<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Tchaa Kozolina</style></author><author><style face="normal" font="default" size="100%">Poyodi Kola</style></author><author><style face="normal" font="default" size="100%">Diana Obistioiu</style></author><author><style face="normal" font="default" size="100%">Doris Floares</style></author><author><style face="normal" font="default" size="100%">Aboudoulatif Diallo</style></author><author><style face="normal" font="default" size="100%">Batomayena Bakoma</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Polyphenolic Characterization of Aqueous Extract and Comparative Antioxidant and Antibiofilm activities of Xylopia aethiopica Fruit Aqueous and Essential Oil Extracts against Candida Biofilms</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Antibiofilm</style></keyword><keyword><style  face="normal" font="default" size="100%">crystal violet</style></keyword><keyword><style  face="normal" font="default" size="100%">HPLC-DAD</style></keyword><keyword><style  face="normal" font="default" size="100%">individual polyphenols</style></keyword><keyword><style  face="normal" font="default" size="100%">Xylopia aethiopica</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2026</style></year><pub-dates><date><style  face="normal" font="default" size="100%">October 2026</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">18</style></volume><pages><style face="normal" font="default" size="100%">358-366</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction: &lt;/strong&gt;The increasing resistance of &lt;em&gt;Candida &lt;/em&gt;species to conventional antifungals necessitates the search for new bioactive compounds. &lt;em&gt;Xylopia aethiopica&lt;/em&gt; is a medicinal plant known for its antifungal properties, yet its impact on fungal biofilms remains to be explored. This study characterized the polyphenolic profile of &lt;em&gt;Xylopia aethiopica&lt;/em&gt; hydroethanolic fruit extract and compared the antibiofilm activity of its aqueous extracts and essential oils against &lt;em&gt;Candida &lt;/em&gt;biofilms. &lt;strong&gt;Methodes: &lt;/strong&gt;Total phenols and flavonoids were quantified, and individual compounds were identified via HPLC-DAD. The antioxidant capacity was evaluated by DPPH (2,2-diphenyl-1-pyrylhydrazyl) test. The antibiofilm potential was evaluated using the crystal violet assay to measure biomass reduction and assess the impact on the yeast-tohypha transition. &lt;strong&gt;Results: &lt;/strong&gt;Analyses revealed a rich profile characterized by high yields of epicatechin, phenolic acids, rosmarinic acid, and resveratrol, which impart significant antioxidant properties. In vitro assays demonstrated that among the aqueous extracts, only the hydromethanolic extract (1:2) inhibited biofilms. Conversely, the essential oils exhibited strong dose-dependent efficacy, with hydrodistillation proving superior to steam distillation in restricting the biofilm growth of&lt;em&gt; C. albicans&lt;/em&gt; and &lt;em&gt;C. parapsilosis&lt;/em&gt;. &lt;strong&gt;Conclusion: &lt;/strong&gt;These findings suggest that &lt;em&gt;Xylopia aethiopica&lt;/em&gt; is a potent source of antibiofilm agents. The essential oil obtained by hydrodistillation represents a promising alternative for eradicating resistant &lt;em&gt;Candida &lt;/em&gt;communities, highlighting the crucial impact of the extraction method on bioactivity.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">358</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Tchaa Kozolina&lt;sup&gt;1,3,5*&lt;/sup&gt;, Poyodi Kola&lt;sup&gt;2&lt;/sup&gt;, Diana Obistioiu&lt;sup&gt;3&lt;/sup&gt;, Doris Floares&lt;sup&gt;3&lt;/sup&gt;, Aboudoulatif Diallo&lt;sup&gt;4&lt;/sup&gt;, Batomayena Bakoma&lt;sup&gt;5&lt;/sup&gt; &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Laboratory of pharmaceutical sciences, Faculty of health sciences, Doctoral school ED732-STIS, University of Lome, 01 BP: 1515, Lome, TOGO.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Laboratory of applied agronomic and biological sciences (LaSABA), Faculty of sciences and techniques, University of Kara, BP: 404, Kara, TOGO.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Interdisciplinary research platform, University of life sciences “King Michael I” from Timisoara, Calea Aradului 119, 300645 Timisoara, ROMANIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Department of pharmacy, Laboratory of pharmacology-toxicology, Faculty of health sciences, University of Lomé, BP: 1515, Lome, TOGO.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Department of pharmacy, Laboratory of pharmaceutical sciences, Faculty of health sciences, University of Lomé, BP: 1515, Lome, TOGO.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Jorge Coronado-Olano</style></author><author><style face="normal" font="default" size="100%">Ritva Repo-Carrasco-Valencia</style></author><author><style face="normal" font="default" size="100%">Oscar Reategui</style></author><author><style face="normal" font="default" size="100%">Emily Toscano</style></author><author><style face="normal" font="default" size="100%">Elisa Valdez</style></author><author><style face="normal" font="default" size="100%">Mirko Zimic</style></author><author><style face="normal" font="default" size="100%">Ivan Best</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Inhibitory activity against α-amylase and α-glucosidase by phenolic compounds of quinoa (Chenopodium quinoa Willd.) and cañihua (Chenopodium pallidicaule Aellen) from the Andean region of Peru</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Andean grains</style></keyword><keyword><style  face="normal" font="default" size="100%">DPPH radical scavenging assay</style></keyword><keyword><style  face="normal" font="default" size="100%">HPLC-DAD</style></keyword><keyword><style  face="normal" font="default" size="100%">in vitro antidiabetic activity</style></keyword><keyword><style  face="normal" font="default" size="100%">Polyphenols</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2021</style></year><pub-dates><date><style  face="normal" font="default" size="100%">July 2021</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">13</style></volume><pages><style face="normal" font="default" size="100%">896-901</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background:&lt;/strong&gt; &lt;em&gt;Chenopodium quinoa&lt;/em&gt; Willd. and &lt;em&gt;Chenopodium pallidicaule&lt;/em&gt; Aellen are grains from the Andean region of Peru, which in addition to having a high nutritional value, have health-promoting properties related to the prevention of chronic diseases such as diabetes. &lt;strong&gt;Objetive:&lt;/strong&gt; The present study aimed to identify phenolic compounds associated with an inhibition of carbohydrate hydrolyzing enzymes associated with type 2 diabetes. &lt;strong&gt;Material and Methods: &lt;/strong&gt;Two varieties of quinoa and two varieties of cañihua from the Puno Region in Peru, were evaluated. Total phenolics, total flavonoids, identification of phenolic compounds and antioxidant activity &lt;em&gt;in vitro&lt;/em&gt; were measured by Folin-Ciocalteu assay, aluminum chloride colorimetric method, HPLC-DAD and DPPH radical scavenging assay, respectively. &lt;em&gt;In vitro &lt;/em&gt;hypoglycemic activity was evaluated through the inhibition of the α-amylase and α-glucosidase enzymes. Results: Gallic acid, rutin and chlorogenic acid were identified by HPLC-DAD in the varieties of quinoa and cañihua. The latter showed significantly higher levels of chlorogenic acid compared to quinoa varieties (&lt;em&gt;p&lt;/em&gt;&amp;lt;0.05). Both Andean grains exhibited inhibition of key-enzymes linked to type 2 diabetes, presenting IC&lt;sub&gt;50&lt;/sub&gt; values of 7.99 to 34.05 and of 8.07 to 1158 μg/mL for α-amylase and α-glucosidase, respectively. Total phenolics, total flavonoids, DPPH radical scavenging assay, gallic acid and chlorogenic acid showed the greatest contribution to the inhibitory activity of the α-glucosidase enzyme (&lt;em&gt;p&lt;/em&gt;&amp;lt;0.05). &lt;strong&gt;Conclusion:&lt;/strong&gt; Our findings suggest that the phenolic compounds present in the varieties of quinoa and cañihua could modulate the inhibition of carbohydrate hydrolyzing enzymes associated with type 2 diabetes.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">4</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">896</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Jorge Coronado-Olano&lt;sup&gt;1,5&lt;/sup&gt;, Ritva Repo-Carrasco-Valencia&lt;sup&gt;1&lt;/sup&gt;, Oscar Reategui&lt;sup&gt;2&lt;/sup&gt;, Emily Toscano&lt;sup&gt;3&lt;/sup&gt;, Elisa Valdez&lt;sup&gt;4&lt;/sup&gt;, Mirko Zimic&lt;sup&gt;3&lt;/sup&gt;, Ivan Best&lt;sup&gt;6,&lt;/sup&gt;*&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Facultad de Industrias Alimentarias, Universidad Nacional Agraria La Molina, Lima, PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Carrera de Ingeniería Agroforestal, Universidad Científica del Sur, Lima, PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Laboratorio de Bioinformática y Biología Molecular, Laboratorios de Investigación y Desarrollo (LID), Universidad Peruana Cayetano Heredia, Lima, PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Universidad Nacional Federico Villarreal, Lima, PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Hersil S. A. Laboratorios Industriales Farmacéuticos, Lima, PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;6&lt;/sup&gt;Unidad de Investigación en Nutrición, Salud, Alimentos Funcionales y Nutracéuticos, Universidad San Ignacio de Loyola (UNUSANUSIL), Calle Toulon 310, 15024 Lima, PERU.&lt;/p&gt;
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