<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">G. Narayanan</style></author><author><style face="normal" font="default" size="100%">K Prabhu</style></author><author><style face="normal" font="default" size="100%">Anath Bandhu Chaudhury</style></author><author><style face="normal" font="default" size="100%">Mudiganti Ram Krishna Rao</style></author><author><style face="normal" font="default" size="100%">V S Kalai Selvi</style></author><author><style face="normal" font="default" size="100%">N S Muthiah</style></author><author><style face="normal" font="default" size="100%">Sruthi Dinakar</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Cardioprotective Role of Partharishtam on Isopreterenol Induced Myocardial Infarction in Animal Model</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Catalase</style></keyword><keyword><style  face="normal" font="default" size="100%">Creatine phosphokinase</style></keyword><keyword><style  face="normal" font="default" size="100%">GSH</style></keyword><keyword><style  face="normal" font="default" size="100%">Isoproterenol</style></keyword><keyword><style  face="normal" font="default" size="100%">Myocardial Infarction</style></keyword><keyword><style  face="normal" font="default" size="100%">Partharishtam</style></keyword><keyword><style  face="normal" font="default" size="100%">Polyherbal</style></keyword><keyword><style  face="normal" font="default" size="100%">Propranolol</style></keyword><keyword><style  face="normal" font="default" size="100%">SOD</style></keyword><keyword><style  face="normal" font="default" size="100%">Troponin I</style></keyword><keyword><style  face="normal" font="default" size="100%">Troponin T</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2021</style></year><pub-dates><date><style  face="normal" font="default" size="100%">March 2021</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">13</style></volume><pages><style face="normal" font="default" size="100%">591-595</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;Myocardial infarction (MI) is one of the key causes of high death rate globally. We report the cardio protective effect of an Ayurvedic polyherbal formulation Partharishtam on isoproterenol induced myocardial infarction on albino rats. Administration of Isoproterenol to normal albino rat triggers MI evident from the significant changes in key biomolecules tested in blood serum and cardiac tissues. The cardio protective role of Partharishtam was compared with a standard medicine, Propranolol on some of the known identifying markers of MI such as, Troponin I and T, creatine phosphokinase serum (CPK-S), creatine phosphokinase myoglobulin isozyme fraction (CPK-MB) and oxidative enzymes like super oxide dismutase (SOD), reduced glutathione (GSH) and catalase. There was an appreciable decrease in the levels of Troponin 1 and T, CPK-S and CPK-MB after the treatment of Partharishtam on Isoproterenol induced MI rats. In vivo anti-oxidative enzyme studies also revealed the increase in the levels of SOD, GSH and catalase to near normalcy after the treatment of Partharishtam in MI rats, which is very much comparable to the commonly used drug Propranolol to treat MI patients. Histopathological analysis confirmed the cardio protective properties of Partharistham in rat model. We did not find any side effects or toxicity of Partharishtam when tested on the normal rats. Thus, polyherbal formulation Partharishtam could be considered as safe medicine for MI.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">2</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">591</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;G. Narayanan&lt;sup&gt;1&lt;/sup&gt;, K Prabhu&lt;sup&gt;2&lt;/sup&gt;, Anath Bandhu Chaudhury&lt;sup&gt;3&lt;/sup&gt;, Mudiganti Ram Krishna Rao&lt;sup&gt;4,&lt;/sup&gt;*, V S Kalai Selvi&lt;sup&gt;5&lt;/sup&gt;, N S Muthiah&lt;sup&gt;6&lt;/sup&gt;, Sruthi Dinakar&lt;sup&gt;7&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Research Scholar, Dept. of Anatomy, Sree Balaji Medical College and Hospital, INDIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Associate Professor, Dept of Anatomy, Sree Balaji Medical College and Hospital, INDIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Assistant Professor of Biology, Chair Department of Natural Sciences, Stillman College, P. O. Box. 1430, Tuscaloosa, Alabama, USA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Professor, Dept of Industrial Biotechnology, Bharath Institute of Higher Education and Research, Chennai, INDIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Professor, Dept of Biochemistry, Sree Balaji Medical College and Hospital, Chennai, INDIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;6&lt;/sup&gt;Department of Pharmacology, Sree Balaji Medical College and Hospital, Chennai, INDIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;7&lt;/sup&gt;Ayurvedic Physician, Kottakkal Arya Vaidhya Sala, Chennai, INDIA.&lt;/p&gt;
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