<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">D. R Ch Sekhara Reddy</style></author><author><style face="normal" font="default" size="100%">G Siva Kumar</style></author><author><style face="normal" font="default" size="100%">B. M. Vrushabendra Swamy</style></author><author><style face="normal" font="default" size="100%">K. Phani Kumar</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Protective effect of cissampelos pareira linn. Extract on gentamicin-induced nephrotoxicity and oxidative damage in rats</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Cissampelos pareira</style></keyword><keyword><style  face="normal" font="default" size="100%">Creatinine</style></keyword><keyword><style  face="normal" font="default" size="100%">DPPH</style></keyword><keyword><style  face="normal" font="default" size="100%">Gentamicin</style></keyword><keyword><style  face="normal" font="default" size="100%">Glucose</style></keyword><keyword><style  face="normal" font="default" size="100%">Glutathione</style></keyword><keyword><style  face="normal" font="default" size="100%">Lipid peroxidation</style></keyword><keyword><style  face="normal" font="default" size="100%">Reducing power</style></keyword><keyword><style  face="normal" font="default" size="100%">urea</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2014</style></year><pub-dates><date><style  face="normal" font="default" size="100%">26th May 2014</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">6</style></volume><pages><style face="normal" font="default" size="100%">59-67</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Objective:&lt;/strong&gt; To evaluate the potential nephroprotective and antioxidant activity of hydroalcoholic Cissampelos pareira (&lt;em&gt;C. pareira&lt;/em&gt;) whole plant extract using gentamicin-induced rats. &lt;strong&gt;Methods:&lt;/strong&gt; For studying acute toxicity study, single oral dose of 2g/kg hydroalcoholic extract of &lt;em&gt;C. pareira&lt;/em&gt; was evaluated in rats by oral gavage. The nephroprotective activity was evaluated using gentamicin-induced model in rats. &lt;em&gt;In-vitro&lt;/em&gt; antioxidant activity was evaluated by using DPPH assay and reducing power assay. &lt;em&gt;In-vivo&lt;/em&gt; antioxidant activity was evaluated by using glutathione and lipid peroxidation estimations in gentamicin-induced rats. Hydroalcoholic &lt;em&gt;C. pareira&lt;/em&gt; whole plant extract was given at a dose of 200 and 400 mg/kg p.o. &lt;strong&gt;Results:&lt;/strong&gt; For acute toxicity testing rats administered with the extract at a dose 2 g/ kg. the result showed no toxicity. Hydroalcoholic &lt;em&gt;C. Pareira&lt;/em&gt; whole plant extract (200 and 400 mg/kg p.o) significantly decrease the elevated urinary glucose levels in the urine, decrease the elevated urea and creatinine levels in blood and increase the urinary creatinine levels in gentamicin-induced nephrotoxic rats. The extract had shown significant dose dependent increase in the DPPH and reducing power activity. There were a dose dependent decreasing and increasing of lipid peroxidation, glutathione levels in hydoalcoholic extract treated groups respectively. &lt;strong&gt;Conclusion:&lt;/strong&gt; This study exhibits that hydroalcoholic &lt;em&gt;C. pareira&lt;/em&gt; whole plant extract poses nephroprotective activity which may be due to its antioxidant activity.&lt;/p&gt;&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Key words: &lt;/strong&gt;Gentamicin, &lt;em&gt;Cissampelos pareira&lt;/em&gt;, creatinine, urea, glucose, lipid peroxidation, glutathione, reducing power, DPPH.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">4</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;D. R Ch Sekhara Reddy&lt;sup&gt;1*&lt;/sup&gt;, G. Siva Kumar &lt;sup&gt;2&lt;/sup&gt;, B. M. Vrushabendra Swamy&lt;sup&gt;2&lt;/sup&gt; and K. Phani Kumar&lt;/strong&gt;&lt;sup&gt;&lt;strong&gt;1&lt;/strong&gt;&lt;/sup&gt;&lt;/p&gt;&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Acharya Nagarjuna University College of Pharmaceutical Sciences, Nagarjuna Nagar, Guntur-522510, India&lt;/p&gt;&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Gautham College of Pharmacy, Bhuvaneswari Nagar, Bengaluru-560032, India.&lt;/p&gt;</style></auth-address></record></records></xml>