<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Adyan Donastin</style></author><author><style face="normal" font="default" size="100%">Muhammad Amin</style></author><author><style face="normal" font="default" size="100%">Yulistiani</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Mechanism of High Dosage Vitamin D Supplementation on The Lung Function and Quality of Life of Stable COPD Patients</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">6MWT</style></keyword><keyword><style  face="normal" font="default" size="100%">COPD</style></keyword><keyword><style  face="normal" font="default" size="100%">FEF25-75</style></keyword><keyword><style  face="normal" font="default" size="100%">FEV1</style></keyword><keyword><style  face="normal" font="default" size="100%">FVC</style></keyword><keyword><style  face="normal" font="default" size="100%">HDAC2</style></keyword><keyword><style  face="normal" font="default" size="100%">MDA</style></keyword><keyword><style  face="normal" font="default" size="100%">MMP-9</style></keyword><keyword><style  face="normal" font="default" size="100%">Nrf2</style></keyword><keyword><style  face="normal" font="default" size="100%">Oxidative stress</style></keyword><keyword><style  face="normal" font="default" size="100%">QOL.</style></keyword><keyword><style  face="normal" font="default" size="100%">Vitamin D</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2023</style></year><pub-dates><date><style  face="normal" font="default" size="100%">June 2023</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">15</style></volume><pages><style face="normal" font="default" size="100%">274-278</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background: &lt;/strong&gt;Oxidative stress results from the amplification mechanism of COPD, which leads to decreased lung function and the quality of life of the sufferers. Vitamin D has a function in reducing oxidative stress levels through several mechanisms, which can be revealed by analyzing several biomarkers to determine the role of vitamin D on lung function and the quality of life of stable COPD patients. &lt;strong&gt;Methods: &lt;/strong&gt;The subjects included GOLD 2 and 3 stable COPD patients who had 25(OH)D levels of &amp;lt; 32 ng/ml and were receiving bronchodilator Indacaterol maleate therapy. The biomarkers examined included Nrf2, HDAC2, MDA, MMP-9, pulmonary function tests 6MWT, and QOL. The patients in the control and treatment groups were administered with vitamin D at a dose of 1,000 and 5,000 IU, respectively, for three months.&lt;strong&gt; Results:&lt;/strong&gt; The administration of vitamin D to the patients in the control and treatment groups can significantly reduce oxidative stress, as evidenced by reduced MDA (p-value &amp;lt; 0.01) and MMP-9 levels (p-value &amp;lt; 0.01). Vitamin D affects exercise tolerance, as evidenced by 6MWT (p-value = 0.01). Vitamin D affects the quality of life, as evidenced by 6MWT (p-value = 0.01). Vitamin D affects Nrf2 levels (p-value = 0.08) and HDAC2 (p-value = 0.01). &lt;strong&gt;Conclusion: &lt;/strong&gt;The pathway analysis through the study of the Nrf2, HDAC2, MMP-9, and MDA levels does not prove that vitamin D can prevent decreased lung function and quality of life in patients with stable COPD.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><work-type><style face="normal" font="default" size="100%">Original Article </style></work-type><section><style face="normal" font="default" size="100%">274</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p&gt;&lt;strong&gt;Adyan Donastin&lt;sup&gt;1&lt;/sup&gt;, Muhammad Amin&lt;sup&gt;2,*&lt;/sup&gt;, Yulistiani&lt;sup&gt;3&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p&gt;&lt;sub&gt;1&lt;/sub&gt;Doctoral-Level Medical Science Study Program, Faculty of Medicine, Airlangga University, Surabaya, INDONESIA; Faculty of Medicine, Nahdhatul Ulama Surabaya University, Surabaya, INDONESIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;2&lt;/sup&gt;Pulmonology and Respiratory Medicine, Faculty of Medicine, Airlangga University, Surabaya, INDONESIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;3&lt;/sup&gt;Faculty of Pharmacy, Airlangga University, Surabaya, INDONESIA.&lt;/p&gt;
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