<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">B. Lalruatfela</style></author><author><style face="normal" font="default" size="100%">P. B. Lalthanpuii</style></author><author><style face="normal" font="default" size="100%">C. Lalrinmawia</style></author><author><style face="normal" font="default" size="100%">K. Lalchhandama</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Immunomodulatory and Antiallergic Potentials of the Bioactive  Compounds of Ginger</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Allergy</style></keyword><keyword><style  face="normal" font="default" size="100%">Ginger</style></keyword><keyword><style  face="normal" font="default" size="100%">Histamine Receptor; Leukotriene Receptor</style></keyword><keyword><style  face="normal" font="default" size="100%">Molecular Modelling</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2023</style></year><pub-dates><date><style  face="normal" font="default" size="100%">December 2023</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">15</style></volume><pages><style face="normal" font="default" size="100%">1166-1176</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background: &lt;/strong&gt;Allergy is an ever-increasing immune disorder and is often fatal under certain circumstances. Lack of total curative medication prompts the search for various compounds as the lead molecules. Ginger, &lt;em&gt;Zingiber officinale Roscoe&lt;/em&gt;, is a well-established medicinal plant in different traditional practices. Its use as antiallergic or anti-inflammatory agent has been vindicated but the underlying mechanism of action is yet unknown. &lt;strong&gt;Method:&lt;/strong&gt; In this study, we analyzed the phytocompounds characterized from ginger for their binding affinities on cysteinyl leukotriene receptor 1 (CysLTR1) and histamine H1 receptor (H1R) by molecular docking. The molecular interactions were compared against known agonists and antagonists of the two receptors. &lt;strong&gt;Results: &lt;/strong&gt;The data indicate that ginger compounds have high binding affinity for both LTR1 and H1R comparable to those of antiallergic medications. The highest binding affinities were recorded for gingerenone-A (-7.3 kcal/mol) and zingiberol (-7.2 kcal/mol) on LTR1; and gingerenone-A (-8.7 kcal/mol) and α-curcumene (-8.0 kcal/mol) on H1R.&lt;strong&gt; Conclusion: &lt;/strong&gt;In addition to antiallergic activity, molecular predications on the probable biological activities of the ginger compounds show that they can have a variety of medicinal applications including immunomodulatory and anticancer activities.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">1166</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;B. Lalruatfela&lt;sup&gt;1&lt;/sup&gt; , P. B. Lalthanpuii&lt;sup&gt;2&lt;/sup&gt; , C. Lalrinmawia&lt;sup&gt;2 &lt;/sup&gt;, K. Lalchhandama&lt;sup&gt;1,2&lt;/sup&gt;*&lt;/strong&gt;&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Zoology, Pachhunga University College, Mizoram University, Aizawl 796001, INDIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;2&lt;/sup&gt;DBT-BUILDER National Laboratory, Pachhunga University College, Mizoram University, Aizawl 796001, INDIA.&lt;/p&gt;
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