<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Fitria Agustina</style></author><author><style face="normal" font="default" size="100%">Fadilah Fadilah</style></author><author><style face="normal" font="default" size="100%">Wimpie Pangkahila</style></author><author><style face="normal" font="default" size="100%">Anak Agung Gde Putra Wiraguna</style></author><author><style face="normal" font="default" size="100%">I Gusti Ayu Sri Mahendra Dewi</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Study of Sericin Sequences from Bombyx mori as Antiaging through ROS with Molecular Simulation and DPPH Evaluation</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">DPPH.</style></keyword><keyword><style  face="normal" font="default" size="100%">LOX</style></keyword><keyword><style  face="normal" font="default" size="100%">ROS</style></keyword><keyword><style  face="normal" font="default" size="100%">Sericin</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2022</style></year><pub-dates><date><style  face="normal" font="default" size="100%">October 2022</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">14</style></volume><pages><style face="normal" font="default" size="100%">632-641</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;The presence of ROS is associated with aging, which is damage caused by free radical reactions. ROS causes oxidation of low density lipoprotein (LDL), which builds up in plaque and contributes to inflammation. With aldehyde secondary products of lipid peroxidation such as Malondialdehyde (MDA), lipoxygenase, and xanthine oxidase as markers of oxidative stress, oxidized LDL causes endothelial dysfunction and cell apoptosis. The antioxidant 1,1 diphenyl-2-picrylhydrazyl (DPPH) sericin from &lt;em&gt;Bombyx mori&lt;/em&gt; was tested &lt;em&gt;in silico&lt;/em&gt; and &lt;em&gt;in vitro&lt;/em&gt; in this study. The &lt;em&gt;Bombyx mori&lt;/em&gt; peptide sequences QAYADYHSDPNGGSA (SP4) and ASSSFDASSA (SP7) had lower Gibbs energy for lipooxygenase (LOX) than native ligands, with values of -23.1044, -21.0056, and -10.3275 kcal/mol, respectively. hydrogen bonding to Gln289, Asp293, and Gly569. While ASSSFDASSA (SP7) has a higher Gibbs energy for xanthine oxidase (XOX), SEASSSTQATTVS (SP 5) has a lower Gibbs energy with values of -20.1839, -17.8952, and -11.8921 kcal/mol, respectively. While the cavity binding of the xanthine oxidase peptide binding SP5 and SP7 is located at the Glu802, Asp872, and Ser876 binding sites, the DPPH test confirmed&lt;em&gt; in vitro&lt;/em&gt; that the 10% sericin Gel had an IC50 of 19.7394 ppm compared to 3.71 ppm ascorbic acid. The findings of the preceding study demonstrate that sericin, as an antioxidant, is one of the candidates for antiaging.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">632</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Fitria Agustina&lt;sup&gt;1,*&lt;/sup&gt;, Fadilah Fadilah&lt;sup&gt;2&lt;/sup&gt;, Wimpie Pangkahila&lt;sup&gt;3&lt;/sup&gt;, Anak Agung Gde Putra Wiraguna&lt;sup&gt;4&lt;/sup&gt;, I Gusti Ayu Sri Mahendra Dewi&lt;sup&gt;5&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Doctoral Program in Anti-Aging Medicine, Faculty of Medicine, Universitas Udayana, Bali, INDONESIA. Dermatovenereolgist, FitSkinClinic, Bekasi, INDONESIA&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Medical Chemistry, Universitas Indonesia, Bioinformatics Core Facilities - IMERI, Faculty of Medicine, Universitas Indonesia, Jakarta, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Concentration in Anti-Aging Medicine, Master Program in Biomedical Science, Faculty of Medicine, Universitas Udayana, Bali, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Dermatology and Venereology Department, Faculty of Medicine, Universitas Udayana, Bali, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Pathology Anatomy Department, Faculty of Medicine, Universitas Udayana, Bali, INDONESIA.&lt;/p&gt;
</style></auth-address></record></records></xml>