<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Piracha Jumpa-ngern</style></author><author><style face="normal" font="default" size="100%">Parunkul Tungsukruthai</style></author><author><style face="normal" font="default" size="100%">Chuntida Kamalashiran</style></author><author><style face="normal" font="default" size="100%">Somboon Kietinun</style></author><author><style face="normal" font="default" size="100%">Kesara Na- Bangchang</style></author><author><style face="normal" font="default" size="100%">Kusuma Sriyakul</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Safety Assessment of Oral Lysiphyllum strychnifolium Aqueous Extract in Healthy Volunteers</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Clinical study</style></keyword><keyword><style  face="normal" font="default" size="100%">Healthy volunteers</style></keyword><keyword><style  face="normal" font="default" size="100%">Lysiphyllum strychnifolium</style></keyword><keyword><style  face="normal" font="default" size="100%">Safety</style></keyword><keyword><style  face="normal" font="default" size="100%">Yanang Daeng</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2024</style></year><pub-dates><date><style  face="normal" font="default" size="100%">February 2024</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">16</style></volume><pages><style face="normal" font="default" size="100%">235-240</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background:&lt;/strong&gt; &lt;em&gt;Lysiphyllum strychnifolium&lt;/em&gt; (LS), widely known as Ya nang daeng in Thailand, is a traditional herbal remedy that has long been used to promote health and treat diverse health conditions, especially detoxification, by alleviating the severity of symptoms and lowering the risks associated with toxic exposures. Although it is extensively used in Thailand, human safety studies have been lacking. Thus, this study aimed to examine the safety of using LS capsules in healthy participants through a Phase I clinical trial. &lt;strong&gt;Objective:&lt;/strong&gt; This study aimed to investigate the safety of aqueous extract of LS in twenty-four healthy Thai participants. &lt;strong&gt;Method: &lt;/strong&gt;The participants were received 1,000 mg of LS aqueous extract each morning before their meals for seven days. All participants were examined safety assessment including history taking, physical examination, and laboratory tests at day 0, 8 and 14 (follow-up). &lt;strong&gt;Results:&lt;/strong&gt; The findings showed that there were no significant side effects or abnormalities found during the history taking, physical examination, or laboratory evaluation. Particularly, when compared to baseline, participants who received LS experienced statistically significant reductions in blood sugar, triglyceride, LDL cholesterol, and creatinine (P &amp;lt; 0.05), but still within normal ranges. &lt;strong&gt;Conclusions:&lt;/strong&gt; Dietary supplementation with 1,000 mg of LS aqueous extract per day may have a beneficial effect on blood sugar and cholesterol management while remaining safe for healthy people.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">235</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Piracha Jumpa-ngern&lt;sup&gt;1&lt;/sup&gt;, Parunkul Tungsukruthai&lt;sup&gt;1&lt;/sup&gt;, Chuntida Kamalashiran&lt;sup&gt;1&lt;/sup&gt;, Somboon Kietinun&lt;sup&gt;1&lt;/sup&gt;, Kesara Na-Bangchang&lt;sup&gt;2,3&lt;/sup&gt;, Kusuma Sriyakul&lt;sup&gt;1,&lt;/sup&gt;*&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Integrative Medicine, Chulabhorn International College of Medicine, Thammasat University, Pathumthani 12120, THAILAND.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Graduate Program in Bioclinical Sciences, Chulabhorn International College of Medicine, Thammasat. University, Pathum Thani 12120, THAILAND.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Drug Discovery and Development Center, Office of Advanced Science and Technology, Thammasat University, Pathumthani 12120, THAILAND.&lt;/p&gt;
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