<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Sisilia Teresia Rosmala Dewi</style></author><author><style face="normal" font="default" size="100%">M Sabir</style></author><author><style face="normal" font="default" size="100%">Sesilia Rante Pakadang</style></author><author><style face="normal" font="default" size="100%">Sainal Edi Kamal</style></author><author><style face="normal" font="default" size="100%">Santi Sinala</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Anti-Cancer Potential of Nggorang Leaves Extract (Salvia Occidentalis SW.) as a Protein P53 Supressor in T47D Cells</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Anticancer</style></keyword><keyword><style  face="normal" font="default" size="100%">Nggorang Leaves Extract (Salvia occidentalis Sw)</style></keyword><keyword><style  face="normal" font="default" size="100%">Protein P53</style></keyword><keyword><style  face="normal" font="default" size="100%">T47D</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2021</style></year><pub-dates><date><style  face="normal" font="default" size="100%">July 2021</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">13</style></volume><pages><style face="normal" font="default" size="100%">1036-1045</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;Breast cancer is one of the most common types of cancer in women. The high incidence of breast cancer has led to the development of anticancer drugs that are more selective against cancer cells without damaging normal tissues. One of the alternatives in cancer treatment by looking for natural sources that can be developed, Nggorang leaves (&lt;em&gt;Salvia occidentalis &lt;/em&gt;Sw.). This plant is found in Tenda Village, Langke Rembong District, Manggarai Regency, NTT Province, when the leaves are harvested for one year and are used as medicine. As a preventive, this leaf has been used for generations as an anticancer (7 leaves boiled with 200 ml of water to 100 ml and then drunk), for wounded breast cancer (crushed leaves and attached to the wound); stamina enhancer, cough, influenza, hemorrhoids, diarrhea, nosebleeds (Primary data, 2014). This study aims to prove the potential of EDG (Nggorang Leaves Extract) as an antiproliferative against Hela cancer cells and protein P53 suppressor. The method used is the Quasy experiment, because this study uses laboratory tests in sample testing. The results of the cytotoxic test of Nggorang Leaves Extract have the potential to be anti-proliferative against cancer cells T47D IC50 at 201 ppm and Nggorang Leaves Extract (EDG) has the potential to increase p53 gene suppression in T47D cancer cells by 94.13% at a concentration of 50 ppm.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">4</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">1036</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Sisilia Teresia Rosmala Dewi&lt;sup&gt;1&lt;/sup&gt;, M. Sabir&lt;sup&gt;2&lt;/sup&gt;, Sesilia Rante Pakadang&lt;sup&gt;1&lt;/sup&gt;, Sainal Edi Kamal&lt;sup&gt;3&lt;/sup&gt;, Santi Sinala&lt;sup&gt;1,&lt;/sup&gt;*&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Health Polytechnic of the Makassar Ministry of Health, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Faculty of Medicine University of Tadulako Palu, INDONESIA. 3Polytechnic Sandi Karsa Makassar, INDONESIA.&lt;/p&gt;
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