<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Desi Novianti</style></author><author><style face="normal" font="default" size="100%">I Nyoman Ehrich Lister</style></author><author><style face="normal" font="default" size="100%">Ali Napiah Nasution</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Hepatoprotective Potential of Coffea arabica Extract Against Carbon Tetrachloride Induced Liver Damage: Ultrasonographic and Cytokine Evaluation</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">CCl₄</style></keyword><keyword><style  face="normal" font="default" size="100%">Coffea arabica</style></keyword><keyword><style  face="normal" font="default" size="100%">Cytokines</style></keyword><keyword><style  face="normal" font="default" size="100%">Hepatotoxicity</style></keyword><keyword><style  face="normal" font="default" size="100%">liver protection</style></keyword><keyword><style  face="normal" font="default" size="100%">Ultrasonographic</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2025</style></year><pub-dates><date><style  face="normal" font="default" size="100%">December 2025</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">17</style></volume><pages><style face="normal" font="default" size="100%">742-750</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;Carbon tetrachloride (CCl₄) is a hepatotoxic agent widely used to model liver injury in experimental animals, and coffee (&lt;em&gt;Coffea arabica&lt;/em&gt;) extract is known to contain various bioactive compounds with antioxidant and anti-inflammatory potential. This study aimed to evaluate the hepatoprotective activity of &lt;em&gt;Coffea arabica&lt;/em&gt; extract in male Wistar rats induced with CCl₄ through phytochemical analysis, liver biochemical parameters (albumin, bilirubin, SGOT, SGPT), inflammatory cytokines (TNF-α, IL-6, CRP), and liver morphology observations using ultrasonography and histopathology. The extract contained alkaloids, flavonoids, triterpenoids, saponins, and glycosides, with total phenolic and flavonoid contents of 51.32 mg GAE/g and 1.25 mg QE/g extract, respectively, and moderate antioxidant activity (IC₅₀ = 124.36 ppm). Administration of the extract at 300 mg/kg BW significantly improved liver structure, reduced TNF-α (120.62 ± 21.78 pg/mL), IL-6 (68 ± 14.44 pg/mL), CRP (199.0 ± 41.5 pg/mL), SGOT (147.0 ± 34.28 g/dL), and SGPT (69.6 ± 9.94 g/dL) levels, while increasing albumin (2.94 ± 0.34 g/dL) and reducing bilirubin (0.09 ± 0.04 mg/dL), approaching normal conditions. The 300 mg/kg BW dose showed the most optimal protective effect compared to other treatment groups, as evidenced by improvements in biochemical parameters, liver morphology, and hepatic histology, indicating that &lt;em&gt;Coffea arabica&lt;/em&gt; extract has strong potential as an effective hepatoprotective agent against CCl₄-induced liver damage&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">742</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Desi Novianti&lt;sup&gt;1*&lt;/sup&gt;, I Nyoman Ehrich Lister&lt;sup&gt;2&lt;/sup&gt;, Ali Napiah Nasution&lt;sup&gt;2&lt;/sup&gt; &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Doctoral Program, Faculty of Medicine, Dentistry, and Health Science, Universitas Prima Indonesia, Medan 20118, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Family Medicine, Faculty of Medicine, Dentistry, and Health Science, Universitas Prima Indonesia, Medan 20118, INDONESIA&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Ica Yulianti Pulungan</style></author><author><style face="normal" font="default" size="100%">Ermi Girsang</style></author><author><style face="normal" font="default" size="100%">Ermi Girsang</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Protective Role of Centella asiatica Extract Against Carbon Tetrachloride–Induced Hepatic Damage: A Biochemical and Ultrasonographic Study</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Anti-inflammatory</style></keyword><keyword><style  face="normal" font="default" size="100%">Antioxidant</style></keyword><keyword><style  face="normal" font="default" size="100%">Centella asiatica</style></keyword><keyword><style  face="normal" font="default" size="100%">Cytokines</style></keyword><keyword><style  face="normal" font="default" size="100%">Hepatoprotective</style></keyword><keyword><style  face="normal" font="default" size="100%">Ultrasonography</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2025</style></year><pub-dates><date><style  face="normal" font="default" size="100%">December 2025</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">17</style></volume><pages><style face="normal" font="default" size="100%">760-769</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;This study aimed to evaluate the hepatoprotective activity of &lt;em&gt;Centella asiatica&lt;/em&gt; extract on Wistar rats induced with carbon tetrachloride (CCl&lt;sub&gt;₄&lt;/sub&gt;). The extract is known to contain active compounds such as flavonoids, phenolics, and triterpenoids, which contribute to its antioxidant and anti-inflammatory effects. The total phenolic and flavonoid contents were 70.31 mg GAE/g and 13.49 mg QE/g, respectively, with very strong antioxidant activity (IC&lt;sub&gt;₅₀&lt;/sub&gt; = 48.45 ppm). Evaluation through ultrasonography and histopathology revealed structural improvement in the liver of treated groups, particularly at doses of 200 and 300 mg/ kgBW, marked by reduced abnormal echogenicity and improved liver parenchyma, along with a decrease in histopathological score from 2 to 1. The administration of the extract also significantly reduced proinflammatory cytokines TNF-α and IL-6 (P≤0.05), as well as CRP levels, indicating strong anti-inflammatory potential. In addition, liver function showed meaningful recovery, with the highest albumin level recorded at 200 mg/kgBW (3.00 ± 0.52 g/dL), and a significant reduction in bilirubin level at 300 mg/kgBW to 0.102 ± 0.040 mg/dL. Significant decreases were also observed in SGOT and SGPT enzyme levels in the treatment groups, especially at 300 mg/kgBW, indicating protection of hepatocyte integrity. In conclusion, this study demonstrated that Centella asiatica extract possesses hepatoprotective effects through antiinflammatory, antioxidant, and liver function-restorative mechanisms. These findings support the potential development of pegagan as a phytopharmaceutical agent for adjunct therapy in liver disorders and highlight the need for further studies on its active compounds and long-term safety.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">760</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Ica Yulianti Pulungan&lt;sup&gt;1*&lt;/sup&gt;, Ermi Girsang&lt;sup&gt;2&lt;/sup&gt;, Yolanda Eliza Putri Lubis&lt;sup&gt;3&lt;/sup&gt; &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Doctoral Program, Faculty of Medicine, Dentistry, and Health Science, Universitas Prima Indonesia, Medan 20118, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Biochemistry and Molecular Biology, Faculty of Medicine, Dentistry, and Health Science, Universitas Prima Indonesia, Universitas Prima Indonesia, Medan 20118, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Public Health and Preventive Medicine, Faculty of Medicine, Dentistry, and Health Science, Universitas Prima Indonesia, Universitas Prima Indonesia, Medan 20118, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Muhammad Arifin Parenrengi</style></author><author><style face="normal" font="default" size="100%">Ahmad Data Dariansyah</style></author><author><style face="normal" font="default" size="100%">Wihasto Suryaningtyas</style></author><author><style face="normal" font="default" size="100%">Dyah Fauziah</style></author><author><style face="normal" font="default" size="100%">I Ketut Sudiana</style></author><author><style face="normal" font="default" size="100%">Budi Utomo</style></author><author><style face="normal" font="default" size="100%">Prastiya Indra Gunawan</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Effects of Cerebrospinal Fluid Drainage on Pro-Inflammatory and Anti-Inflammatory Cytokines Expression in the Subventricular Zone of Kaolin-Induced Hydrocephalic Rats</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">cerebrospinal fluid drainage</style></keyword><keyword><style  face="normal" font="default" size="100%">Cytokines</style></keyword><keyword><style  face="normal" font="default" size="100%">Kaolin-induced hydrocephalus</style></keyword><keyword><style  face="normal" font="default" size="100%">Neuroinflammation</style></keyword><keyword><style  face="normal" font="default" size="100%">Neuroprotective</style></keyword><keyword><style  face="normal" font="default" size="100%">subventricular zone</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2024</style></year><pub-dates><date><style  face="normal" font="default" size="100%">February 2024</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">16</style></volume><pages><style face="normal" font="default" size="100%">20-27</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background:&lt;/strong&gt; To determine the neuroprotective effect of CSF drainage by analyzing its impact on the expression and the ratio of pro- and anti-inflammatory cytokines in the subventricular zone in kaolininduced hydrocephalic rats. &lt;strong&gt;Method:&lt;/strong&gt; Sprague-Dawley rats of 23 weeks of age (n=36) were used in this study. The rats were randomly divided into normal control, hydrocephalus, and CSF drainage-treated groups. Hydrocephalus was obtained by injecting 0,05 cc of 20% kaolin suspension into the cisterna magna. The CSF drainage-treated group had ventricular tapping seven days after kaolin induction. The rats were sacrificed 7, 14, or 21 days after kaolin induction. The brain was removed and prepared for immunohistochemistry analysis to detect IL-1&lt;em&gt;β&lt;/em&gt;, IL-6, TNF-&lt;em&gt;α&lt;/em&gt;, and IL-10 cytokines expression. &lt;strong&gt;Results: &lt;/strong&gt;Immunohistochemistry analysis revealed that the expression of pro-inflammatory cytokines was significantly increased in hydrocephalus groups than in the control group. In contrast, the expression of anti-inflammatory cytokine was significantly decreased. CSF drainage had a neuroprotective effect by reducing pro-inflammatory cytokine expression and increasing anti-inflammatory cytokine expression. In the hydrocephalus group, the ratios of IL-1&lt;em&gt;β&lt;/em&gt;/IL-10, IL-6/IL-10, and TNF-&lt;em&gt;α&lt;/em&gt;/IL-10 increased toward a pro-inflammatory status. After CSF drainage, the ratios of IL-1&lt;em&gt;β&lt;/em&gt;/IL-10, IL-6/IL-10, and TNF-&lt;em&gt;α&lt;/em&gt;/IL-10 shifted toward an anti-inflammatory status. &lt;strong&gt;Conclusion: &lt;/strong&gt;CSF drainage protects the brain from excessive neuroinflammatory processes in kaolin-induced hydrocephalic rats. Additional investigation is warranted to ascertain the use of inflammatory cytokines expression as a valuable biomarker for hydrocephalus. Furthermore, research on anti-inflammatory drug administration in clinical settings is required.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">20</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p&gt;&lt;strong&gt;Muhammad Arifin Parenrengi&lt;sup&gt;1,*&lt;/sup&gt;, Ahmad Data Dariansyah&lt;sup&gt;1&lt;/sup&gt;, Wihasto Suryaningtyas&lt;sup&gt;1&lt;/sup&gt;, Dyah Fauziah&lt;sup&gt;2&lt;/sup&gt;, I Ketut Sudiana&lt;sup&gt;2&lt;/sup&gt;, Budi Utomo&lt;sup&gt;3&lt;/sup&gt;, Prastiya Indra Gunawan&lt;sup&gt;4&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Neurosurgery, Faculty of Medicine, Universitas Airlangga - Dr. Soetomo General Academic Hospital, Surabaya, INDONESIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Anatomical Pathology, Faculty of Medicine, Universitas Airlangga, Surabaya, INDONESIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Public Health and Preventive Medicine, Faculty of Medicine, Universitas Airlangga, Surabaya, INDONESIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;4&lt;/sup&gt;Department of Child Health, Faculty of Medicine, Universitas Airlangga, Surabaya, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Maslichah Mafruchati</style></author><author><style face="normal" font="default" size="100%">Wan Irjani Wan Ismail</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">The Aqueous Leaf Extract of Moringa Oleifera had Immunomodulatory Effects on Sheep that had Been Infected by Fasciola Gigantica, Clostridium Novyi Naturally and Impact to Fasciola gigantica Non-Embryonated</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Anthelmintic</style></keyword><keyword><style  face="normal" font="default" size="100%">Antimicrobial</style></keyword><keyword><style  face="normal" font="default" size="100%">Cytokines</style></keyword><keyword><style  face="normal" font="default" size="100%">Moringa oleifera</style></keyword><keyword><style  face="normal" font="default" size="100%">Public health.</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2023</style></year><pub-dates><date><style  face="normal" font="default" size="100%">April 2023</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">15</style></volume><pages><style face="normal" font="default" size="100%">304-309</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;M., which received a (C), was the study's main objective. The whole thing was eaten. a couple of quotes from (C. dispersed in a liquid. has antibacterial properties (&lt;em&gt;E. elegans&lt;/em&gt;). It's necessary to remove the body. C. Eczema on the face is comparable to this. Sheep and novyi both had organic infections. &lt;em&gt;novyi.&lt;/em&gt; Following different combinations of treatments, a heavy dose of treatment, and a light dose, fasciolitis manifested in all three groups of infected sheep. The treatment groups received an oral 150 mg/kg aqueous &lt;em&gt;M. oleifera &lt;/em&gt;leaf extract every 48 hours for 21 days. Body mass, fecal egg counts, blood anti-Fasciola IgG levels, cytokines (IL-2, IL-17, and IL-10), and C. the elegans' bacterial inhabitants jokingly strike up a conversation with everyone there. Sheep with light and heavy infections gained more weight after receiving &lt;em&gt;M. oleifera&lt;/em&gt; treatment and had lower fecal egg counts than control groups; sheep with light infection had a 100% reduction in egg count. The serum concentrations of IL-2, IL-17, and IgG all significantly decreased after M. oleifera treatment. There were significantly higher levels of IL-10 in sheep with both mild and severe infections. C's feces contained noticeably fewer bacteria after taking moringa extract. The two novyi groups had varying degrees of infection severity. Fabricio (F. (as well as OleiferaMdot). C. &lt;em&gt;noteworthy&lt;/em&gt; and &lt;em&gt;novyi.&lt;/em&gt; M. oleifera aqueous extracts showed a concentration-dependent ovicidal effect on F. gigantica non-embryonated.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">2</style></issue><work-type><style face="normal" font="default" size="100%">Original Article </style></work-type><section><style face="normal" font="default" size="100%">304</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Maslichah Mafruchati&lt;sup&gt;1,*&lt;/sup&gt;, Wan Irjani Wan Ismail&lt;sup&gt;2&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Veterinary Anatomy, Faculty of Veterinary Medicine (60115), UniversitasAirlangga, Mulyorejo, C Campus, Surabaya, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Science and Marine Environment, Universiti Malaysia Terengganu, Terengganu, MALAYSIA.&lt;/p&gt;
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