<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Olivia Des Vinca Albahana Napitupulu</style></author><author><style face="normal" font="default" size="100%">Gusbakti Rusip</style></author><author><style face="normal" font="default" size="100%">Maya Sari Mutia</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Therapeutic Effects of Combined Zinc and α-Tocopherol Administration in a Rat Model of Staphylococcus aureus-Induced Sepsis</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">CRP</style></keyword><keyword><style  face="normal" font="default" size="100%">Histopathology</style></keyword><keyword><style  face="normal" font="default" size="100%">IL-6</style></keyword><keyword><style  face="normal" font="default" size="100%">Oxidative stress</style></keyword><keyword><style  face="normal" font="default" size="100%">Sepsis</style></keyword><keyword><style  face="normal" font="default" size="100%">Staphylococcus aureus</style></keyword><keyword><style  face="normal" font="default" size="100%">TNF-α</style></keyword><keyword><style  face="normal" font="default" size="100%">Vitamin E</style></keyword><keyword><style  face="normal" font="default" size="100%">zinc</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2025</style></year><pub-dates><date><style  face="normal" font="default" size="100%">December 2025</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">17</style></volume><pages><style face="normal" font="default" size="100%">275-283</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;Sepsis induces systemic inflammation through excessive production of proinflammatory cytokines, leading to oxidative stress, tissue damage, and multiorgan dysfunction. This study aimed to evaluate the synergistic effects of combined zinc and vitamin E (α-tocopherol) supplementation on inflammatory and biochemical parameters in&lt;em&gt; Staphylococcus aureus&lt;/em&gt;-induced sepsis in male Wistar rats. Thirty rats were divided into six groups: (1) normal control, (2) Placebo control (sepsis without therapy), (3) positive control (levofloxacin 45 mg/kg BW + zinc 0.9 mg/kg BW + vitamin E 250 mg/kg BW), and (4–6) treatment groups receiving combined zinc (0.9, 1.8, and 2.7 mg/kg BW) with vitamin E (250 mg/kg BW). Sepsis was induced intraperitoneally, followed by treatment according to group. On day 9, serum levels of TNF-α, IL-6, CRP, AST, ALT, urea, creatinine, and albumin were analyzed, while lung and kidney, were examined histologically. The combination of zinc and vitamin E significantly decreased TNF-α, IL-6, and CRP levels while improving biochemical parameters and increasing serum albumin compared to the untreated group (p ≤ 0.05). The highest efficacy was observed with zinc 2.7 mg/kg BW and vitamin E 250 mg/kg BW, which showed over 50% reduction in tissue damage, reduced inflammatory cell infiltration and interstitial hemorrhage in lung tissue, and improved hepatic cellular regeneration. These findings suggest that zinc and vitamin E exert synergistic anti-inflammatory and antioxidative effects, indicating their potential as adjuvant therapy in sepsis management.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">275</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Olivia Des Vinca Albahana Napitupulu&lt;sup&gt;1&lt;/sup&gt;, Gusbakti Rusip&lt;sup&gt;2*&lt;/sup&gt;, Maya Sari Mutia&lt;sup&gt;3&lt;/sup&gt; &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Doctoral Program, Faculty of Medicine, Universitas Prima Indonesia, Medan, INDONESIA&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Family Medicine, Faculty of Medicine, Universitas Prima Indonesia, Medan, INDONESIA&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Deparment of Histology, Faculty of Medicine, Universitas Prima Indonesia, Medan, INDONESIA&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Novita Sari</style></author><author><style face="normal" font="default" size="100%">Bambang Pujo Semedi</style></author><author><style face="normal" font="default" size="100%">Prananda Surya Airlangga</style></author><author><style face="normal" font="default" size="100%">Kohar Hari Santoso</style></author><author><style face="normal" font="default" size="100%">Maulydia</style></author><author><style face="normal" font="default" size="100%">Budi Utomo</style></author><author><style face="normal" font="default" size="100%">Christrijogo Sumartono</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Can Ventilator Settings Influence Lung Damage Biomarkers KL-6 and CRP during One Lung Ventilation?</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">CRP</style></keyword><keyword><style  face="normal" font="default" size="100%">KL-6</style></keyword><keyword><style  face="normal" font="default" size="100%">One lung ventilation</style></keyword><keyword><style  face="normal" font="default" size="100%">Thoracotomy</style></keyword><keyword><style  face="normal" font="default" size="100%">Ventilator</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2024</style></year><pub-dates><date><style  face="normal" font="default" size="100%">April 2024</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">16</style></volume><pages><style face="normal" font="default" size="100%">455-459</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background:&lt;/strong&gt; Volume-controlled (VCV) or pressure-controlled ventilation (PCV) modes are most often used during OLV. This is a prospective observational analytical study of patients undergoing thoracic surgery with OLV. &lt;strong&gt;Method:&lt;/strong&gt; 40 patients underwent thoracic surgery using one lung ventilation (OLV) from December 2023 to February 2024. All patients received lung protective ventilation (PLV) with a tidal volume of 6 ml/ kgPBW during OLV with PEEP 5-7 cmH2O and were divided into two groups: one with a ventilator in volume-controlled mode (VCV) and the other with pressure-controlled mode (PCV). KL-6, CRP, and p/f ratio were measured before OLV, 2 hours after OLV, and 24 hours after the operation was completed. Respiratory variables during OLV were recorded. &lt;strong&gt;Results:&lt;/strong&gt; KL-6 and CRP levels in PCV and VCV groups were significantly different. There were significant differences in the values of Ppeak (p &amp;lt;0.001), PEEP (p = 0.008), Cstat (p = 0.004) and driving pressure (p &amp;lt;0.001) in both groups. The correlation between changes in KL-6 and CRP levels and the P/F ratio were very weak and insignificant. Cytokines play an important role in the inflammatory response in the lungs. Several determining factors of blood flow are gravity, lung disease, surgery, and hypoxic pulmonary vasoconstriction. Duration of OLV may affect the pulmonary inflammatory response and is correlated with the duration of OLV.&lt;strong&gt; Conclusion: &lt;/strong&gt;There is no association found between KL-6 and CRP in PCV and VCV mode during thoracotomy with OLV.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">2</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">455</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p&gt;&lt;strong&gt;Novita Sari&lt;sup&gt;1&lt;/sup&gt;, Bambang Pujo Semedi&lt;sup&gt;2*&lt;/sup&gt;, Prananda Surya Airlangga&lt;sup&gt;2&lt;/sup&gt;, Kohar Hari Santoso&lt;sup&gt;2&lt;/sup&gt;, Maulydia&lt;sup&gt;2&lt;/sup&gt;, Budi Utomo&lt;sup&gt;3&lt;/sup&gt;, Christrijogo Sumartono&lt;sup&gt;2&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;1&lt;/sup&gt;Study Program of Anesthesiology and Intensive Care, Faculty of Medicine, University of Airlangga – Dr Soetomo General Hospital, Surabaya, Indonesia&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Anesthesiology and Intensive Care, Faculty of Medicine, University of Airlangga – Dr Soetomo General Hospital, Surabaya, INDONESIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Public Health and Preventive Medicine, Faculty of Medicine, University of Airlangga – Dr Soetomo General Hospital, Surabaya, INDONESIA.&lt;/p&gt;
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