt;&lt;/p&gt;&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Pharmacology, Drug Discovery Laboratory, Shri Ram Institute of Technology-Pharmacy, Jabalpur, Madhya Pradesh, India,&lt;/p&gt;&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Pharmacology, Pharmaceutics Research Laboratory, Shri Ram Institute of Technology-Pharmacy, Jabalpur, Madhya Pradesh, India.&lt;/p&gt;</style></auth-address></record></records></xml>