<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Manish Kumar,</style></author><author><style face="normal" font="default" size="100%">Milind Parle</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Pharmacological Evaluation of Cucumber for Cognition Enhancing Effect on Brain of Mice</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Acetylcholinesterase</style></keyword><keyword><style  face="normal" font="default" size="100%">Cholesterol</style></keyword><keyword><style  face="normal" font="default" size="100%">Dementia</style></keyword><keyword><style  face="normal" font="default" size="100%">Glucose</style></keyword><keyword><style  face="normal" font="default" size="100%">Hypoxia</style></keyword><keyword><style  face="normal" font="default" size="100%">object recognition task</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2014</style></year><pub-dates><date><style  face="normal" font="default" size="100%">8th April 2014</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">6</style></volume><pages><style face="normal" font="default" size="100%">100-107</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Introduction:&lt;/strong&gt; Cucumber is fruit of &lt;em&gt;Cucumis sativus&lt;/em&gt; var. &lt;em&gt;sativus&lt;/em&gt; L. which has been used traditionally in gastrointestinal problems, skin problems and as coolant in salad for body and brain. Cucumber is a great folk medicine used to reduce heat and inflammation. Cognitive effects of cucumber are assessed in this study.&lt;strong&gt; Methods:&lt;/strong&gt; Fresh fruits of &lt;em&gt;Cucumis sativus&lt;/em&gt; L. were ground and a paste was prepared which consisted of different concentrations of cucumber (10, 20, 30 % w/w). The three doses were given ad &lt;em&gt;libitum&lt;/em&gt; to mice for 15 successive days. Animal models utilized were sodium nitrite induced hypoxia and object recognition task. Biochemical analysis employed estimation of acetylcholinesterase activity in brain, serum glucose levels, cholesterol levels, brain lipid peroxidation (MDA) levels and reduced glutathione levels in brain of mice.&lt;strong&gt; Results:&lt;/strong&gt; 6g/kg and 9g/kg doses of cucumber significantly (&lt;em&gt;P&lt;/em&gt;&amp;lt; 0.05, &lt;em&gt;P&lt;/em&gt;&amp;lt; 0.01) increased frequency of entry, number of entry and duration of entry in small compartment in sodium nitrite induced hypoxia model and depicted significantly (&lt;em&gt;P&lt;/em&gt;&amp;lt; 0.05, &lt;em&gt;P&lt;/em&gt;&amp;lt; 0.001) enhanced exploratory activity in object recognition task model. Further, biochemical analysis indicated good potential of cucumber in cognition enhancement. 9 g/kg dose (&lt;em&gt;P&lt;/em&gt;&amp;lt; 0.001) reduced brain &lt;strong&gt;AchE&lt;/strong&gt; activity along with blood glucose and serum cholesterol levels. 6 g/kg dose (&lt;em&gt;P&lt;/em&gt;&amp;lt; 0.01) replenished brain GSH levels and reduced lipid peroxides. &lt;strong&gt;Conclusion:&lt;/strong&gt; Cucumber increased cognition in rodents.&lt;/p&gt;&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Key words: &lt;/strong&gt;Hypoxia, object recognition task, acetylcholinesterase, glucose, cholesterol, dementia.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Manish Kumar&lt;sup&gt;a,&lt;/sup&gt;&lt;sup&gt;*&lt;/sup&gt; and Milind Parle&lt;/strong&gt;&lt;sup&gt;&lt;strong&gt;b &lt;/strong&gt;&lt;/sup&gt;&lt;/p&gt;&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;a&lt;/sup&gt;Keshav College of Pharmacy, Salwan, Karnal 132046, India&lt;sup&gt;&lt;/sup&gt;&lt;/p&gt;&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;b&lt;/sup&gt;Department of Pharmaceutical Sciences, Guru Jambheshwar University of Science and Technology, Hisar, Haryana 125001, India.&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Guenzet Akila,</style></author><author><style face="normal" font="default" size="100%">Krouf Djamil,</style></author><author><style face="normal" font="default" size="100%">Berzou Saadia</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Portulaca oleracea extract increases lecithin:cholesterol acyltransferase and paraoxonase 1 activities and enhances reverse cholesterol transport in streptozotocin-induced diabetic rat</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">apo A-I</style></keyword><keyword><style  face="normal" font="default" size="100%">Cholesterol</style></keyword><keyword><style  face="normal" font="default" size="100%">LCAT</style></keyword><keyword><style  face="normal" font="default" size="100%">lipoprotein peroxidation</style></keyword><keyword><style  face="normal" font="default" size="100%">PON1</style></keyword><keyword><style  face="normal" font="default" size="100%">Portulaca oleracea</style></keyword><keyword><style  face="normal" font="default" size="100%">Rats</style></keyword><keyword><style  face="normal" font="default" size="100%">Streptozotocin</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2014</style></year><pub-dates><date><style  face="normal" font="default" size="100%">8th April 2014</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">6</style></volume><pages><style face="normal" font="default" size="100%">1-9</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Background:&lt;/strong&gt; Plant extracts are generally assumed to be more acceptable and less hazardous than synthetic compounds and could be alternative antidiabetic treatments. &lt;em&gt;Portula caoleracea&lt;/em&gt; has been used as one of the traditional edible and medicinal plant in Algeria to treat diabetes. The aim of the present study was to determine the effects of lyophilized aqueous extract of &lt;em&gt;Portulaca oleracea&lt;/em&gt; on high-density lipoproteins composition, paraoxonase (PON1) and lecithin:cholesterol acyltransferase (LCAT) activities in streptozotocin-induced diabetic rat. &lt;strong&gt;Methods:&lt;/strong&gt; Diabetes was induced intraperitonially by a single injection of streptozotocin (STZ) (60mg/kg bw). Twelve diabetic rats, weighing 263&amp;plusmn;5g, were divided into two groups fed a casein diet supplemented or not with&lt;em&gt; Portulaca oleracea&lt;/em&gt; extract (1g/kg bw), for 4 weeks.&lt;strong&gt; Results:&lt;/strong&gt; At d28, in&lt;em&gt; Portulaca oleracea&lt;/em&gt; treated vs untreated diabetic group, glycemia, serum total cholesterol (TC), triacylglycerols (TG) and phospholipids (PL) concentrations were decreased significantly (&lt;em&gt;p&lt;/em&gt;&amp;lt;0.05). The hypolipidemic effect induced by &lt;em&gt;Portulaca oleracea&lt;/em&gt; extract was due to the reduction of total cholesterol (TC) in LDL-HDL&lt;sub&gt;1&lt;/sub&gt; (-51%) and C-HDL&lt;sub&gt;3&lt;/sub&gt; (-21%).&lt;em&gt; Portulaca oleracea&lt;/em&gt; treatment improved PON1 and LCAT activities by 48%. HDL3-UC (acyl group acceptor) and -PL (enzyme substrate) were diminished respectively by 47% and 82%, whereas HDL&lt;sub&gt;2&lt;/sub&gt;-CE concentrations (product of LCAT reaction) were increased by 44%. Moreover, HDL-C levels were found to be positively correlated with PON1 activity (r=0.96, &lt;em&gt;p&lt;/em&gt;&amp;lt;0.05). Serum, LDL-HDL&lt;sub&gt;1&lt;/sub&gt;, HDL&lt;sub&gt;2&lt;/sub&gt; and HDL&lt;sub&gt;3&lt;/sub&gt; TBARS levels were respectively, 2.9-, 2.6-, 2.4- and 2.8-fold lower in &lt;em&gt;Portulaca oleracea&lt;/em&gt; treated than untreated diabetic groups. &lt;strong&gt;Conclusion:&lt;/strong&gt; These findings reflect the potential antihyperglycemic and hypolipidemic of &lt;em&gt;Portulaca oleracea&lt;/em&gt; extract, in STZ-induced diabetic rat. Moreover,&lt;em&gt; Portulaca oleracea&lt;/em&gt; extract restores PON1 and ameliorates the reverse cholesterol transport (RCT) by enhancing LCAT activity, therefore could prevent many diabetic complications by reducing dyslipidemia and oxidative damage.&lt;/p&gt;&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Key words: &lt;/strong&gt;Rats, Streptozotocin, &lt;em&gt;Portulaca oleracea&lt;/em&gt;, Cholesterol, PON1, LCAT, apo A-I, lipoprotein peroxidation.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Guenzet Akila, Krouf Djamil and Berzou Saadia&lt;/strong&gt;&lt;/p&gt;&lt;p style=&quot;text-align: justify;&quot;&gt;Laboratoire de Nutrition Clinique et M&amp;eacute;tabolique, D&amp;eacute;partement de Biologie, Facult&amp;eacute; des Sciences de la Nature et de la Vie. Universit&amp;eacute; d&amp;rsquo;Oran. 31100 Oran, Alg&amp;eacute;rie.&lt;/p&gt;</style></auth-address></record></records></xml>