<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Nur Sofiatul Aini</style></author><author><style face="normal" font="default" size="100%">Viol Dhea Kharisma</style></author><author><style face="normal" font="default" size="100%">Muhammad Hermawan Widyananda</style></author><author><style face="normal" font="default" size="100%">Ahmad Affan Ali Murtadlo</style></author><author><style face="normal" font="default" size="100%">Rasyadan Taufiq Probojati</style></author><author><style face="normal" font="default" size="100%">Dora Dayu Rahma Turista</style></author><author><style face="normal" font="default" size="100%">Muhammad Badrut Tamam</style></author><author><style face="normal" font="default" size="100%">Vikash Jakhmola</style></author><author><style face="normal" font="default" size="100%">Dony Novaliendry</style></author><author><style face="normal" font="default" size="100%">Riso Sari Mandeli</style></author><author><style face="normal" font="default" size="100%">Budhi Oktavia</style></author><author><style face="normal" font="default" size="100%">Muhammad Thoriq Albari</style></author><author><style face="normal" font="default" size="100%">Saddam Al Aziz</style></author><author><style face="normal" font="default" size="100%">Muhammad Raffi Ghifari</style></author><author><style face="normal" font="default" size="100%">Okta Suryani</style></author><author><style face="normal" font="default" size="100%">Putri Azhari</style></author><author><style face="normal" font="default" size="100%">Muhammad Arya Ghifari</style></author><author><style face="normal" font="default" size="100%">Devi Purnamasari</style></author><author><style face="normal" font="default" size="100%">Agariadne Dwinggo Samala</style></author><author><style face="normal" font="default" size="100%">Mirella Fonda Maahury</style></author><author><style face="normal" font="default" size="100%">ANM Ansori</style></author><author><style face="normal" font="default" size="100%">Rahadian Zainul</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Bioactive Compounds from Purslane (Portulaca oleracea L.) and Star Anise (Illicium verum Hook) as SARS-CoV-2 Antiviral Agent via Dual Inhibitor Mechanism: In Silico Approach</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Antiviral agent</style></keyword><keyword><style  face="normal" font="default" size="100%">Illicium verum Hook</style></keyword><keyword><style  face="normal" font="default" size="100%">in silico</style></keyword><keyword><style  face="normal" font="default" size="100%">Portulaca oleracea L.</style></keyword><keyword><style  face="normal" font="default" size="100%">SARS-CoV-2</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2022</style></year><pub-dates><date><style  face="normal" font="default" size="100%">August 2022</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">14</style></volume><pages><style face="normal" font="default" size="100%">352-357</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes the COVID-19 pandemic that infects humans and attacks the body's immune system. The purpose of the study was to identify the potential of bioactive compounds in purslane (&lt;em&gt;Portulaca oleracea&lt;/em&gt; L.) and star anise (&lt;em&gt;Illicium verum&lt;/em&gt; Hook) via a dual inhibitor mechanism against SARS-CoV-2 proteases with an&lt;em&gt; in silico &lt;/em&gt;approach. The samples were obtained from PubChem and RSCB PDB. Antivirus probability prediction was performed on PASS Online. Virtual screening was performed with PyRx via molecular docking. Visualization was used by PyMol and Discovery Studio. Compounds with the best antiviral potential are indicated by the low binding affinity value to the target proteins, namely SARS-CoV-2 TMPRSS2 and PLpro. The results showed that purslane luteolin has the best antiviral potential. However, further studies are required to validate this computational prediction.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">4</style></issue><work-type><style face="normal" font="default" size="100%">Original Article </style></work-type><accession-num><style face="normal" font="default" size="100%">14</style></accession-num><section><style face="normal" font="default" size="100%">352</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Nur Sofiatul Aini&lt;sup&gt;1&lt;/sup&gt;, Viol Dhea Kharisma&lt;sup&gt;2&lt;/sup&gt;, Muhammad Hermawan Widyananda&lt;sup&gt;2,3&lt;/sup&gt;, Ahmad Affan Ali Murtadlo&lt;sup&gt;2&lt;/sup&gt;, Rasyadan Taufiq Probojati&lt;sup&gt;2,4&lt;/sup&gt;, Dora Dayu Rahma Turista&lt;sup&gt;5&lt;/sup&gt;, Muhammad Badrut Tamam&lt;sup&gt;6&lt;/sup&gt;, Vikash Jakhmola&lt;sup&gt;7&lt;/sup&gt;, Dony Novaliendry&lt;sup&gt;8,9&lt;/sup&gt;, Riso Sari Mandeli&lt;sup&gt;8,10&lt;/sup&gt;, Budhi Oktavia&lt;sup&gt;8,11&lt;/sup&gt;, Muhammad Thoriq Albari&lt;sup&gt;8,12&lt;/sup&gt;, Saddam Al Aziz&lt;sup&gt;8,13&lt;/sup&gt;, Muhammad Raffi Ghifari&lt;sup&gt;8,12&lt;/sup&gt;, Okta Suryani&lt;sup&gt;8,11&lt;/sup&gt;, Putri Azhari&lt;sup&gt;8,14&lt;/sup&gt;, Muhammad Arya Ghifari&lt;sup&gt;8,12&lt;/sup&gt;, Devi Purnamasari&lt;sup&gt;8,15,&lt;/sup&gt; Agariadne Dwinggo Samala&lt;sup&gt;8,16&lt;/sup&gt;, Mirella Fonda Maahury&lt;sup&gt;17&lt;/sup&gt;, ANM Ansori&lt;sup&gt;18&lt;/sup&gt;, Rahadian Zainul&lt;sup&gt;8,11,*&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Faculty of Mathematics and Natural Sciences, State University of Surabaya, Surabaya, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Division of Molecular Biology and Genetics, Generasi Biologi Indonesia Foundation, Gresik, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Biology, Faculty of Mathematics and Natural Sciences, Brawijaya University, Malang, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Faculty of Agriculture, Universitas Kadiri, Kediri, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Biology Education Department, Faculty of Teacher Training and Education, Mulawarman University, Samarinda, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;6&lt;/sup&gt;Department of Biology, Faculty of Sciences and Technology, Universitas Muhammadiyah Lamongan, Lamongan, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;7&lt;/sup&gt;Uttaranchal Institute of Pharmaceutical Sciences, Uttaranchal University, Dehradun, INDIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;8&lt;/sup&gt;Center for Advanced Material Processing, Artificial Intelligence, and Biophysics Informatics (CAMP-BIOTICS), Universitas Negeri Padang, Padang, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;9&lt;/sup&gt;Study Program of Informatics, Faculty of Engineering, Universitas Negeri Padang, Padang, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;10&lt;/sup&gt;Environmental Science, Postgraduate Programme, Universitas Negeri Padang, Padang, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;11&lt;/sup&gt;Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Negeri Padang, Padang, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;12&lt;/sup&gt;Department of Information Technology, Faculty of Computer Sciences, Universitas Brawijaya, Malang, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;13&lt;/sup&gt;Department Mathematics Education, Faculty of Mathematics and Natural Sciences, Universitas Negeri Padang, Padang, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;14&lt;/sup&gt;Department of Agricultural Technology, Faculty of Agricultural Technology, Andalas University, Padang, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;15&lt;/sup&gt;Department of Radiology Engineering, Universitas Awal Bros, Pekanbaru, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;16&lt;/sup&gt;Department Informatics and Computer Engineering Education, Faculty of Engineering, Universitas Negeri Padang, Padang, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;17&lt;/sup&gt;Chemistry Department, Faculty Mathematics and Natural Sciences, Universitas Pattimura, Ambon, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;18&lt;/sup&gt;Professor Nidom Foundation, Surabaya, INDONESIA&lt;/p&gt;
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