<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Bannan Muthi'atul Af-idah</style></author><author><style face="normal" font="default" size="100%">Muhammad Hanafi</style></author><author><style face="normal" font="default" size="100%">Berna Elya</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Antioxidant and Alpha Glucosidase Inhibitor Screening of Merremia peltata L. as Potential Traditional Treatment for Diabetes Mellitus</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Alpha-glucosidase inhibitor</style></keyword><keyword><style  face="normal" font="default" size="100%">Antidiabetic</style></keyword><keyword><style  face="normal" font="default" size="100%">Antioxidant</style></keyword><keyword><style  face="normal" font="default" size="100%">Merremia peltata</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2021</style></year><pub-dates><date><style  face="normal" font="default" size="100%">July 2021</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">13</style></volume><pages><style face="normal" font="default" size="100%">902-908</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction: &lt;/strong&gt;&lt;em&gt;Merremia peltata&lt;/em&gt; is ethnomedicine plant used as traditional medicine in Sulawesi, Sumatra, Maluku and Papua. &lt;em&gt;M. peltata&lt;/em&gt; is used for diabetic. Diabetes mellitus therapy with inhibit activity of alpha glucosidase enzyme could delay absorption of monosaccharides after a meal and interrupt glucose transport into the circulation. &lt;strong&gt;Objective: &lt;/strong&gt;This research purpose is to investigate in vitro antioxidant activity and alpha glucosidase enzyme inhibitor leaves and stem extract of &lt;em&gt;M. peltata.&lt;/em&gt; Method: The Stem and leaves of &lt;em&gt;M. peltata &lt;/em&gt;were extracted sequentially using the UAE method using hexane, ethyl acetate, and methanol as mobile phase/solvent. The &lt;em&gt;M. peltata &lt;/em&gt;extracts were subjected to the antioxidant activity assay by the DPPH radical scavenging and FRAP method. Antidiabetic activity was determined by an enzymatic alpha glucosidase inhibitor. &lt;strong&gt;Result:&lt;/strong&gt; The extract which had best performance in antioxidant activity was stem ME with value of IC&lt;sub&gt;50 &lt;/sub&gt;in DPPH 47.41 μg/mL and total antioxidant power 340.04 μmol/g. This study showed that leaves and stem extract of M .peltata have potential alpha glucosidase inhibitors for diabetic therapy. Stem ME had the best activity with IC&lt;sub&gt;50 &lt;/sub&gt;value 47.44 μg/mL, almost two times better than acarbose as a positive control (IC&lt;sub&gt;50&lt;/sub&gt; = 98.38 μg/mL). Leaves ME, leaves EA, and stem EA also give better activity of alpha glucosidase inhibitors than acarbose with IC&lt;sub&gt;50 &lt;/sub&gt;value 67.24 μg/mL, 69.38 μg/mL, and 72.85 μg/mL, respectively.&lt;strong&gt; Conclusion: &lt;/strong&gt;&lt;em&gt;M. peltata &lt;/em&gt;has potential antioxidant and alpha glucosidase inhibitor activity for diabetic therapy.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">4</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">902</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Bannan Muthi'atul Af-idah&lt;sup&gt;1&lt;/sup&gt;, Muhammad Hanafi&lt;sup&gt;2&lt;/sup&gt;, Berna Elya&lt;sup&gt;1,&lt;/sup&gt;*&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Faculty of Pharmacy, Universitas Indonesia, Kampus UI Depok, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Indonesian Institute of Sciences and Faculty of Pharmacy, University of Pancasila, INDONESIA.&lt;/p&gt;
</style></auth-address></record></records></xml>