<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Yousra.A. Nomier</style></author><author><style face="normal" font="default" size="100%">Anugeetha Thacheril Mohanan</style></author><author><style face="normal" font="default" size="100%">Walaa A. El-Dakroury</style></author><author><style face="normal" font="default" size="100%">Dallin A. Hassan</style></author><author><style face="normal" font="default" size="100%">Sermugapandian Nithya</style></author><author><style face="normal" font="default" size="100%">Aamena Jabeen</style></author><author><style face="normal" font="default" size="100%">Eman Merghani Ali Mohammed</style></author><author><style face="normal" font="default" size="100%">Moataz B. Zewail</style></author><author><style face="normal" font="default" size="100%">Gihan F. Asaad</style></author><author><style face="normal" font="default" size="100%">Zeinah Y. Abbady</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Overview of Cancer and Treatment Challenges: Harnessing the Anti-cancer Potential of Jasminum Sambac and its Nanoparticle Formulations</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Anti-cancer</style></keyword><keyword><style  face="normal" font="default" size="100%">Anti-oxidant</style></keyword><keyword><style  face="normal" font="default" size="100%">Cancer therapy</style></keyword><keyword><style  face="normal" font="default" size="100%">Cytotoxic</style></keyword><keyword><style  face="normal" font="default" size="100%">Jasminum Sambac</style></keyword><keyword><style  face="normal" font="default" size="100%">Nanoparticle</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2024</style></year><pub-dates><date><style  face="normal" font="default" size="100%">October 2024</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">16</style></volume><pages><style face="normal" font="default" size="100%">1069-1076</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;Cancer research strives to discover effective treatment strategies that target tumour cells while minimising the negative effects of traditional chemotherapy. Studies conducted on plant-based leads have yielded promising therapeutic activities, prompting researchers to remain vigilant in exploring further plant-based studies. Research has shown that phytochemicals found in the roots, leaves, and flowers of Jasminum sambac &lt;em&gt;(J.sambac&lt;/em&gt;) have demonstrated various active functions, including anti-inflammatory, antimicrobial, immunomodulatory, and anxiolytic effects. The progress made in nanoparticle drug delivery systems for cancer treatment is noteworthy as it allows for higher doses of medication to be delivered directly to cancer cells while minimising the negative impact on healthy cells. Various reports showcase the nanoparticle synthesis of &lt;em&gt;J.sambac&lt;/em&gt; for screening multiple diseases. This review provides an overview of cancer and the challenges of available treatments while exploring the potential of &lt;em&gt;J.sambac&lt;/em&gt; for its anticancer, cytotoxic, and antioxidant properties. Furthermore, it sheds light on the recent advances made in nanoparticle formulations of Jasminum sambac for cancer and other ailments. Disseminating these updates could encourage additional exploration into the potential anti-cancer properties of&lt;em&gt; J.sambac &lt;/em&gt;and foster the development of nanoparticles for more effective cancer treatment.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">1069</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p&gt;&lt;strong&gt;Yousra.A. Nomier&lt;sup&gt;1*&lt;/sup&gt;, Anugeetha Thacheril Mohanan&lt;sup&gt;2 &lt;/sup&gt;*, Walaa A. El-Dakroury&lt;sup&gt;3&lt;/sup&gt;, Dallin A. Hassan&lt;sup&gt;2&lt;/sup&gt;,&amp;nbsp;Sermugapandian Nithya&lt;sup&gt;4&lt;/sup&gt;, Aamena Jabeen&lt;sup&gt;5&lt;/sup&gt;, Eman Merghani Ali Mohammed&lt;sup&gt;6&lt;/sup&gt;,&amp;nbsp;Moataz B. Zewail&lt;sup&gt;3&lt;/sup&gt;, Gihan F. Asaad&lt;sup&gt;7&lt;/sup&gt; , Zeinah Y. Abbady&lt;sup&gt;8&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;1&lt;/sup&gt;Pharmacology and Clinical Pharmacy Department, College of Medicine and Health Sciences, Sultan Qaboos University, Muscat, OMAN.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;2&lt;/sup&gt;Pharmacology and Toxicology Department, College of Pharmacy, Jazan University, P.O Box 114, Postal code 45142, Jazan, KINGDOM OF SAUDI ARABIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Badr University in Cairo (BUC), Badr City, Cairo 11829, EGYPT.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;4&lt;/sup&gt;Department of Pharmacology, Sri Ramachandra Faculty of Pharmacy, Sri Ramachandra Institute of Higher Education and Research (SRIHER) (DU), Porur, Chennai 116, INDIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;5&lt;/sup&gt;Pharmaceutics Department, College of Pharmacy, Jazan University, P.O Box 114, Postal code 45142, Jazan, KINGDOM OF SAUDI ARABIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;6&lt;/sup&gt;Clinical Practice Department, College of Pharmacy, Jazan University, P.O Box 114, Postal code 45142, Jazan, KINGDOM OF SAUDI ARABIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;7&lt;/sup&gt;Pharmacology Department, Medical Division, National Research Centre (ID: 60014618), Dokki, Giza, EGYPT.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;8&lt;/sup&gt;Pharmacy College, German University, Cairo, EGYPT&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Janany Manimaran</style></author><author><style face="normal" font="default" size="100%">Daruliza Kernain Mohd Azman</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">RETRACTED: The Effects of Andrographolide on Apoptosis in PC-3 Cell Line Via the Involvement of Caspases 3, 8 And 9</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Andrographolide</style></keyword><keyword><style  face="normal" font="default" size="100%">Anti-cancer</style></keyword><keyword><style  face="normal" font="default" size="100%">Apoptosis</style></keyword><keyword><style  face="normal" font="default" size="100%">Caspase.</style></keyword><keyword><style  face="normal" font="default" size="100%">PC-3 cell line</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2023</style></year><pub-dates><date><style  face="normal" font="default" size="100%">August 2023</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">15</style></volume><pages><style face="normal" font="default" size="100%">612-621</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;The Article has been Retracted based on the Authors' Request.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">4</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">612</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Janany Manimaran, Daruliza Kernain Mohd Azman*&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;Institute for Research in Molecular Medicine, University of Science Malaysia, 11800 Gelugor, Pulau Pinang, MALAYSIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Asep Sukohar</style></author><author><style face="normal" font="default" size="100%">Suharyani</style></author><author><style face="normal" font="default" size="100%">Sutyarso</style></author><author><style face="normal" font="default" size="100%">Hendri Busman</style></author><author><style face="normal" font="default" size="100%">Nuning Nurcahyani</style></author><author><style face="normal" font="default" size="100%">Evi Kurniawaty</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Antioxidant and Cytotoxic Activities of Melinjo (Gnetum gnemon L.) Seed Fractions on HeLa Cell Line an In Vitro</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Anti-cancer</style></keyword><keyword><style  face="normal" font="default" size="100%">Antioxidant</style></keyword><keyword><style  face="normal" font="default" size="100%">Cytotoxic</style></keyword><keyword><style  face="normal" font="default" size="100%">HeLa.</style></keyword><keyword><style  face="normal" font="default" size="100%">Melinjo</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2022</style></year><pub-dates><date><style  face="normal" font="default" size="100%">June 2022</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">14</style></volume><pages><style face="normal" font="default" size="100%">559-564</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction&lt;/strong&gt;: Medicinal plants have been investigated for possible anti-cancer effects. One of them is&lt;em&gt; Gnetum gnemon&lt;/em&gt; L (melinjo). This study aims determined&lt;em&gt; in vitro &lt;/em&gt;antioxidant activity and the cytotoxic effects of polar, semipolar and non polar melinjo seed fractions againts HeLa cell line. &lt;strong&gt;Methods: &lt;/strong&gt;The melinjo seed were extracted with ethanol as a solvent. Then, the fractionation was done using liquidliquid extraction method with three different polarity solvent. Cytotoxic activity was carried out using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) colorimetric assay in HeLa cell lines at concentrations ranging from 25 to 400 μg/mL. Antioxidant activity was determined by the diphenyl picryl hidrazil (DPPH) radical scavenging method. &lt;strong&gt;Results: &lt;/strong&gt;Phytochemical screening indicated the presence of phyto-constituents like flavonoids, terpenoid and tanin. The DPPH scavenging activity by the melinjo seed aqueous, ethyl acetate and N-hexane fraction was 733,12 ± 18,95 μg/mL; 68,40 ± 1,9 μg/mL and 2035,70 ± 65,59 μg/mL, respectively. The cytotoxic activity of the melinjo seed fractions showed that the ethyl acetate was the most active fraction against HeLa cell line with IC&lt;sub&gt;50&lt;/sub&gt; value 45,27 μg/mL.&lt;strong&gt; Conclusion:&lt;/strong&gt; In this study, we have observed that the melinjo seed fractions exhibited antioxidant and cytotoxic activity against HeLa cell lines. This is presumably due to the content of phytochemicals and stilbenoids such as resveratrol and gnetin C. Melinjo seeds are more potent as anticancer Compared with other plants that also contain RSV such as grape extract (&lt;em&gt;Vitis vinifera&lt;/em&gt; L.) against lung cancer cells (A549). From the three fractions, the ethyl acetate fraction had the highest antioxidant and cytotoxic effect compared to the water and n-hexane fractions. &lt;em&gt;Gnetum gnemon&lt;/em&gt; L. can be considered as a potential source of anticancer agents. However, more research is needed to determine the mechanism of action.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><accession-num><style face="normal" font="default" size="100%">11</style></accession-num><section><style face="normal" font="default" size="100%">559</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Asep Sukohar1, Suharyani&lt;sup&gt;1,2,*&lt;/sup&gt;, Sutyarso&lt;sup&gt;2&lt;/sup&gt;, Hendri Busman&lt;sup&gt;2&lt;/sup&gt;, Nuning Nurcahyani&lt;sup&gt;2&lt;/sup&gt;, Evi Kurniawaty&lt;sup&gt;1&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Faculty of Medicine, University of Lampung, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Magister Biology, Faculty of Mathematics and Natural Sciences, University of Lampung, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Faris Alrumaihi</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Garlic and its Active Compounds: A Novel Strategy to Fight Diseases Through Modulating Biological Activities</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Ajoene</style></keyword><keyword><style  face="normal" font="default" size="100%">Allicin</style></keyword><keyword><style  face="normal" font="default" size="100%">Anti-cancer</style></keyword><keyword><style  face="normal" font="default" size="100%">Anti-inflammatory Effect</style></keyword><keyword><style  face="normal" font="default" size="100%">Anti-oxidant</style></keyword><keyword><style  face="normal" font="default" size="100%">Diallyl disulfide</style></keyword><keyword><style  face="normal" font="default" size="100%">Garlic</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2020</style></year><pub-dates><date><style  face="normal" font="default" size="100%">September 2020</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">12</style></volume><pages><style face="normal" font="default" size="100%">1463-1474</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;Throughout history, many plants and their products have been widely used as medicines for the prevention and treatment of different diseases in many cultures. &lt;em&gt;Garlic (Allium sativum)&lt;/em&gt;, is commonly used as a spice and traditionally used for its medicinal value since ancient times. Recent studies support the effects of garlic and its extracts in a wide range of applications. Due to the presence of sulfur containing compounds, high trace mineral content and enzymes, garlic has been reported to have implications in disease management and play a role as anti-diabetic, anti-microbial, anti-obesity, anti-oxidant and anti-tumor, dyslipidaemia effect, neuroprotective, cardio-preventive and photo-protection effects. It contains various active compound such as allicin, ajoene, diallyl disulfide and S-allyl-cysteine that modulates various biological cascades and prevent the pathogenesis. This review illustrates the role of garlic and their active ingredients in the health management based on in vivo and in vitro studies.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Review Article</style></work-type><section><style face="normal" font="default" size="100%">1463</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Faris Alrumaihi*&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;Department of Medical Laboratories, College of Applied Medical Sciences, Qassim University, Buraydah, SAUDI ARABIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Saleh A Almatroodi</style></author><author><style face="normal" font="default" size="100%">Mohammed A Alsahli</style></author><author><style face="normal" font="default" size="100%">Ahmad Almatroudi</style></author><author><style face="normal" font="default" size="100%">Arshad Husain Rahmani</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Ocimum sanctum: Role in Diseases Management Through Modulating Various Biological Activity </style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Anti-cancer</style></keyword><keyword><style  face="normal" font="default" size="100%">Anti-oxidant effect</style></keyword><keyword><style  face="normal" font="default" size="100%">Health promoting effect</style></keyword><keyword><style  face="normal" font="default" size="100%">Ocimum sanctum</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2020</style></year><pub-dates><date><style  face="normal" font="default" size="100%">August 2020</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">12</style></volume><pages><style face="normal" font="default" size="100%">1198-1205 </style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;Medicinal plants are used commonly by traditional medical practitioners in their daily practice for the treatment of various diseases. The treatment based on natural products are preferred because they are more economic and have lesser side-effects. In this regards, &lt;em&gt;Ocimum sanctum&lt;/em&gt; commonly known as holy basil or tulsi is used in the diseases cure and treatment since ancient time. &lt;em&gt;Ocimum sanctum &lt;/em&gt;has been proven health promoting effect through modulation of various biological activates. &lt;em&gt;Ocimum sanctum &lt;/em&gt;shows therapeutic role through its anti-oxidant, anti-inflammatory, anti-microbial, anti-diabetic, hepatoprotective and wound healing effects. Besides, the constituents of holy basil have been confirmed to have a noteworthy effect in cancer management through inhibition of cancer development and progression. Further, the synergistic effect of &lt;em&gt;Ocimum sanctum &lt;/em&gt;component with anti-cancer drugs has been proven as it reduces the growth of cancer. Molecular mechanism and human clinical trials based should be performed to avail its role in diseases cure and management. This review comprehensively summarizes the role of holy basil in disease management through&lt;em&gt; in vivo &lt;/em&gt;and&lt;em&gt; in vitro &lt;/em&gt;study.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><work-type><style face="normal" font="default" size="100%">Review Article</style></work-type><section><style face="normal" font="default" size="100%"> 1198</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Saleh A. Almatroodi, Mohammed A. Alsahli, Ahmad Almatroudi, Arshad Husain Rahmani*&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;Department of Medical Laboratories, College of Applied Medical Sciences, Buraydah 52571, Qassim University, SAUDI ARABIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Sharada L Deore</style></author><author><style face="normal" font="default" size="100%">Poonam B Bhansali</style></author><author><style face="normal" font="default" size="100%">Bhushan A Baviskar</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Pharmacognostic, Phytochemical and in vitro Biological Evaluation of Blepharis repens (Vahl) Roth</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Anti-cancer</style></keyword><keyword><style  face="normal" font="default" size="100%">Anti-microbial</style></keyword><keyword><style  face="normal" font="default" size="100%">Anti-oxidant</style></keyword><keyword><style  face="normal" font="default" size="100%">Bioautography</style></keyword><keyword><style  face="normal" font="default" size="100%">Blepharisrepens</style></keyword><keyword><style  face="normal" font="default" size="100%">HL-60</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2020</style></year><pub-dates><date><style  face="normal" font="default" size="100%">August 2020</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">12</style></volume><pages><style face="normal" font="default" size="100%">952-961</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;em&gt;Blepharis repens&lt;/em&gt; (Vahl) Roth of Acanthaceae family, commonly known as Hadsan in Marathi and Haridachchu in Kannada, is threatened species due to exploitation from natural habitat.&lt;strong&gt; Objectives: &lt;/strong&gt;The objective of present study is to establish scientifically well evaluated pharmacognostic and biological efficacy parameters. &lt;strong&gt;Methods: &lt;/strong&gt;Microscopical parameters of leaf, root and stem are evaluated. Powder microscopy, physicochemical analysis, elemental analysis, fluorescence analysis, preliminary phytochemical screening and estimation of major phytoconstituents of whole herb powder are carried out. &lt;em&gt;In vitro &lt;/em&gt;biological evaluation of Blepharisrepens carried out for antioxidant potential by DPPH method, &lt;em&gt;in vitro&lt;/em&gt; anticancer activity by SRB assay and antimicrobial efficacy by both agar well diffusion and bioautography methods. &lt;strong&gt;Results:&lt;/strong&gt; Morphologically, roots are cylindrical and elongated, leaf has symmetric base, entire margin, acute apex while stem is cylindrical, elongated. Microscopic evaluation reveals that both leaf and stem are covered with trichomes. Leaf has unicellular uniseriate trichomes while stem has multi-cellular uniseriate covering trichomes. Physicochemical evaluation revealed that total ash, acid insoluble ash and water-soluble ash values 13.85 7.7 and 3.1% respectively. Petroleum ether, alcohol and water extractive values found 0.84%, 1.64%, and 3.52% respectively. Loss on drying value is found 3.43%. Element analysis of whole herb confirms presence of nitrogen, sulphate and carbonate. Fluorescence tests are performed by treatment with different acids and alkalis and exposure to ultraviolet light. Phytochemical screening shows presence of carbohydrates, alkaloids, tannins, flavonoids and saponins. Estimation of phytochemicals like carbohydrate, alkaloid, tannin and flavonoid found 5.78%, 1.43%, 5.7% and 1.48% respectively. Biological evaluation reveals that plant has significant antioxidant and antimicrobial activity while plant is devoid of &lt;em&gt;in-vitro &lt;/em&gt;anticancer activity against human leukemia cell line HL-60.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">952</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Sharada L. Deore*, Poonam B. Bhansali, Bhushan A. Baviskar &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;Department of Pharmacognosy and Phytochemistry, Government College of Pharmacy, Kathora naka, Amravati (Maharashtra) 444604, INDIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Girish H V</style></author><author><style face="normal" font="default" size="100%">Vinod A B</style></author><author><style face="normal" font="default" size="100%">Dhananjaya B L</style></author><author><style face="normal" font="default" size="100%">Satish Kumar D</style></author><author><style face="normal" font="default" size="100%">Senthil Duraisamy</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">The Anticancer Potential of Pavonia odorata extract on Human Breast (MD-MB-231), Prostate (PC-3) and Lung (Calu-6) Cancer cell lines</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Alternative medicine</style></keyword><keyword><style  face="normal" font="default" size="100%">Anti-cancer</style></keyword><keyword><style  face="normal" font="default" size="100%">Drugs</style></keyword><keyword><style  face="normal" font="default" size="100%">Indian Medicinal plants</style></keyword><keyword><style  face="normal" font="default" size="100%">Inhibition.</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2016</style></year><pub-dates><date><style  face="normal" font="default" size="100%">09/2015</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">8</style></volume><pages><style face="normal" font="default" size="100%">28-30</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;margin-left: -9pt; text-align: justify;&quot;&gt;&lt;strong&gt;Introduction:&lt;/strong&gt; A huge reservoir of bioactive compounds exists in many species of plants, only a small percentage of which have been examined and continued to be an important source of anticancer agents. Worldwide effects are ongoing to identify new anticancer compounds from plants. With the current decline in the number of new molecular entities from the pharmaceutical industry, novel anticancer agents are being sought from traditional medicines. &lt;strong&gt;Objective:&lt;/strong&gt; In the present study we investigated the efficacy of methanol extracts of &lt;em&gt;Pavonia odorata, &lt;/em&gt;for its clonogenic inhibition on Human Breast cancer (MD-MB-231), Prostate cancer (PC-3) and Lung cancer (Calu-6) cell lines. &lt;strong&gt;Materials and&lt;/strong&gt; &lt;strong&gt;Methods:&lt;/strong&gt; The cytotoxic effect was evaluated by MTT assay. &lt;strong&gt;Results:&lt;/strong&gt; The methanol extract of &lt;em&gt;P. odorata &lt;/em&gt;showed significant cytotoxicity against MD-MB-231 and Calu-6, when compared to PC-3cells&lt;em&gt;. &lt;/em&gt;&lt;strong&gt;Conclusion:&lt;/strong&gt; The methanol extracts of &lt;em&gt;P. odorata, &lt;/em&gt;showed effective cytotoxic activities in a dose dependent manner. Future work will be interesting to know the chemical composition and also better understanding the mechanism of action will help in developing it as drug for therapeutic application.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">28</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Girish H V&lt;sup&gt;1&lt;/sup&gt;, Vinod A B&lt;sup&gt;1&lt;/sup&gt;, Dhananjaya B L&lt;sup&gt;2&lt;/sup&gt;, Satish Kumar D&lt;sup&gt;1&lt;/sup&gt; and Senthil Duraisamy&lt;sup&gt;1&lt;/sup&gt; &lt;/strong&gt;&lt;/p&gt;

&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Phytochemistry, G7 Synergon Private Limited, Tatanagar, Sahakarnagar Post, Bangalore, India.&lt;/p&gt;

&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Toxinology/Toxicology and Drug Discovery Unit, Centre for Emerging Technologies (CET), Jain University, Kanakpura Taluk, Ramanagara-562112, India.&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Suvitha Syam,</style></author><author><style face="normal" font="default" size="100%">Ahmad Bustamam,</style></author><author><style face="normal" font="default" size="100%">Rasedee Abdullah,</style></author><author><style face="normal" font="default" size="100%">Mohamed Aspollah Sukari,</style></author><author><style face="normal" font="default" size="100%">Najihah Mohd Hashim,</style></author><author><style face="normal" font="default" size="100%">Maizatulakmal Yahayu,</style></author><author><style face="normal" font="default" size="100%">Pouya Hassandarvish,</style></author><author><style face="normal" font="default" size="100%">Syam Mohan,</style></author><author><style face="normal" font="default" size="100%">Siddig Ibrahim Abdelwahab</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Cytotoxicity and Oral Acute Toxicity Studies of b-mangostin Isolated from Cratoxylum arborescens</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Acute toxicity</style></keyword><keyword><style  face="normal" font="default" size="100%">Anti-cancer</style></keyword><keyword><style  face="normal" font="default" size="100%">Cratoxylum arborescens</style></keyword><keyword><style  face="normal" font="default" size="100%">β-mangostin</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2014</style></year><pub-dates><date><style  face="normal" font="default" size="100%">18th Feb,2014</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">6</style></volume><pages><style face="normal" font="default" size="100%">47-56</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Introduction:&lt;/strong&gt; The objective of this study was to investigate the cytotoxicity and oral acute toxicity of &amp;beta;-mangostin isolated from &lt;em&gt;Cratoxylum arborescens&lt;/em&gt;. Material and methods: Healthy male and female ICR mice (8 weeks) were fed orally with 250 and 500mg/kg of &amp;beta;-mangostin. Body weight of each animal was measured and any gross behavioral change was observed daily. Hematological and clinical biochemical parameters as well as histopathological analysis were carried out on 15th day. The level of oxidative stress was analyzed using MDA and GSH measurement.&lt;strong&gt;Discussion:&lt;/strong&gt; The results showed that oral administration of the &amp;beta;-mangostin had no adverse effect on the growth rate, hematological and clinical biochemical parameters. Histological studies showed that the treatments did not induce any pathological changes in the liver and kidney. The compound at both the doses did not alter the oxidative stress biomarkers. The &lt;em&gt;in vitro&lt;/em&gt; cytotoxicity of &amp;beta; Mangostin was investigated in HepG2, A549, MCF-7, MDA-MB-231 and PC3 cells. There was significant cytotoxicity in both type of breast cancer cells (MCF-7 and MDA-MB-231). In conclusion, our results show that there was no treatment-related acute toxicity in mice following 14-days oral administration of 250 and 500mg/kg of &amp;beta;-mangostin. &lt;strong&gt;Conclusion:&lt;/strong&gt; The results showed that the compound can be selected for detailed &lt;em&gt;in vitro&lt;/em&gt; and &lt;em&gt;in vivo&lt;/em&gt; breast cancer research.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Key words: &lt;/strong&gt;&lt;em&gt;Cratoxylum arborescens&lt;/em&gt;, β-mangostin, acute toxicity, anti-cancer.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Suvitha Syam&lt;sup&gt;*,1&lt;/sup&gt;, Ahmad Bustamam&lt;sup&gt;1,*&lt;/sup&gt;, Rasedee Abdullah&lt;sup&gt;2&lt;/sup&gt;, Mohamed Aspollah Sukari&lt;sup&gt;3&lt;/sup&gt;, Najihah Mohd Hashim&lt;sup&gt;4&lt;/sup&gt;, Maizatulakmal Yahayu&lt;sup&gt;4&lt;/sup&gt;, Pouya Hassandarvish&lt;sup&gt;4&lt;/sup&gt;, Syam Mohan&lt;sup&gt;5&lt;/sup&gt; and Siddig Ibrahim Abdelwahab&lt;/strong&gt;&lt;sup&gt;&lt;strong&gt;5&lt;/strong&gt;&lt;/sup&gt;&lt;/p&gt;&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;UPM-MAKNA Cancer Research Laboratory, Institute of Bioscience, University Putra Malaysia, Serdang, Selangor, Malaysia,&lt;/p&gt;&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Veterinary Pathology and Microbiology, Faculty of Veterinary, University Putra Malaysia, Serdang, Selangor, Malaysia,&lt;/p&gt;&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Chemistry, Faculty of Science, University Putra Malaysia, Serdang, Selangor, Malaysia,&lt;/p&gt;&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Department of Pharmacy, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia,&lt;/p&gt;&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Medical Research Centre, Jazan University, P.O. Box 114 Jazan, Kingdom of Saudi Arabia.&lt;/p&gt;</style></auth-address></record></records></xml>